Overexpression of <i>AtruLEA1</i> from <i>Acer truncatum</i> Bunge Enhanced <i>Arabidopsis</i> Drought and Salt Tolerance by Improving ROS-Scavenging Capability by Shaofeng Li, Huijing Meng, Yanfei Yang, Jinna Zhao, Yongxiu Xia, Shaoli Wang, Fei Wang, Guangshun Zheng, Jianbo Li

“…Compared to wild-type (WT) plants, plants with overexpressed <i>AtruLEA1</i> exhibited increased activities of antioxidant enzymes under drought stress. …”
Get full text

The expression profile of genes associated with behavior, stress, and adult neurogenesis along the hippocampal dorsoventral axis in tame and aggressive foxes by Yu. V. Alexandrovich, E. V. Antonov, S. G. Shikhevich, A. V. Kharlamova, L. V. Meister, Y. V. Makovka, D. V. Shepeleva, R. G. Gulevich, Yu. E. Herbeck

“…The hippocampus is functionally heterogeneous along its dorsoventral axis, with its ventral compartment being more closely involved in stress regulation. …”
Get full text

Impact of the COVID-19 pandemic on utilisation of facility-based essential maternal and child health services from March to August 2020 compared with pre-pandemic March–August 2019... by Grace J Chan, Delayehu Bekele, Bezawit Mesfin Hunegnaw, Kimiko Van Wickle, Chalachew Bekele, Fanos Ashenafi Gebremeskel, Michelle Korte, Christine Tedijanto, Lisanu Taddesse

“…Enablers of service utilisation included communities’ decreased fear of COVID-19 and awareness-raising activities.Conclusion We observed a decline in essential MNCH services particularly in sick children and new family planning visits. …”
Get full text

Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Formi... by Ivan Iliev, Galina Yahubyan, Elena Apostolova-Kuzova, Mariyana Gozmanova, Daniela Mollova, Iliya Iliev, Lena Ilieva, Mariana Marhova, Velizar Gochev, Vesselin Baev

“…Furthermore, genome-wide sequencing and analysis of <i>L. brevis</i> DPL5 with cutting-edge Nanopore technology has uncovered over 50 genes linked to probiotic activity, supporting its ability to adapt and thrive in the harsh gut environment. …”
Get full text

Metabolic engineering of Yarrowia lipolytica for the production and secretion of the saffron ingredient crocetin by Tingan Zhou, Young-Kyoung Park, Jing Fu, Piotr Hapeta, Cinzia Klemm, Rodrigo Ledesma-Amaro

“…Therefore, a two-step temperature-shift fermentation strategy was adopted to optimize yeast growth and biosynthetic enzyme activity, bringing a 2.3-fold increase in crocetin titer. …”
Get full text

Characteristics of subacute stroke patients who achieve earlier independence in real-life walking performance during hospitalization by Kenji Kawakami, Shigeo Tanabe, Daiki Kinoshita, Ryo Kitabatake, Hiroo Koshisaki, Kenta Fujimura, Yoshikiyo Kanada, Hiroaki Sakurai

“…Conclusion: Early improvement in “real-life walking” was associated with younger age, greater cognitive function, and greater “test-setting walking” ability on admission. Low activities of daily living independence and “test-setting walking” ability hindered early progress. …”
Get full text

Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma by Brandon Wee Siang Phon, Shalini Sundramurthi Chelliah, Dina El-Rabie Osman, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin

“…Staple GBM phenotypes, such as GBM stem cells and increased activation of the PI3K/Akt/NF-κB pathway, have been implicated in the expression of several ABC transporters. …”
Get full text

Hidden blood loss and risk factors after percutaneous endoscopic transforaminal lumbar interbody fusion by Meng Ge, Meng Ge, Fangbing Zhu, Fangbing Zhu, Weibin Du, Weibin Du, Zhengcong Ye, Zhengcong Ye, Zhenfei Xiong, Zhenfei Xiong, Lukai Zhang, Lukai Zhang, Hua Zhou, Hua Zhou, Jun Yang, Jun Yang

