Synthesis and Oral Hypoglycemic Activity of 3-[5'-Methyl-2'-aryl-3'-(thiazol-2ʺ-yl amino) thiazolidin-4'-one]coumarin Derivatives by Deepthi Kini, Manjunath Ghate

“…All the synthesized compounds were characterized and screened for hypoglycemic activity. Some of the compounds exhibited promising activity.…”
Get full text

Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro by Thanh Nguyen Tan, Hieu Tran Trung, Quang Le Dang, Hien Vu Thi, Hoang Dinh Vu, Tuan Nguyen Ngoc, Hoai Thu Thi Do, Thanh Huong Nguyen, Dang Ngoc Quang, Thang Tran Dinh

“…Notably, chisocheton compound G (3) isolated from A. polystachya and khayanolide B (8) isolated from S. macrophylla were the most potent antifungal limonoids and exhibited a dose-dependent activity against Phytophthora species. Compounds 2 and 9 displayed moderate activity against M. oryzae. …”
Get full text

Self-reported sexually transmitted infections and associated factors among sexually active men in East Africa: a multilevel analysis of recent demographic and health surveys by Beminate Lemma Seifu, Yohannes Mekuria Negussie, Bezawit Melak Fente, Zufan Alamrie Asmare, Angwach Abrham Asnake, Meklit Melaku Bezie, Hiwot Atlaye Asebe

“…An adjusted OR with the corresponding 95% CI was used to estimate the strength of the association, and statistical significance was set at a p value <0.05.Results The pooled prevalence of self-reported STIs among sexually active men in East Africa was 5.22% (95% CI: 5.34, 5.69). …”
Get full text

Ten days of supplementation with a standardized Boswellia serrata extract attenuates soreness and accelerates recovery after repeated bouts of downhill running in recreationally active men by Dawna Salter, Himana Yalamanchi, Aiswarya Yalamanchi, Amulya Yalamanchi

“…Frontiers in Sports and Active Living…”
Get full text

2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities by Raman Singh, Vidushi Gupta, Antresh Kumar, Kuldeep Singh

“…The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. …”
Get full text

Adsorption of Some Transition Metal Ions [Cu(II), Fe(III), Cr(III) and Au(III)] onto Lignite-Based Activated Carbons Modified by Oxidation by Paunka St. Vassileva, Albena K. Detcheva

“…The uptake of Au(III) ions was almost 100% for the three adsorbents investigated, being greater than 300 mg/ℓ and independent of the pH over the pH range studied. The initial activated carbon proved to be the most suitable for the selective adsorption of Au(III) ions from aqueous solutions in the presence of other transition metal ions, while its oxidized modification Ch-P exhibited an enhanced adsorption efficiency towards transition metals.…”
Get full text

Free Radical-Scavenging, Anti-Inflammatory, and Antibacterial Activities of Water and Ethanol Extracts Prepared from Compressional-Puffing Pretreated Mango (Mangifera indica L.)... by Chun-Yung Huang, Chia-Hung Kuo, Chien-Hui Wu, Ai-Wei Kuan, Hui-Ru Guo, Yu-Hua Lin, Po-Kai Wang

“…The phenolic compound compositions as well as the free radical-scavenging, anti-inflammatory, and antibacterial activities of water extract (WE) and ethanol extract (EE) from nonpuffed (NP) and compressional-puffed (CP) mango peels were further evaluated. …”
Get full text

Modified Endothelial Activation and Stress Index: A New Predictor for Survival Outcomes in Classical Hodgkin Lymphoma Treated with Doxorubicin-Bleomycin-Vinblastine-Dacarbazine-Based Therapy by Fazıl Çağrı Hunutlu, Hikmet Öztop, Vildan Gürsoy, Tuba Ersal, Ezel Elgün, Şeyma Yavuz, Selin İldemir Ekizoğlu, Azim Ali Ekizoğlu, Vildan Özkocaman, Fahir Özkalemkaş

“…Thus, a biomarker that can predict patients with early progression at the time of diagnosis is an unmet clinical need. Endothelial activation and stress index (EASIX) and its variant modified EASIX (mEASIX) is a scoring system currently used for the prediction of prognosis in hematologic malignancies. …”
Get full text

Interferon (IFN)-gamma (γ) inducible protein 10 (IP-10) in the diagnosis of latent and active tuberculosis in Bacille Calmette Guerin (BCG)-vaccinated pediatric population. by Magdalena Druszczynska, Michał Seweryn, Sebastian Wawrocki, Anna Pankowska, Anastasiia Kulbachko, Magdalena Jurczak, Magdalena Kowalewska-Pietrzak

