Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine by Panagiota Voukelatou, Elissavet Sfendouraki, Theodoros Karianos, Sofia Saranti, Dimitrios Tsitsimelis, Ioannis Vrettos, Andreas Kalliakmanis

“…Considering the results and in the absence of another diagnosis, the patient was treated with 30 mg prednisone daily and mesalazine, as treatment of active UC. Subsequently, the patient’s condition improved markedly and the fever retreated. …”
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Design, Synthesis, enzyme inhibitory activity and molecular docking studies of new 1,2,3-triazole linked nucleobases by Aditya Aggarwal, Chanchal Vashisth, Komal Bharti, Neera Raghav, Surender Kumar

“…Interestingly, four compounds, including 5d, 5h, 5k and 5m displayed excellent potent level of enzyme inhibitory activity at 10−7 M concentration. Further, molecular docking analysis revealed that some compounds shown significant binding interactions with target sites. …”
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A heteropolysaccharide from Rhodiola rosea L.: preparation, purification and anti-tumor activities in H22-bearing mice by Yaru Wu, Qing Wang, Huiping Liu, Lulu Niu, Mengyu Li, Qi Jia

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Contribution of Phosphorylation Modification to Stability and Antibacterial Activity of Egg White Protein Nanogels Loaded with Cinnamon Bark Essential Oil by Sheng-Qi Rao, Xin-Ru Gao, Hui Liu, Zhi-Rong Wang, Zhen-Quan Yang

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Mini Review: Anticholinergic Activity as a Behavioral Pathology of Lewy Body Disease and Proposal of the Concept of “Anticholinergic Spectrum Disorders” by Koji Hori, Kimiko Konishi, Misa Hosoi, Hiroi Tomioka, Masayuki Tani, Yuka Kitajima, Mitsugu Hachisu

“…Given the relationship between anticholinergic activity (AA) and Alzheimer’s disease (AD), we rereview our hypothesis of the endogenous appearance of AA in AD. …”
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Antiviral Activity and Underlying Mechanism of <i>Moslae herba</i> Aqueous Extract for Treating SARS-CoV-2 by Yan Feng, Qiong Ge, Jian Gao, Zhuoying Wu, Yunyi Zhang, Haiyan Mao, Beibei Wu, Changping Xu

Subjects: “…SARS-CoV-2…”
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Mitochondrial dysfunction-driven AMPK-p53 axis activation underpins the anti-hepatocellular carcinoma effects of sulfane sulfur by Xue Zheng, Yuhua Luo, Rui Huo, Yiwen Wang, Youbang Chen, Mianrong Chen, Qi Zhao, Kexin Li, Hanyi Zhang, Xiaotong Li, Xiang Li, Hui Zhang, Zaopeng He, Li Huang, Chun-tao Yang

“…The impact of PSCP on HCC was assessed in vitro and in vivo, focusing on the expression and activity of p53 and AMP-activated protein kinase (AMPK), as well as mitochondrial function. …”
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Genetic Tendency Analysis and Comprehensive Antioxidant Activity Evaluation of Leaves and Flowers of Loquat F₁ Generation by Qixuan Zhu, Xiaoying Li, Hang Ge, Zhixuan Wang, Binjun Wang, Junwei Chen, Hongxia Xu

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Unveiling the nutraceutical potential of indigenous and exotic eggplant for bioactive compounds and antioxidant activity as well as its suitability to the nutraceutical industry by Yvonne Angel Lyngdoh, Yvonne Angel Lyngdoh, Partha Saha, Partha Saha, Bhoopal Singh Tomar, Rakesh Bhardwaj, Laxman L. Nandi, Mohita Srivastava, Bishal Gurung, Jeetendra Kumar Ranjan, Paresh Chaukhande

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Antioxidant and Chelating Activity of Nontoxic Jatropha curcas L. Protein Hydrolysates Produced by In Vitro Digestion Using Pepsin and Pancreatin by Santiago Gallegos Tintoré, Cristina Torres Fuentes, Javier Solorza Feria, Manuel Alaiz, Julio Girón Calle, Alma Leticia Martínez Ayala, Luis Chel Guerrero, Javier Vioque

“…The antioxidant and metal chelating activities in J. curcas protein hydrolysates have been determined. …”
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Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases by Shih-Wen Huang, Yein-Gei Lai, Hao-Ting Liao, Chin-Ling Chang, Ruo-Yu Ma, Yung-Hsiang Chen, Yae-Huei Liou, Zhen-Qi Wu, Yu-Chen Wu, Ko-Jiunn Liu, Yen-Tsung Huang, Jen-Lung Yang, Ming-Shen Dai, Nan-Shih Liao

