Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Robust in vitro and in vivo data demonstrate the efficacy of this approach and CaO2@ZIF8:CUR@PAA as an anticancer platform, paving the way for nanomaterials in immune-triggered cancer therapy.Highlights: - A new calcium accumulation nanoplatform plays a role in activate antitumor immunity.- Double-locked structure slows down the premature decomposition of CaO2.- The platform allows Ca2+ and H2O2 to accumulate in tumor cells.- This leads to mitochondrial dysfunction, apoptosis, and M1 macrophage polarization.- Potent anti-tumor effects are seen both in vitro and in vivo.Keywords: Calcium ion load, controlled-release nanomaterials, two-layer protective shell, pH responsive drug release, reactive oxygen species, anti-cancer…”
Get full text

Gambaran Hitung Jenis Leukosit pada Pasien Penyakit Paru Obstruktif Kronik yang Dirawat di RSUP Dr. M. Djamil Padang by Revi Sofiana Martantya, Ellyza Nasrul, Masrul Basyar

“…Cigarette smoke, air pollution, and recurrent infections in the respiratory tract can activates alveolar macrophages to release inflammatory mediators that stimulate granulocytic and monocytic progenitors in the bone marrow that can affect leukocyte counts in peripheral blood. …”
Get full text

Biodiversity Patterns of Rocky Coastal and Human-Made Structures in Gheshm Shorelines; Role of Slope and Tidal Levels Characteristics in Determining Patterns of Biodiversity by Marzieh Razaghi, Ali Nasrolahi, Ehsan Kamrani, Mohammad Sharif Ranjbar, Amir Vazirizadeh

“…Introduction: The coastal landscapes are constantly changing due to the increasing demand for structures aimed at economic, residential, and tourism activities. Human-made constructions such as breakwaters, piers, and seawalls have become characteristic features alongside shallow habitats in intertidal and subtidal zones. …”
Get full text

Evaluation of Simulated Weightlessness Model of Hindlimb Unloading Miniature Pigs and Their Tissue Damage by TU Yingxin, JI Yilan, WANG Fei, YANG Dongming, WANG Dongdong, SUN Zhixin, DAI Yuexin, WANG Yanji, KAN Guanghan, WU Bin, ZHAO Deming, YANG Lifeng

“…Additionally, western blotting was employed to detect the expression levels of skeletal muscle atrophy-related proteins, including muscle-specific RING finger protein 1 (MuRf-1) and muscle atrophy F-box (MAFbx, as known as Atrogin-1), while immunohistochemistry was used to detect the expression of glial fibrillary acidic protein (GFAP), an indicator of astrocyte activation in the brain, reflecting the pathophysiological functional changes across systems. …”
Get full text

Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage by Johanna Richter, Amanda J. Cork, Yvette Ong, Nadia Keller, Andrew J. Hayes, Mark A. Schembri, Amy V. Jennison, Mark R. Davies, Kate Schroder, Mark J. Walker, Stephan Brouwer

Subjects: Get full text

L’aqueduc du Gier à Lyon : la complexité de la protection au titre des monuments historiques by Josiane Boulon

“…He then began to travel and draft reports about the country’s ancient buildings. This active approach led to the presentation in 1840 of the first list of ancient buildings requiring preservation. …”
Get full text

GPR87 promotes invasion and migration through the RHO/ROCK pathway in non-small cell lung cancer by LIU Chenxi, HAN Lin, YANG Yi, ZHOU Han, LIU Yayun, SHENG Deqiao

“…In SK-MES-1 and A549 cells, GPR87 can activate the RHOA/ROCK1 signaling pathway, promote the expression of MMPs, and ultimately promote the invasion and migration of NSCLC.…”
Get full text

Application of care bundles based on the concept of enhanced recovery after surgery in perioperative nursing of patients undergoing laparoscopic cholecystectomy (基于加速康复外科理念的集束化干预在腹... by FANG Shuheng (房树恒), ZHU Hengmei (朱恒美), DONG Zhitao (董志涛), HE Dandan (贺丹丹)

“…The time to first postoperative exhaustion, time to off-bed activities and hospital stays in the observation group were shorter than those in the control group (P＜0. 05). …”
Get full text

THE PUBLIC DEBT OF UKRAINE: A NEW DIMENSION OF DYNAMICS AND ARCHITECTURE OF THE MODEL FRAMEWORK OF THE MANAGEMENT SYSTEM by Serhii Petrukha, Nina Petrukha, Roman Miakota

“…In this context, it is assumed that one of the conditions for the successful implementation of the fiscal correction is the completion of the active phase of the war by the end of 2025 and the consideration of additional caveats regarding the maintenance of a high debt burden in the short, medium and probably the long term perspective due to significant budgetary costs for reconstruction of infrastructure, social protection and economic development. …”
Get full text

The Benefits of Using a Small Caliber Ureteroscope in Evaluation and Management of Urethral Stricture by Walid Shahrour, Pankaj Joshi, Craig B. Hunter, Vikram S. Batra, Hazem Elmansy, Sandesh Surana, Sanjay Kulkarni

“…If the urethral caliber is >4.5 Fr and particularly those who are sexually active, ventral inlay with buccal mucosal grafts (BMGs) is performed. …”
Get full text

Progress of research on aviation kerosene preparation using bioethanol by Pan LI, Yu ZHAO, Xingguo WU, Lulu ZHANG, Junhao HU, Wei CHEN, Jing BAI, Chun CHANG, Shuqi FANG

