Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma by Chun-Nan Yeh, Yu-Chan Chang, Yi-Chen Yeh, Yu-Chao Wang, Dennis Shin-Shian Hsu, Meng-Lun Lu, Michael Hsiao, Ming-Huang Chen, Nai-Jung Chiang, Shin-Yi Chung, Chien-Jung Huang, Ming-Hsien Chan, Tzu-Sheng Hsu, Yi-Ping Hung

“…Immunohistochemistry and RNA sequencing were employed to assess TLSs and TILs presence and activity. Differential gene expression and signature of immune cell composition were examined by GeoMx Digital Spatial Profiler and Cancer Transcriptome Altas analysis.Results TLS-positive (N=7) patients demonstrated significantly better immunotherapy outcomes compared with TLS-negative (N=9) patients, including higher objective response rates (71% vs 0%) and disease control rates (100% vs 67%). …”
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Exercise-induced anxiety impairs local and systemic inflammatory response and glucose metabolism in C57BL/6J mice by I. Gálvez, M.C. Navarro, S. Torres-Piles, L. Martín-Cordero, M.D. Hinchado, E. Ortega

“…Phagocytic/microbicide activity, the expression of M1/M2 phenotype markers (CD11c, iNOS, CD206, ARG-1) and cytokines of the inflammatory response (MCP-1, IL-8, IL-6, TNF-α, TGF-β, IL-10) of peritoneal macrophages were determined via flow cytometry. …”
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Physiological and multi-omics analysis revealed the mechanism of arbuscular mycorrhizal fungi to cadmium toxicity in green onion by Kunhao Xie, Yixuan Chen, Xiaoqin Wang, Xiaoya Zhou, Yizhe Cheng, Xianchang Yu, Jun Wang, Mintao Sun, Yansu Li, Chaoxing He

“…Thus, AMF enhance Cd tolerance in green onions by sequestering Cd in roots, restricting its translocation, modulating antioxidant defenses and inducing the expression of genes involved in the phenylpropanoid biosynthesis and phenylalanine metabolism pathways. …”
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Blockchain-assisted improved interval type-2 fuzzy deep learning-based attack detection on internet of things driven consumer electronics by Rana Alabdan, Bayan Alabduallah, Nuha Alruwais, Munya A. Arasi, Somia A. Asklany, Omar Alghushairy, Fouad Shoie Alallah, Abdulrhman Alshareef

“…Using machine learning (ML) methods and anomaly detection algorithms, IDS can rapidly identify abnormal activities, unauthorized access, or malicious behaviours within the IoT ecosystem, thus preserving the integrity of interconnected devices and networks, safeguarding sensitive data, and protecting against cyber-attacks. …”
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Sustainability index analysis of the black soldier fly (Hermetia illucens) cultivation from food waste substrate by A.D. Santoso, T. Handayani, R.A. Nugroho, A.I. Yanuar, N. Nadirah, E.S. Rohaeni, E. Widjaja, M.A.M. Oktaufik, U. Ayuningtyas, Y.P. Erlambang, R. Herdioso, M.N. Rofiq, R. Hutapea, A.L. Sihombing, B. Rustianto, I.M.A.D Susila, D. Irawan, D. Iskandar, S. Indrijarso, G.D. Widiarta

“…BACKGROUND AND OBJECTIVES: Most food waste is dominated by domestic activities consisting of large numbers of organic pollutants, such as nitrogen and phosphate potentially hazardous to the environment. …”
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Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer by Luca Mastracci, Patrizio Castagnola, Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci

“…Proteomics and systems biology showed that peritumoral treatment with either SFNs-OVA or SFNs-CpG dramatically modified tumor microenvironment with respect to the control (CTR), mainly involving functional modules and hubs related to angiogenesis, inflammatory mediators, immune function, T complex and serpins expression, redox homeostasis, and energetic metabolism. …”
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Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC by Xiangxian Che, Xi Tian, Zhenda Wang, Shuxuan Zhu, Shiqi Ye, Yue Wang, Yihan Chen, Yiyun Huang, Aihetaimujiang Anwaier, Peifeng Yao, Yijia Chen, Keting Wu, Yifei Liu, Wenhao Xu, Hailiang Zhang, Dingwei Ye

