Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes by Sadegh Faramarzi, Arianna Bassan, Kevin P. Cross, Xinning Yang, Glenn J. Myatt, Donna A. Volpe, Lidiya Stavitskaya

“…Furthermore, five quantitative structure-activity relationship (QSAR) models were developed to predict not only time-dependent inhibition of CYP3A4, an enzyme that metabolizes approximately 50% of all marketed drugs, but also reversible inhibition of 3A4, 2C9, 2C19 and 2D6. …”
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Bicyclic peptide-enhanced covalent inhibitor of SARS-CoV-2 3CL protease by Qian Wang, Yanhui Wang, Jian Li, Hong Liu, Shiyu Chen

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Similarities and differences in physiological adaptation to cadmium interactions with nitrogen levels between two aquatic iris life forms in urban wetlands by Zhenzuo Lei, Yuan Jiang, Yanqiong Meng, Yiyong Li, Yucong Li, Tao Hu, Yanjun Ma

“…Additionally, under the combined stress of N and Cd, evergreen irises exhibited higher malondialdehyde (MDA) content and antioxidant enzyme activity than deciduous irises, whereas deciduous irises had higher chlorophyll content and aboveground biomass. …”
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Analysis of Forest Cover in the Tumba-Lediima Nature Reserve (RTL-DRC) by Sylvestre Frey, André Musas A Musas, Nestor Anzola Kibamba, Sebastien Kidushi Mboma, Tege Simboni Simboni, Djonive Munene Asidi

“…The main drivers of deforestation identified are agricultural expansion, illegal exploitation of forest resources and urbanization. These activities have led to the fragmentation of critical habitats, putting endemic and threatened species at risk, while also compromising the ecological integrity of the reserve. …”
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Molecular response to multiple trace element contamination of the European sardine by Beauvieux, Anaïs, Fromentin, Jean-Marc, Saraux, Claire, Romero, Diego, Couffin, Nathan, Brown, Adrien, Metral, Luisa, Bertile, Fabrice, Schull, Quentin

“…In marine ecosystems, the presence of trace elements resulting from anthropogenic activities has raised concerns regarding their potential effects on marine organisms. …”
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Dietary inclusion of African bush mango (Irvingia gabonensis) seed improves sexual performance in sexually inexperienced rats by Olasunkanmi Omojokun, Akindele Famurewa, Ganiyu Oboh, Jemima Enang, Stella Ijeh

“…Arginase and PDE-5 inhibitory activities were also higher in the same group. Conclusion: This study suggests that ABM promotes sexual behavior and improves penile erection as a treatment for ED, justifying its use in folk medicine for this purpose.…”
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99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting by Adli A. Selim, Tamer M. Sakr, Basma M. Essa, Galal H. Sayed, Kurls E. Anwer

“…Compound 3 (4-((3-cyano-4-(2,4-dichlorophenyl)-6-phenylpyridin-2-yl)amino)-N-(diaminomethylene)benzenesulfonamide) exhibited remarkable anti-cancer activity against MCF-7 cells. The chemical reduction method was employed to create compound 3-citrate-AuNPs. …”
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A comprehensive environmental index for monitoring ecological quality of typical alpine wetlands in Central Asia by Jiudan Zhang, Junli Li, Changming Zhu, Anming Bao, Amaury Frankl, Philippe De Maeyer, Tim Van de Voorde

“…Furthermore, the driving factors behind these changes were analyzed by combining meteorological precipitation data with human activities. Long-term monitoring results indicate that the Bayanbulak Wetland has experienced significant expansion, with its ecological quality improving remarkably over the past 45 years, particularly in the Big Urdus basin. …”
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Integrative assessment of heavy metal risks in mining polluted sediments and soils of Aguascalientes, Mexico by Thanya Crespo-Toledo, Francisco Avelar-González, Alma Guerrero-Barrera, Kerry Mitchell, Laura Yamamoto-Flores, Oscar Flores-Amaro

“…Residual metals from mining activities pose significant risks to both the environment and human health, especially when they exist in bioavailable and mobile forms. …”
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Sociological approach in managing high school violence in Serbia in the COVID - 19 postpandemic period by Milosavljević-Stević Milena, Radosavljević Života, Anđelković Aleksandar

“…This is significant as the intensity of violence not directly related to war activities is drastically increasing, even with dramatic consequences. …”
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Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease S... by V. T. Ivashkin, V. P. Chulanov, N. A. Mamonova, M. V. Maevskaya, M. S. Zharkova, I. N. Tikhonov, P. O. Bogomolov, E. V. Volchkova, A. S. Dmitriev, O. O. Znojko, E. A. Klimova, K. V. Kozlov, I. E. Kravchenko, E. Yu. Malinnikova, R. V. Maslennikov, M. I. Mikhailov, K. E. Novak, I. G. Nikitin, V. E. Syutkin, E. V. Esaulenko, A. A. Sheptulin, E. N. Shirokova, N. D. Yushchuk

