Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease by Liu X, Zhang Y, Wang Y, Xu Y, Xia W, Liu R, Xu S

“…Then, the receiver operating characteristic (ROC) curves were plotted for each DIRG, and those with an area under the curve (AUC) greater than 0.9 were selected for subsequent analysis. …”
Get full text

Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Robust in vitro and in vivo data demonstrate the efficacy of this approach and CaO2@ZIF8:CUR@PAA as an anticancer platform, paving the way for nanomaterials in immune-triggered cancer therapy.Highlights: - A new calcium accumulation nanoplatform plays a role in activate antitumor immunity.- Double-locked structure slows down the premature decomposition of CaO2.- The platform allows Ca2+ and H2O2 to accumulate in tumor cells.- This leads to mitochondrial dysfunction, apoptosis, and M1 macrophage polarization.- Potent anti-tumor effects are seen both in vitro and in vivo.Keywords: Calcium ion load, controlled-release nanomaterials, two-layer protective shell, pH responsive drug release, reactive oxygen species, anti-cancer…”
Get full text

THE PUBLIC DEBT OF UKRAINE: A NEW DIMENSION OF DYNAMICS AND ARCHITECTURE OF THE MODEL FRAMEWORK OF THE MANAGEMENT SYSTEM by Serhii Petrukha, Nina Petrukha, Roman Miakota

“…In this context, it is assumed that one of the conditions for the successful implementation of the fiscal correction is the completion of the active phase of the war by the end of 2025 and the consideration of additional caveats regarding the maintenance of a high debt burden in the short, medium and probably the long term perspective due to significant budgetary costs for reconstruction of infrastructure, social protection and economic development. …”
Get full text

Progress of research on aviation kerosene preparation using bioethanol by Pan LI, Yu ZHAO, Xingguo WU, Lulu ZHANG, Junhao HU, Wei CHEN, Jing BAI, Chun CHANG, Shuqi FANG

“…Therefore, a catalyst is proposed for carbon–carbon coupling reaction of aqueous ethanol to produce high-carbon alcohols. The catalyst, with its satisfactory water resistance, can retain its activity and selectivity for high-carbon alcohols even in the presence of water and effectively inhibit the interference of water molecules, thereby increasing the efficiency and stability of the catalytic reaction. …”
Get full text

Divulgação de evidências científicas sobre Práticas Integrativas e Complementares em Saúde by Luciana Fernandes Paulino, Maria Eduarda Ramos da Silva, Yasmin Aguiar Faria Lima, Marina Soares Gonçalves, Thaís Matera Ferraro Teixeira, Neemias Lima da Silva, Bárbara de Lacerda Santos Oliveira, Bianca Nunes Gomes, Fátima Helena do Espírito Santo, Gleyce Moreno Barbosa

“…The challenges contributed to improving this work, which was constantly built jointly by the team to democratize health access in its integrality. Keywords: Knowledge Diffusion; Integral Health; Self-Care; Public Health …”
Get full text

Evaluasi TKTI Puri Saron Hotel Seminyak dengan Framework Cobit 5 by Norsa Yudhi Arso, Made Wisnu Antara Kesiman, Dewa Gede Hendra Divayana

“…The findings of the analysis are centered on the COBIT Process, specifically the domains (EDM04) IT Resources, (APO01) Consistency Management, (APO03) IT Architecture, (APO04) IT Innovation, (APO07) Resource Management, (BAI04) Balancing Flows and Future Needs , (BAI09) Company Assets, (BAI10) Configuration Management, (DSS01) Operations Management, (DSS03) Managing Company Life Cycle Problems, and ( The process of planning, assessing and adjusting Puri Saron Hotel Seminyak for a better direction, and most of the domain activities have been executed, policies and norms have been written, and communication has improved. …”
Get full text

Relato de uma extensão em tempos de isolamento social: Criação de um recurso educacional sobre matemática na pandemia de COVID-19 by Leila Thomazelli Thieghi, Fabio Luiz Sant'Anna Cuppo

“…Throughout the text, several of the topics addressed by the project are presented, as well as its societal impact, its contribution to the learning of undergraduate students involved in the extension program, and the project's outcomes, such as invitations for lectures and interviews, culminating in the proposal of a highly useful educational resource for high school and university students and teachers. …”
Get full text

Analisis Dukungan Petugas Kesehatan Dalam Optimalisasi Competence Baby Care Pada Ibu muda Melalui Pendekatan Maternal Sensitivity Models Berbasis Keluarga (Analysis of Health Of... by diyan indriyani

“…Discussion: It is suggested to the health officials to have more effective and well structured program design in building public perception of baby care, including the training of cadres on an ongoing basis so that the activities of table 5 on Maternal and Child Health services can be improved.   …”
Get full text

Pathogenic potential of ornithogenic <i>Escherichia coli</i> strains detected in the Earth's polar regions by Batyrbek I. Aslanov, Daniil V. Azarov, Maria A. Makarova, Elizaveta G. Marysheva, Lyudmila A. Kraeva, Aleksey S. Mokhov, Ekaterina A. Lebedeva, Nikita E. Goncharov, Natalya V. Lebedeva, Dmitry A. Starikov, Victoria V. Kolodzhieva, Dmitry E. Polev, Artemy E. Goncharov

