Development of therapeutic supplement using roasted-cashew-nut to protect cerebral vasoconstriction injury triggered by mixture of petroleum hydrocarbons in the hypothalamus and hi... by J.K. Akintunde, V.O. Akomolafe, R.N. Ugbaja, A.M. Olude, A.D. Folayan

“…Petroleum-related activities have been a health global risk concern, particularly in the limbic disorders. …”
Get full text

An Evidence-Based Update on the Impact of Local Antimicrobials as Adjunct to Periodontal Therapy by Nabaz Yahya Hussein, Sadat Abdulla Aziz, Twana Mohammed M. Ways, Omed Amiri, Hisham Al-Obaidi, Dianne Ford

“…CHX demonstrated the greatest clinical improvement due to its broad-spectrum antimicrobial activity, strong substantivity, and its application in sustained-release formulations. …”
Get full text

Molecular mechanisms of cis-oxygen bridge neonicotinoids to Apis mellifera Linnaeus chemosensory protein: Surface plasmon resonance, multiple spectroscopy techniques, and molecular modeling by Xiangshuai Li, Shiyu Li, Yang Liu, Li Cui, Daibin Yang, Shuning Chen, Xusheng Shao, Huizhu Yuan, Xiaojing Yan

“…Molecular docking and dynamics simulations further illustrated the stability of these interactions within the active site of the protein. Of particular interest, cis-structured neonicotinoids demonstrated distinct binding characteristics compared to their trans-structured counterparts, including an inverse relationship between the binding constant and temperature. …”
Get full text

The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study by Saade Abdalkareem Jasim, Bashar Mudhaffar Abdullah, Patricio Yánez-Moretta, Wesam R. Kadhum, Yasser Fakri Mustafa, Enas R. Alwaily, Munther Abosoda, Ali Alsalamy, Sada Ghalib Al-Musawi, Alaa A. Omran

“…Here, we introduced a patient having lung cancer proved by Computed Tomography (CT) and pathological findings. The treatment effect of PM was assessed and presented based on CT and laboratory examinations for this patient as a first human case study. …”
Get full text

Genomic insights and comparative analysis of Colletotrichum species associated with anthracnose fruit rot and crown rot of strawberry in North Carolina by Tika B. Adhikari, Norman Muzhinji, Ashley N. Philbrick, Frank J. Louws, Frank J. Louws

“…The predicted gene models included effectors (339 to 480), secondary metabolic gene clusters (67 to 90), and carbohydrate-active enzymes (800 to 1,060), with C. siamense isolates exhibiting the highest numbers in these categories. …”
Get full text

Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…During the proteomics analysis, AKT-phosphorylation in the aerobic respiration inhibitor group exhibited an apparent disparity and activity. Our study demonstrated that changes in H3K18la in BC and its downstream transcription factor PPARD support cell survival under anaerobic glycolysis conditions. …”
Get full text

Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB) by Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker

“…During human odontoblast development, computational analysis predicts that early FGF and BMP activation followed by later HH signaling is crucial. …”
Get full text

MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway by Zigui Chen, Chao Liu, Wei Zheng, Zhilong Li, Yuanhui Tang, Jun Peng, Changfeng Miao, Dandan Zheng, Ying Xia

“…Abstract Epithelial‒mesenchymal transition (EMT) is a process in which polar epithelial cells transform into active mesenchymal cells and acquire invasion and migration capabilities (Cano CE, Motoo Y, Iovanna JL in Sci World J 10, 2010). …”
Get full text

Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies by Aishwarja Dey, Subarna Rani, Rabindra Nath Acharyya, Apurba Kumar Barman, Khondoker Shahin Ahmed, Nripendra Nath Biswas, Shrabanti Dev, Asish Kumar Das

“…Method: The toxicity was screened by mortality rate, and behavioral changes in mice. Anti-allergic activity test was conducted on TDI induced allergy model mice by assessing the common allergic symptoms such as sneezing, scratching, nasal score as well as total and differential WBC counts. …”
Get full text

Effects of different fertilization treatments on ground-dwelling arthropods and their functional groups in agricultural landscapes by Ziqi Bian, Ziqi Bian, Lyuyi Liu, Lyuyi Liu, Yan Li, Yan Li, Yanli Li, Yanli Li, Shengyan Ding, Shengyan Ding