“…Also, these recommendations present approaches to active screening of hepatitis in risk groups, preventive and rehabilitation measures after the end of treatment.Conclusion. …”
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Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology by Chauveau, Carine, Roby, Dominique

“…In nature, plants defend themselves against pathogen attack by activating an arsenal of defense mechanisms. During the last decades, work mainly focused on the understanding of qualitative disease resistance mediated by a few genes conferring an almost complete resistance, while quantitative disease resistance (QDR) remains poorly understood despite the fact that it represents the predominant and more durable form of resistance in natural populations and crops. …”
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Orange sweet potato flour production: Comparative effects on ultrasound, drying, storage, and techno-economic assessment by Analaura Gómez-Cisneros, Alberto Ordaz, Liliana Santos-Zea, Anayansi Escalante-Aburto, Edith Ponce-Alquicira, Mariel Calderón-Oliver

“…Therefore, this study aimed to evaluate the effects of 3 factors and their interaction: ultrasound treatment (40 kHz, 10 min at 25 °C), storage time after ultrasound (0–96 h), and drying methods (cabinet dehydration and freeze-drying) to obtain sweet potato flour without reducing bioactive compounds, color and antioxidant activity, as well as its techno-economic feasibility. …”
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Molecular imprinted polymer-based potentiometric approach for the determination of carvedilol and ivabradine hydrochloride in dosage form, spiked human plasma and in presence of th... by Nermine V. Fares, Haitham A. El Fiky, Dina A. Ahmed, Maha F. Abd El Ghany, Amr M. Badawey, Mahmoud A. Tantawy

“…Solid contact ion-selective electrodes with wide range of applications have been developed for analysis of these two active ingredients. Those types of electrodes have common drawbacks. …”
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Comparative performance of tuberculin and defined-antigen cocktails for detecting bovine tuberculosis in BCG-vaccinated cattle in natural settings by Abebe Fromsa, Andrew J. K. Conlan, Sreenidhi Srinivasan, Balako Gumi, Wegene Bedada, Miserach Zeleke, Dawit Worku, Matios Lakew, Biniam Tadesse, Berecha Bayissa, Asegedech Sirak, Musse Girma Abdela, Getnet Abie Mekonnen, Tesfaye Chibssa, Maroudam Veerasami, Gareth J. Jones, H. Martin Vordermeier, Nick Juleff, James L. N. Wood, Gobena Ameni, Vivek Kapur

“…Before exposure, the DIVA skin, DIVA IGRA, and tuberculin tests showed 100% specificity in unvaccinated control calves. After exposure, the DIVA skin, DIVA IGRA, and comparative cervical tuberculin (CCT) tests had comparable sensitivities of 46% (95% CI 36, 56), 45% (95% CI 35, 55), and 47 (95% CI 37, 57), respectively, when assessed against animals positive by M. bovis culture PCR. …”
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Native versus non-native Prosopis woody species: Which fertilize the soil better? by Moslehi Maryam, Ahmadi Farzad, Matinizadeh Mohammad, Sadeghi Seyed Mousa, Izadi Masoumeh, Faunae Nafiseh, Alizadeh Tahereh, Shackleton Ross T.

“…Three soil samples per site were pooled for chemical and microbial analysis. …”
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Temporally and Spatially Controlled Age-Related Prostate Cancer Model in Mice by Sen Liu, Keyi Shen, Zixuan Li, Seleste Rivero, Qiuyang Zhang

“…Unlike Pb-Cre knock-in models (which are spatially but not temporally controlled), the expression of Cre is activated to knock out Pten from the mice's prostate epithelial cells once injected. …”
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Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…Given its pivotal role in the early stages of influenza A infections, intense drug discovery efforts have been undertaken to target HA in the past decades. …”
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Nurture-U student mental health longitudinal survey: a study protocol by Kate E Saunders, Samuel R Chamberlain, Jemima Dooley, Edward R Watkins, Liz Forty, Sarah Rees, Anne C Duffy, Anthony Quinn, Ellen Marshall, Lucy Dorey, Kevin A Matlock, Alexandra Newbold, Lucy J Robinson

“…Data will be de-identified and securely stored, with results disseminated through academic publications, social media and student engagement activities.…”
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How to build a framework to establish a patient research partner network in rheumatology research: a report of a 2-year implementation project by Maarten de Wit, Oliver Distler, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Muriel Elhai, Rucsandra Dobrota, Adrian Ciurea, Caroline Ospelt, Raphael Micheroli, Dania Diem, Stefan Dudli, Kristina Buerki, Stacey Grealis, Melpomeni Toitou, Silke Ludwig, Chantal Britt, Florian Klett, Isabelle Steeb, Tanja Maletic, Andreas Eisenring, Penelope Jane Timpert-Argust, Eva Camarillo-Retamosa

“…Background Patient research partners (PRPs) are people living with a relevant disease who actively contribute to research. Their contribution is beneficial for any research project. …”
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