Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction by Jingrun Lin, Xiaoqiu Zhu, Xuan Li, Yu Hong, Yaohui Liang, Siqi Chen, Chenzhuo Feng, Lin Cao

“…Results Aging significantly affected mice’s spontaneous activity in the open field test (F1, 28 = 8.933, P < 0.01) and the proportion of time spent in the center area (F1, 28 = 5.387, P < 0.05). …”
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Dietary supplementation of composite feed additive reduces enteric methane production and enhances feed efficiency, milk production and immunity in Murrah buffalo (Bubalus bubalis) by Avijit Dey, Shyam S. Paul, Satbir S. Dahiya, Ashok K. Balhara, Jerome Andonissamy, Balbir S. Punia, Yendrembam M. Chanu

“…The feed supplement was developed at the institute, composed of an ideal combination of methane inhibitors, alternate hydrogen sinks, and some rumen-stimulating agents (Indian Patent Grant No. 388717 dated 08.02.2022) and its efficacy examined through a series of in vitro experiments. …”
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Spatiotemporal evolution and driving force analysis of drought characteristics in the Yellow River Basin by Meiying Wang, Yangbo Chen, Jingyu Li, Yanjun Zhao

“…The center of drought activity is concentrated in the midstream, where it underwent two significant shifts: from the 1960 s to the 1980 s, the drought center moved northeastward, then shifted westward until the 2000 s, with longest displacement of 414.41 km to the east-northeast. …”
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Nyadran and Paguyuban Budiluhur in Caring for Inter-Religious Harmony by Anif Musyafa’ah Harnianti, Fina Farikhatun Nurul Maqfiroh, Khozinatul Mabruroh, Abdul Najib, Muhammad Syihabuddin Alawy

“…This qualitative study employs descriptive methods, including observation, semi-structured interviews, and field documentation of the Nyadran tradition and the activities of Paguyuban Budiluhur. The findings indicate that social actions lean towards instrumental rationality, as the Nyadran tradition has been institutionalized in the village's annual agenda, and Paguyuban Budiluhur has become an established foundation. …”
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Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort by Doron Boltin, Zohar Levi, Tsachi Tsadok Perets, Hemda Schmilovitz-Weiss, Rachel Gingold-Belfer, Ram Dickman, Iris Dotan

“…The 13C-urea breath test result (C13-UBT) utilizes H. pylori urease activity and is a highly accurate diagnostic assay. …”
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Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats by Wen Han, Hao Wang, Longxiang Su, Yun Long, Na Cui, Dawei Liu

“…Expectedly, rapamycin decreased the activity of the mTOR pathway in both sham-operated rats (p<0.0001) and CLP rats (p<0.01). …”
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A Muscle Physiology-Based Framework for Quantifying Training Load in Resistance Exercises by Frank Imbach, Stéphane Perrey, Thomas Brioche, Robin Candau

“…Muscle function impairments mainly occurred at low intensities–long series, and high intensities, supported by greater RFD rate decay and changes in electromyographic activity. Therefore, accounting for muscle fatigue kinetics within objective TL indexes and using dimension reduction methods better described physiological responses to RE. …”
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Contrasting seasonal patterns in particle aggregation and dissolved organic matter transformation in a sub-Arctic fjord by M. G. Digernes, Y. V. Bodur, M. Amargant-Arumí, O. Müller, J. A. Hawkes, S. G. Kohler, U. Dietrich, M. Reigstad, M. L. Paulsen

“…However, in both periods, bacterial activity and EPS concentrations increased throughout the incubations, showing that bacterial degradation and physical DOM aggregation drive the transformations of POM and DOM in concert but at varying degrees under different environmental conditions.…”
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Characterization and molecular detection of pathogenicity and antibiotic resistance genes in Vibrio parahaemolyticus isolated from Pacific white shrimp by Muhammad Arif Mulya, Fachriyan Hasmi Pasaribu, Usamah Afiff, Munti Yuhana

“…The alpha hemolysis activity was also confirmed by the amplicon of 199 bp in all isolates. …”
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Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments by Anam Razzaq, Zaheer Ullah Khan, Aasim Saeed, Kiramat Ali Shah, Naveed Ullah Khan, Bouzid Menaa, Haroon Iqbal, Farid Menaa

“…LNFs also exerted a significantly stronger antibacterial activity both in-vitro and in-vivo. LNFs were significantly safer and more efficient for bacterial clearance-induced faster chronic wound healing. …”
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Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids by Janesh Pillay, Antine W. Flikweert, Matijs van Meurs, Marco J. Grootenboers, Simone van der Sar-van der Brugge, Peter H. J. van der Voort, Morten A. Karsdal, Jannie M. B. Sand, Diana J. Leeming, Janette K. Burgess, Jill Moser

“…Abstract Background Severe and critical COVID-19 is characterized by pulmonary viral infection with SARS-CoV-2 resulting in local and systemic inflammation. …”
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Game-thinking; utilizing serious games and gamification in nursing education – a systematic review and meta-analysis by Mats Nylén-Eriksen, Marko Stojiljkovic, Daniela Lillekroken, Katrin Lindeflaten, Elisabeth Hessevaagbakke, Tone Nygaard Flølo, Olav Johannes Hovland, Ada Marie Svarstad Solberg, Sylvia Hansen, Ann Kristin Bjørnnes, Christine Tørris