“…Abstract Background Integrin alpha 5 (ITGA5) was previously confirmed to be related to prognosis in several cancer types; however, its function in clear cell renal cell carcinoma (ccRCC) and how this molecule regulates tumor progression and the tumor microenvironment (TME) remain to be elucidated. …”
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The neutrophil–lymphocyte ratio as a risk factor for all-cause mortality among individuals with resolved HBV infection: evidence from the NHANES 1999–2018 by Chen Qiu, Chaojie Yu, Lanlan Yang, Siqi Liu, Qian Zhang, Shengnan Jia, Wenrui Wang, Zhenjing Jin, Dongdong Yu

“…Those with elevated NLR levels faced a substantially higher mortality risk compared to those with lower levels, as indicated by a Hazard Ratio (HR) of 1.84, with a 95% Confidence Interval (CI) of 1.17 to 2.89 (p < 0.05). The predictive accuracy of the model was substantial, as evidenced by the Area Under the Curve (AUC) for ROC curves at 3, 5, and 10 years, which were 0.873, 0.870, and 0.862, respectively. …”
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Cross-code comparison of the edge codes SOLPS-ITER, SOLEDGE2D and UEDGE in modelling a high-power neon-seeded scenario in the DTT by M. Moscheni, M. Wigram, H. Wu, C. Meineri, C. Carati, E. De Marchi, M. Greenwald, P. Innocente, B. LaBombard, F. Subba, R. Zanino

“…The strong link between Z _eff , main ion density and unified ion temperature emphasises the need of proper assessments of impurity cross-field transport, with its implications on core contamination and wall erosion. …”
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Companion animal and equine clinical research: a Nordic perspective by Bodil Ström Holst, Alejandro Engelmann, Gittan Gröndahl, Lotta Gunnarsson, Anita Haug Haaland, Anna Hielm-Björkman, Lars Moe, Marie Rhodin, Henrik Rönnberg, Marie Stråhle, Ylva Toljander, Annemarie Thuri Kristensen, Malin Hagberg Gustavsson

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Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromi... by Walaa K. Bazina, Wesam A. Tawfik, Nadia A. Abd Elghany, Saadea Saadony, Zulhisyam Abdul Kari, Muna Omer Alamoudi, Mohamed Y. M. Aly, Abuelhassan Elshazly Younis, Roshmon Thomas Mathew, Moaheda E. H. Eissa, Mohammad Bodrul Munir, Saadiah Ibrahim, Ismail Yousef, Yusuf O. H. Omar, El-Sayed Hemdan Eissa, Heba E. Abd Elnabi

“…Biochemical parameters, serum digestive enzyme activity, and antioxidant levels improved significantly with dietary supplementation. …”
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KNJIŽEVNIK I GRAD by Helena Sablić Tomić

“…Lokalne trgovine šire se u sve razgranatiju trgovačku privredu, a čime industrijski kompleksi pokrivaju prikrivati većinu gradskih područja. …”
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Enhanced photocatalytic degradation of Rhodamine B using polyaniline-coated XTiO3(X = Co, Ni) nanocomposites by Mariyem Abouri, Abdellah Benzaouak, Mohamed Elouardi, Lahcen El Hamdaoui, Fatima Zaaboul, Khalil Azzaoui, Belkheir Hammouti, Rachid Sabbahi, Shehdeh Jodeh, Mohammed Alaoui El Belghiti, Adnane El Hamidi

“…Abstract In this study, novel polyaniline-coated perovskite nanocomposites (PANI@CoTiO3 and PANI@NiTiO3) were synthesized using an in situ oxidative polymerization method and evaluated for the photocatalytic degradation of Rhodamine B (RhB) a persistent organic pollutant. …”
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MOMENT registry: Patients with advanced non-small-cell lung cancer harboring MET exon 14 skipping treated with systemic therapy by Michael Thomas, Petros Christopoulos, Wade T Iams, Julien Mazieres, Alexis B Cortot, Nir Peled, Gabriele Minuti, Egbert F Smit, Francois Audhuy, Karin Berghoff, S Peter Eggleton, Frank Fries, Maike Hildenbrand, Peter Liu, Seyed Hamidreza Mahmoudpour, Christoph Menzel, Dina Oksen

“…Data collection includes biomarker testing results, demographics, baseline clinical characteristics, treatment details and effectiveness, safety information and imaging. Registry site inclusion is dependent on confirmation that local METex14 skipping detectionmethods are sufficient to confirm METex14 skipping status.MOMENT is currently active at more than 60 sites across Europe and North America and approximately 700 patients are expected to be enrolled within the next 4 years. …”

