Activation of cannabinoid type 2 (CB2) receptors promotes the maintenance of redox homeostasis and protects against oxidative distress in the Neotropical freshwater fish matrinxã Brycon amazonicus (Characiformes: Bryconidae) by Suzana Luisa Alves Fernandes, Yan Costa Gonçalves, Francisco Tadeu Rantin, Ana Lúcia Kalinin, Diana Amaral Monteiro

“…In both the liver and the heart, CB1+CB2 activation led to significant increases in catalase (CAT) and glutathione peroxidase (GPx) activities, accompanied by decreases in glutathione reductase (GR) activity. …”
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Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-γ to Inhibit the NF-κB/NLRP3 Inflammatory Axis in Spinal Cord Neurons by Jie Fu, Baoxia Zhao, Chaobo Ni, Huadong Ni, Longsheng Xu, Qiuli He, Miao Xu, Chengfei Xu, Ge Luo, Jianjun Zhu, Jiachun Tao, Ming Yao

“…We found that rosiglitazone treatment relieved bone cancer-induced mechanical hyperalgesia in a dose-dependent manner, promoted the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) in spinal cord neurons, and inhibited the activation of the nuclear factor-kappa B (NF-κB)/nod-like receptor protein 3 (NLRP3) inflammatory axis induced by BCP. …”
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Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice by Minghui Wang, Shangsheng Yao, Dehua He, Mulan Qahar, Jinqing He, Meifang Yin, Jun Wu, Guang Yang

“…Moreover, T2DM inhibited the activation of Lgr5 HFSC and the expression of WNT4 and WNT8A. …”
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A multi-modal social media data analysis framework: Exploring the complex relationships among urban environment, public activity, and public perception—A case study of Xi’an, China by Chuyi Guo, Yuchi Yang

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Effects of intrathecal administration of sodium nitroprusside and nicardipine on cerebral pial microcirculation, cortical tissue oxygenation, and electrocortical activity in the early post-resuscitation period in a porcine cardiac arrest model. by Hyoung Youn Lee, Najmiddin Mamadjonov, Kyung Woon Jeung, Yong Hun Jung, Wan Young Heo, Yong Soo Cho, Byung Kook Lee, Tag Heo

“…The mean arterial pressure was lower in the nicardipine group (coefficient [95% confidence interval {CI}], -15.824 [-24.082 to -7.566]) and higher in the SNP group (coefficient [95%CI], 11.232 [2.974-19.490]) compared to the saline group. …”
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The global, regional, and national burden of type 2 diabetes mellitus attributable to low physical activity from 1990 to 2021: a systematic analysis of the global burden of disease study 2021 by Jiehua Wei, Luying Fan, Zixuan He, Senmao Zhang, Ying Zhang, Xidi Zhu, Fan Xia, Xinli Song, Lizhang Chen, Zhiyong Zou, Tingting Wang

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Bone marrow mesenchymal stem cell-originated exosomes suppress activation of hepatic stellate cells through the miR-144-3p/SLC7A11 axis by Yanqin Hao, Rong Wang, Qing Zhou, Jiaolong Ren

Subjects: “…hepatic stellate cell activation…”
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PCR-detection rates of T. pallidum ssp. pallidum in swab samples from the Czech Republic (2004–2022): Combined RPR, IgM, and PCR tests efficiently detect active syphilis by Eliška Vrbová, Petra Pospíšilová, Eliška Dastychová, Martina Kojanová, Miluše Kreidlová, Daniela Vaňousová, Filip Rob, Přemysl Procházka, Alena Krchňáková, Vladimír Vašků, Radim Strnadel, Olga Faustmannová, Monika Dvořáková Heroldová, Ivana Kuklová, Hana Zákoucká, David Šmajs

“…A combination of RPR + PCR, or a combination of all three tests (RPR, IgM, and PCR) can therefore be used to reliably detect active syphilis cases, including reinfections. Our findings show that the reverse algorithm for detecting syphilis could be substantially improved by adding IgM and PCR testing.…”
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Activity of Aztreonam-avibactam and other β-lactamase inhibitor combinations against Gram-negative bacteria isolated from patients hospitalized with pneumonia in United States medical centers (2020–2022) by Helio S. Sader, Rodrigo E. Mendes, S. J. Ryan Arends, Timothy B. Doyle, Mariana Castanheira