“…Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.tb) infection (LTBI) that have a high risk of progressing to active TB disease remains a significant diagnostic hurdle.…”
Get full text

Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway by Yuqin Ye, Zhenyu Zhao, Hongyu Xu, Xin Zhang, Xinhong Su, Yongxiang Yang, Xinguang Yu, Xiaosheng He

“…The results showed that a marked upregulation of S1PR1 occurred with a peak at 7 days after trauma, revealing an enhancement of proliferation and neuronal differentiation of NSCs in hippocampus due to S1PR1 activation. More importantly, it was suggested that mitogen-activated protein kinase-Erk kinase (MEK)/Erk cascade was required for S1PR1-meidated neurogenesis and neurocognitive recovery following TBI. …”
Get full text

Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice by Tianchan Peng, Jian Xiang, Yun Tian, Xiaogen Tang, Lina Wang, Lijuan Gao, Oscar Junhong Luo, Li’an Huang, Guobing Chen

“…Objective: To investigate the geroprotective effects of Lycium barbarum glycopeptide (LbGp) and its potential mechanisms in a D-galactose-induced accelerated aging mouse model. …”
Get full text

Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione, para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity by Rakesh N. Mistry, K. R. Desai

“…Structure elucidation of synthesised compounds has been made on the basis of elemental analysis, I.R. spectral studies and 1H N.M.R. spectral studies. The antimicrobial activity of the synthesised compounds has been studied against the cultures “Staphylococcus aureus”, “Escherichia coli” and “Candela albicans”.…”
Get full text

Comprehensive Characterization of the Odor-Active Compounds in Different Processed Varieties of Yunnan White Tea (<i>Camellia sinensis</i>) by GC×GC-O-MS and Chemometrics by Junaid Raza, Baosong Wang, Yue Duan, Huanlu Song, Ali Raza, Dongfeng Wang

Subjects: Get full text

Nutritional Composition, Antinutritional Factors, Antioxidant Activities, Functional Properties, and Sensory Evaluation of Cactus Pear (Opuntia ficus-indica) Seeds Grown in Tigray Region, Ethiopia by Tewelde Hailemicheal Reda, Mulubrhan Kahsay Atsbha

Get full text

Synthesis, Characterization and Primary Antimicrobial, Antifungal Activity Evaluation of Schiff bases of 4-Chloro-(3-substituted-phenylimino) - methyl-[2H] - chromene-2-one by Amit Kasabe, Vijay Mohite, Jayesh Ghodake, Jaydeep Vidhate

“…Seldom did a particular structural modification lead to uniform alteration in activity in all tests. The substitution which appeared to be most important for high order of activity in the number of test was the 3-chloro phenylimino group. …”
Get full text

Feasibility and effectiveness of a group therapy combining physical activity, surf therapy and cognitive behavioral therapy to treat adolescents with depressive disorders: a pilot study by Bettina Hearn, Monica Biscaldi, Reinhold Rauh, Christian Fleischhaker

Subjects: Get full text

Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway by Zhou A, Feng HY, Fan CN, Wang J, Yuan ZY, Xu GH, Li CF, Huang WF, Yi LT

“…Our research aims to elucidate the potential antidepressant mechanisms of asiaticoside, a bioactive compound known for its neuroprotective and immunomodulatory properties.Methods: The antidepressant-like properties of asiaticoside in a model of chronic restraint stress (CRS)-induced depression in mice, with a particular focus on its interaction with ferroptosis-related pathways.Results: The behavioral results revealed that asiaticoside significantly ameliorated CRS-induced depressive symptoms, as evidenced by increased sucrose preference and reduced immobility time. …”
Get full text

Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correlation by Ana Cristina Araújo Lemos Silva, Blenda Sousa Carli Rodrigues, Adilha Misson Rua Micheletti, Sebastião Tostes, Antonio Carlos Oliveira Meneses, Mário Leon Silva-Vergara, Sheila Jorge Adad

“…There was no difference when compared the frequency of lesion among the groups; however, toxoplasmosis was less common while HIV encephalitis was more frequent in group C related to A. …”
Get full text

Finding Ways to Lift Barriers to Care for Chronic Pain Patients: Outcomes of Using Internet-Based Self-Management Activities to Reduce Pain and Improve Quality of Life by Kevin Rod

“…To evaluate the impact of Internet-based patient self-management education and activities on patients’ pain, anxiety, and quality of life in patients who could not access multidisciplinary pain management. …”
Get full text

Correction: Efficacy and safety of jaktinib hydrochloride tablets in active axial spondyloarthritis: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial

Get full text