HPK1 kinase inhibitor: a sufficient approach to target HPK1 to modulate T cell activation in cancer immunotherapy compared with degraders by Qin Wang, Xinyi Zhu, Jing Li, Sanjia Xu, Ali Wang, Xinwen Zhang, Xingxing Wang, Xiaopeng Cai, Haimei Xing, Ye Liu, Xuesong Liu, Zhiwei Wang, Lai Wang, Lai Wang, Xi Yuan

“…BackgroundHematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family. …”
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The E3-ligase Siah2 activates mitochondrial quality control in neurons to maintain energy metabolism during ischemic brain tolerance by Maria Josè Sisalli, Elena D’Apolito, Ornella Cuomo, Giovanna Lombardi, Michele Tufano, Lucio Annunziato, Antonella Scorziello

“…By contrast, hypoxia reduced the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), a marker of mitochondrial biogenesis, whereas its expression was increased after reoxygenation thus improving mitochondrial membrane potential, mitochondrial calcium content, and mitochondrial morphology, hence leading to neuroprotection in IPC. …”
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Oral S2-Ag85 DNA Vaccine Activated Intestinal Cell dsDNA and RNA Sensors to Promote the Presentation of Intestinal Antigen by Dang Sheng, Sui Xin, Wu Dongxing, Wen Shubo, Song Yang, Chen Zeliang, Zhai Jingbo

“…The S2-Ag85A vaccine was effective in activating dsDNA and RNA transduction pathways in intestinal cells and improving intestinal antigen presentation in mice.…”
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Role of visual function and performance of activities of daily living in cognitive function in patients with mild cognitive impairment: a cross-sectional study by Chunhui Zhou, Ganfeng Yang, Marc Theeboom, Hua Yang, Ruiting Zhu, Zijian Zhou, Dong Zhu

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Context-dependent similarity analysis of analogue series for structure–activity relationship transfer based on a concept from natural language processing by Atsushi Yoshimori, Jürgen Bajorath

Subjects: “…Active analogue series…”
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Regulation of S100A8/A9 (Calprotectin) Binding to Tumor Cells by Zinc Ion and Its Implication for Apoptosis-Inducing Activity by Yuichi Nakatani, Masatoshi Yamazaki, Walter J. Chazin, Satoru Yui

“…These results suggest that S100A8/A9 induces apoptosis by direct binding to MM46 cells, and that this activity is regulated by zinc.…”
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Assessing the impact of COVID-19 on residents’ activities using baidu heat map data: from the lockdown era to the post-pandemic era by Jinyu Zhang, Xuesheng Zhao, Dongxue Han

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Exploring Antibacterial Activity of Fish Protein Hydrolysate In Vitro Against Vibrio Strains and Disease Resistance to V. harveyi in Turbot (Scophthalmus maximus) by Yuliang Wei, Lu Wang, Yanlu Li, Qiang Ma, Mengqing Liang, Houguo Xu

“…Results of the feeding trial showed that FPH enhanced antioxidant and immune responses before V. harveyi challenge as modulating immunoglobulin M (IgM), catalase (CAT), and myeloperoxidase (MPO) activities in serum, as well as the number of goblet cells in the intestine. …”
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Compact 999.6 nm Actively Q-Switched Yb3+:LuAlO for Laser-Induced Breakdown Spectroscopy Laser by A. Rudenkov, V. Kisel, A. Yasukevich, K. Hovhannesyan, A. Petrosyan, N. Kuleshov

“…Compact actively Q-switched diode-pumped lasers based on Yb3+-materials are of practical importance for wide range of scientific, industrial and biomedical applications. …”
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Active Management of Third Stage of Labor: Practice and Associated Factors among Obstetric Care Providers in North Wollo, Amhara Region, Ethiopia by Wondwosen Molla, Asresash Demissie, Marta Tessema

“…World Health Organization strongly recommends that every obstetrical provider at birth needs to have knowledge and skills on active management of the third stage of labor and use it routinely for all women. …”
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Are interventions for low-income groups effective in changing healthy eating, physical activity and smoking behaviours? A systematic review and meta-analysis by Stephan U Dombrowski, Marie Johnston, Nicola McCleary, Eleanor R Bull

