In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders by Stephen Tunmise Akanbi, Joshua Ayodele Yusuf, Thompson Oluwaferanmi Ayandele, Dayo Samson Oladipupo, Darasimi Racheal Olorunlowu, Blessing Dorcas Olawuyi, Joshua Oluwafisayo Adepoju, Dolapo Emmanuel Opasina, Elizabeth Kehinde Opoola, Uchenna Victor Ugwuanyi, Olufunto Omodele Adeleye

“…Abstract Background Parkinson’s disease (PD) is a neurodegenerative condition marked by the gradual degeneration of dopaminergic neurons in the substantia nigra, leading to depletion of the dopaminergic neurons in the substantia nigra as well as degeneration as and decreased activity in the putamen. This study aims to identify the role of putamen in non-motor PD symptoms as well as potential therapeutic target in the putamen of PD. …”
Get full text

The Climate-forming role of the production process of the forests of Ukraine by Platon Tretyak, Nelia Lukianchuk, Hryhoriy Krynytskyy

“…The above-mentioned cooling of the air by forest vegetation has an important climate-forming significance, since it leads to a general decrease in air temperature and an increase in its relative humidity. In order to improve the above-described material-and-energy indicators of the vital activity of forest vegetation, attention should be focused on the need to increase the area of forests and their productivity. …”
Get full text

Integrative application of licorice root extract and melatonin improves faba bean growth and production in Cd-contaminated saline soil by Shimaa A. Abd El Mageed, Ali A. S. Sayed, Ahmed Shaaban, Khaulood A. Hemida, Abdelsattar Abdelkhalik, Wael M. Semida, Ibrahim A. A. Mohamed, Mohammed A. H. Gyushi, Yasmine H. Abd Elmohsen, Taia A. Abd El Mageed

“…Application of LRE + Mt significantly mitigated the Cd-induced oxidative damage by increasing the activity of reactive oxygen species (ROS) scavenging enzymes such as superoxide dismutase, catalase, ascorbate peroxidase, and glutathione reductase, in parallel with enhanced ascorbate and reducing glutathione content. …”
Get full text

Unveiling the Microbial Symphony of Amasi: A Targeted Metagenomic 16S rRNA, ITS, and Metabolites Insights Using Bovine and Caprine Milk by Betty Olusola Ajibade, Titilayo Adenike Ajayeoba, Saheed Sabiu, Konstantin V. Moiseenko, Sizwe Vincent Mbona, Errol D. Cason, Tatyana V. Fedorova, Oluwatosin Ademola Ijabadeniyi

Subjects: Get full text

Biochemical composition of tomato fruits of various colors by A. B. Kurina, A. E. Solovieva, I. A. Khrapalova, A. M. Artemyeva

“…Mill. genetic resources collection includes 7678 accessions of one cultivated and nine wild species, which in turn provides ample opportunities for searching for information on the variability of the content of biologically active substances and searching for sources with a high content of them in the gene pool. …”
Get full text

Telomerase inhibiting phytochemicals derived from Blumea eriantha for cancer treatment: A comprehensive computational analysis by Rahil Ummar Faruk Abbu, Shaik Mohammad Abdul Fayaz, Divyashree M S, Raghu Chandrashekhar H, Prasanna Kumar Reddy Gayam, Archana Mahadev Rao

“…This study investigates the anti-telomerase activity of twelve phytochemicals derived from Blumea eriantha for cancer treatment. …”
Get full text

Estado nutricional y niveles de actividad física en adolescentes de instituciones educativas públicas y privadas by María V Arias-Silva, Valentina Pedreros-Lemuz, Angie L Rodríguez-Perdomo, Raúl A González-Lozano, Jorge A Ramos-Castaneda

“…Se evaluó el nivel de actividad física mediante el instrumento Physical Activity Questionnaire para adolescentes, y el estado nutricional mediante el índice de masa corporal para la edad. …”
Get full text

Structural variability of sunflower gene for methionine-rich albumin SFA8 by I. N. Anisimova, N. V. Alpatieva, S. V. Goryunova, D. V. Goryunov, Al. V. Konarev, V. A. Gavrilova, E. E. Radchenko

“…The 2S albumins of sunflower and other oilseed plants possess a high nutritional quality, the defense activity against fungi diseases casual gents and also valuable functional properties. …”
Get full text

The application of biochar and organic fertilizer substitution regulates the diversities of habitat specialist bacterial communities within soil aggregates in proso millet farmland by Lixin Tian, Yawei Wang, Doudou Jin, Yulong Zhou, Bauyrzhan Mukhamed, Dan Liu, Baili Feng

“…OF + B treatment also markedly elevated the contents of total nitrogen (TN), soil organic carbon (SOC), nitrate nitrogen (NO3 −-N), ammonium nitrogen (NH4 +-N), as well as activities of C-, N-, and P-acquiring enzymes, enhanced the carbon limitation, and reduced the nitrogen limitation in the bulk soil and macro-aggregates. …”
Get full text

Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation by Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida

“…The mitogen‐activated protein kinase (MAPK) extracellular signal‐regulated kinase 5 (ERK5) is emerging as a promising target in cancer. …”
Get full text

Macrophage heterogeneity and oncogenic mechanisms in lung adenocarcinoma: insights from scRNA-seq analysis and predictive modeling by Han Zhang, Jiaxing Dai, Qiuqiao Mu, Xiaojiang Zhao, Ziao Lin, Ziao Lin, Kai Wang, Meng Wang, Meng Wang, Daqiang Sun

“…Finally, RT-PCR confirmed the expression of model genes in LUAD, and cellular experiments explored the carcinogenic mechanism of COL5A1.ResultsWe found that signals such as SPP1 and MIF were more active in tumor tissues, indicating potential oncogenic roles of macrophages. …”
Get full text

What happens to patients in the long term when we do not repair their cuff tears? Ten-year rotator cuff quality of life index (RC-QOL) outcomes following nonoperative treatment of... by Richard S. Boorman, MD, MSc, FRCSC, Kristie D. More, MSc, Sarah L. Koles, MD, MSc, FRCPC

“…Two patients had crossed over from the successful group to undergo surgery between 5 and 11 years (one had an acute traumatic injury and the other reported aggravation with activity). Conclusion: Nonoperative treatment is an effective and lasting option for many patients with a chronic, full-thickness rotator cuff tear. …”
Get full text

EGCG improve meat quality, restore lipid metabolism disorder and regulate intestinal flora in high-fat fed broilers by Lujia Gao, Chen Liu, Jiaqi Wu, Ying Cui, Man Zhang, Chongpeng Bi, Anshan Shan, Xiujing Dou

“…Dietary EGCG may have induced some of the alterations due to increased activity of the enzymes catalase (CAT) and superoxide dismutase (SOD), as well as decreased oxidation of proteins and lipids. …”
Get full text

Identification of novel fructo-oligosaccharide bacterial consumers by pulse metatranscriptomics in a human stool sample by Catherine Prattico, Emmanuel Gonzalez, Lharbi Dridi, Shiva Jazestani, Kristin E. Low, D. Wade Abbott, Corinne F. Maurice, Bastien Castagner

“…ABSTRACT Dietary fibers influence the composition of the human gut microbiota and directly contribute to its downstream effects on host health. As more research supports the use of glycans as prebiotics for therapeutic applications, the need to identify the gut bacteria that metabolize glycans of interest increases. …”
Get full text

Evaluation of modified interventions of integrated Traditional Chinese and western medicine in nursing of stroke patients (中风患者中西医结合优化护理干预效果观察)... by LI Yanmin (李艳敏), HUANG Chaoping (黄朝萍)

“…All patients received routine nursing interventions in the rehabilitation training, and those in the observation group were given modified interventions of integrated Traditional Chinese and western medicine. The Activity of Daily Living (ADL) and Fugl-Meyer Assessment (FMA) scores were compared between two groups, and patients’ satisfaction with nursing service was evaluated by using self-made questionnaire. …”
Get full text

Quantification of antimicrobial use on Irish dairy farms: A comparison of three recording methods by Hannah Martin, Edgar Garcia Manzanilla, Simon J. More, Robert Hyde, Conor McAloon

“…When compared with the reference method, VET data had excellent reliability (95% CI of CCC: 0.992–0.998). The MB data had good to excellent reliability (95% CI of CCC: 0.776–0.936). …”
Get full text

Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

“…IntroductionImmunonutrition, defined as the potential of foods, nutrients and dietary patterns to modulate the immune system activity, has been proposed as a strategy to enhance the immune response in both metabolic and immune-mediated diseases. …”
Get full text

Personality's Time Perspective as a Resource for Overcoming the Identity Crisis at Different Stages of Life Realization by E.M. Meshcheryakova, A.V. Seryy, M.S. Yanitskiy

“…</strong>Investigating the role of personality's time perspective in overcoming the identity crisis and determining its potential as a resource of personal growth at different stages of life realization. …”
Get full text

Bergapten alleviates senescence of chondrocytes in osteoarthritis by YE Yuanlan, LIU Kaiwen, PAN Yiming

“…Senescence β-galactosidase (SA-β-Gal) staining kit was employed to detect the change of SA-β-Gal level in the cells. …”
Get full text

HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation by Juliet A. Emamaullee, Mariusz Bral, Glenda Meeberg, Aldo J. Montano-Loza, Vincent G. Bain, Kelly Warren Burak, David Bigam, A. M. James Shapiro, Norman Kneteman

“…Among untreated HCV+ patients who underwent LT, 81.5% (N=22/27) received DAA post-LT, with 82.6% achieving SVR post-LT (N=18/22). 82.1% (N=23/28) of untreated post-LT patients underwent liver biopsy prior to therapy, and 52.2% had at least F1 METAVIR fibrosis. 87.5% (N=14/16) of active waitlist patients received DAA and achieved SVR. …”
Get full text