mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular Endothelial Barrier by Shan-Shan Meng, Feng-Mei Guo, Li-Li Huang, Ying-Zi Huang, Jian-Feng Xie, Cong-Shan Yang, Hai-Bo Qiu, Yi Yang

“…Taken together, these highlight activation mTORC2 pathway could also contribute to vascular endothelial barrier recovery by MSC-secreted HGF in LPS stimulation.…”
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MCL Plays an Anti-Inflammatory Role in Mycobacterium tuberculosis-Induced Immune Response by Inhibiting NF-κB and NLRP3 Inflammasome Activation by Qingwen Zhang, Xinru Jiang, Weigang He, Kailin Wei, Jinxia Sun, Xiangyang Qin, Yuejuan Zheng, Xin Jiang

“…Meanwhile, MCL dramatically suppressed Mtb-induced activation of iNOS and COX2 as well as subsequent production of NO. …”
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Author Correction: Noninvasive rejuvenation strategy of nickel-rich layered positive electrode for Li-ion battery through magneto-electrochemical synergistic activation by Haochen Gong, Yu Cao, Baoshan Zhang, Jinsong Zhang, Yiming Zhang, Huili Wang, Shaojie Zhang, Xiaoyi Wang, Yue Mao, Shuo Liu, Chengyu Han, Qianxin Xiang, Chaoyi Zhou, Jie Sun

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Release of Gentamicin and Vancomycin from Preformed Spacers in Infected Total Hip Arthroplasties: Measurement of Concentrations and Inhibitory Activity in Patients’ Drainage Fluids and Serum by Dario Regis, Andrea Sandri, Elena Samaila, Anna Benini, Manuel Bondi, Bruno Magnan

“…The local release kinetics of G and V from PMMA cement was similar, exerting a pronounced, combined inhibitory effect in the implant site. The inhibitory activity of drainage fluids showed substantial intersubject variability related to antibiotic concentrations and differed according to the pathogens tested. …”
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Bioanalytical method development, in-vivo pharmacokinetic evaluation, ex-vivo platelet aggregation inhibition activity of a novel solid dispersion formulation of ticagrelor by Abhishek Srivastava, Abhishek Srivastava, Simrata Bedi, Abhishesh Kumar Mehata, Datta Maroti Pawde, Ketan Vinayakrao Hatware, Mohammad Ahmad Khan, M. S. Muthu, Uma Bhandari

“…Additionally, the ex-vivo antiplatelet aggregation activity was evaluated.ResultsThe developed method was accurate and linear (100 ng−800 ng) to quantify the drug in plasma. …”
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Prevalence and Predictors of Nonadherence to Diet and Physical Activity Recommendations among Type 2 Diabetes Patients in Southwest Ethiopia: A Cross-Sectional Study by Getandale Zeleke Negera, Dariowani Charles Epiphanio

“…Female gender (AOR: 2.6, 95% CI [1.52–4.56]), age > 60 years (AOR: 2.9, 95% CI [1.12–7.42]), being illiterate (AOR: 4.2, 95% CI [1.86–9.73]), diabetes duration of >5 years (AOR: 2.5, 95% CI [1.42–4.41]), and lack of social support (AOR: 2.4, 95% CI [1.42–4.35]) were independent predictors of nonadherence to physical activity recommendations. …”
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Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons by Sanjana Chauhan, Darrell R. Smith, Shiva Shariati-Ievari, Abhay Srivastava, Sanjiv Dhingra, Michel Aliani, Paul Fernyhough

“…We investigated the role of the heat-sensing transient receptor potential melastatin-3 (TRPM3) cation channel in M1R antagonism-mediated nerve regeneration and explored the potential of TRPM3 activation to facilitate axonal plasticity. Methods: Dorsal root ganglion (DRG) neurons from adult control or diabetic rats were cultured and treated with TRPM3 agonists (CIM0216, pregnenolone sulfate) and M1R antagonists pirenzepine (PZ) or muscarinic toxin 7 (MT7). …”
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The Mechanical Criterion of Activation and Instability of Normal Fault Induced by the Movement of Key Stratum and Its Disaster-Causing Mechanism of Rockburst in the Hanging Wall Mining by Lyu Pengfei, Lu Jiabin, Wang Eryu, Chen Xuehua

“…Understanding the criterion of the fault activation instability and the disaster-causing mechanism of rockburst under the influence of mining is the theoretical premise and important guarantee of safe and efficient coal mining. …”
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M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b by Chiara Parisi, Giulia Napoli, Pablo Pelegrin, Cinzia Volonté

“…At present, the mechanisms by which microglia actively participate to both toxic and neuroprotective actions in ALS constitute an important matter of research. …”
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Identification of Proteins with Potential Osteogenic Activity Present in the Water-Soluble Matrix Proteins from Crassostrea gigas Nacre Using a Proteomic Approach by Daniel V. Oliveira, Tomé S. Silva, Odete D. Cordeiro, Sofia I. Cavaco, Dina C. Simes

