Synthesis of chitosan/PVA/copper oxide nanocomposite using Anacardium occidentale extract and evaluating its antioxidant, antibacterial, anti-inflammatory and cytotoxic activities by Manickam Rajkumar, S. I. Davis Presley, Prabha Govindaraj, Dharmalingam Kirubakaran, Farha Farahim, Talat Ali, Mohd Shkir, Sellapillai Latha

“…Abstract Nanotechnology has witnessed remarkable advancements in recent years, capturing considerable attention in diverse biomedical applications. …”
Get full text

Synthesis and Antidepressant Activity of Some New 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline Derivatives by Pravin O. Patil, Sanjay B. Bari

“…The present paper showed significant antidepressant activity for all compounds of the series and no significant change in locomotor activity of mice. …”
Get full text

WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis by Enrico Briguglio, Rosanna Di Paola, Irene Paterniti, Emanuela Mazzon, Giacomo Oteri, Giancarlo Cordasco, Salvatore Cuzzocrea

“…We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis. …”
Get full text

Bp-13 PLA2: Purification and Neuromuscular Activity of a New Asp49 Toxin Isolated from Bothrops pauloensis Snake Venom by Georgina Sucasaca-Monzón, Priscila Randazzo-Moura, Thalita Rocha, Frank Denis Torres-Huaco, Augusto Vilca-Quispe, Luis Alberto Ponce-Soto, Sérgio Marangoni, Maria Alice da Cruz-Höfling, Léa Rodrigues-Simioni

“…Bp-13 showed allosteric enzymatic behavior and maximal activity at pH 8.1, 36°–45°C. Full Bp-13 PLA2 activity required Ca2+; its PLA2 activity was inhibited by Mg2+, Mn2+, Sr2+, and Cd2+ in the presence and absence of 1 mM Ca2+. …”
Get full text

A 10 GHz Dual-Loop PLL With Active Cycle-Jitter Correction Achieving 12dB Spur and 29% Jitter Reduction by Yu-Ping Huang, Yu-Sian Lu, Wei-Zen Chen

Subjects: Get full text

Tumor-associated-fibrosis and active collagen-CD44 axis characterize a poor-prognosis subtype of gastric cancer and contribute to tumor immunosuppression by Yingqi Yang, Haohan Sun, Hongkai Yu, Luyao Wang, Chang Gao, Haokun Mei, Xiaomeng Jiang, Minghui Ji

“…Abstract Background Tumor-associated fibrosis modifies the tumor microenvironment (TME), hinders the infiltration and activity of cytotoxic immune cells, and is a critical pathological process leading to the ineffectiveness of tumor immunotherapy in gastric cancer (GC). …”
Get full text

HIV status and contraceptive use in Zimbabwe among sexually active adolescent girls and women: Secondary analysis of Zimbabwe Demographic Health survey data by G Musuka, G Murewanhema, Z Mukandavire, I Chingombe, D Cuadros, F Mutenherwa, T Dzinamarira, R Eghtessadi, N Malunguza, M Mapingure

Subjects: Get full text

Retraction Note: Novel magnetic organic–inorganic hybrids based on aromatic polyamides and ZnFe2O4 nanoparticles with biological activity by Reza Eivazzadeh-Keihan, Mostafa Ghafori Gorab, Hooman Aghamirza Moghim Aliabadi, Mohammad mahdavi, Ali Reza Akbarzadeh, Ali Maleki, Hossein Ghafuri

Get full text

YTHDF1 Regulates RELA m6A Modification and Activates the NF‐Kappa B Signaling Pathway to Promote the Mechanism of Gastric Cancer by Yangyuan Huang, Shihao Liang, Liping Li, Qingyu Zeng, Bin Li

“…It is very important to explore the pathogenesis pathways of GC and provide strong support for its treatment. However, the mechanism of occurrence and development of GC is still unclear. …”
Get full text

Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures by Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer, Heather A. Enright

“…We found that exposure to TNF-α produced both a concentration-independent and concentration-dependent response in neural activity. Burst duration was significantly reduced within a few days of exposure regardless of concentration (1 pg/mL – 100 ng/mL) but returned to baseline after 7 days. …”
Get full text

Concentration-dependent effects of immunomodulatory cocktails on the generation of leukemia-derived dendritic cells, DCleu mediated T-cell activation and on-target/off-tumor toxicity by Hazal Aslan Rejeski, Hazal Aslan Rejeski, Anne Hartz, Anne Hartz, Elias Rackl, Elias Rackl, Lin Li, Lin Li, Christoph Schwepcke, Christoph Schwepcke, Kai Rejeski, Kai Rejeski, Christoph Schmid, Christoph Schmid, Andreas Rank, Andreas Rank, Jörg Schmohl, Doris Kraemer, Peter Bojko, Helga Maria Schmetzer, Helga Maria Schmetzer

