Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimental Verification by Ren J, Liu Z, Qi X, Meng X, Guo L, Yu Y, Dong T, Li Q

“…Additive Sishen decoction (ASSD) is a widely used traditional Chinese medicine for the treatment of RA; however, its active ingredients and the mechanism of its therapeutic effects remain unclear.Methods: To predict the ingredients and key targets of ASSD, we constructed “drug-ingredient-target-disease” and protein–protein interaction networks. …”
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TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

“…Our investigation identifies TMEM45A as a potential driver of palbociclib resistance and its association with increased cellular glycolysis. …”
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Variations in the physicochemical properties of soil, enzyme activities, and the characteristics of bacterial communities within algal biocrusts and subsoils across different plant communities by Haonian Li, Zhongju Meng, Xiaomen Ren, Yanlong Han

“…However, it is still unknown whether differences in vegetation communities drive differences in soil bacterial communities, soil physicochemical properties, and enzyme activities in ABSCs and subsoils. Soil samples were collected from sites with and without algal crusts in the vicinity of shrub canopies within two representative plant communities (i.e., Salix psammophila and Hedysarum scoparium), in the Hobq Desert, as well as from mobile sandy lands. …”
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Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression by Zhenhua Liu, Mengke Wang, Lijun Meng, Yixiao Chen, Qiuyi Wang, Yan Zhang, Xuefeng Xi, Wenyi Kang

“…Patrinia scabiosaefolia, is used as wild vegetable in China for more than 2 000 years, with a variety of pharmacological activities, including anti-inflammatory, anti-tumor and hypoglycemic. …”
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Release Profile and Antibacterial Activity of <i>Thymus sibthorpii</i> Essential Oil-Incorporated, Optimally Stabilized Type I Collagen Hydrogels by Caglar Ersanli, Ioannis Skoufos, Konstantina Fotou, Athina Tzora, Yves Bayon, Despoina Mari, Eleftheria Sarafi, Konstantina Nikolaou, Dimitrios I. Zeugolis

“…Although the strong antimicrobial activity of various EOs has already been studied and revealed, their characteristic high sensitivity and volatility drives the need towards a more efficient drug administration method via a biomaterial system. …”
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Multispecies pasture diet and cow breed affect the functional lipid profile of milk across lactation in a spring-calving dairy system by Renata Kostovska, Gaetan Drouin, Joaquín J. Salas, Mónica Venegas-Calerón, Brendan Horan, John T. Tobin, Tom F. O'Callaghan, Sean A. Hogan, Alan L. Kelly, Laura G. Gómez-Mascaraque

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Aspilia africana (Pers.) C.D. Adams and Manihot esculenta Crantz Exhibit Antibacterial Activity against Resistant Salmonella typhi Strains by Richard Agyen, Yaw Duah Boakye, Theresa Appiah Agana, Vivian Etsiapa Boamah, Clement Osei Akoto, Michael Owusu, Francis Adu, Christian Agyare

“…Aspilia africana and Manihot esculenta have been reported to exhibit activity against S. typhi; however, this study aimed to investigate the effect of A. africana and M. esculenta against resistance strains of S. typhi. …”
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Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression by Xiaotong Chen, Kai Wei, Shanshan Peng, Na Liu, Leqi He, Biying Wu, Meifang Shi, Yong Lin

Subjects: “…Physical activity…”
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Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization by Guokun Liu, Xuan Du, Li Xiao, Qing Zeng, QianLing Liu

“…Up to now, the detailed function of FGD5-AS1 in cervical cancer and its underlying molecular mechanisms remain uninvestigated. …”
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N-Doped Graphene Quantum Dot Nanoparticle Synthesis of Optical Active Thermal Stable Polyurea Nanocomposites Using Polybutadiene Chain Modification by Zahra Rahmatpanah, Mir Mohammad Alavi Nikje, Maryam Dargahi

“…In this regard, nitrogen-doped graphene quantum dots were synthesized from a one-pot hydrothermal reaction of citric acid with urea in an aqueous solution. An in situ polymerization approach was used for the synthesis of polyurea from the reaction of telechelic amine functionalized polybutadiene and toluene diisocyanate (TDI) in the presence of the DBTDL catalyst. …”
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An HPLC-based Assay to Study the Activity of Cyclic Diadenosine Monophosphate (C-di-AMP) Synthase DisA from Mycobacterium smegmatis by Avisek Mahapa, Sudhanshu Gautam, Arti Rathore, Dipankar Chatterji

