Influence of Polyphenol Extract from Evening Primrose (Oenothera Paradoxa) Seeds on Proliferation of Caco-2 Cells and on Expression, Synthesis and Activity of Matrix Metalloproteinases and Their Inhibitors by Szewczyk Karolina, Lewandowska Urszula, Owczarek Katarzyna, Sosnowska Dorota, Gorlach Sylwia, Koziołkiewicz Maria, Hrabec Zbigniew, Hrabec Elżbieta

“…The aim of our studies was to evaluate the influence of a polyphenol extract from defatted seeds of evening primrose on human colorectal adenocarcinoma Caco-2 cell proliferation and matrix metalloproteinases (MMPs) synthesis and activity. To assess the effect of evening primrose extract on Caco-2 cell proliferation, crystal violet staining and sulforhodamine B (SRB) assays were used whereas mRNA expression and activity of MMPs were evaluated by RT-PCR and gelatin zymography.…”
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A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties? by Vasiliki D. Papakonstantinou, Nefeli Lagopati, Effie C. Tsilibary, Constantinos A. Demopoulos, Athanassios I. Philippopoulos

“…In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. …”
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MsCL-P1: A multifunctional C-type lectin from largemouth bass (Micropterus salmoides) with broad microbe binding and agglutination activities by Siyi She, Ying Ye, Fengyao Guo, Shun Yang, Mengmeng Huang, Hui Fei

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High Glucose Exacerbates TNF-α-Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through Upregulation and Activation of TNF Receptor 1 by Wenjun Zhu, Qihong Qiu, Haoyuan Luo, Fuping Zhang, Juan Wu, Xiaorui Zhu, Min Liang

“…High glucose exacerbates TNF-α-induced proliferative inhibition in human periodontal ligament stem cells through the upregulation and activation of TNF receptor 1. Inhibition of intracellular ROS expression by vitamin C partially rescues PDLSCs in terms of cell proliferation.…”
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Phenolic Content and Antioxidant and Antimicrobial Activities of Malva sylvestris L., Malva oxyloba Boiss., Malva parviflora L., and Malva aegyptia L.... by Khalid A. Shadid, Ashok K. Shakya, Rajashri R. Naik, Nidal Jaradat, Husni S. Farah, Naeem Shalan, Nooman A. Khalaf, Ghaleb A. Oriquat

“…Regarding the ferrous ion chelating activity of the extract, the methanolic extract of M. sylvestris exhibits appreciable activity with IC50 values of 52.7 ± 1.8 µg/ml. …”
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Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats by Shadae R. Foster, Lowell L. Dilworth, Jean Sparks, Ruby L. Alexander-Lindo, Felix O. Omoruyi

“…This study evaluated the effect of combined inositol hexakisphosphate (IP6) and inositol supplement on organ weight, intestinal ATPase activities, complete blood count, and serum analytes in streptozotocin (STZ)-induced type 2 diabetic rats. …”
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Trajectories of Objectively Measured Physical Activity among Secondary Students in Canada in the Context of a Province-Wide Physical Education Policy: A Longitudinal Analysis by Erin Hobin, Jannice So, Laura Rosella, Melisa Comte, Steve Manske, Jonathan McGavock

“…Lower levels of physical activity are associated with childhood obesity. School physical education (PE) policies have been identified as critical to improve child and adolescent physical activity levels but there has been little evaluation of such policies. …”
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Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway by Li-juan Du, Bing Pang, Yu-meng Tan, Ya-nan Yang, Mei-zhen Zhang, Qing Pang, Min Sun, Qing Ni

“…Malondialdehyde and glutathione peroxidase content and superoxide dismutase activity were measured using commercial kits. The expression of PI3K/AKT/FOXO1 signaling pathway-related signal molecules, and that of apoptotic indicators Bax, P27, and Caspase-3, was quantified using western blotting. …”
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The development and pilot testing of a behavioral activation-based treatment for depressed mood and multiple health behavior change in patients with recent acute coronary syndrome. by Emily C Gathright, Katherine Diaz Vickery, Woubeshet Ayenew, Matthew C Whited, Melissa Adkins-Hempel, Michelle Chrastek, Jill K Carter, Rochelle K Rosen, Wen-Chih Wu, Andrew M Busch

“…Behavioral Activation for Health and Depression (BA-HD) was developed and pilot tested in a multiphase iterative process.…”
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Granulocyte-Macrophage Colony-Stimulating Factor-Activated Neutrophils Express B7-H4 That Correlates with Gastric Cancer Progression and Poor Patient Survival by Zhi-guo Shan, Zong-bao Yan, Liu-sheng Peng, Ping Cheng, Yong-sheng Teng, Fang-yuan Mao, Kun Fan, Yuan Zhuang, Yong-liang Zhao

