Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival by Anna Darlene van der Heiden, Raphaela Pensch, Sophie Agger, Heather L. Gardner, William Hendricks, Victoria Zismann, Shukmei Wong, Natalia Briones, Bryce Turner, Karin Forsberg-Nilsson, Cheryl London, Kerstin Lindblad-Toh, Maja Louise Arendt

“…While previous studies on canine DLBCL (cDLBCL) have significantly advanced our understanding of the disease, the majority of this research has relied on whole-exome sequencing, which is limited in its ability to detect copy number aberrations and other genomic changes beyond coding regions. …”
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Cardiac manifestations of Fabry disease in G3Stg/GlaKO and GlaKO mouse models-Translation to Fabry disease patients. by Abirami Kugadas, Pietro Artoni, Wanida Ruangsiriluk, Meng Zhao, Natalia Boukharov, Rizwana Islam, Dmitri Volfson, Katayoun Derakhchan

“…Fabry disease (FD) is an X-linked disorder of glycosphingolipid metabolism caused by mutations in the GLA gene encoding alpha-galactosidase A (α-Gal). Loss of α-Gal activity leads to progressive lysosomal accumulation of α-Gal substrate, predominately globotriaosylceramide (Gb3) and its deacylated derivative globotriaosylsphingosine (lyso-Gb3). …”
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A Multi‐Center Prospective Study on the Healing of Neuro‐Ischemic Ulcers in Singapore: A Prospective Cohort Study by Lingyan Meng, Priya Bishnoi, Zhiwen Joseph Lo, Enming Yong, Tze Tec Chong, David Carmody, Rajesh Babu Dharmaraj, Yi Zhen Ng, Keith Harding, Pei Ho

“…Dependent activity of daily living (adjusted HR: 0.74; 95% CI: 0.55–1.01) was also potentially a risk factor for slow healing with borderline significance. …”
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Real-World Persistence and Effectiveness of Upadacitinib versus Other Janus Kinase Inhibitors and Tumor Necrosis Factor Inhibitors in Australian Patients with Rheumatoid Arthritis by Peter Youssef, Sabina Ciciriello, Talib Tahir, Joanna Leadbetter, Belinda Butcher, Miriam Calao, Nicole Walsh, Catherine O’Sullivan, Tegan Smith, Geoffrey Littlejohn

“…Median persistence (Kaplan–Meier) and effectiveness (Disease Activity Score 28-joint C-reactive protein, three variables [DAS28CRP{3}]) were evaluated for UPA-treated patients and in three propensity score-matched cohorts: UPA monotherapy versus combination therapy, UPA versus other JAKis, and UPA versus TNFis. …”
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In vivo pharmacokinetic and pharmacodynamic study and cutoff of florfenicol against Riemerella anatipestifer in ducks by Hui-Lin Zhang, Fa-Lei Li, Hui-Yang Chen, Ding-Mei Qin, Shu-Jun Sun, Meng-Meng Zhang, Huan-Zhong Ding, Yong Liu

“…The data obtained were fitted to a sigmoidal Emax model. The results demonstrated that AUC24h/minimum inhibitory concentration (MIC) (R2 = 0.930) and Cmax/MIC (R2 = 0.930) were the optimal PK/PD parameters for describing the antibacterial activity of FF. …”
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Goose astrovirus induces apoptosis and endoplasmic reticulum stress in gosling hepatocytes by Zhihua Lu, Haiqin Li, Xiaona Gao, Duanfeng Fu, Haoyu Huang, Cheng Huang, Meiqin Wu, Xiaoquan Guo

“…Further, GoAstV infection activated ERS-related factors, including GRP78, IRE1α, PERK, ATF6, eIF2α, ATF4, CHOP, TRAF2, and JNK, induced the expression of pro-apoptotic factors (Caspase-3, Caspase-9, and Bax), and inhibited the mRNA and protein expression of the anti-apoptotic factor Bcl-2. …”
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Perbedaan Kadar Superokside Dismutase pada Remaja dengan Dismenore Primer dan Tanpa Dismenore Primer by Yanti ., Ermawati ., Eliza Anas

“…Primary dysmenorrhoe increased uterine activity or increased uterine contractions cause arteriolar vasospasm resulting in ischemia and lower abdominal  cramping and increased a lots of oxygen produced. …”
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Clinical Features of COVID‐19 Associated Pulmonary Aspergillosis: A Multicenter, Retrospective Study by Yasheng Zhan, Guojun He, Cheng Zhong, Yake Yao, Jiangying Zhou, Tong Li, Hua Zhou

“…For patients with COVID‐19 with these high‐risk factors, Aspergillus culture and GM testing should be performed actively to avoid delaying the diagnosis of CAPA.…”
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Slowly digestible starch impairs growth performance of broiler chickens offered low-protein diet supplemental higher amino acid densities by inhibiting the utilization of intestina... by Caiwei Luo, Yao Yu, Gang Meng, Jianmin Yuan

“…The SDS diet significantly decreased BW and BWG of broilers from 22 to 42 days of age, distal ileal starch digestibility, jejunal amylase and chymotrypsin activities, and mRNA expression of GLUT2 and y + LAT1 compared to the corn starch diet (P < 0.05). …”
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Short-term Effects of Sling Exercise Combined with Massage on the Treatment of Neck Type Cervical Spondylopathy by LI Jianfei, ZHAO Hong, CHEN Qian, LI Li, ZHANG Deqi

