Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity by Ana Aguinaga-Barrilero, Patricia Castro-Sánchez, Ignacio Juárez, Alberto Gutiérrez-Calvo, Noelia Rodríguez-Pérez, Adela Lopez, Remedios Gómez, José M. Martin-Villa

“…Evaluation of caspase-3 activity showed higher levels in T cell extracts of patients, and this activity could be decreased by 70% with the use of the inhibitor Ac-DEVD-FMK, although CD3ζ expression levels did not recover. …”
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What behavior is important behavior? A systematic review of how wild and zoo-housed animals differ in their time-activity budgets by Robert Kelly, Marianne Freeman, Paul Rose, Paul Rose

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Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture by Ilia Manolov, Sevda Raleva, Petya Genova, Alexey Savov, Liliana Froloshka, Daniela Dundarova, Radka Argirova

“…No effect on late steps of viral replication has been found using cells chronically producing HIV-1LAI virus. La(W) demonstrated anti-HIV activity (IC50=21.4μM) close to maximal nontoxic concentration. …”
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Adaptive Finite-Time Fault-Tolerant Control for Half-Vehicle Active Suspension Systems with Output Constraints and Random Actuator Failures by Jie Lan, Tongyu Xu

“…The problem of adaptive finite-time fault-tolerant control (FTC) and output constraints for a class of uncertain nonlinear half-vehicle active suspension systems (ASSs) are investigated in this work. …”
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Improved jet lag recovery is associated with a weaker molecular biological clock response around the time of expected activity onset by Marie-Claire Boutrin, Melissa E. S. Richardson, Feyikemi Oriola, Samira Bolo

“…While factors such as jet lag, variations in day length, and light at night are known disruptors to the timing of activity onset following rest, the molecular consequence of the intersection of multiple disruptions is less understood.MethodsHere, we expose mice to a jet lag paradigm under two light-dark (LD) conditions (12:12 LD and 8:16 LD) coupled with additional light exposure at night during the recovery period (known as negative masking), previously demonstrated to improve jet lag-related memory loss in mice.ResultsOur results show that jet lag exposure in both LD cycles (to a greater extent in 8:16 LD) increased the fold-change of circadian gene expression in the SCN relative to the dark onset. …”
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Fabrication of Hybrid Materials Based on Waste Polyethylene/Porous Activated Metakaolinite Nanocomposite as an Efficient Membrane for Heavy Metal Desalination Processes by Mahmoud F. Mubarak, Mohamed A. Zayed, Ayman Nafady, Abeer E. L. Shahawy

“…Hybrid nanostructure materials derived from activated metakaolinite are of growing importance due to their intriguing structural/functional properties and promising biomedical/environmental applications, especially designing desalination membranes. …”
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Lactobacillus gasseri LGV03-derived indole-3-lactic acid ameliorates immune response by activating aryl hydrocarbon receptor by Zikang Zhang, Kangdi Zheng, Zhao Zhang, Longbin Cao, Lizhu Lin, Weimin Sun, Feng Qiu

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Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial by Chia-Hua Liang, Yung-Hsiang Lin, Yung-Kai Lin, Chi-Fu Chiang

“…Thus, banana flower extract (HappyAngel®) can stimulate hair growth and inhibit the activation of hair loss genes.…”
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Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities. by Kristina N Delgado, Melissa J Caimano, Isabel C Orbe, Crystal F Vicente, Carson J La Vake, André A Grassmann, M Anthony Moody, Justin D Radolf, Kelly L Hawley

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Potential involvement of peroxisome proliferator-activated receptors in the inhibition of mammary lipid synthesis during diet-induced milk fat depression by A. Haile, D.E. Oliveira, Y.R. Boisclair, D.E. Bauman, K.J. Harvatine

“…The interaction of PPAR-γ chemical agonist troglitazone and antagonist T0070907 and CLA was then investigated in bovine mammary epithelial cells. The activation and inhibition of PPAR-γ did not overcome trans-10,cis-12 CLA inhibition of lipogenesis despite the agonist stimulating PPAR-γ expression. …”
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Discovering the anti-parasitic activity of melatonin loaded lecithin/chitosan nanoparticles against giardiasis and cryptosporidiosis in Balb/c infected mice by Mohamed Nasser, Mona B. Abd El-atif, Habiba Alaa, Mariam Abdelaziz, Mariam Mustafa, Mustafa Masour, Salma Magdy, Salma Mohsen, Yomna El Karamany, Alyaa Farid