Physico-Chemical Properties of Granular Sorbents Based on Natural Bentonite Modified by Polyhydroxocations of Aluminum and Iron (III) by Co-Precipitation by Bakytgul Kussainova, Gaukhar Tazhkenova, Ivan Kazarinov, Marina Burashnikova, Raigul Ramazanova, Yelena Ivashchenko, Bekzat Saurbayeva, Batima Tantybayeva, Ainur Seitkan, Gulsim Matniyazova, Khalipa Sadiyeva, Aisha Nurlybayeva, Aidana Bazarkhankyzy

“…It is shown that the use of natural bentonite for the development of technology for the production of granular sorbents based on it has an undeniable advantage, firstly, in terms of its chemical and structural properties, it is easily and effectively modified, and secondly, having astringent properties, granules are easily made on its basis, which turn into ceramics during high-temperature firing. …”
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Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance by Beemnet Amdemicael, Kun Yang, Briana N.C. Chronister, Caroline Mackey, Xin Tu, Sheila Gahagan, Danilo Martinez, Harvey Checkoway, David R. Jacobs, Jr., Jose Suarez-Torres, Suzi Hong, Jose R. Suarez-Lopez

“…Cytokines can alter neural network activity to induce neurocognitive changes. This work seeks to investigate the association between inflammation and neurobehavior in adolescents living in a rural region of Ecuador. …”
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Presence of liver metastasis correlated with high tumor abundance and indicated adverse prognostic feature in EGFR mutation non-small-cell lung cancer patients by Piyada Sitthideatphaiboon, Pronwasun Simseekeaw, Chinachote Teerapakpinyo, Nicha Zungsontiporn, Wariya Chintanapakdee, Itthi Itthisawatpan, Shanop Shuangshoti, Virote Sriuranpong, Thanisa Tongbai, Chanida Vinayanuwattikun

“…Presence of liver metastasis was significantly correlated with number of metastasis sites > 3 and ctEGFR CqMut-low (45.8%). Liver metastasis was an independent factor of reduced PFS and OS by multivariate analysis with an HR = 2.41 [95% CI 1.27–4.60, p-value 0.007]) and HR = 2.96 [95% CI 1.35–6.51, p-value 0.007], respectively. …”
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Analysis of egg quality and growth-related factors during embryogenic development of olive flounder (Paralichthys olivaceus) fed different broodstock diets by Ji-Sung Moon, Minji Seong, Si-Chan Kim, Josel Cadangin, Ji-Hye Lee, Eun-Seo Lee, Bong-Seung Seo, Haham Kim, Su-Jin Park, Jukyoung Kim, Jinho Lee, Seunghyung Lee, Youn-Hee Choi

“…The egg quality parameters such as spawned eggs volume, fertilization rate, egg diameter, oil globule diameter, oil globule volume, hatching rate, malformation rate, and survival activity index (SAI) were compared after feeding either EP or MP to broodstocks for 2 months. …”
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Proteomic and serologic assessments of responses to mRNA-1273 and BNT162b2 vaccines in human recipient sera by Thomas E. Hickey, Uma Mudunuri, Heidi A. Hempel, Troy J. Kemp, Nancy V. Roche, Keyur Talsania, Brian A. Sellers, James M. Cherry, Ligia A. Pinto

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Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts by Arbi Guetat, Slimen Selmi, Abdelrhman T. Abdelwahab, Marwa A. Abdelfattah, Abd Ealrhman M. Elhaj, Roaa T. Mogharbel, M. J. A. Abualreish, Abdullah F. Alanazi, Karim Hosni, Naceur Mejri, Abdennacer Boulila

“…Moreover, treatment with S. deserti hydroethanolic extract relieved oxidative stress (reduction of MDA and H2O2) and the activity of antioxidant enzymes SOD, CAT and GPx. The presence of several phenolic compounds (derivatives of ferulic, coumaric, and caffeic acids, among other derivatives) could at least in part explain the obtained data and empower the use of S. deserti as a source of bioactive ingredients with antioxidant, antidiabetic and antihyperlipidemic properties.DiscussionOur research has unveiled S. deserti as a source of potential to effectively manage diabetes and its associated dyslipidemia by improving antioxidant status, recovery of the liver and kidney functions and presumably by increasing insulin secretion and sensitivity of peripheral tissues to insulin.…”
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