The characteristics of dermatology inpatients seen at the quaternary Inkosi Albert Luthuli Central Hospital in Durban, South Africa, over a 5-year period – 2015 - 2020 by L Mthembu, J T Masuka, K Duze, A Mosam

“…However, dermatology consultation services have remained active, offering care to patients admitted for non-cutaneous indications by other specialties. …”
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A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor by Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret

“…Molecular modelling studies also revealed that ARIP binds β-arrestins as does V2Rpp, the phosphorylated peptide derived from V2R, and that replacing the p-Ser and p-Thr residues of V2Rpp with Glu residues does not alter ARIP’s inhibitory activity on β-arrestin recruitment. Importantly, ARIP exerted an opioid-sparing effect in vivo, as intrathecal injection of ARIP potentiated morphine’s analgesic effect in the tail-flick test, consistent with previous findings of genetic inhibition of β-arrestins. …”
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Long-term results of antiviral therapy in patients with chronic hepatitis C with sustained virologic response by T. M. Ignatova, T. N. Lopatkina, V. P. Chulanov, Ye. V. Gaydasheva, S. N. Batskikh, G. V. Mikhaylovskaya, D. T. Abdurakhmanov, S. Yu. Karpov, Ye. N. Nikulkina, O. A. Chernova

“…Application of ultraresponsive PCR method allowed to reveal relapse half a year prior to its clinical and laboratory manifestation in 2 cases. …”
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Profile of Lumbar Spinal Stenosis Patients at Dr. M. Djamil Central Public Hospital from 2018-2022 by Inasa Faiza Akbar, Roni Eka Sahputra, Eka Fithra Elfi, Rizki Rahmadian, Dina Arfiani Rusjdi, Nelmi Silvia

“…Many LSS patients were housewives (42.62%) and reported light work activity (63.1%). The most common cause of LSS was degenerative factors (59%). …”
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JWST, ALMA, and Keck Spectroscopic Constraints on the UV Luminosity Functions at z ∼ 7–14: Clumpiness and Compactness of the Brightest Galaxies in the Early Universe by Yuichi Harikane, Akio K. Inoue, Richard S. Ellis, Masami Ouchi, Yurina Nakazato, Naoki Yoshida, Yoshiaki Ono, Fengwu Sun, Riku A. Sato, Giovanni Ferrami, Seiji Fujimoto, Nobunari Kashikawa, Derek J. McLeod, Pablo G. Pérez-González, Marcin Sawicki, Yuma Sugahara, Yi Xu, Satoshi Yamanaka, Adam C. Carnall, Fergus Cullen, James S. Dunlop, Eiichi Egami, Norman Grogin, Yuki Isobe, Anton M. Koekemoer, Nicolas Laporte, Chien-Hsiu Lee, Dan Magee, Hiroshi Matsuo, Yoshiki Matsuoka, Ken Mawatari, Kimihiko Nakajima, Minami Nakane, Yoichi Tamura, Hiroya Umeda, Hiroto Yanagisawa

“…We find that ∼70% of the bright galaxies at z ∼ 7 exhibit clumpy morphologies with multiple subcomponents, suggesting merger-induced starburst activity, which is consistent with SED fitting results showing bursty star formation histories. …”
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Internal Dosimetry in Patients Undergoing Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-[DOTA0-Tyr3] Octerotate: A Single-Center Experience by Elahe Mahmoudi, Mahasti Amoui, Mohammad Reza Deevband, Elahe Pirayesh, Mohammad Reza Asgari, Mehdi Ghorbani

“…The patients had a mean age of 53.5 ± 12 years (ranging from 36 to 70 years) and imaging data were collected at roughly 0 to 2 hours, 4 to 6 hours, 18 to 24 hours, and 36 to 48 hours after the injection of 6401± 628.4 MBq (range of 5500 MBq-7400 MBq) of 177Lu-[DOTA0-Tyr3] octerotate. Models of time-activity were established for different organs. Finally, using absorbed dose formulation and IDIAC-Dosage software, the mean absorbed dose in the organs was determined. …”
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Staphylococcus aureus susceptibilities from wounds of patients who use illicit fentanyl by Drew T. Dickinson, Stephen Saw, Lauren Dutcher, Christina Maguire, Adrienne Terico, Margaret Lowenstein, Sonal Patel

“…PWUF would benefit from joint management by infectious diseases and addiction medicine experts to ensure prescription of active therapy. Additional study is needed of PWUF in other regions. …”
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Saponin content in medicinal plants in response to application of organic and inorganic fertilizers: a meta-analysis by Junyan Lv, Junyan Lv, Shouzan Liu, Shouzan Liu, Chunli Hu, Lan Ding, Hongzhen Wang, Hongzhen Wang, Xin Li, Feng Yang, Feng Yang, Qiong Shen, Qiong Shen, Hongbin Zhang, Hongbin Zhang, Guobiao Ma, Guobiao Ma, Shaobo Zhang, Yan Bai, Yan Bai

“…However, systematic investigations on the influence of various fertilizers on the concentration of active compounds in saponin-containing medicinal plants remain insufficient. …”
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Effect of the adhesive added of copper applied with electric current on the ceramic/resin cement bond by Gabriel Augusto Silveira Sousa, Marcos Henrique Ramos da Silva, Lourenço Correr-Sobrinho, Rafael Pino Vitti, Evandro Piva, Rafael Leonardo Xediek Consani

