CEERS: Increasing Scatter along the Star-forming Main Sequence Indicates Early Galaxies Form in Bursts by Justin W. Cole, Casey Papovich, Steven L. Finkelstein, Micaela B. Bagley, Mark Dickinson, Kartheik G. Iyer, L. Y. Aaron Yung, Laure Ciesla, Ricardo O. Amorín, Pablo Arrabal Haro, Rachana Bhatawdekar, Antonello Calabrò, Nikko J. Cleri, Alexander de la Vega, Avishai Dekel, Ryan Endsley, Eric Gawiser, Mauro Giavalisco, Nimish P. Hathi, Michaela Hirschmann, Benne W. Holwerda, Jeyhan S. Kartaltepe, Anton M. Koekemoer, Ray A. Lucas, Sara Mascia, Bahram Mobasher, Pablo G. Pérez-González, Giulia Rodighiero, Kaila Ronayne, Sandro Tacchella, Benjamin J. Weiner, Stephen M. Wilkins

“…These results can be explained if galaxies at higher redshift experience an increase in star formation variability and form primarily in short, active periods, followed by a lull in star formation (i.e., “napping” phases). …”
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Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism by Andrea Fumagalli, Anna Castells-Nobau, Dakshat Trivedi, Josep Garre-Olmo, Josep Puig, Rafel Ramos, Lluís Ramió-Torrentà, Vicente Pérez-Brocal, Andrés Moya, Jonathan Swann, Elena Martin-Garcia, Rafael Maldonado, José Manuel Fernández-Real, Jordi Mayneris-Perxachs

“…Global plasma metabolomics by CIL LC-MS in IRONMET identified an enrichment of methylhistidine, phenylacetate, alpha-linolenic and linoleic acid, and secondary bile acid metabolism associated with increased levels of 3-methylhistidine, phenylacetylgluamine, adrenic acid, and isolithocholic acid in the HMs group. …”
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Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction by Lijiang Wei, Naifu Wan, Wentong Zhu, Chenchen Liu, Zeyu Chen, Wuwei Rong, Lujun Zhang, Meifeng Xie, Yueqi Qin, Ting Sun, Qing Jing, Ankang Lyu

“…Although existing reports indicating that mixed lineage kinase domain-like protein (MLKL) is involved in macrophage necroptosis and inflammasome activation, the downstream mechanism of MLKL in necroptosis remain poorly characterized in AMI. …”
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SNORA37/CMTR1/ELAVL1 feedback loop drives gastric cancer progression via facilitating CD44 alternative splicing by Banghe Bao, Minxiu Tian, Xiaojing Wang, Chunhui Yang, Jiaying Qu, Shunchen Zhou, Yang Cheng, Qiangsong Tong, Liduan Zheng

“…Mechanistically, as an ELAV like RNA binding protein 1 (ELAVL1)-generated snoRNA, SNORA37 directly bound to cap methyltransferase 1 (CMTR1) to facilitate its interaction with ELAVL1, resulting in nuclear retention and activity of ELAVL1 in regulating alternative splicing of CD44. …”
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Indoor and Ambient Air Pollution in Chennai, India during COVID-19 Lockdown: An Affordable Sensors Study by Naveen Puttaswamy, V. Sreekanth, Ajay Pillarisetti, Adithi R. Upadhya, Sudhakar Saidam, Balachandar Veerappan, Krishnendu Mukhopadhyay, Sankar Sambandam, Ronak Sutaria, Kalpana Balakrishnan

“…Due to COVID-19 related lockdowns, some TAPHE-2 activities were delayed; however, continuous indoor and outdoor air quality data were collected in and around Chennai, India. …”
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Biologically targeted discovery-replication scan identifies G×G interaction in relation to risk of Barrett’s esophagus and esophageal adenocarcinoma by Li Yan, Qianchuan He, Shiv P. Verma, Xu Zhang, Ann-Sophie Giel, Carlo Maj, Kathryn Graz, Elnaz Naderi, Jianhong Chen, Mourad Wagdy Ali, Puya Gharahkhani, Xiang Shu, Kenneth Offit, Pari M. Shah, Hans Gerdes, Daniela Molena, Amitabh Srivastava, Stuart MacGregor, Claire Palles, René Thieme, Michael Vieth, Ines Gockel, Thomas L. Vaughan, Johannes Schumacher, Matthew F. Buas

