Suggested Topics within your search.
Suggested Topics within your search.
- Constitutional court 10
- Court of Appeal 9
- Law reports, digests, etc 9
- Health 7
- Judgements and orders 7
- Study and teaching 7
- Women 7
- Economic development 6
- Physical fitness 6
- Supreme court 6
- History 5
- Judgement and orders 5
- Law 5
- Economic policy 4
- High court 4
- History and criticism 4
- LANGUAGE ARTS & DISCIPLINES / Communication Studies 4
- Sociolinguistics 4
- Court of appeal 3
- Economic conditions 3
- Educational technology 3
- Electric wiring, Interior 3
- Feminism 3
- Globalization 3
- LANGUAGE ARTS & DISCIPLINES / Linguistics / General 3
- LANGUAGE ARTS & DISCIPLINES / Linguistics / Sociolinguistics 3
- Language and languages 3
- Political activity 3
- Technological innovations 3
- methods 3
-
65481
<i>Rubus idaeus RiACS1</i> Gene Is Involved in Ethylene Synthesis and Accelerates Fruit Ripening in <i>Solanum lycopersicum</i>
Published 2025-01-01“…Overexpression of <i>RiACS1</i> increased the activity of ACC synthase, ethylene release rate, and respiration rate during the transchromic phase. …”
Get full text
Article -
65482
The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells
Published 2024-09-01“…SCFAs exert various metabolic functions, which in part can be explained by activation of G protein-coupled receptors (Gpr) 41 and 43. …”
Get full text
Article -
65483
Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia
Published 2025-01-01“…Immune analysis revealed associations between biomarkers and immune cell activity. A regulatory network was informed by biomarker expression and database predictions, in which KCNQ1OT1 modulates ACSF2 expression via hsa-miR-200b-3p. …”
Get full text
Article -
65484
Novel combination strategy of high intensity focused ultrasound (HIFU) and checkpoint blockade boosted by bioinspired and oxygen-supplied nanoprobe for multimodal imaging-guided ca...
Published 2023-01-01“…Flow cytometry and immunofluorescence were used to clarify the potential mechanism of HIFU+M@P-SOP and their role in anti-programmed death ligand-1 (PD-L1) therapy.Results Guided by photoacoustic/MR/ultrasound (US) multimodal imaging, M@P-SOP was abundantly enriched in tumor, which greatly enhanced HIFU’s killing of tumor tissue in situ, induced stronger tumor immunogenic cell death, stimulated dendritic cell maturation and activated CD8+ T cells. …”
Get full text
Article -
65485
Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells
Published 2025-01-01“…IntroductionLiver fibrosis is a globally prevalent chronic liver disease, often representing the advanced stage of various chronic liver conditions. Despite its widespread occurrence, there is currently no widely accepted or effective treatment for liver fibrosis. …”
Get full text
Article -
65486
Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney
Published 2025-01-01“…These results indicate that renal function is impaired, oxidative stress and trace element metabolism disorder, nuclear factor-E2 related factor 2 (Nrf2) is activated into the nucleus to induce the expression of related antioxidant proteins (such as HO-1, NQO1). …”
Get full text
Article -
65487
Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study
Published 2024-12-01“…IntroductionModifiable risk factors play an important role in preventing dementia and reducing its progression. Regular physical activity already in midlife, which relies on intact multisensory balance control, can help to decrease the risk of dementia. …”
Get full text
Article -
65488
A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation
Published 2025-01-01“…A natural small molecule product U4-I05 diminished the stem-like features of CSCs and enhanced their sensitivity to oxaliplatin and 5-fluorouracil by targeting inhibition of its deubiquitinating enzyme activity through binding the catalytic domain of USP4 (311 cysteine site) at nanomolar concentrations, triggering proteasome-mediated degradation of β-catenin and Twist1. …”
Get full text
Article -
65489
Immune microenvironment features underlying the superior efficacy of neoadjuvant immunochemotherapy over chemotherapy in local advanced gastric cancer