“…The levels of fibrinogen, activated partial thromboplastin time, prothrombin time, thrombin time, and platelet count as well as the pre- and postoperative hematocrit and hemoglobin levels were collected. …”
Get full text

Mucosal Immunization with an Influenza Vector Carrying SARS-CoV-2 N Protein Protects Naïve Mice and Prevents Disease Enhancement in Seropositive Th2-Prone Mice by Mariia V. Sergeeva, Kirill Vasilev, Ekaterina Romanovskaya-Romanko, Nikita Yolshin, Anastasia Pulkina, Daria Shamakova, Anna-Polina Shurygina, Arman Muzhikyan, Dmitry Lioznov, Marina Stukova

Subjects: Get full text

Impact of meropenem exposure on fluoroquinolone and carbapenem resistance in Pseudomonas aeruginosa infection in inpatients in a Japanese university hospital: Insights into oprD mu... by Tadanori Yamochi, Kazuhisa Ugajin, Rintaro On, Sho Inoue, Hiromi Ikeda, Toshiko Yamochi, Masafumi Takimoto, Issei Tokimatsu

“…Conclusions: In dual fluoroquinolone- and carbapenem-resistant P. aeruginosa, alterations in the OprD porin and the presence of an active EP are primary resistance mechanisms. Meropenem exposure within the past 59 days may have contributed to the selection of the oprD mutant overexpressing mexB, and meropenem exposure within the past 6 months may have contributed to meropenem resistance.…”
Get full text

Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response by Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder, Terra L. Lasho, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harrington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik

“…Using single-cell multiomics sequencing, we identify cell-specific gene expression changes associated with DNMT3A mutations, along with significant epigenomic deregulation affecting enhancer accessibility, resulting in overexpression of interleukin-32 (IL-32), a proinflammatory cytokine that can result in inflammasome activation in monocytes and macrophages. Finally, we show with single-cell resolution that the loss of function of DNMT3A is directly associated with increased chromatin accessibility in mutant cells. …”
Get full text

The Frequency of <i>DPYD</i> c.557A>G in the Dominican Population and Its Association with African Ancestry by Mariela Guevara, Carla González de la Cruz, Fernanda Rodrigues-Soares, Ernesto Rodríguez, Caíque Manóchio, Eva Peñas-Lledó, Pedro Dorado, Adrián LLerena

“…The <i>DPYD</i> genotype is linked to variability in enzyme activity, 5-FU elimination, and toxicity. Approximately 10–40% of patients treated with fluoropyrimidines develop severe toxicity. …”
Get full text

High prevalence of overweight/obesity and central obesity among women in a rural district of Nepal in 2012–2013: a population-based study by Chandra Yogal, Chandra Yogal, Astrid Kamilla Stunes, Astrid Kamilla Stunes, Sunila Shakya, Biraj Karmarcharya, Rajendra Koju, Mats P. Mosti, Mats P. Mosti, Miriam K. Gustafsson, Miriam K. Gustafsson, Bjørn Olav Åsvold, Bjørn Olav Åsvold, Berit Schei, Unni Syversen, Unni Syversen

“…Our findings underscore the need for public health programs addressing nutritional patterns and physical activity to prevent obesity.…”
Get full text

The role of natural exosomes from SHED-MSC in immunoregulation of M0/M1 polarized macrophage cells by Ali Fallah, Abasalt Hosseinzadeh Colagar, Ayyoob Khosravi, Ayyoob Khosravi, Azadeh Mohammad-Hasani, Azadeh Mohammad-Hasani, Mohsen Saeidi, Mohsen Saeidi

“…The levels of anti-inflammatory and antioxidant markers, including CD206, Arg-1, IL-10, TGF-β, TAC, CAT, and SOD, which act as immunosuppressive macromolecules, were elevated. …”
Get full text