“…Summary: Inherited genetics represents an important contributor to risk of esophageal adenocarcinoma (EAC), and its precursor Barrett’s esophagus (BE). Genome-wide association studies have identified ∼30 susceptibility variants for BE/EAC, yet genetic interactions remain unexamined. …”
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Adaptive mechanisms to hypoxia and hyperoxia in juvenile turbot, Scophthalmus maximus by Yi Chen, Yuntian Zhang, Rongwei Zhang, Hongsheng Deng, Xiangyu Meng, Kotoya Inaba, Tatsu Osato, Xiaoran Zhao, Xiaoran Zhao, Yuzhe Han, Yuzhe Han, Tongjun Ren, Tongjun Ren

“…In hematological indicators, there are ways to help adapt to hypoxia and hyperoxia, including increased red blood cell (RBC) and hemoglobin (HGB) counts; gas and ion balance; elevated blood urea nitrogen (BUN) and malondialdehyde (MDA); increased polyphenol oxidase (PPO) and lysozyme (LZM) activity. Although turbot have adaptive mechanisms to both hypoxia and hyperoxia, extended exposure to hypoxia detrimentally affects growth, whereas hyperoxia facilitates it. …”
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Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–20... by Getahun Kahsay Abay, Mebrahtu Teweldemedhin Shfare, Teklay Gebrecherkos Teklu, Kibriti Mehari Kidane, Tsega Kahsay Gebremeskel, Atsebaha Gebrekidan Kahsay, Kebede Embaye Gezae, Saravanan Muthupandian, Tsehaye Asmelash Degene

“…Among the included studies done in Africa, the overall pooled proportion of ESBL-PE was reported to be 28% (95% CI 25–31%). ESBL-PE prevalence differed by region, the pooled estimates for East and North Africa were 29% (95% CI 20–38%) and 19% (95% CI 6–33%), respectively. …”
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Current methods for detecting and assessing HIV-1 antibody resistance by Stanley Odidika, Stanley Odidika, Stanley Odidika, Martin Pirkl, Martin Pirkl, Thomas Lengauer, Thomas Lengauer, Thomas Lengauer, Philipp Schommers, Philipp Schommers, Philipp Schommers

Subjects: “…HIV…”
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Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways by Md. Niaj Morshed, Reshmi Akter, Imran Mahmud, Ah-Yeong Gwon, Jin Woo Jeang, Yeong-Geun Lee, Dae Won Park, Deok Chun Yang, Yeon Ju Kim, Se-Chan Kang

“…The present study explored the possible antiobesogenic and osteoprotective properties of the gut metabolite ginsenoside CK to clarify its influence on lipid and atherosclerosis pathways, thereby validating previously published hypotheses. …”
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Molecular-genetic pathways of hepatitis C virus regulation of the expression of cellular factors PREB and PLA2G4C, which play an important role in virus replication by E. L. Mishchenko, A. A. Makarova, E. A. Antropova, A. S. Venzel, T. V. Ivanisenko, P. S. Demenkov, V. A. Ivanisenko

“…Therapeutic approaches based on activity inhibition of viral non-structural proteins NS3, NS5A, and NS5B are undergoing clinical trials. …”
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Image-based robotic (ROSA® knee system) total knee arthroplasty with inverse kinematic alignment compared to conventional total knee arthroplasty by Henriëtte M. Eijking, Isobel M. Dorling, Emil H. van Haaren, Roel Hendrickx, Thijs Nijenhuis, Martijn G.M. Schotanus, Lee Bouwman, Jasper Most, Bert Boonen

“…Secondary outcomes include clinical metrics (leg alignment, implant and patient survival), surgical parameters (adverse events, surgery duration, blood loss, hospital stay length, medication use), patient-reported outcomes (symptoms, quality of life, pain), mobility and physical activity measurements, metabolic syndrome, cost-efficacy, and gait and continuous glucose monitoring. …”
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Bearberry in the treatment of acute uncomplicated cystitis (BRUMI): protocol of a multicentre, randomised double-blind clinical trial by Péter Hegyi, Noémi Gede, Szilárd Váncsa, Barbara Tóth, András Jávorházy, Péter Nyirády, Boglárka Csupor-Löffler, Péter Birinyi, George Zhanel, Kurt Naber, Reinhard Länger, Nóra Vörhendi, Dezső Csupor