“…Migratory bird colonies and high latitude avian colonies may be points of active intraspecies and interspecies contact between different animal species, accompanied by the spread of pathogens. …”
Get full text

Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma by Parissa Tabrizian, Rebecca Marino, Sherrie Bhoori, Marcus Zeitlhoefler, Neil Mehta, Vanessa Banz, Salvatore Gruttadauria, Massimo Iavarone, Chiara Mazzarelli, Nicolò Simonotti, Francis Yao, Vincenzo Mazzaferro, Josep M. Llovet

“…Concerns about graft safety and rejection have limited its exploration in the neoadjuvant setting of liver transplantation (LT). …”
Get full text

Anti-LAG-3 antibody LBL-007 plus anti-PD-1 antibody toripalimab in advanced nasopharyngeal carcinoma and other solid tumors: an open-label, multicenter, phase Ib/II trial by Gang Chen, Dong-Chen Sun, Yi Ba, Ya-Xiong Zhang, Ting Zhou, Yuan-Yuan Zhao, Hong-Yun Zhao, Wen-Feng Fang, Yan Huang, Zhen Wang, Chao Deng, De-Sheng Hu, Wei Wang, Jin-Guan Lin, Gui-Ling Li, Su-Xia Luo, Zhi-Chao Fu, Hai-Sheng Zhu, Hui-Li Wang, Sheng-Li Cai, Xiao-Qiang Kang, Li Zhang, Yun-Peng Yang

“…In immunotherapy-naive NPC patients (n = 12), ORR was 33.3%, disease control rate (DCR) was 75%, and median progression-free survival (PFS) was 10.8 months (95% CI, 1.3 to not estimated). In IO-treated NPC patients (n = 17), ORR was 11.8%, DCR was 64.7%, and median PFS was 2.7 months (95% CI, 1.4 to 4.9). …”
Get full text

IGJR 1/2020: Housing crisis: How can we improve the situation for young people? by IF and FRFG

“…The journal is released biannually and employs a double-blind peer review process. Its editorial board consists of about 50 internationally renowned experts from ten different countries. …”
Get full text

IGJR 1/2020: Housing crisis: How can we improve the situation for young people? by IF and FRFG

“…The journal is released biannually and employs a double-blind peer review process. Its editorial board consists of about 50 internationally renowned experts from ten different countries. …”
Get full text

Age-related changes in brain signal variability in autism spectrum disorder by Priyanka Sigar, Nicholas Kathrein, Elijah Gragas, Lauren Kupis, Lucina Q. Uddin, Jason S. Nomi

“…While atypical brain function has been identified in individuals with ASD using fMRI task-activation and functional connectivity approaches, little is known about age-related relationships with resting-state BSV and repetitive behaviors in ASD. …”
Get full text

Construction of Multi-level Ecological Corridor System for National Parks: A Case Study of the Proposed Nanling National Park by Yi DENG, Zeyu HUANG, Ziyi MAO, Jinling HUANG

“…ObjectiveInfluenced by natural environmental changes and human activities, habitat fragmentation has become a widespread phenomenon in protected areas. …”
Get full text

Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, I. . A.s. Trukhmanov, Ye. K. Baranskaya, O. B. Dronova, O. V. Zayratyants, R. G. Sayfutdinov, A. A. Sheptulin, T. L. Lapina, S. S. Pirogov, Yu. A. Kucheryavy, O. A. Storonova, D. N. Andreyev

“…Implementation of clinical guidelines can promote improvement of healthcare quality for GERD patients and prevent complications, in particular if terms of treatment will be observed, at active outpatient follow­up for certain groups of patients.…”
Get full text

Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…MDMs exposed to Delta showed a failure in the activation of the adaptive immune response, and this correlates with the more severe symptoms developed by people affected with this SARS-CoV-2 variant.…”
Get full text

Most prevalent jobs of young master’s degree graduates by detailed field of study by Marc Frenette, Tomasz Handler

“…Beyond the monetary gains, the satisfaction derived from one’s day-to-day work activities may also matter in overall life satisfaction. …”
Get full text

Implementing a nurse-enabled, integrated, shared-care model involving specialists and general practitioners in early breast cancer post-treatment follow-up (EMINENT): a single-cent... by Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel McKavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma McKinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. McPhail, Katharine Cuff, Laisa Teleni, Jon Emery

“…Feasibility and effectiveness outcome measures, including health-related quality of life (primary outcome), physical activity and nutrition, patient experience, and financial toxicity were collected at baseline, and at 3-, 6-, and 12-months, with health service utilisation data at 24-months. …”
Get full text

Design, evaluation, and future projections of the NARCliM2.0 CORDEX-CMIP6 Australasia regional climate ensemble by G. Di Virgilio, G. Di Virgilio, J. P. Evans, J. P. Evans, F. Ji, F. Ji, E. Tam, J. Kala, J. Andrys, C. Thomas, D. Choudhury, C. Rocha, S. White, Y. Li, M. El Rafei, R. Goyal, M. L. Riley, J. Lingala

“…Noah-MP confers smaller improvements in simulating precipitation, except for large improvements over Australia's southeast coast. Activating Noah-MP's dynamic vegetation cover and/or runoff options primarily improves the simulation of minimum temperature. …”
Get full text