“…The following protocol is designed to be generic, enabling the study of c-di-AMP synthase activity from other bacterial species. However, modifications may be required depending on the specific activity of c-di-AMP synthase from different bacterial sources.…”
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Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway by Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

“…Our previous work reported that activation of CD137 signaling promotes intraplaque angiogenesis. …”
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Synthesis, Characterization and Antifungal Activity of Novel Quinazolin-4-one Derivatives Containing 8-Hydroxyquinazoline Ligand and its Various Metal Complexes by R. T. Vashi, S. B. Patel

“…These complexes also been tested for their antifungal activities.…”
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A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis by Elbio Leiguez, Karina Cristina Giannotti, Mariana do Nascimento Viana, Márcio Hideki Matsubara, Cristina Maria Fernandes, José Maria Gutiérrez, Bruno Lomonte, Catarina Teixeira

“…MT-III, a snake venom GIIA sPLA2, which shares structural and functional features with mammalian GIIA sPLA2s, activates macrophage defense functions including lipid droplet (LDs) formation, organelle involved in both lipid metabolism and inflammatory processes. …”
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Seasonal Variations in Chemical Composition and Antibacterial and Antioxidant Activities of <i>Rosmarinus officinalis</i> L. Essential Oil from Southwestern Romania by Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Andrei Biţă, Felicia Tuţulescu, Antonia Radu, Maria Viorica Ciocîlteu, George Dan Mogoşanu

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Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro by E. G. Zakirova, Y. V. Vyatkin, N. A. Verechshagina, V. V. Muzyka, I. O. Mazunin, K. E. Orishchenko

“…In this article, we demonstrate for the first time that the modification of gRNA by integration of specific mitochondrial import determinants in the gRNA scaffold does not affect the activity of the gRNA/Cas9 complex in vitro.…”
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Study of Electrical Transport Properties of Thin Films Used as HTL and as Active Layer in Organic Solar Cells, through Impedance Spectroscopy Measurements by Camilo A. Otalora, Andres F. Loaiza, Gerardo Gordillo

“…Impedance spectroscopy (IS) is used for studying the electrical transport properties of thin films used in organic solar cells with structure ITO/HTL/active layer/cathode, where PEDOT:PSS (poly(3,4-ethylenedioxythiophene):polystyrene sulfonic acid) and CuPC (tetrasulfonated copper-phthalocyanine) were investigated as HTL (hole transport layer) and P3HT:PCBM (poly-3-hexylthiophene:phenyl-C61-butyric acid methyl ester) blends prepared from mesitylene and chlorobenzene based solutions were studied as active layer and Ag and Al were used as cathode. …”
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A handheld milk conductivity sensing device (Mylee) for measuring secretory activation progress in lactating women: a device validation study by Sharon Haramati, Anastasia Firsow, Daniela Abigail Navarro, Ravid Shechter

“…Conclusions In this study, we demonstrated the reliability and validity of the Mylee device and its ability to detect on-site milk secretory activation in a manner comparable to that of electrolyte-based methods. …”
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Effects of Freeze Vacuum Drying Combined with Hot Air Drying on the Sensory Quality, Active Components, Moisture Mobility, Odors, and Microstructure of Kiwifruits by Lihui Zhang, Yu Qiao, Chao Wang, Li Liao, Lu Liu, Defang Shi, Kejing An, Jianzhong Hu, Qing Xu

“…Dried products were analyzed comprehensively on their sensory quality, active components, moisture mobility, odors, and microstructure. …”
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Curdlan sulphate modulates protein synthesis and enhances NF-κB and C/EBP binding activity in HepG2 cells by A. Guzdek, H. Rokita

“…Gel mobility shift analysis revealed that curdlan sulphate increases the DNA binding activity of NF-κB and C/EBP, suggesting that these transcription factors may participate in the regulatory effects of curdlan sulphate in HepG2 cells.…”
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