An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…A phase 1b was planned to further evaluate ESK-440 safety and antitumor activity at the MTD but was not performed due to sponsor decision. …”
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Determining the alignment of assessment items with curriculum goals through document analysis by addressing identified item flaws by Humaira Fayyaz Khan, Shazia Qayyum, Huma Beenish, Rehan Ahmed Khan, Samina Iltaf, Lubna Rani Faysal

“…Abstract Background Assessment shapes educational activities and curriculum mapping, influences learning outcomes, and motivates students. …”
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Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…Further, %inhibition of platelet aggregation from AT-10 treatment in poor metaboliser group was significantly higher than the clopidogrel treatments in extensive metaboliser group.Overall pharmacokinetic comparison in all subjects indicates that AT-10 gives greater exposure to active Metabolite H4 than clopidogrel.Conclusion AT-10 showed better inhibition of platelet aggregation in poor metabolizers as compared to Clopidogrel. …”
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A Retrospective Observational Cohort Analysis of Oncology Patients with Febrile Neutropenia in the Emergency Department of a Tertiary Care Hospital in Oman by Badar Al-Aamri, Aisha AL Breiki, Darpanarayan Hazra, Talib Al-Aamri, Manar Al-Shehi

“…Most patients (89.3%) presented with active cancer, and the mean neutrophil count was 0.18. …”
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Organ Donation Conversations on X and Development of the OrgReach Social Media Marketing Strategy: Social Network Analysis by Wasim Ahmed, Mariann Hardey, Josep Vidal-Alaball

“…Social media platforms, such as X, contain conversations from the public, and key stakeholders maintain an active presence on the platform. ObjectiveThe goal is to develop insights into organ donation discussions on a popular social media platform (X) and understand the context in which users discussed organ donation advocacy. …”
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The impact of land use transition on ecosystem service value in Lixiahe area: Multi-scenario simulation based on Markov-FLUS model by CHEN Xinwei, LI Hongbo, ZHANG Wenbo, GE Xiaoping

“…In the context of ecological civilization construction, simulating the land use transformation in this region under multiple scenarios and its impact on the value of ecosystem services have practical guiding significance. …”
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Changes in the Structural and Functional Albumin Properties in Patients with Decompensated Liver Cirrhosis by A. A. Turkina, M. V. Maevskaya, M. S. Zharkova, V. T. Ivashkin

“…Our data allow us to raise the question of the need to use the EPR test to determine indications for albumin replacement therapy in patients with cirrhosis and the presence of ascites, even at normal values of its serum concentration.…”
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Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

“…Mechanistically, the upregulation of miR-223-3p in LPS-EVs triggers autophagy and ferroptosis in AMs by activating Hippo signaling via the targeting of MEF2C. …”
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The role of sex, age, and BMI in treatment decisions for knee osteoarthritis: conservative management versus total knee replacement by Fabiola Ojeda, Laura Tío, Francisco Castro-Domínguez, Simone Tassani, Jerome Noailly, Jordi Monfort

“…Methods This case–control study compared patients assigned to TKR versus conservative management, examining subjects aged 60–75 years with radiographically confirmed KOA (Kellgren–Lawrence grades 2–3), with all participants evaluated by blinded clinicians using validated assessment tools including Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Hospital Anxiety and Depression Scale (HADs), Pain Catastrophizing Scale (PCS) and Daily physical activity (DPA) questionnaires. The study employed multivariate analysis of variance for continuous variables at both patient and knee levels, followed by univariate analysis of variance for significant factors, while logistic and linear regression analyses were used to calculate odds ratios, with Bonferroni corrections applied to adjust p-values for multiple comparisons. …”
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Translation, cross-cultural adaptation and validation of the composite physical function scale in Chinese community-dwelling older adults by Jiaying Qi, Jing Xu, Hui Zhang, Mingshuai Feng, Hongyan Meng, Li Wang

“…Construct validity analysis revealed a significant difference in C-CPF scores amongst older adults in groups of different ages, regular exercise and physical activity habits (P < 0.01). Criterion validity was tested for the correlation between the results of C-CPF and the Senior Fitness Test (r = 0.446, P < 0.01). …”
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Effect of power training on physical functional performance of patients with Parkinson's disease: A systematic review and meta-analysis of randomized controlled trials. by Samuel Brito de Almeida, Emmanuelle Silva Tavares Sobreira, Charles Phillipe de Lucena Alves, Danielle Pessoa Lima, Janine de Carvalho Bonfadini, Manoel Alves Sobreira-Neto, Thiago Holanda Freitas, Simony Lira do Nascimento, Pedro Braga-Neto

