Mid-Infrared High-Power InGaAsSb/AlGaInAsSb Multiple-Quantum-Well Laser Diodes Around 2.9 μm by Hongguang Yu, Chengao Yang, Yihang Chen, Jianmei Shi, Juntian Cao, Zhengqi Geng, Zhiyuan Wang, Haoran Wen, Enquan Zhang, Yu Zhang, Hao Tan, Donghai Wu, Yingqiang Xu, Haiqiao Ni, Zhichuan Niu

“…In this paper, we put up an active region with a high valence band offset and excellent crystalline quality with high luminescence to improve the laser’s performance. …”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…The overexpression of PINK1 induced Prdx2 expression and effectively attenuated palmitic acid‐induced apoptosis through the c‐Jun amino‐terminal kinase (JNK) and mitogen‐activated protein kinase (p38) pathways, whereas siRNA‐mediated Prdx2 knockdown abolished the protective effect of PINK1. …”
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Antibiotic Susceptibility Patterns and Virulence Profiles of Classical and Hypervirulent <i>Klebsiella pneumoniae</i> Strains Isolated from Clinical Samples in Khyber Pakhtunkhwa,... by Azra, Taj Ali Khan, Ihtisham Ul Haq, Woranich Hinthong, Susana Campino, Aisha Gohar, Noman Khan, Muhammad Kashif, Ihsan Ullah, Taane G. Clark

“…Most isolates (59/64, 92.1%) were resistant against ampicillin, highlighting its limited efficacy against these strains. Conversely, the lowest resistance was observed for tigecycline, with only 15% (10/64) of the isolates showing resistance, indicating its potential utility as a treatment option. …”
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Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis by Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu

“…Abstract Background Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20–30% of CRC patients already present with liver metastases. …”
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Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…Previous studies have reported the diverse effects of D-2HG in pathophysiological processes, yet its role in breast cancer remains largely unexplored. …”
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Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption by Yue Xu, Xiuying Xiao, Chunxiao Ma, Ziyi Wang, Wenxin Feng, Hanyu Rao, Wei Zhang, Ningyuan Liu, Rebiguli Aji, Xiangjun Meng, Wei‐Qiang Gao, Li Li

“…Abstract Background Inflammatory bowel disease (IBD) presents a significant challenge due to its intricate pathogenesis. NSD2, a histone methyltransferase responsible for dimethylating histone 3 at lysine 36, is associated with transcriptional activation. …”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Downregulation of miR-26a activated the LIMS1/integrin-linked kinase (ILK) signaling pathway in the heart and kidney, which represents a common molecular mechanism underlying inflammation and fibrosis in heart and kidney tissues during CKD. …”
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Shared genetic risk and causal associations between Post-traumatic stress disorder and migraine with antithrombotic agents and other medications by Charlotte K. Bainomugisa, Dagmar Bruenig, Heidi G. Sutherland, Lyn R. Griffiths, Dale R. Nyholt, Divya Mehta

“…The genes in the genomic regions shared between PTSD and medication use traits were enriched in neural-related pathways such as neuron development, neurogenesis and protein kinase activity. These results provide further insight into the genetically controlled biological and environmental factors underlying the shared etiology between PTSD and migraine. …”
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Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors by Qiang Wang, Qing Yi, Wei Xiong, Rui Duan, Jianfei Qian, Liuling Xiao, Miao Xian, Pan Su, Chuanchao Zhang, Yabo Li, Ling Zhong, Chengyun Zheng

“…Total mouse IgG or Ig2b ELISA or QuickGel split beta SPE kits and in vivo bioluminescent imaging were used to monitor MM tumor burden. …”
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Global comparison of the economic costs of coronary heart disease: a systematic review and meta-analysis by Lan Gao, Susan Brumby, Crystal Man Ying Lee, George Mnatzaganian, Suzanne Robinson, Helen Brown, Rachel Huxley, Anna Peeters, Dan Xu, James Boyd, Sean Randall, Adrienne O’Neil, Sangita Shakya, Sarah Gauci, Anita Shrestha, James Lucas

“…Objectives Coronary heart disease (CHD) is the leading cause of global morbidity and mortality, yet no comprehensive evaluation of its global economic costs exists. We conducted a systematic review with meta-analysis to examine the costs of CHD treatment by region and CHD subtypes, examine whether there are cost difference by sex, and examine costing methodologies.Design We conducted a systematic review and meta-analysis of non-randomised studies.Data sources We searched Medline, Embase, CINAHL, EconLit and Google Scholar from 1 January 2000 to February 2023.Eligibility criteria for selecting studies We included observational studies reporting economic costs of CHD treatment and outcomes for adults that were published in English.Data extraction and synthesis Data extraction and quality assessment were independently undertaken by two reviewers. …”
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Sustainability assessment of animal feed production from by-products of Sago palm smallholder industry by Allaily ., A.D. Santoso, M.N. Rofiq, N.A. Sasongko, H. Daulay, E.I. Wiloso, E. Widjaja, B.N. Utomo, A.I. Yanuar, S. Suryani, Y.P. Erlambang, U.N. Thiyas, D. Iskandar, A. Anhar, M. Rahmawati, T. Simamora, Y. Yusriani, G. Maghfirah, M. Ammar

“…The data were obtained from 5 entrepreneurs of Sago palm smallholder industry in Simeulue Regency, out of a total of 7 active Sago processing factories. Subsequently, the data were analyzed using Multidimensional Scaling method with rapid appraisal software. …”
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Acceptability and efficacy of the culturally adapted problem management plus intervention for people with disability in Pakistan: a pilot cluster randomized controlled trial by Basharat Hussain, Basharat Hussain, Muhammad Tahir Khalily, Muhammad Tahir Khalily, Ahmed Waqas, Atif Rahman, Ioannis Angelakis, Anum Nisar, Sabir Zaman, Tanveer Akhtar

