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7661
Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation
Published 2025-01-01“…This study aims to investigate the impact of CS on trophoblast cell proliferation and regulated cell death (RCD) by examining its interference with iron-sulfur cluster (ISC) proteins and the CIA pathway. …”
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7662
Exploring sustainable construction: A case study on the potential of municipal solid waste incineration ashes as building materials in San Andres island
Published 2025-07-01“…Additionally, the ash met the performance specifications required for use in road construction materials, demonstrating its potential for use in different construction applications. …”
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7663
BIOMETRIC CHARACTERISTICS AND STRESS LEVELS OF GLASS EEL (Anguilla sp.) IN THE SOUTHERN ESTUARIES OF SUKABUMI, WEST JAVA
Published 2025-02-01“…Therefore, eels that are suitable for cultivation activities come from the Cimandiri River Estuary, while the eel location that needs conservation is the Cibuni River Estuary.…”
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7664
Increase in methemoglobin fraction due to the use of glyceryl trinitrate patches in preterm infants: a case report and literature review
Published 2025-02-01“…While GTN is effective for neonatal ischemia, its dosing, and safety lack consistent guidelines. …”
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7665
Nanofertilizers benefited maize to cope oxidative stress under saline environment
Published 2025-02-01“…Results revealed that nano Zn and Si significantly increased the activities of antioxidant enzymes (SOD, POD, CAT, APX) under saline conditions along with growth parameters. …”
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7666
Fate and long-lasting therapeutic effects of mesenchymal stromal/stem-like cells: mechanistic insights
Published 2025-02-01“…However, the limited use of MSCs in clinical practice can be attributed to a lack of understanding of the fate of MSCs in patients after administration and long term MSC-derived therapeutic activity. While the known physiological effectors of viable MSCs make a relative contribution, an innate property of MSCs as a therapeutic agent is their caspase-dependent cell death. …”
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7667
Evaluation of the effect on antimicrobial properties, color, roughness and curing time of glass ionomer cement incorporated with silver and copper nanoparticles
Published 2025-02-01“…The biofilms were then collected and plated on Mitis-Salivarius-Bacitracin (MSB) agar and Sabouraud dextrose agar for Streptococcus mutans and Candida albicans, respectively. …”
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7668
Comparative functional analysis of a new CDR1-like ABC transporter gene in multidrug resistance and virulence between Magnaporthe oryzae and Trichophyton mentagrophytes
Published 2025-02-01“…MoCdr1 and TmCdr1 are conserved in structures and functions, and both involved in drug resistance and pathogenicity by analogously regulating gene expression levels related to transporter activity, MAPK signaling pathway, and metabolic processes. …”
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7669
Influence of Regional Pollution Outflow on Particle Number Concentration and Particle Size in Airshed of Guangzhou, South China
Published 2022-06-01“…Average particle number concentration (PNC) was 6.3 × 103 cm–3 and 9.7 × 103 cm–3, respectively, at urban and suburban sites, indicating the severe particulate matter (PM) pollution. …”
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7670
Genetically edited human placental organoids cast new light on the role of ACE2
Published 2025-02-01“…Despite increased expression of ACE2 protein, ACE2 enzyme activity was significantly decreased in ACE2 rs2074192 TT placental organoids. …”
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7671
Study on the regulation of tea polyphenols on the structure and gel properties of myofibrillar protein from Neosalanx taihuensis
Published 2025-01-01“…Among the three TP compounds, EGCG, due to its higher number of phenolic rings, formed complexes with MP that exhibited greater antioxidant activity. …”
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7672
Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice
Published 2025-01-01“…In vitro experiments using H9C2 myocardial cells demonstrated that PS-NPs activate the TNF-α/NF-κB and P38/MAPK signaling pathways and thereby induce inflammatory infiltration and oxidative stress. …”
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7673
Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study
Published 2025-02-01“…Fucosylated (Fu)-Hp purified from SPs upregulates inflammatory cytokines and chemokines, along with NLRP3 inflammasome activation. Single-cell RNA sequencing identifies a distinct macrophage-like cell population with increased expressions of inflammatory mediators and FUT4 in response to Fu-Hp. …”
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7674
Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu...
Published 2025-02-01“…The PGEVs were isolated by ultracentrifugation and sucrose gradient centrifugation method and contained adequate functional components such as proteins, lipids, RNAs and active molecules. PGEVs exhibited remarkable stability, tolerating acidic digestion and undergoing minimal changes in simulated gastrointestinal fluid. …”
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7675
Spatial-temporal differentiation and influencing factors of ecosystem health in Three-River-Source national Park
Published 2025-02-01“…It reveals the independent and interactive effects of its influencing factors. We found that: (1) Despite the overall positive trend observed in TNP’s ecosystem health, the trend remains relatively weak, and the health level predominantly dominated by the fragile level during the study period. (2) The spatial variation in ecosystem health within TNP was pronounced, with a noticeable increase moving from the northwest to the southeast area. …”
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7676
Fluids, faulting and earthquakes in the brittle crust: recent advances and new challenges
Published 2024-05-01“…Lastly, increase or decrease of $p_{f}$ in depth due to human activities such as hydrocarbon extraction, dam impoundment, gas storage or geothermal energy production result in many cases in the inception or enhancement of seismic activiy, adding clues in favor of a relationship between fluids and earthquakes.…”
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7677
The role of the interleukin family in liver fibrosis
Published 2025-02-01“…Among these, the interleukin family activates a complex cascade of responses, including cytokines, chemokines, adhesion molecules, and lipid mediators, playing a key role in the initiation and regulation of inflammation, as well as innate and adaptive immunity. …”
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7678
The Spatio-temporal Evolution of NDVI in the Three Gorges Reservoir Area Driven by the Synergistic Effect of two Factors over the Past 21 Years
Published 2024-12-01“…[Objective] To clarify the spatio-temporal characteristics of vegetation evolution in the Three Gorges Reservoir Area, and to quantitatively analyze the relationships between vegetation and key determinants, including climate, terrain, and human activities. [Methods] Based on Normalized Difference Vegetation Index (NDVI) data, a suite of analytical techniques was employed, including Theil-Sen Median Trend Analysis, the Mann-Kendall Test for significance, Hurst Exponent Analysis, and Geographic Detector Modeling, to investigate the spatio-temporal patterns and driving forces of NDVI within the Three Gorges Reservoir Area from the year 2000 to 2020. …”
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7679
Six events that shaped antibody approvals in oncology
Published 2025-02-01“…Finally, we explore the development of ipilimumab, the first immune checkpoint-inhibiting antibody that activates the immune system to kill cancer cells, and the discovery that allowed the use of checkpoint inhibitors across all cancer types based on the presence of genetic markers. …”
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7680
Tannins for food preservation and human health: A review of current knowledge
Published 2025-06-01“…The phenolic structure of tannins has also the potential to be used in food, nutraceutical and pharmaceutical industries.Tannins exhibit a high level of biological activity. Therefore, a number of advantages such as antioxidant, anticancer, anti-allergic, and antimicrobial properties, have been verified in recent research. …”
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