“…Studies reporting follow-up results suggested that effects were maintained over time for diet (SMD 0.16, 95% CI 0.08 to 0.25) but not physical activity (SMD 0.17, 95% CI −0.02 to 0.37) or smoking (RR 1.11, 95% CI 0.93 to 1.34).Conclusions Behaviour change interventions for low-income groups had small positive effects on healthy eating, physical activity and smoking. …”
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Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity by Congcong Zhang, Anja Waldmann, Winfried S Wels, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Nina Müller, Pranav Oberoi

“…The ability of this molecule, termed NKAB-ErbB2, to redirect NKG2D-expressing effector cells to ErbB2-positive tumor cells of different origins was investigated using peripheral blood mononuclear cells, ex vivo expanded NK cells, and NK and T cells engineered with an NKG2D-based chimeric receptor.Results On its own, bispecific NKAB-ErbB2 increased lysis of ErbB2-positive breast carcinoma cells by peripheral blood-derived NK cells endogenously expressing NKG2D more effectively than an ErbB2-specific IgG1 mini-antibody able to induce antibody-dependent cell-mediated cytotoxicity via activation of CD16. …”
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Synthesis and Antibacterial Activity of Some Derivatives of 2-Methylbenzimidazole Containing 1,3,4-Oxadiazole or 1,2,4-Triazole Heterocycle by Cong Nguyen Tien, Duc Tran Thi Cam, Ha Bui Manh, Dat Nguyen Dang

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Influence of Ce Doping on the Electrical and Optical Properties of TiO2 and Its Photocatalytic Activity for the Degradation of Remazol Brilliant Blue R by Aisha Malik, S. Hameed, M. J. Siddiqui, M. M. Haque, M. Muneer

“…It is also observed that the impedance increases with an increase in dopant concentration. The photocatalytic activity of the synthesized particles (Ce-doped TiO2) with dopant concentration of 9% (Ce) showed the highest photocatalytic activity for the degradation of the dye derivative Remazol Brilliant Blue R in an immersion well photochemical reactor with 500 W halogen linear lamp in the presence of atmospheric oxygen.…”
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Caesarean Section Rates and Activity-Based Funding in Northern Norway: A Model-Based Study Using the World Health Organization’s Recommendation by Jan Norum, Tove Elisabeth Svee

“…Norwegian hospitals are paid per CS (activity-based funding), employing the diagnosis-related group (DRG) system. …”
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Study of interfacial bonding properties and shrinkage deformation of cement-alkali activated gradient-structured composite in complex environments with temperature-humidity changes by Xinzhe Li, Ganyou Jiang, Naishuang Wang, Yisong Wei, Zheng Chen, Zheng Chen, Jing Li, Jing Li, Ben Chen, Ben Chen, Jiamin Yu, Jiamin Yu

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Harmonious regulation flavor and lipid oxidation in dry-cured tenderloin through electrical stimulation: A study on lipase activity and sensory correlations by Lisha Lan, Li Chen, Xiaolin Zhong, Weiguo Cao, Ying Zhou, Jing Wan, Yuanyuan Liu, Qinjin Zhu

“…The study's results revealed that electrical stimulation enhanced lipase activity and accelerated lipid oxidation. Compared to the control group, the electrically stimulated samples exhibited higher total amino acid and fatty acid contents. …”
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Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice by Jui-Chi Tsai, Yi-Wen Lin, Chun-Yao Huang, Feng-Yen Lin, Chien-Sung Tsai

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Healing beyond bone: a qualitative study of the core decompression experience of physically active patients with stage II hip avascular necrosis by Mehmet Yiğit Gökmen, Habibe Sevim Gökmen, Mesut Uluöz, Özhan Pazarcı, Alaaddin Levent Özgözen, Ender Ali Uluç, Osman Çiloğlu

“…This study aims to understand the experiences of physically active patients diagnosed with stage II AVN who have undergone core decompression surgery during their follow-up period, allowing for a broader evaluation of the experiences of this patient group. …”
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Active Peptic Ulcer Disease in Patients with Hepatitis C Virus-Related Cirrhosis: The Role of Helicobacter pylori Infection and Portal Hypertensive Gastropathy by Maria Dore, Daniela Mura, Stefania Deledda, Emmanouil Maragkoudakis, Antonella Pironti, Giuseppe Realdi

“…The purpose of the present study was to investigate the role of H pylori infection and portal hypertension gastropathy in the prevalence of active peptic ulcer among dyspeptic patients with compensated hepatitis C virus (HCV)-related cirrhosis.…”
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