“…IPS e.max Press ceramic discs included in rigid polyvinyl chloride tubes with chemically activated acrylic resin were divided into four groups (n = 10): RX + UA (silane + universal adhesive); RX + UA + EC (silane + universal adhesive + electrical current); RX + EA (silane + experimental adhesive); and RX + EA + EC (silane + experimental adhesive + electrical current). …”
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Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species by Montserrat Torres-Oliva, Elisa Buchberger, Alexandra D. Buffry, Maike Kittelmann, Genoveva Guerrero, Lauren Sumner-Rooney, Pedro Gaspar, Georg C. Bullinger, Javier Figueras Jimenez, Fernando Casares, Saad Arif, Nico Posnien, Maria D. S. Nunes, Alistair P. McGregor, Isabel Almudi

“…We discovered that the activity of an otd eye enhancer is consistent with the difference in the expression of this gene between species, with the D. mauritiana enhancer sequence driving earlier expression than that of D. simulans. …”
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Development and validation of a risk prediction model for PICC-related venous thrombosis in patients with cancer: a prospective cohort study by Zeyin Hu, Mengna Luo, Ruoying He, Zhenming Wu, Yuying Fan, Jia Li

“…Four risk factors were identified as key predictors of PICC-RVT, including “diabetes requiring insulin (OR: 8.016; 95% CI 1.157–55.536), major surgery (within 1 month and operation time > 45 minutes) (OR: 0.023; 95% CI 1.296–30.77), reduced limb activities of the PICC arm (OR: 6.687; 95% CI 2.024–22.09)” and “catheter material (OR: 3.319; 95% CI 0.940–11.723)”. …”
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Influence of COVID-19 Lockdown on Self-Efficacy in Endodontics among Dental Students by Jelena Vidas Hrstić, Ema Paljević, Ivana Brekalo Pršo, Ivana Vidović Zdrilić, Luka Šimunović, Elvis Božac, Romana Peršić Bukmir

“…The post hoc analysis confirmed the between-group difference (2.838; p < 0.05) in the arithmetic mean between the lockdown-affected and non-lockdown-affected groups. Active participation and length of time in a dental office (between several days and one year of experience) were associated with an increase in self-efficacy. …”
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Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats by Gisela Belén Sarrible, María Victoria Bazzano, Caterina Koutsovitis, María Guillermina Bilbao, Rodrigo Hernán Da Cuña, Melanie Neira, Julián Alberto Bartolomé, Evelin Mariel Elia

“…Coenzyme Q10 (CoQ10), known for enhancing reproductive outcomes in various pathologies, is not fully understood for its effects on obesity treatment. Here, obesity was modeled using CAF-fed rats to assess CoQ10's impact on metabolic and ovarian disruptions caused by obesity. …”
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Changes in the intestinal microbiota induced by the postnatal environment and their association with hypertension by Patrizia Dardi, Camille Perella Coutinho, Sarah de Oliveira, Simone Aparecida Teixeira, Renaide Rodrigues Ferreira Gacek, Eduardo Purgatto, Marco Aurélio Ramirez Vinolo, Marcelo Nicolás Muscará, Luciana Venturini Rossoni

“…Our findings revealed significant differences in the microbiota's composition and its metabolic activity in young non-fostered SHR (SS) vs. …”
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Effects of pyrazosulfuron-ethyl on caudal fin regeneration in zebrafish larvae by Chenkai Ge, Zhijun Ye, Weitao Hu, Jingrong Tang, Huimin Li, Fasheng Liu, Xinjun Liao, Jianjun Chen, Shouhua Zhang, Zigang Cao

“…Pyrazosulfuron-ethyl exposure resulted in the decreased number of neutrophils and macrophages, and the downregulation of immune related gene expression levels during caudal fin. Using LPS to activate inflammation can effectively rescue the fin regeneration defects induced by pyrazosulfuron-ethyl. …”
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Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…Results: Studies indicate that alantolactone and isoalantolactone exhibit significant anti-cancer activities through various mechanisms. These include the induction of apoptosis, regulation of the cell cycle, inhibition of angiogenesis, and suppression of metastasis. …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…Results Pristine, 200 nm SiNPs induced minimal changes to energy metabolism and proteomic profiles in vitro while treatment with SAD SiNPs resulted in mitochondrial membrane hyperpolarization, inhibited mitochondrial respiration, increased reactive oxygen species generation, and redox proteomic trends suggesting activation of aryl hydrocarbon receptor (AHR) and other signaling pathways with known roles in mitochondrial inhibition and CKD progression. …”
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A new scheme for boosting in situ Fenton-like reaction in plant pathogenic tissues for selective structural degradation of capsid proteins by Jun Ma, Ming Chen, Yujie Wang, Jiaying Li, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen

“…Inducing viral capsid protein (CP) degradation via hydroxyl radicals (∙OH) generated by an in situ Fenton-like reaction within plant pathogenic tissues is proposed for combating plant viruses in this study. …”
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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…Objective Impaired hepatic expression of protein tyrosine phosphatase delta (PTPRD) is associated with increased STAT3 transcriptional activity and reduced survival from hepatocellular carcinoma in patients with chronic hepatitis C virus infection. …”
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From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…Recent advancements have demonstrated the technology's potential to restore cellular homeostasis and alleviate disease phenotypes, thereby prompting a variety of clinical trials. To date, active trials include treatments for primary open angle glaucoma with MYOC mutations, refractory herpetic viral keratitis, CEP290-associated inherited retinal degenerations, neovascular age-related macular degeneration, and retinitis pigmentosa with RHO mutations. …”
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