“…Further correlation analysis showed that the MPQ scores was negatively correlated with MF value (left: <italic>r</italic>=-0.626, <italic>P</italic>&lt;0.05; right: <italic>r</italic>=-0.695, <italic>P</italic>&lt;0.05); besides the NDI scores decreased with the increase of MF value (left: <italic>r</italic>=-0.692, <italic>P</italic>&lt;0.05; right: <italic>r</italic>=-0.491, <italic>P</italic>&lt;0.05), and the average MF value on the right was lower than that on the left.ConclusionSling exercise combined with massage can significantly reduce the patient's pain, activate and strengthen the neck muscles, improve the neck function of patients. …”
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High BMP7 Expression May Worsen Airway Disease in COPD by Altering Epithelial Cell Behavior by Dong W, Xie M, Ming C, Li H, Xu X, Cui L, Wang W, Li Y

“…Previous research has shown that BMP7 is highly expressed in the airway epithelia of patients with COPD, but its role in airway disease has not been fully elucidated.Methods: A lung tissue cohort and a sputum cohort were included in the study. …”
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Exploration of Degradation Mechanism of Chlorogenic Acids in Stevia Based on UPLC-QTOF MS/MS by Juan-juan WU, Zi-xuan WANG, Yun-he LIAN, Li-juan HOU, Zhi-ping NIU, Wen-chang WANG, Di WU

“…Chlorogenic acids (caffeoylquinic acids, CQAs), as key bioactive components in numerous traditional herbal medicines, are highly acclaimed for their various biological activities and therapeutic benefits. Nonetheless, their stability and therapeutic utility are challenged by the propensity to degrade under various environmental stimuli, including exposure to light, temperature fluctuations, and changes in pH levels. …”
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Çocuklarda Dental Anksiyete: Başarılı Dental Tedavinin Önündeki Engel by Aysun Avşar, Büşra Mutlu

“…By controlling potential threats, the amygdala provides the activation of the sympathetic nervous system with its connections with the hypothalamus; with its connections with the central midbrain, it creates behavioral defense responses such as fight or flight. …”
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The Thermal Tolerance of Springtails in a Tropical Cave, with the Description of a New <i>Coecobrya</i> Species (Collembola: Entomobryidae) from Thailand by Nongnapat Manee, Louis Deharveng, Cyrille A. D’Haese, Areeruk Nilsai, Satoshi Shimano, Sopark Jantarit

“…II, Abd. I, Abd. III and Abd. IV and the anterior face of the ventral tube. The morphological comparison of all known <i>boneti</i> species and a key to the world species of <i>Coecobrya</i> of the <i>boneti</i>-group are given. …”
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Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics by Yujia Shu, Xuanfu Wu, Dongxu Zhang, Shuxia Jiang, Wenqiang Ma

“…In addition, siLnc286.2 treatment can increase HO-1 expression, alleviate the decline of FAC-induced BRL-3A cell activity, and increase lipid ROS (<i>p</i> < 0.05) content. …”
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Microbial community structure and functional traits involved in the adaptation of culturable bacteria within the gut of amphipods from the deepest ocean by Yukun Cui, Yu Xiao, Zhuo Wang, Paiyao Ji, Changhao Zhang, Yongqi Li, Jiasong Fang, Xi Yu

“…ABSTRACT The Hadal Zone is acknowledged for its extreme environmental conditions, especially high hydrostatic pressures. …”
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HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury by Li Zhu, Li Zhu, Qiang Zheng, Xiaodong Liu, Xiaodong Liu, Hao Ding, Mengqing Ma, Jiaxin Bao, Yawen Cai, Changchun Cao

“…Although renal replacement therapy (RRT) remains the cornerstone of treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare settings and regions. …”
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Construction of the bromodomain-containing protein-associated prognostic model in triple-negative breast cancer by Wei Chen, Yushuai Yu, Chenxi Wang, Zirong Jiang, Xiewei Huang, Yidan Lin, Hongjing Han, Qing Wang, Hui Zhang

“…Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and protein-protein interaction (PPI) network analysis were conducted to investigate active pathways and molecular interactions. Prognostic genes were selected through univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses to construct a risk model and calculate risk scores. …”
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Suatu Pendekatan Hibrid Menggunakan Topsis - Entropi pada Penentuan Siswa Penerima Beasiswa Prestasi Berbasiskan Kriteria Objektif by Maria Ulfah Siregar, Titik Nasiroh, Muhammad Mustakim

“…There are ten criteria to determine merit scholars, these are a value of knowledge, a value of skills, a record of merits, organizational activities, the number of extracurriculars, for the number of absences, father's income, mother's income, the number of dependents of parents and scholarship status. …”
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Sedentarismo e inactividad física según sexo, edad y nivel socioeconómico en el País Vasco. Estudio transversal by Marta Ijalba Martínez, Antonio Moreno Llamas, Unai Martín Roncero

“…Conclusions: In the context of the study, there is a different pattern in terms of physical activity and sedentary lifestyle according to socioeconomic level and life cycle.…”
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