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  1. 7801
  2. 7802

    High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone by Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee

    Published 2019-01-01
    “…Levels of tumor suppressor proteins p53 and cav-1 were downregulated while those of the oncogenic protein as c-Myc were upregulated under high glucose and insulin supplementation in HBlEpC cotreated with pioglitazone and metformin. …”
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  3. 7803

    Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma by Stefanie Meyer, Thomas Vogt, Michael Landthaler, Anna Berand, Albrecht Reichle, Frauke Bataille, Andreas H. Marx, Anne Menz, Arndt Hartmann, Leoni A. Kunz-Schughart, Peter J. Wild

    Published 2010-01-01
    “…Based on a biomodulatory approach combining COX/PPAR-targeting with metronomic low-dose chemotherapy metastases of 36 patients participating in a randomized trial with metastatic (stage IV) melanoma were investigated using TMA-3. COX2/PPARG immunoreactivity significantly increased from nevi to primary MM and metastases; COX2 positivity was associated with advanced Clark levels and shorter recurrence-free survival. …”
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  4. 7804

    Lentinan-functionalized PBAE-G-nanodiamonds as an adjuvant to induce cGAS-STING pathway-mediated macrophage activation and immune enhancement by Zhiqiang Zhang, Li Wang, Xia Ma, Hui Wang

    Published 2024-12-01
    “…The impact of this drug delivery system on the activation and maturation of macrophages was then assessed. …”
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  5. 7805

    The relationship between interpersonal trust, family capital, and physical activity behavior among university students: a cross-lagged study by Bo Li, Ying He, Xielin Zhou

    Published 2025-01-01
    “…A longitudinal follow-up survey was conducted among 412 college students in Sichuan Province, using the Interpersonal Trust Scale, Physical Activity Rating Scale, and Family Capital Scale, in two phases over eight weeks from early March (T1) to early May (T2) 2024. (1) The autoregressive path coefficients for interpersonal trust, family capital, and physical activity behavior were 0.51, 0.41, and 0.66, respectively, indicating good stability (p < 0.001). (2) Interpersonal trust at T1 positively predicted family capital at T2 (β = 0.28, p < 0.001), and family capital at T1 also positively predicted interpersonal trust at T2 (β = 0.23, p < 0.001), indicating a mutual influence between family capital and interpersonal trust. (3) Family capital at T1 did not predict physical activity behavior at T2 (p > 0.05), but physical activity behavior at T1 positively predicted family capital at T2 (β = 0.20, p < 0.001), indicating that physical activity behavior is a causal variable for family capital. (4) Interpersonal trust at T1 positively predicted physical activity behavior at T2 (β = 0.16, p < 0.001), while physical activity behavior at T1 did not predict interpersonal trust at T2 (p > 0.05), suggesting that interpersonal trust is a causal variable for physical activity behavior. (5) Family capital mediated the relationship between interpersonal trust and physical activity behavior (α = 0.046), with a confidence interval of [0.014,0.097]. …”
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  6. 7806

    Joint intelligent optimization design of the active region and electron blocking layer for AlGaN-based deep ultraviolet LEDs by Jinglei Wang, Huimin Lu, Jianhua Ma, Yifan Zhu, Zihua Zhang, Tongjun Yu, Xuecheng Wei, Hua Yang, Jianping Wang

    Published 2025-01-01
    “…Aiming to enhance the internal quantum efficiency (IQE) of AlGaN-based deep ultraviolet light-emitting diodes (DUV LEDs), the active region based on the V-shaped quantum well (QW) and the electron-blocking layer (EBL) structure are jointly optimized using intelligent algorithms in this work. …”
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  7. 7807
  8. 7808
  9. 7809

    Using systems mapping within the process evaluation of a randomised controlled trial of the ACE active ageing programme in England and Wales by Helen Hawley-Hague, Colin Greaves, Diane Crone, Afroditi Stathi, Nick Cavill, Amy Davies, Katie E Chatwin, Zsofia Szekeres, Janet Withall, Janice Thompson

    Published 2024-07-01
    “…In this paper, we describe an innovative approach to using system mapping as part of the process evaluation of a randomised controlled trial of the Active, Connected, Engaged (ACE) community-based active ageing programme.Method Ten participatory workshops were held across three of the ACE sites (Cardiff, Stoke-on-Trent and Manchester, UK). …”
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  10. 7810
  11. 7811

    Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation by Jiawei Huang, Qingwen Deng, Lai Ling Tsang, Guozhu Chang, Jinghui Guo, Ye Chun Ruan, Chi Chiu Wang, Gang Li, Hon Fai Chan, Xiaohu Zhang, Xiaohua Jiang

    Published 2025-02-01
    “…Conclusions MSCs From perinatal tissues particularly hUCMSCs and hCVMSCs significantly enhance diabetic wound healing through PI3K/AKT pathway activation while hDCMSCs exhibited weaker efficacy. …”
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  12. 7812

    PAK5 Induces EMT and Promotes Cell Migration and Invasion by Activating the PI3K/AKT Pathway in Ovarian Cancer by Diyou Li, Yinglin Pan, Yating Huang, Ping Zhang, Xuhong Fang

    Published 2018-01-01
    “…Ovarian cancer is the most lethal gynecologic cancer and currently ranks fifth in causing cancer-related deaths among women. P21cdc42/rac1-activated kinase 5 (PAK5) is a newly identified protein that has been indicated to have oncogenic potential. …”
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  13. 7813

    A Novel Linear Active Disturbance Rejection Control Design for Air-Breathing Supersonic Vehicle Attitude System with Prescribed Performance by Chao Ming, Xiaoming Wang

    Published 2020-01-01
    “…Then, a novel linear active disturbance rejection control scheme is proposed for the attitude system to enhance the steady-state and transient-state performances by incorporating the transformed tracking error. …”
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  14. 7814

    Activity Budget and Feeding Ecology of Geladas (Theropithecus gelada obscurus) around Abogedam Church West of Debre Berhan Town, Ethiopia by Dereje Yazezew, Afework Bekele, Hussein Ibrahim

    Published 2020-01-01
    “…The activity recorded for each individual was the first activity that lasts for five seconds. …”
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  15. 7815

    Exendin-4 Improves Diabetic Kidney Disease in C57BL/6 Mice Independent of Brown Adipose Tissue Activation by Shu Fang, Yingying Cai, Fuping Lyu, Hongbin Zhang, Chunyan Wu, Yanmei Zeng, Cunxia Fan, Shaozhou Zou, Yudan Zhang, Ping Li, Ling Wang, YaomingXue, Meiping Guan

    Published 2020-01-01
    “…The role of exendin-4 in brown adipose tissue (BAT) activation was not very clear. This study is to verify the role of BAT involved in renal benefits of exendin-4 in diabetes mellitus (DM). …”
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  16. 7816

    Removal of Methylene Blue from Wastewater by Adsorption onto ZnCl2 Activated Corn Husk Carbon Equilibrium Studies by Maryam Khodaie, Nahid Ghasemi, Babak Moradi, Mohsen Rahimi

    Published 2013-01-01
    “…The removal of methylene blue by activated carbon of corn husk by ZnCl2 activation () was investigated in the present study. …”
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  17. 7817

    A Colorimetric/Fluorescent Dual Sensing System Based on the Enzyme-like Activity of Fluorescent Carbon Quantum Dots for Detection of Glucose by GUAN Huanan, ZHANG Mingyi, WANG Dandan, ZHANG Zhuzehui

    Published 2024-12-01
    “…A colorimetric/fluorescent dual-sensing assay for the detection of glucose was established based on the peroxidase-like activity of fluorescent carbon quantum dots derived from corncob. …”
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  18. 7818

    Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of Musa sinensis L. and Musa paradisiaca L.... by Barnabas Oluwatomide Oyeyinka, Anthony Jide Afolayan

    Published 2020-01-01
    “…There was a significant negative correlation between the total phenol and flavonoid contents of M. sinensis flesh with its DPPH radical scavenging activity and proanthocyanidin content of M. paradisiaca flesh with its DPPH radical scavenging activity. …”
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  19. 7819

    Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design by Szabó Zoltán-István, Székely-Szentmiklósi Blanka, Deák Boglárka, Székely-Szentmiklósi István, Kovács Béla, Zöldi Katalin, Sipos Emese

    Published 2016-06-01
    “…To evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate experimental designs were employed: one for evaluating powder properties and the other for tablet characteristics. …”
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  20. 7820

    The activities of Soviet intelligence service among Russian emigration in post-war Northern China (according to the memoirs of N. A. Martynov) by M. V. Krotova

    Published 2023-05-01
    “…Martynov, is devoted to the activities of the Soviet intelligence service among the Russian emigration in Northern China after World War II in the context of the SovietAmerican confrontation in the initial period of the Cold War. …”
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