“…Therefore, a catalyst is proposed for carbon–carbon coupling reaction of aqueous ethanol to produce high-carbon alcohols. The catalyst, with its satisfactory water resistance, can retain its activity and selectivity for high-carbon alcohols even in the presence of water and effectively inhibit the interference of water molecules, thereby increasing the efficiency and stability of the catalytic reaction. …”
Get full text

Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…Given this, exploring pharmacological alternatives for more effective management of DB associated with ASD is essential. Clozapine, noted for its unique antiaggressive effects in schizophrenia and in various treatment-resistant neuropsychiatric disorders, independent from its antipsychotic efficacy, remains underexplored in youths with ASD facing severe and persistent DB. …”
Get full text

Divulgação de evidências científicas sobre Práticas Integrativas e Complementares em Saúde by Luciana Fernandes Paulino, Maria Eduarda Ramos da Silva, Yasmin Aguiar Faria Lima, Marina Soares Gonçalves, Thaís Matera Ferraro Teixeira, Neemias Lima da Silva, Bárbara de Lacerda Santos Oliveira, Bianca Nunes Gomes, Fátima Helena do Espírito Santo, Gleyce Moreno Barbosa

“…The challenges contributed to improving this work, which was constantly built jointly by the team to democratize health access in its integrality. Keywords: Knowledge Diffusion; Integral Health; Self-Care; Public Health …”
Get full text

Depressive symptoms among the oldest-old in China: a study on rural-urban differences by Chaoqun Hu, Qinqin Jiang, Yuan Yuan, Bing Hou, Zhe Zhao, Yijun Liu, Jinhai Sun, Lei Yuan

“…In urban areas, age (90-99: β = -0.583, 95%CI = -1.008 to -0.158), annual income (rich: β = -0.699, 95%CI = -1.368 to -0.029), smoking (yes: β = -0.752, 95%CI = -1.376 to -0.127), exercise (yes: β = -1.447, 95%CI = -1.828 to -1.065), self-rated health status (good: β = -2.994, 95% CI = -3.362 to -2.625) were protective factors against depressive symptoms, and married status (other: β = 1.222, 95%CI = 0.564 to 1.880) were risk factors. …”
Get full text

Vertical gradients of neutral winds observed by ICON and estimated by the Horizontal Wind Model during the geomagnetic storm on August 26−28, 2021 by JiaWei Wu, Chao Xiong, YuYang Huang, YunLiang Zhou

“…Both meridional and zonal winds during the active geomagnetic period observed by ICON show distinguishable vertical shear structures at different stages of the storm. …”
Get full text

Transurethral Water Vapor Ablation: Potential for a Novel Prostate Cancer Management Strategy by Warlick CA, Spilseth BD, Dixon CM

“…Currently, many men with low-risk disease are offered active surveillance, during which the prostate cancer is closely monitored for any changes, whereas men with intermediate or high-risk localized cancers are more often considered for surgical removal of the prostate or treatment with radiation. …”
Get full text

Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field ¹H NMR Investigation by Kayleigh Hunwin, Georgina Page, Mark Edgar, Mohammed Bhogadia, Martin Grootveld

“…<b>Introduction/Objectives:</b> Since the biological activities and toxicities of ‘foreign’ and/or excess levels of metal ions are predominantly determined by their precise molecular nature, here we have employed high-resolution ¹H NMR analysis to explore the ‘speciation’ of paramagnetic Ni(II) ions in human saliva, a potentially rich source of biomolecular Ni(II)-complexants/chelators. …”
Get full text

NaHS alleviates neuropathic pain in mice by inhibiting IL-17-mediated dopamine (DA) neuron necroptosis in the VTA by Jun Wang, Nan Zhang, Hong-Zheng Liu, Jin-Liang Wang, Yong-Bo Zhang, Dong-Dong Su, Li-Min Zhang, Bao-Dong Li, Hui-Tao Miao, Jun Miao

“…It has been revealed that inflammatory activation triggers necroptosis by stimulating mixed lineage kinase domain-like protein (MLKL), leading to progressive neuronal demise. …”
Get full text

Preventing sensory and motor dysfunctions in children receiving neurotoxic chemotherapy: PrepAir study - an update by Céline Hammadou, Bianca Celine Schmidli, Christina Schindera, Nicolas von der Weid, Uta Tacke, Oliver Faude, Sarah Koch, Fiona Streckmann

“…Depending on the neurotoxic agent, 52-100% of children are affected by CIPN (Kandula et al. 2016). We hypothesize that CIPN plays a crucial role for childrens well-being and reintegration and its prevention is of utmost importance. …”
Get full text

N‐terminal pro brain natriuretic peptide reference values in community‐dwelling older adults by Ulrike Braisch, Wolfgang Koenig, Dietrich Rothenbacher, Michael Denkinger, Nele Friedrich, Stephan B. Felix, Till Ittermann, Marcus Dörr, Dhayana Dallmeier

“…Our results attempt to provide a frame for the further investigation of age‐specific NT‐proBNP cut‐offs in older adults. Considering the demographic changes, further evaluation of NT‐proBNP URL in larger samples of older adults followed by the validation of age‐specific cut‐off values for the identification of heart failure in those 65 years or older are urgently needed.…”
Get full text