“…<h4>Introduction</h4>Parkinson's disease (PD) is becoming more prevalent, highlighting the urgency of developing treatments to minimize its effects on muscular strength and physical function. …”
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Mobility Aware Spectrum Handoff in 6G-Enabled Cognitive Radio Vehicular Centralized and Ad-Hoc Networks by Shanidul Hoque, Hemanta Kumar Sahu, Mohammed Nazibul Hasan, Rajesh Saha

“…These performance measuring metrics are derived for various SH schemes: intracell/intrapool SH, intracell/interpool SH, intercell/intrapool SH, and intercell/interpool SH, considering the primary user (PU) activity model and CU mobility. Considering <inline-formula> <tex-math notation="LaTeX">$D_{th}$ </tex-math></inline-formula> as the waiting threshold period for CU, we analyze the effect PU&#x2019;s arrival rate and <inline-formula> <tex-math notation="LaTeX">$D_{th}$ </tex-math></inline-formula> on the performance measuring metrics in two different network architectures: Cognitive Radio-Vehicular Ad-Hoc Network (CR-VANET) and Cognitive Radio-Vehicular Centralized Network (CR-VCNET). …”
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Efficient adsorption of ofloxacin in a novel nanocomposite formed by nano-hexagonal boron nitride fused with zeolite imidazolite skeleton-8: Experimental and molecular dynamics sim... by Zefang Huang, Yuankai Hong, Yiqun Cui, Huiying Guo, Yan Long, Jinshao Ye

“…Adsorption capacity depended on the initial h-BN content, with lower X content resulting in more active sites and stronger adsorption capacity. Equilibrium adsorption capacities were 145.46, 124.91, and 58.16 mg·g−1 for X values of 29.82 %, 45.93 %, and 62.95 %, respectively. …”
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Combination of Gilbert's syndrome and gastrointestinal diseases by G. M. Dubrovina, O. K. Botvinyev, A. I. Kolotilina

“…To detect relation between Gilbert's syndrome (GS) and other diseases of a gastrointestinal tract (GIT).Key points. Gilbert's syndrome - hereditary, unconjugated jaundice related to decrease of activity of uridinediphosphate glucuronosyltransferase 1А1 (UGT 1А1) in the liver. …”
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KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA by Xiaowei Lu, Kui Hu, Dandan Zhang, Xuefeng Yin, Jifeng Nie, Kai Zhao

“…Cell proliferation was assessed utilizing the Cell Counting Kit-8 assay and EDU staining. Cell apoptosis was evaluated using flow cytometry, and apoptosis-related proteins was examined by western blotting. …”
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Relationship between dietary intake and atherogenic index of plasma in cardiometabolic phenotypes: a cross-sectional study from the Azar cohort population by Shirin Soheilifard, Elnaz Faramarzi, Reza Mahdavi

“…The Atherogenic Index of Plasma (AIP) is a predictive marker for cardiovascular risk, but its association with dietary intake across cardiometabolic phenotypes remains underexplored. …”
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Lumbopelvic Stability and Trunk Muscle Contractility of Individuals with Chronic Ankle Instability by Ryan S McCann, Kelly Johnson, Ashley M B Suttmiller

“…Self-reported function was measured with the Foot and Ankle Ability Measure Activity of Daily Living (FAAM-ADL) and Sport (FAAM-S) subscales. …”
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Anticancer properties of Dillenia suffruticosa (Griffith Ex. Hook. F. &amp; Thomsom) Martelli by Ika Rahayu, Susana Elya Sudrajat, Kris Herawan Timotius

“…Further research is needed to explore its roles in autophagy, cell differentiation, and the tumor microenvironment.…”
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HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) by Aijaz Zeeshan Khan, Omer Sabir, Adnan Hussain Shahid, Muhammad Bilal Basit, Syeda Arzinda Fatima Shah, Qamar Sajad

“… Background: Dengue Fever, also known as break-bone fever, is a viral illness and transmitted to humans by bites of infected Aedes aegypti and Aedes albopictus mosquitoes. …”
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DIGITAL AND NON-DIGITAL GAMES IN YOUNG LEARNER EFL CLASSROOMS AT WARTIME IN UKRAINE by Ilona Huszti, Enikő Nagy-Kolozsvári, Márta Fábián

“…One of the most crucial implications to be gleaned from this research lies in the urgent need for educators to actively integrate age-appropriate and educationally sound digital games and applications into their existing EFL curricula. …”
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