Study protocol for a randomised controlled trial of a care partner assisted intervention to improve oral health of individuals with mild dementia by Bei Wu, Gary Yu, Brenda L Plassman, Patricia Poole, Shahrzad Siamdoust, Melanie Bunn, Bobbi Burwell, Yaolin Pei, Christine Downey, Danni Gomes, Angela Kamer, A Leak Bryant, Ruth A Anderson

“…Oral health outcomes will be compared across the three groups. The duration of the active intervention is 3 months, with an additional 3-month maintenance phase. …”
Get full text

Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction by Hongjian Zhou, Zhipeng Xu, Chun Jiang, Qiuyue Wu, Chuanyue Zhang, Zhenyu Liu, Xiaoxue Zhang, Weiwei Li, Yujia Pang, Jing Zhang, Wenju Pan, Min Chen, Xinyi Xia

“…Mechanistically, This IR-induced disruption was linked to IR-induced inhibition of NF-κB/Rela and Bclaf1 activity. Notably, NF-κB agonists were found to ameliorate this damage via upregulating Bclaf1 and spliceosome-related genes expression, thereby normalizing splicing patterns and rescuing IR-induced spermatogenesis disorders. …”
Get full text

Genetic and biochemical characterization of staphylococci occurring in Novosibirsk, Russia by Y. N. Kozlova, N. V. Fomenko, V. V. Morozova, I. V. Saranina, A. Yu. Tikunov, D. A. Ganichev, A. G. Samokhin, V. V. Pavlov, O. M. Rozhnova, I. A. Bondar’, E. V. Zenkova, V. V. Nimaev, V. V.  Klimontov, N. V. Tikunova

“…Identification of coagulase positive strains was performed using a standard biochemical method and by real­time PCR of the coa gene. 100 % coincidence between the presence of the gene and coagulase activity for S. aureus strains was recorded, which suggests that detection of the coa gene can be used as a correct method for S. aure us identification. …”
Get full text

Health- and Non–Health-Related Corporate Social Responsibility Statements in Top Selling Restaurant Chains in the U.S. Between 2012 and 2018: A Content Analysis by Megan P. Mueller, PhD, Alyssa Leib, MS, Deborah C. Glik, PhD, Sara N. Bleich, PhD, Jason Wang, PhD, Catherine M. Crespi, PhD, May C. Wang, DrPH

“…There were increases in corporate social responsibility statements by chain restaurants over the study period from 186 corporate social responsibility statements in 2012 to 1,218 corporate social responsibility statements in 2018, with most statements focused on philanthropy (37.1% of coded statements), community activities that were not health related (18.4% of coded statements), and sustainability initiatives (18.3% of coded statements). …”
Get full text

Trends and factors associated with delays in the first prenatal consultation in Guinea by Tiany Sidibe, Mamadou Dioulde Balde, Sadan Camra, Ramata Diallo, Bienvenu Salim Camara, Karifa Kourouma, Madeleine Toure, Kaba Saran Keita, Fanta Barry, Maimouna Balde

“…The factors associated with the delay in performing the ANC1 were: being aged 35–49 years (adjusted odds ratio [AOR]: 1.36; 95% confidence interval [CI]: 1.08–1.69); Living in a poor household (AOR: 1.87; 95% CI: 1.64–2.13), living in Boké (AOR: 2.13; 95% CI: 1.58–2.87), and N’zerekore (AOR: 4.97; 95% CI: 3.58–6.91). …”
Get full text

An Enhanced Three-Band Algorithm for Retrieving Phycocyanin Concentration from Satellite Data in Plateau Inland Lake by Dajun Yuan, Bo-Hui Tang, Dong Wang, Junyi Chen, Zhen Zhang, Zhitao Fu

“…The frequency and spatial extent of cyanobacterial bloom outbreaks have increased in recent years due to climate warming and human activities, causing significant harm to inland water ecosystems. …”
Get full text