“…Nacre, when implanted in vivo in bones of dogs, sheep, mice, and humans, induces a biological response that includes integration and osteogenic activity on the host tissue that seems to be activated by a set of proteins present in the nacre water-soluble matrix (WSM). …”
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Artemisia capillaris with two novel active compounds, Kawarayomogin I and II, inhibits HYBID (KIAA1199) expression as well as hyaluronic acid degradation by Kazal Boron Biswas, Yuka Kawai, Satoshi Nakagawa, Kyoko Kanai, Hiroyuki Kojima, Teruaki Masutani, Masayoshi Oyama, Arunasiri Iddamalgoda, Kotaro Sakamoto

“…The molecular size distribution of HA was evaluated by incubating fluorescein isothiocyanate (FITC)-labeled large HA (1200–1600 kDa) in NHDF for certain time followed by measuring different sizes of FITC-labeled HA in the cultured medium by HPLC. …”
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Starvation Affects the Muscular Morphology, Antioxidant Enzyme Activity, Expression of Lipid Metabolism-Related Genes, and Transcriptomic Profile of Javelin Goby (Synechogobius hasta) by Xiangning Chen, Yili Xu, Xiangyu Cui, Siying Zhang, Xiangqi Zhong, Juntao Ke, Yuze Wu, Zhiyu Liu, Chaoqing Wei, Zhujin Ding, Jianhe Xu, Hanliang Cheng

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Phage vB_KlebPS_265 Active Against Resistant/MDR and Hypermucoid K2 Strains of <i>Klebsiella pneumoniae</i> by Vyacheslav I. Yakubovskij, Vera V. Morozova, Yuliya N. Kozlova, Artem Yu. Tikunov, Valeria A. Fedorets, Elena V. Zhirakovskaya, Igor V. Babkin, Alevtina V. Bardasheva, Nina V. Tikunova

“…<i>Klebsiella</i> phage vB_KlebPS_265 (KlebP_265) and its host strain were isolated from the sputum of a patient with <i>Klebsiella</i> infection. …”
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Extraction of Phosphate from Polluted Waters Using Calcium Alginate Beads Doped with Active Carbon Derived from A. aspera Plant as Adsorbent by Ravulapalli Sujitha, Kunta Ravindhranath

“…An adsorbent prepared by entrapping active carbon derived from the stems of Achyranthes aspera plant in the calcium alginate beads (CABAA) has been investigated for its adsorption nature towards the removal of phosphate by varying various physicochemical parameters. …”
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New Approach of the Oxidant Peroxo Method (OPM) Route to Obtain Ti(OH)4 Nanoparticles with High Photocatalytic Activity under Visible Radiation by André E. Nogueira, Lucas S. Ribeiro, Luiz F. Gorup, Gelson T. S. T. Silva, Fernando F. B. Silva, Caue Ribeiro, Emerson R. Camargo

“…Characterization results reveal that peroxo groups on the surface of the catalyst had a great influence on the optical properties of the Ti(OH)4 and consequently in its photocatalytic property. This catalyst showed a high photocatalytic activity for the degradation of organic pollutants under visible radiation, reaching approximately 98% removal of both the dye and the drug in 150 min of reaction. …”
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Rapid Screening and Quantitative Determination of Active Components in Qing-Hua-Yu-Re-Formula Using UHPLC-Q-TOF/MS and HPLC-UV by Xin Shao, Jie Zhao, Xu Wang, Yi Tao

“…A high-performance liquid chromatography (HPLC) method was developed to simultaneously determine the following six active components in QHYRF: danshensu, paeoniflorin, acteoside, lithospermic acid, salvianolic acid B, and salvianolic acid C. …”
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Studies of the Interaction between Isoimperatorin and Human Serum Albumin by Multispectroscopic Method: Identification of Possible Binding Site of the Compound Using Esterase Activity of the Protein by Samira Ranjbar, Yalda Shokoohinia, Sirous Ghobadi, Nooshin Bijari, Saeed Gholamzadeh, Nastaran Moradi, Mohammad Reza Ashrafi-Kooshk, Abbas Aghaei, Reza Khodarahmi

“…Furthermore, the synchronous fluorescence spectra show that the microenvironment of the tryptophan residues does not have obvious changes. Site marker compettive and fluorescence experiments revealed that the binding of isoimperatorin to HSA occurred at or near site I. …”
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Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at diagnosis by Jihye Chung, Jang Woo Ha, Yong-Beom Park, Yong-Beom Park, Sang-Won Lee, Sang-Won Lee

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Investigating the production and synergistic antibacterial activity of bacteriocin-like substance from Brevibacillus laterosporus SA-14 (TISTR 2453) for enhanced wound healing by Husna Madoromae, Apichart Atipairin, Malatee Tayeh, Monthon Lertcanawanichakul

“…However, the addition of nitrogen sources, including skim milk, peptone, and beef extract resulted in high antibacterial activity at 48 h, with skim milk being the most effective for BLS production. …”
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The Role of IL-17 Promotes Spinal Cord Neuroinflammation via Activation of the Transcription Factor STAT3 after Spinal Cord Injury in the Rat by Shaohui Zong, Gaofeng Zeng, Ye Fang, Jinzhen Peng, Yong Tao, Keke Li, Jingmin Zhao

“…In this study, we investigated the role of IL-17 via activation of STAT3 in the pathophysiology of SCI. Objective. …”
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