“…Abstract Background The digital shift in higher education is moving from teacher-focused models to active learning with digital technologies, including the integration of game-based learning strategies. …”
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The Role of Dectin-1-Akt-RNF146 Pathway in &beta;-Glucan Induced Immune Trained State of Monocyte in Sepsis by Guo C, Xu P, Luo W, Zhang J, Sun X, Hoang H, Ma D, Wu D, Zhong J, Miao C

“…Moreover, RNF146 regulated dectin-1-Akt-mTOR signaling in the trained immune state of murine monocyte/macrophage RAW264.7 cell line and the expression of RNF146 was dependent on dectin-1-Akt activation. The inhibition of dectin-1 by its antagonist laminarin downregulated Akt-RNF146 signaling and partially reversed β-glucan induced trained immunity in septic mice.Conclusion: RNF146 and Akt are downregulated in the immunosuppression period of sepsis, while increased after β-glucan pretreatment induced trained immunity in septic mice. …”
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Lansia Aktif dan Berdaya: Studi Perilaku Prososial pada Kader Surabaya Hebat by Widya Annisa Royani, Cicilia Larasati Rembulan

“…Participants were selected using purposive sampling technique, with characteristics of Surabaya Hebat cadres who have been active for at least 2 years in Lontar Village Surabaya, aged 60 years and above. …”
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WHO public health laboratories webinar series – an online platform to disseminate testing recommendations and best practices during health emergencies by Céline Barnadas, Lisa Stevens, Natacha Milhano, Ana Carolina Barbosa de Lima, Bruce Struminger, Lauren Burke, Sébastien Cognat

“…The series utilized sessions on cross-cutting topics to run routinely and to keep a high level of engagement with laboratory professionals globally. …”
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Optimizing Growth and Yield in Mulched Cotton Through Aerated Subsurface Drip Irrigation in Southern Xinjiang by Yuxi Zhang, Baolin Yao, Peining Niu, Zhu Zhu, Yan Mo, Fayong Li, Sanmin Sun

“…Additionally, both aerating and increasing irrigation quotas not only enhanced the cotton leaf area index (LAI) but also delayed leaf area decay, contributing to prolonged photosynthetic activity. Aerating also favorably influenced the distribution of above-ground biomass in cotton towards budding and boll stages, with the biomass share of buddings, flowers, and bolls averaging 62.98% under aerated conditions versus 62.27% under non-aerated conditions during the boll opening stage. …”
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Prognosis and factors related to severe secondary hyperparathyroidism in long-term peritoneal dialysis patients by Yanmei Li, Xiaonan Feng, Na Chen, Shuhua Song, Min Yu, Yan Wang, Hongxia Zhang, Li Wang, Menghua Chen, Na Tian

“…After adjusting for confounding factors, higher (each 100-pg/mL increase) baseline PTH levels (95% confidence interval (CI) 1.206–1.649, p < .001), longer (each 1-year increase) dialysis vintages (95% CI 1.013–1.060, p = .002), higher concomitant diabetes rates (95% CI 1.375–10.374, p = .010), and lower (each 1-absolute unit decrease) Kt/V values (95% CI 0.859–0.984, p = .015) were independent risk factors for progression to sSHPT in patients on PD. …”
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Dietary supplementation of Astragalus polysaccharide or its nanoparticles enhances testicular hemodynamics, echotexture, scrotal circumference, concentration of testosterone, estradiol, nitric oxide, and total antioxidant capacity, and semen quality in mature Ossimi rams by Eman Fayez, Ali Salama, Mohamed Ahmed Ismail, Fady Sayed Youssef, Zaher Mohamed Rawash, MR Oshba, Haney Samir

“…Serum testosterone (T) and estradiol (E2) concentrations were determined by ELISA kits, while nitric oxide (NO) and total antioxidant capacity (TAC) were measured spectrophotometrically. …”
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Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice by Weifeng Gu, Tingting Zheng, Wen Li, Xinkai Luo, Xiaowei Xu, Ying Wang, Chaoming Mao, Yongbin Ma, Liyang Dong

“…Abstract Background Asthma is a prevalent respiratory disease, and its management remains largely unsatisfactory. Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in reducing airway inflammation in experimental allergic diseases, representing a potential alternative treatment for asthma. …”
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Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies by Amani M. El Sisi, Essam M. Eissa, Ahmed H. E. Hassan, Marina A. Bekhet, Fatma I. Abo El-Ela, Eun Joo Roh, Rasha M. Kharshoum, Adel A. Ali

“…<b>Background/Objectives</b>: Mirtazapine (MRZ) is a psychotropic drug prescribed to manage serious sorts of depression. By virtue of its extensive initial-pass metabolic process with poor water solubility, the ultimate bioavailability when taken orally is a mere 50%, necessitating repeated administration. …”
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