“…Studying arthropod diversity, community structure, and soil physico-chemical properties under various fertilization treatments is crucial to understanding the impact of agricultural activities. We used pitfall traps to catch ground-dwelling arthropods four times a year, and analyzed arthropod abundance and biodiversity indices under different fertilization treatments The study revealed that Lycosidae and Araneidae were the dominant family in the study area. …”
Get full text

Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis by Jiaqi Yao, Yuhong Jiang, Pengcheng Zhang, Yifan Miao, Xiajia Wu, Hang Lei, Zhijun Xie, Yong Tian, Xianlin Zhao, Juan Li, Lv Zhu, Meihua Wan, Wenfu Tang

“…Histidine triad nucleotide-binding protein 2 (HINT2) has been implicated in the development of various diseases, whereas its involvement in the progression of AP remains unclear. …”
Get full text

Heterogeneous graph convolutional neural network for protein-ligand scoring by Kevin Crampon, Alexis Giorkallos, Xavier Vigouroux, Stephanie Baud, Luiz Angelo Steffenel

“…Aim: Drug discovery is a long process, often taking decades of research endeavors. It is still an active area of research in both academic and industrial sectors with efforts on reducing time and cost. …”
Get full text

PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53 by Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu, Di Wang

“…However, the detailed roles of PTOV1 and its underlying mechanism in CRC remain unclear. …”
Get full text

Research on Carbon Sequestration Capacity of Urban Park Green Space in the Central Urban Area of Beijing and Driving Factors Thereof by Xiuping LIU, Songting ZHAO, Xinyu LI, Jiale LI, Xing WANG

“…Urban green spaces, as an important component of urban ecosystems, are the only element that directly increases carbon sinks and indirectly reduces carbon emissions in cities. While beautifying the environment, they play an extremely important role in ecological benefits and carbon sequestration. …”
Get full text

Irrigation Management of HLB-Affected Trees by Davie Mayeso Kadyampakeni, Kelly T. Morgan, Mongi Zekri, Rhuanito Ferrarezi, Arnold W. Schumann

“…Any degree of water stress or imbalance can produce a deleterious change in physiological activity of growth and production of citrus trees.  …”
Get full text

Cobalt titanate nanocatalyst for enhanced photodegradation of atrazine: kinetics, degradation efficiency, and mechanistic analysis by Jeremiah Suleiman Nuhu, Femi Emmanuel Awe, Rajni Garg, Rishav Garg, Nnabuk Okon Eddy, Hazratullah Paktin

“…Thermogravimetric analysis (TGA) showed that the nanoparticles remained stable up to 800 °C. The photocatalytic activity of CoTiO₃ NPs was tested under sunlight irradiation and the results obtained demonstrated excellent efficiency compared to the photolysis reaction. …”
Get full text

Design, formulation and antimicrobial assessment of a traditional Iranian antiperspirant formula from Rosa damascena flowers and Myrtus communis leaves. by Maryam Alipanah, Gholamhossein Yousefi, Zahra Sobhani, Mohammad Ali Jahromi, Mohammad Zarshenas

“…The dilution method was used to reduce the concentration of antimicrobial protective components in the formulation and neutralize any residual activity. Most of the resulting formulated suspension products showed consistency in texture, a light brown appearance, and a pH value of 5.15. …”
Get full text

Impact of the Timing of Enzyme Replacement Therapy Initiation and Cognitive Impairment Status on Outcomes for Patients with Mucopolysaccharidosis II (MPS II) in the United States:... by Karen S. Yee, David Alexanderian, Yidie Feng, Xiaowei Ren, Bernd Schweikert, Olulade Ayodele

“…**Background:** Mucopolysaccharidosis II (MPS II; Hunter syndrome; OMIM 309900) is a rare, X-linked, lysosomal storage disease caused by deficient iduronate-2-sulfatase activity. Accumulation of glycosaminoglycans results in multisystemic disease manifestations, which may include central nervous system involvement and cognitive impairment (CI). …”
Get full text

Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma. by Anton W Roodnat, Chelsey Doyle, Breedge Callaghan, Karen Lester, Megan Henry, Carl Sheridan, Declan J McKenna, Colin E Willoughby, Sarah D Atkinson

“…Pseudoexfoliation glaucoma is a severe form of secondary open angle glaucoma and is associated with activation of the TGF-β pathway by TGF-β1. MicroRNAs (miRNAs) are small non-coding RNA species that are involved in regulation of mRNA expression and translation. …”
Get full text