“…Participants reported that this cultural alignment made the coping strategies more relatable and easier to adopt, contributing to improvements in both their mental health and somatic symptoms.Clinical Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT04981522, identifier NCT04981522.…”
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Thrombolysis, time-to-treatment and in-hospital outcomes among young adults with ischaemic stroke in China: findings from a nationwide registry study in China by Yong-Jun Wang, Xin Yang, Qi Zhou, Hao Li, Xia Meng, Yong Jiang, Li-Ping Liu, Yi-long Wang, Hong-Qiu Gu, Zi-Xiao Li, Xing-Quan Zhao, Chun-Juan Wang, Chelsea Liu, Hai-yan Wang, Ying-Yu Jiang

“…Compared with older adults, a higher proportion of young adults received IV tPA among patients without contraindicaitons (7.2% vs 6.1%, adjusted OR (aOR) 1.13, 95% CI 1.10 to 1.17) and among patients without contraindications and with onset-to-door time ≤3.5 hours (23.6% vs 19.3%, aOR 1.20, 95% CI 1.15 to 1.24). …”
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Progressive systemic inflammation precedes decompensation in compensated cirrhosis by Rubén Sánchez-Aldehuelo, Càndid Villanueva, Joan Genescà, Juan Carlos García-Pagán, Elisa Castillo, José Luis Calleja, Carles Aracil, Rafael Bañares, Luis Téllez, Lorena Paule, Rosa María Morillas, María Poca, Beatriz Peñas, Salvador Augustin, Juan G. Abraldes, Edilmar Alvarado-Tapias, Jaume Bosch, Agustín Albillos

“…We assessed markers of inflammation (interleukin-6 [IL-6], tumor necrosis factor-alpha, von Willebrand factor [vWF], C-reactive protein), macrophage activation (CD14, CD163), intestinal barrier integrity (fatty acid-binding protein [FABP], haptoglobin), and bacterial translocation (lipopolysaccharide [LPS]). …”
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Effects of the MyBFF@school obesity intervention program with nutrition education intervention on nutrition knowledge and attitude of secondary schoolchildren: a cluster randomized... by Rusidah Selamat, Junidah Raib, Nur Azlina Abdul Aziz, Norlida Zulkafly, Ainan Nasrina Ismail, W Nurul Ashikin W Mohamad, Ainol Aizuddin Zulkiply, Muhammad Yazid Jalaludin, Fuziah Md. Zain, Zahari Ishak, Abqariyah Yahya, Abdul Halim Mokhtar

“…Apart from physical activity, nutrition is important in any obesity intervention package. …”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb in acute and subacute Stroke (RHOMBUS II): results of a feasibility randomised controlle... by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Elmar Kal, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Acceptability was assessed through a satisfaction questionnaire. Impairment, activity and participation outcomes were also collected at baseline and 7 weeks to assess their suitability for use in a definitive trial.Randomisation Computer-generated, allocation sequence concealed by opaque, sealed envelopes.Blinding Participants and assessors were not blinded; statistician blinded for data processing and analysis.Results 192 stroke survivors were screened for eligibility, and 24 were recruited and randomised. …”
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Identification and validation of BATF as a prognostic biomarker and regulator of immune cell infiltration in acute myeloid leukemia by Zhe Zhao, Dongmei Wang, Dongmei Wang, Xue Sheng, Shuying Li, Tingting Liu, Mengyuan Chang, Lei Feng, Di Zhang, Chunyan Ji, Chunyan Ji, Fei Lu, Jingjing Ye

“…In the meantime, the prognostic value of BATF was evaluated using univariate and multivariate analyses, receiver operating characteristic (ROC) curve (AUC) analysis, and Kaplan-Meier (KM) survival analysis. …”
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Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…Particularly, Matrigel™ coating induced spheroid growth under certain coating thickness and cell seeding density but did not improve NCM metabolic activity. Current methodologies in NCM isolation, culture, and research applications were summarized. …”
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Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus by Fátima Cano-Cano, Almudena Lara-Barea, Álvaro Javier Cruz-Gómez, Francisco Martín-Loro, Laura Gómez-Jaramillo, María Carmen González-Montelongo, María Mar Roca-Rodríguez, Lucía Beltrán-Camacho, Lucía Forero, Javier J. González-Rosa, Mª Carmen Durán-Ruiz, Ana I. Arroba, Manuel Aguilar-Diosdado

“…Predictive analysis highlighted 15 common proteins, up- or downregulated in PBMCs from patients with T1DM and MS patients vs. healthy controls, involved in the immune system activity (BTF3, TTR, CD59, CSTB), diseases of the neuronal system (TTR), signal transduction (STMN1, LAMTOR5), metabolism of nucleotides (RPS21), proteins (TTR, ENAM, CD59, RPS21, SRP9) and RNA (SRSF10, RPS21). …”
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Single-Nucleus RNA Sequencing Reveals Cellular Transcriptome Features at Different Growth Stages in Porcine Skeletal Muscle by Ziyu Chen, Xiaoqian Wu, Dongbin Zheng, Yuling Wang, Jie Chai, Tinghuan Zhang, Pingxian Wu, Minghong Wei, Ting Zhou, Keren Long, Mingzhou Li, Long Jin, Li Chen

“…Additionally, these cells exhibited more active communication with other cell types compared to 170-day-old pigs. …”
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