“…Background Bearberry (Arctostaphylos uva-ursi) leaf is available as a treatment of uncomplicated cystitis in several European countries. The antimicrobial activity of its extracts and some of its individual constituents has been observed in vitro; however, the efficacy of bearberry compared with standard antimicrobial therapy has not been assessed yet.Objective The objective of the study is to assess the safety and non-inferiority of bearberry as an alternative therapy in the treatment of acute uncomplicated cystitis in comparison with standard antibiotic therapy (fosfomycin).Methods and analysis This is a randomised controlled double-blinded multicentre trial. …”
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Growth Performance, Serum Biochemical Profile, Oxidative Status, and Fertility Traits in Male Japanese Quail Fed on Ginger (Zingiber officinale, Roscoe) Essential Oil by Tchoffo Herve, Kana Jean Raphaël, Ngoula Ferdinand, Folack Tiwa Laurine Vitrice, Adoum Gaye, Moussa Mahamat Outman, Ngouozeu Moyo Willy Marvel

“…The serum content in total protein and globulin and the antioxidant enzymes activities increased in treated birds compared to the control. …”
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Synergistic photothermal conversion and visible-light photodegradation of antibiotic in S-type TiO2 derived Ti3C2-MXene loaded on NaYF4: Tm3+, Er3+, Yb3+ @BiOI by Seyyedeh Fatemeh Hosseini, Mir Saeed Seyed Dorraji, Shiva Mohajer, Seyedeh Narges Saeedi, Masoumeh Kianfar, Alexandr V. Koshelev, Nataliya A. Arkharova, Denis N. Karimov

“…Excellent catalytic activity is explained by the S-scheme mechanism, which produces holes at the valence band and superoxide radicals at the conductive band in the BiOI and Ti3C2, respectively. …”
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Effects of public roads on wildlife-vehicle collisions in two protected areas, Hluhluwe-iMfolozi Park and iSimangaliso Wetland Park, in KwaZulu-Natal, South Africa by Cameron T. Cormac, Cormac Price, Wendy Collinson, Dave J. Druce, Jarryd P. Streicher, Colleen T. Downs

“…Wildlife faces growing threats from anthropogenic activities, especially infrastructure. Protected areas (PAs) are not exempt, particularly those that experience high traffic volumes on public road passages both within and on their peripheries. …”
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Biodegradation of Phenol at High Initial Concentration by <i>Rhodococcus opacus</i> 3D Strain: Biochemical and Genetic Aspects by Tatiana O. Anokhina, Tatiana Z. Esikova, Valentina N. Polivtseva, Nataliya E. Suzina, Inna P. Solyanikova

“…The decomposition of the toxicant was catalyzed by the enzymes catechol 1,2-dioxygenase and <i>cis</i>,<i>cis</i>-muconate cycloisomerase. The role of protocatechuate 3,4-dioxygenase in biodegradative processes is discussed. …”
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Effect of Eight-Week Transcranial Direct-Current Stimulation Combined with Lat Pull-Down Resistance Training on Improving Pull-Up Performance for Male College Students by Qian Li, Jiaqi Yan, Hanya Dai, Minjie Qiao, Mingxin Gong, Wenxin Niu, Ye Yang, Lejun Wang

“…Additionally, muscle activation of BR, PD, and PM decreased significantly in both groups, while the RT + tDCS group also demonstrated a significant reduction in TB coactivation after training. …”
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Multi-omics elucidates the kidney damage caused by aquatic Cu via the gut-kidney axis in ducks by Mingcai Duan, Jinyu Liu, Zhaoxia Cai, Li Chen, Yong Tian, Wenwu Xu, Tao Zeng, Tiantian Gu, Lizhi Lu

“…GO and KEGG enrichment analyses were most involved in Interleukin-1 Receptor Activity, Taurine and hypotaurine metabolism, Nitrogen metabolism, and Proximal tubule bicarbonate reclamation. …”
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Little Red Dots: Rapidly Growing Black Holes Reddened by Extended Dusty Flows by Zhengrong Li, Kohei Inayoshi, Kejian Chen, Kohei Ichikawa, Luis C. Ho

“…The UV−optical spectrum is described by dust-attenuated AGN emission, featuring a red optical continuum at λ  > 4000 Å and a flat UV spectral shape established through a gray extinction curve at λ  < 3000 Å, due to the absence of small-size grains. …”
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