“…For Kit-M, we noted optimal generation of DC-subsets at intermediary concentration ranges of PGE1 (0.25-4.0 µg/mL), which facilitated upregulation of activated and memory T-cells upon mixed lymphocyte culture, and efficient anti-leukemic activity in cytotoxicity assays. …”
Get full text

Erratum to “Hyperglycemia Induces Toll-Like Receptor-2 and -4 Expression and Activity in Human Microvascular Retinal Endothelial Cells: Implications for Diabetic Retinopathy” by Uthra Rajamani, Ishwarlal Jialal

Get full text

Arabidopsis 3‐Deoxy‐d‐Arabino‐Heptulosonate 7‐Phosphate (DAHP) Synthases of the Shikimate Pathway Display Both Manganese‐ and Cobalt‐Dependent Activities by Ryo Yokoyama, Hiroshi A. Maeda

“…Despite their sequence similarity, these Arabidopsis KDOPS proteins showed no DHS activity. Meanwhile, optimization of the DHS assay conditions led to the successful detection of DHS‐Co activity from Arabidopsis DHS recombinant proteins. …”
Get full text

Comparison of Pregnancy Outcome between 4 and 6 cm Cervical os Dilatation to Demarcate Active Phase of Labour: A Cross-Sectional Study by Nadzirah Mohd Fathil, Rahana Abd Rahman, Azmawati Mohd Nawi, Ixora Kamisan Atan, Aida Hani Kalok, Nor Azlin Mohamed Ismail, Zaleha Abdullah Mahdy, Farin Masra, Zuhailah Muhammad, Shuhaila Ahmad

“…A cervical os dilatation of 6 cm reduces the risk of caesarean section by 11% (95% CI, 0.01-0.9) and increases three times more the need for analgesia (AOR=3.44, 95% CI, 1.2-9.4). …”
Get full text

Multivariate polynomial fit: Decay heat removal system and pectin degrading Fe3O4‐SiO2 nanobiocatalyst activity by Boopathi Muthusamy, Sujatha Ramalingam, Senthil Kumar Chandran, Sathish Kumar Kannaiyan

“…Abstract Herein, multivariate Lagrange's interpolation polynomial (MLIP) and multivariate least square (MLS) methods are used to derive linear and higher‐order polynomials for two varied applications. (1) For an effective fabrication of Pectin degrading Fe3O4‐SiO2 Nanobiocatalyst activity (IU/mg). Here, the three parameters namely: pH value, pectinase loading and temperature as independent variables are optimized for the maximal of anobiocatalyst activity as a dependent variable. (2) For a passive system reliability estimation of decay heat removal (DHR) of a nuclear power plant. …”
Get full text

Analisis Unit Cost Pelayanan Unit Laboratorium Rumah Sakit Naili DBS Tahun 2017 dengan Metode Activity Based Costing (ABC) by Ressa Oasthttamadea, Menkher Manjas, Yurniwati Yurniwati

“…Activity-Based Costing (ABC) merupakan metode akuntansi yang mengidentifikasi dan mengalokasikan biaya kepada aktivitas. …”
Get full text

Adsorptive Removal of Methylene Blue onto ZnCl2 Activated Carbon from Wood Apple Outer Shell: Kinetics and Equilibrium Studies by N. Bhadusha, T. Ananthabaskaran

“…Methylene blue dye removal from aqueous solution was investigated using ZnCl2 activated carbon prepared from wood apple outer shell (Limonia acidissima, biomass waste). …”
Get full text

The relationship between physical activity and career decision-making self-efficacy in Chinese college students: the mediating roles of self-control and social anxiety by Yuan Fang, Tingting Xu, Maosheng Ye, Changquan Li

Subjects: “…physical activity…”
Get full text

Lessons from COVID-19 and Seoul: Effects of Reduced Human Activity from Social Distancing on Urban CO2 Concentration and Air Quality by Hayoung Park, Sujong Jeong, Ja-Ho Koo, Sojung Sim, Yeon Bae, Yeonsoo Kim, Chaerin Park, Jeongyeon Bang

“…Moreover, the insignificant change in wind speed and wind direction during the months of February and March 2020 compared to 2019 implies that CO2, CO, and NO2 concentrations have not been influenced by meteorological conditions, but mainly by changes in emissions from decreased human activity. Despite the rise in background CO2 concentration, urban contributions of CO2 show a decline of −12.6%, indicating that cities with high emissions have the potential to reduce urban CO2 enhancements and air pollutant concentrations, and ultimately impact the global atmosphere.…”
Get full text

Natural fermentation of bitter gourd (Momordica charantia) and noni fruit (Morinda citrifolia) in honey increases total phenol, total flavonoid, and antioxidant activity by Guardiola Esther Natalia, Sumitro Sutiman Bambang, Widyarti Sri

“…TFC of fermented BG increased from 9.86 QC/g to 41.69 QC/g in 12 weeks of fermentation. The antioxidant activity of fermented BM and BP showed the highest antioxidant activity in the 6-week (0,574 mg TEAC/g and 0.528 mg TEAC/g). …”
Get full text