“…These findings indicate that autologous NK cell therapy is effective in treating established low burden metastases of MHC-I+ tumor cells by activating the cDC-T cell axis at metastatic sites.…”
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Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry by Michael J. Greig, Sherry Niessen, Scott L. Weinrich, Jun Li Feng, Manli Shi, Ted O. Johnson

“…Often, the mutation directly affects a drug’s binding site, effectively blocking binding of the drug, but these mutations can have other effects such as changing the protein turnover half-life. …”
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Association between chronic pain and physical activity in a Swiss population-based cohort: a cross-sectional study by Pedro Marques-Vidal, Peter Vollenweider, Oriane Aebischer, Marc René Suter

“…Daily pain, pain duration, number of painful sites and pain intensity were assessed by questionnaire. …”
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Structure Characterization and Antioxidant Activity of a Novel Polysaccharide from <i>Bacillus natto</i> Fermented Millet Bran by Hanzhuo Zhang, Xia Fan, Wenjie Zhao, Fanqiang Meng, Fengxia Lu, Zhaoxin Lu, Haizhen Zhao

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Content Determination of Active Component in Huangqi Yinyanghuo Group and Its Effects on hTERT and Bcl-2 Protein in Osteosarcoma by Ying Tan, Lei Tan, Shuai Huang, Junfan Lu, Longtan Yu

“…To screen the optimal extraction process and content determination of active component of Huangqi Yinyanghuo group (HYG) and to study the effects of HYG on human telomerase reverse transcriptase (hTERT) and Bcl-2 protein in osteosarcoma (HOS) cells, providing the theoretical basis for clinical application of HYG in treatment of osteosarcoma, orthogonal design table L9(43) was used to design the extraction process of HYG, and icariin was taken as the investigation index to optimize the extraction process of HYG. 0.125, 0.25, 0.5, 1, 2, 4, and 8 μmol/L HYG were taken to act separately on logarithmic growth phase osteosarcoma HOS cells, CCK-8 assay was used to determine cell viability, and immunohistochemical SP assay was used to determine the expression of hTERT and Bcl-2 protein. …”
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Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment by Shana M. Owens, Jeffrey M. Sifford, Gang Li, Steven J. Murdock, Eduardo Salinas, Darby Oldenburg, Debopam Ghosh, Jason S. Stumhofer, Intawat Nookaew, Mark Manzano, J. Craig Forrest

“…Using a small-animal model of gammaherpesvirus pathogenesis, we demonstrate in vivo that the tumor suppressor p53 is activated specifically in B cells latently infected by murine gammaherpesvirus 68. …”
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Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells by Qingjie Fu, Shunsuke Ohnishi, Naoya Sakamoto

“…Transforming growth factor-beta (TGF-β) treatment further activated HSCs and hAMSC-CM significantly inhibited the upregulation of α-Sma and Col1a1 induced by TGF-β. …”
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Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly by Hyoung-Jun Kim, Kitae Ryu, Joo-Hee Kang, Ae-Jin Choi, Tae-il Kim, Jae-Min Oh

“…According to the in vitro anticancer activity test on human cervical cancer HeLa cells, it was revealed that nanohybrids showed twice anticancer activity compared with ferulic acid itself. …”
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Crevicular Alkaline Phosphatase Activity and Rate of Tooth Movement of Female Orthodontic Subjects under Different Continuous Force Applications by Rohaya Megat Abdul Wahab, Maryati Md Dasor, Sahidan Senafi, Asma Alhusna Abang Abdullah, Zulham Yamamoto, Abdul Aziz Jemain, Shahrul Hisham Zainal Ariffin

“…Root resorption was assessed using periapical radiographs before and after the force application. Results. ALP activity at the mesial sites peaked at week 1 for 150 gm group with significant differences when compared with the 100 gm group. …”
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Bioactive Properties of <i>Pentacalia vaccinioides</i> (Kunth) Cuatrec. (Asteraceae) Essential Oils: Evaluation of Antimicrobial and Antioxidant Activities by Luis G. Sequeda-Castañeda, María A. Castellanos-Gómez, Carlos L. A. Céspedes-Acuña

“…Essential oils (EOs) have unique properties, such as antibacterial, antioxidant, and antiviral activities, which are beneficial in various industries, including cosmetics, food, and pharmaceuticals. …”
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