“…Moreover, GC tumor-derived GM-CSF activated neutrophils and induced neutrophil B7-H4 expression via Janus kinase (JAK)-signal transducer and activator of transcription 3 (STAT3) signaling pathway activation. …”
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Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231 by Vincenza Barresi, Carmela Bonaccorso, Domenico A. Cristaldi, Maria N. Modica, Nicolò Musso, Valeria Pittalà, Loredana Salerno, Cosimo G. Fortuna

“…Based on the obtained results, we constructed a Volsurf+ (VS+) model using a dataset of 59 compounds able to predict the in vitro antitumor activity against MCF-7 cancer cell line for new derivatives. …”
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Establishment of wetland conservation networks in response to climate change and anthropogenic activities: A case study from the Liaohe River Basin in Liaoning Province, China by Kexin Chen, Shuxiu Liang, Pifu Cong, Zhaochen Sun

“…Wetlands are undergoing rapid transformations due to climate change and human activities, necessitating proactive conservation efforts. …”
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Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration by Bysani Chandrasekar, Srinivas Mummidi, Vincent G. DeMarco, Yusuke Higashi

“…OxLDL-induced cardiotrophin (CT)-1 expression and CT-1 stimulated SMC proliferation and migration in part via leukemia inhibitory factor receptor (LIFR) and glycoprotein 130 (gp130). …”
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Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E2 and F2α Metabolites, in the Offspring of Rats with Streptozotocin-Induced Diabetes by Hisham Y. Al-Matubsi, Ghaleb A. Oriquat, Mahmoud Abu-Samak, Othman A. Al Hanbali, Maher D. Salim

“…On day 15 of gestation, the fetuses, placentas, and membranes were dissected, examined morphologically, and then homogenized, to measure cyclooxygenase (COX) activities and metabolisms of prostaglandin (PG) E2 (PGEM) and PGF2α (PGFM) levels. …”
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Effectiveness of physical activity interventions on reducing perceived fatigue among adults with chronic conditions: a systematic review and meta-analysis of randomised controlled trials by Ioulia Barakou, Kandianos Emmanouil Sakalidis, Ulric Sena Abonie, Tracy Finch, Katie L. Hackett, Florentina Johanna Hettinga

“…Abstract Fatigue is barrier of physical activity participation in adults with chronic conditions. …”
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Effects of Exercise Training Combined with Increased Physical Activity to Prevent Chronic Pain in Community-Dwelling Older Adults: A Preliminary Randomized Controlled Trial by Tatsuya Hirase, Hideki Kataoka, Shigeru Inokuchi, Jiro Nakano, Junya Sakamoto, Minoru Okita

“…Pain intensity, total number of pain sites, and physical activity were assessed before and 12 weeks after the intervention. …”
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The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity. by Liam C Hunt, Michelle Curley, Kudzai Nyamkondiwa, Anna Stephan, Jianqin Jiao, Kanisha Kavdia, Vishwajeeth R Pagala, Junmin Peng, Fabio Demontis

“…Mechanistically, UBE2D/eff is necessary to maintain optimal proteasome function: UBE2D/eff knockdown reduces the proteolytic activity of the proteasome, and this is rescued by transgenic expression of human UBE2D2, an eff homolog. …”
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Optimization of Soursop (Annona Muricata L.) Leaf Extract in Nanoemulgel And Antiacnes Activity Test Against Propionibacterium Acnes, Staphylococcus Aureus, Staphylococcus Epidermidis Bacteria. by Asyhari, Hanif Fibiana, Cabral, Kibedi B., Wikantyasning, Erindyah R.

“…Soursop leaf extract (Annona muricata L.) has antibacterial activity with active components of alkaloids, flavonoids, steroids, and saponins. …”
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PENGARUH LAMA PENGGUNAAN MULSA DAN DOSIS PUPUK KANDANG TERHADAP PERTUMBUHAN CABAI (Capsilum Annum) SEBAGAI BAHAN PENYUSUN PETUNJUK PRAKTIKUM BIOLOGI KEL... by Zainal Aripin

Subjects: “…learning biology is one area of natural sciences (ipa) which is integral with practical activities. the lab activities are very important in understanding science concepts. one material that requires practical learning activities more meaningful so that…”
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Institutional Transformations of Higher Education: Key Gaps and New Practices. by L. V. Konstantinova, E. S. Titova, A. M. Petrov

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