“…Ceftazidime-avibactam and meropenem-vaborbactam were highly active against KPC and SME producers but showed limited activity against MBL producers. …”
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The antiarthritic effect of CBR‐470‐1 in hypoxic environment is to increase the level of NOD‐like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity by Ao Duan, Zemeng Ma, Xiaolong Shao, Zhencheng Xiong, Chaoyi Zhang, Wenzheng Liu, Guanglin Wang, Shouye Hu, Wei Lin

“…Abstract Background Hypoxia can affect the occurrence and development of inflammation in humans, but its effects on the disease progression of osteoarthritis (OA) remain unclear. …”
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Effect of Ultrafine Powderization and Solid Dispersion Formation via Hot-Melt Extrusion on Antioxidant, Anti-Inflammatory, and the Human Kv1.3 Channel Inhibitory Activities of Angelica gigas Nakai by Yunyao Jiang, Jingpei Piao, Nan Liu, Jincai Hou, Jianxun Liu, Weicheng Hu

“…The potential antioxidant and anti-inflammatory activities of AGN with a different process were compared, and the effect on the human Kv1.3 potassium channel was detected. …”
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A curative effect evaluation of intensity-modulated radiation therapy combined with periorbital triamcinolone acetonide injection in treating thyroid eye disease patients with active extraocular muscle but low CAS by Hao Zhang, Weimin He

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Physicochemical Properties, Antioxidant Activity, and Flavor Profile of Strawberry Fruit-Based Novel Drinking Jelly Made with <i>Gracilaria fisheri</i> Seaweed as a Gelling Agent at Varying Concentrations by Narin Charoenphun, Paramee Noonim, Somwang Lekjing, Chawakwan Nitikornwarakul, Nam Hoang Pham, Karthikeyan Venkatachalam

“…<i>Gracilaria fisheri</i> (GF) is a red seaweed that is widely found in Southeast Asia and has gained attention for its potential bioactive compounds and versatile applications in food products. …”
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FORMULATION AND TEST OF ANTIBACTERIAL ACTIVITY OF EMULGEL ESSENTIAL OIL OF CITRONELLA (CYMBOPOGON NARDUS (L.)... by Sinta Ratna Dewi, Sylvan Septian Ressandy, Lidya Handoko, Jati Pratiwi, Widya Rahmah

“…Conclusion: Inhibitory activity test of the preparations obtained the average diameter of citronella oil emulgel preparations and aloe vera extract at concentrations of F1 (6%:4%), F2 (4%:6%), and F3 (5%:10%) are 11 mm, 10.7 mm and 16 mm and the ability to inhibit bacteria by all concentrations was in a strong category. …”
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Influence of food availability on the diet and activity budget of two western lowland gorilla (Gorilla gorilla gorilla) groups of differing size in the Dzanga-Ndoki National Park, Central African Republic by Terence Fuh Neba, Giuseppe Donati, Angelique Todd, Shelly Masi

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Review and Evaluation of European National Clinical Practice Guidelines for the Treatment and Management of Active Charcot Neuro-Osteoarthropathy in Diabetes Using the AGREE-II Tool Identifies an Absence of Evidence-Based Recommendations by Nichola Renwick, Jennifer Pallin, Rasmus Bo Jansen, Catherine Gooday, Aroa Tardáguila-Garcia, Irene Sanz-Corbalán, Anastasios Tentolouris, Alexandra Jirkovská, Armin Koller, Anna Korzon-Burakowska, Nina Petrova, Frances Game

“…Conclusions: European national CPGs for diabetes provide limited recommendations on active CNO. All guidelines showcased deficits in their methodology, suggesting that more rigorous methods should be employed for diabetes CPG development across Europe.…”
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Mitochondrial ATP-Sensitive K+ Channel Opening Increased the Airway Smooth Muscle Cell Proliferation by Activating the PI3K/AKT Signaling Pathway in a Rat Model of Asthma by Min Gao, Qinran Sun, Qingfa Liu

“…The ASMCs were treated with a potent activator of mitoKATP, diazoxide, or an inhibitor of mitoKATP, 5-hydroxydecanoate (5-HD). …”
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Synthesis and Biological Activity of (Z) –n-(5-Benzylidene-4-oxo-2-substituted- phenylthiazolidin-3-yl)-5-((1, 3-dioxoisoindolin-2-yl)methyl)-2-hydroxybenzamide by M. C. Patel, Dhameliya

“…All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.…”
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The role of text in teaching foreign languages by T. A. Baranovskaya

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