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Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice by Tomoko Kawakami, Nitin Puri, Komal Sodhi, Lars Bellner, Toru Takahashi, Kiyoshi Morita, Rita Rezzani, Tim D. Oury, Nader G. Abraham

“…However, recent reports have suggested an inhibitory effect of ROS on HO activity. In light of these conflicting reports, this study was designed to evaluate effects of chronic oxidative stress on HO system and its role in contributing towards patho-physiological abnormalities observed in extracellular superoxide dismutase (EC-SOD, SOD3) KO animals. …”
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Quercetin as a Precursor for the Synthesis of Novel Nanoscale Cu (II) Complex as a Catalyst for Alcohol Oxidation with High Antibacterial Activity by Zahra Moodi, Ghodsieh Bagherzade, Janny Peters

“…Quercetin has the ability to bind with several metal ions to increase its biological activities. In the last two decades, quercetin has attracted considerable attention due to the biological and pharmaceutical activities such as antioxidant, antibacterial, and anticancer. …”
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Metabolic Activity in Human Intermuscular Adipose Tissue Directs the Response of Resident PPARγ⁺ Macrophages to Fatty Acids by Xiaoying Chen, Sebastian Ludger Schubert, Aline Müller, Miguel Pishnamaz, Frank Hildebrand, Mahtab Nourbakhsh

“…<b>Background/Objectives</b>: Peroxisome proliferator-activated receptor gamma (PPARγ) is a fatty acid-binding transcription activator of the adipokine chemerin. …”
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Synthesis, evaluation of the biological activity against Trypanosoma cruzi and Leishmania donovani.... by Miguel A. Rodríguez, Ali Mijoba, Nereida J. Parra-Giménez, Zuleyma Blanco, Katiuska Chávez, Alirica I. Suárez, Esteban Fernandez-Moreira, Hegira Ramírez, Jaime E. Charris

“…The synthesis and evaluation of the biological activity of a series of 5-nitroimidazole hybrids is described. …”
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Virtual screening and molecular docking of Indonesian phytoconstituents as potential inhibitors of peroxisome proliferator-activated receptor gamma in polycystic ovary syndrome by Tunjungseto Arif, Iffatunnisa Fakhriyah, Pratiwi Intan Winta, Alif Azzam Muhyiddin Afrizal, Ahsan Fadhil, Santoso Budi

“…Peroxisome proliferator-activated receptor-gamma (PPARG) is one of the essential modulators of ovarian steroid hormone synthesis and lipid metabolism. …”
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Proteasome Activity and C-Reactive Protein Concentration in the Course of Inflammatory Reaction in Relation to the Type of Abdominal Operation and the Surgical Technique Used by Marzena Tylicka, Ewa Matuszczak, Maria Karpińska, Adam Hermanowicz, Wojciech Dębek, Halina Ostrowska

“…The aim of this study was to investigate the rate of change in proteasome chymotrypsin-like (ChT-L) activity and C-reactive protein concentration depending on the degree of tissue damage and their correlation with prealbumin concentrations in children before and after abdominal surgery. …”
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Line-Shifting Triarylmethyl Radicals for Imaging of Enzyme Activity Using Overhauser-Enhanced Magnetic Resonance Imaging: Application to Alkaline Phosphatase by Murugesan Velayutham, Martin Poncelet, Ayano Enomoto, Justin L. Huffman, Virat G. Pandya, Kazuhiro Ichikawa, Valery V. Khramtsov, Benoit Driesschaert

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Feasibility of Metatranscriptome Analysis from Infant Gut Microbiota: Adaptation to Solid Foods Results in Increased Activity of Firmicutes at Six Months by Floor Hugenholtz, Jarmo Ritari, Lotta Nylund, Mark Davids, Reetta Satokari, Willem M. de Vos

“…In this study, we describe the feasibility of isolating mRNA from rapidly processed faecal samples and applying deep RNA-Seq analysis to provide insight into the active contributors of the microbial community in early life. …”
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Bruxism repercussions in muscular activation: Ultrasound differences in abdominal wall between women with and without bruxism. A cross-sectional study. by Paula Yela-Lorenzo, Paola Montes-Arenas, Vanesa Abuín-Porras, Ángel González-de-la-Flor, Laura González-Fernández, Jorge Hugo Villafañe, Isabel Mínguez-Esteban

“…Age was not a significant predictor (p = 0.506), suggesting its limited role in this context.<h4>Conclusion</h4>The results of this study support the existence of an association between bruxism and the abdominal wall muscles structure and activation. …”
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