Published 2025-01-01“…Compared with Chemo group, density of CD4+(1904.8 vs. 1530), CD8+(1982.9 vs. 1124.4), CD20+(1115.6 vs. 574), CD38+(1580.4 vs. 1128), CD138+(1237.2 vs. 496.4), and CD56+ (596.8 vs. 159) cells was increased 24.5%, 76.4%, 94.4%, 40.1%, and 149.2% respectively, whereas CD163+ macrophages (994.4 vs. 1706) was decreased 41.7% in Io+Chemo group.ConclusionsOur study favors neoadjuvant Io+Chemo over Chemo and reveals Io+Chemo can induce the formation of an immune-activated microenvironment that make Io+Chemo superior to Chemo.…”
Get full text
Article -
65490
Regulation of glycolipid and amino acid metabolism in juvenile triploid crucian carp (Carassius auratus) by oral administration of aspartic acid
Published 2025-03-01“…Additionally, the gene expression level and enzymatic activity of hepatic aspartate aminotransferase were increased (P < 0.05). …”
Get full text
Article -
65491
Silent cerebral lesions after catheter ablation for atrial fibrillation using cryoballoon, hotballoon, laserballoon and radiofrequency catheters: a Bayesian network meta-analysis
Published 2025-01-01“…The surface under the cumulative ranking curve (SUCRA) values indicated that CBA may be the best therapeutic option (SUCRA = 81.1%). …”
Get full text
Article -
65492
Development of a standardized patient-reported clinical questionnaire for children with spinal pain
Published 2025-01-01“…The questionnaire includes sections for parents/legal guardians and six domains for children covering pain, sleep, activities, trauma, concerns, and treatment, following the International Classification of Functioning, Disability, and Health (ICF). …”
Get full text
Article -
65493
Spatiotemporal characteristics of macroinvertebrate functional feeding groups and biological assessment of water quality in the Hulan River Basin
Published 2025-01-01“…This study demonstrates that macroinvertebrate FFGs are highly sensitive to human activities and agricultural pollution in the midstream and downstream areas of the Hulan River Basin. …”
Get full text
Article -
65494
Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD
Published 2025-02-01“…At ROC analysis uMBG showed a remarkable diagnostic capacity on CKD progression (AUC 0.898) and patients with uMBG ≤310 pmol/L (Best ROC-derived cut-off) had a significantly faster progression to the endpoint (Log-rank 57.9; p < 0.0001). …”
Get full text
Article -
65495
Insights from a codesigned dynamic modelling study of child and adolescent obesity in Australia
Published 2025-01-01“…The model was calibrated to fit the historical prevalence of obesity (R2=0.97, mean squared error (MSE)=4.94E-04). …”
Get full text
Article -
65496
Prevalence of Autoimmune Thyroiditis and Other Autoimmune Diseases in Relation to Serum BAFF/APRIL Levels in Prolactinoma Patients
Published 2024-01-01“…Results: The prevalence of autoimmune thyroiditis (AIT) was 32.1% in the patient group, whereas the prevalence of newly diagnosed AIT was similar to controls (p>0.05). …”
Get full text
Article -
65497
Multi-dimensional outcomes following extracorporeal cardiopulmonary resuscitation
Published 2025-03-01“…Many patients reported dizziness or dyspnea (>52%) during daily activities, with a median New York Heart Association class of 2, EQ-5D-5L score of 53 and elevated NT-proBNP levels. …”
Get full text
Article -
65498
Analysis of Soil Microbial Community Structure and Function in <i>Morchella esculenta</i> Habitats in Jilin Province
Published 2024-12-01“…The functional annotation analysis of soil microorganisms, based on the KEGG database, revealed that within level A (highest tier), metabolic activities were the most prominent. In contrast, at level B (secondary tier), global and overview maps, carbohydrate metabolism, and amino acid metabolism were dominant. …”
Get full text
Article -
65499
Anti-inflammatory effects of Andrographis paniculata (Fah Talai Jone) via TNFα-JNK pathway and bioactive compound identification
Published 2025-02-01“…Background: Andrographis paniculata (Fah Talai Jone), a widely used medicinal plant in traditional medicine, is known for its anti-inflammatory properties. This study investigates its bioactive compounds and their role in alleviating inflammation through the TNF-α-JNK pathway. …”
Get full text
Article -
65500
Germline Single-Nucleotide Polymorphism <i>GFI1-36N</i> Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acu...
Published 2025-01-01“…Since we have demonstrated that GFI1 plays an active role in metabolism, in this study, we investigated whether increased levels of reactive oxygen species (ROS) could contribute to the accumulation of genetic damage in <i>GFI1-36N</i> leukemic cells. …”
Get full text
Article