MyD88 inhibitor TJ-M2010-5 alleviates spleen impairment and inflammation by inhibiting the PI3K/miR-136-5p/AKT3 pathway in the early infection of Trichinella spiralis by Huifang Bai, Qianqian Dang, Guoliang Chen, Lingfeng Xie, Saining Wang, Ning Jiang, Xiaoxia Wu, Shuyan Zhang, Xuelin Wang

“…In conclusion, the study demonstrates that TJ-M2010-5 could effectively alleviate spleen impairment and reduce inflammation in mice infected with T. spiralis in its early stages by blocking the activation of PI3K/miR-136-5p/AKT3.…”
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Consensus evidence-based clinical practice guide for the diagnosis and management of osteoporosis in childhood and adolescence by Yasser El Miedany, Hala Lotfy, Maha El Gaafary, Naglaa Gadallah, Annie Nasr Mehanna, Safaa Mahran, Waleed Hassan, Mohammed Hassan Abu-Zaid, Samar Abdelhamed Tabra, Mohamed Mortada, Ahmed R. Radwan, Dalia El Mikkawy, S. Esam Maher, Ghada Eldrainy, Hala Abdulhady, Marwa Mahgoub, Youmna Amer, Walaa Elwakil

“…This has been attributed to better survival rates of children living with chronic disorders, the increased use of medications known to have a negative impact on the children’s bones, and the increased preference for indoor activities and sedentary life in healthy children. Recent advances in pediatric osteoporosis definition, along with a lack of management recommendations or national consensus on its diagnosis and treatment, have led to a wide range of approaches being implemented to manage this illness. …”
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Description and biomechanical evaluation of the modified laparoscopic-assisted percutaneous gastropexy technique in dogs by Dong Woo Kim, Ho Hyun Kwak, Ho Hyun Kwak, Junhyung Kim, Heung Myong Woo

“…BackgroundTotal laparoscopic gastropexy (TLG) has become increasingly popular due to its minimally invasive nature, requiring only three ports and no additional skin incisions aside from those for port placement. …”
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Multisensory Stimulation in Rehabilitation of Dementia: A Systematic Review by Andrea Calderone, Angela Marra, Rosaria De Luca, Desirèe Latella, Francesco Corallo, Angelo Quartarone, Francesco Tomaiuolo, Rocco Salvatore Calabrò

“…This systematic review aims to explore methods that utilize MSS in the rehabilitation of patients with dementia. Its clinical value is rooted in its ability to offer a deep comprehension of how MSS can be successfully incorporated into rehabilitation treatments. …”
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A new multi-grid bathymetric dataset of the Gulf of Naples (Italy) from complementary multi-beam echo sounders by F. Foglini, M. Rovere, R. Tonielli, G. Castellan, G. Castellan, M. Prampolini, M. Prampolini, F. Budillon, M. Cuffaro, G. Di Martino, V. Grande, S. Innangi, M. F. Loreto, L. Langone, F. Madricardo, A. Mercorella, P. Montagna, C. Palmiotto, C. Pellegrini, A. Petrizzo, L. Petracchini, A. Remia, M. Sacchi, D. Sanchez Galvez, A. N. Tassetti, F. Trincardi

“…Bathymetric big data help characterise the seafloor and its benthic habitats, understand sedimentary records, and support the development of offshore engineering infrastructures. …”
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Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) by Mengmeng Shi, Yike Wang, Peng Lv, Yujie Gong, Qi Sha, Xinyan Zhao, Wen Zhou, Lingtao Meng, Zegang Han, Lingxiao Zhang, Lingxiao Zhang, Yongwang Sun, Yongwang Sun

“…The analysis of the Ka/Ks ratios indicated that the MsADF genes underwent purity-based selection during its evolutionary expansion. The promoter region of these genes was found to contain multiple cis-acting elements related to hormone responses, defence, and stress, indicating that they may respond to a variety of developmental and environmental stimuli. …”
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Potential Research Tool of Stem Cells from Human Exfoliated Deciduous Teeth: Lentiviral Bmi-1 Immortalization with EGFP Marker by Siqi Yao, Lingping Tan, Huan Chen, Xiaojun Huang, Wei Zhao, Yan Wang

“…Stem cells from human exfoliated deciduous teeth (SHED) are a favourable source for tissue engineering, for its great proliferative capacity and the ease of collection. …”
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Incidence and risk factors for Graves’ orbitopathy in patients who underwent anti-inflammatory and immunosuppressive treatment during medical treatment for Graves’ disease: investi... by Natsuko Watanabe, Jaeduk Yoshimura Noh, Ai Kozaki, Ran Yoshimura, Ai Yoshihara, Nami Suzuki, Masako Matsumoto, Miho Fukushita, Aya Kinoshita, Azusa Aida, Hideyuki Imai, Shigenori Hiruma, Toshu Inoue, Kosuke Inoue, Kiminori Sugino, Koichi Ito

“…The GO score, ranging from 0 to 8 points, showed moderate performance (area under the curve: 0.71, cut-off value: 5 points, sensitivity: 0.76, specificity: 0.59, positive predictive value: 0.12, negative predictive value: 0.97). …”
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NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion by Xudi Pang, Xuejun He, Ying Yang, Ling Wang, Yuzhen Sun, Huiming Cao, Yong Liang

“…In the BBB dataset, although it does not outperform the PaDEL descriptor model, its performance closely approximates that of the top single-modal model. …”
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Mogućnost primjene dinamičkog programiranja u problemu transporta by Milorad Bojanić

“…Izloženi problem dinamičkog programiranja u prijevozu tereta spada u klasu specijalno strukturiranih zadataka određivanja ekstrema realne funkcije s više varijabli, čiji argumenti uzimaju vrijednosti iz unaprijed zadane oblasti. …”
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The impact of war on ACS admissions and triage – a single center experience by Sharon Bruoha, Tatiana Stolichny, Vladimir Chitoroga, Michael Shilo, Michael Friger, Jamal Jafari, Evgeny Chernogoz, Maggie Cohen Grisaru, Amos Katz, Chaim Yosefy, Gili Givaty

“…The Israel-Gaza war that erupted on October 7th, 2023, provided a tragic opportunity to explore the effect of war on the epidemiology, characteristics, and management of patients with acute coronary syndrome (ACS) living in areas of active armed conflict. Methods: All patients admitted with ACS to our medical center, between October 7th, 2023, and January 6th, 2024, were retrospectively included. …”
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Thermal Response and Degressive Reaction Study of Oxo-Biodegradable Plastic Products Exposed to Various Degradation Media by S. M. Al-Salem, A. Y. Al-Nasser, M. H. Behbehani, H. H. Sultan, H. J. Karam, M. H. Al-Wadi, A. T. Al-Dhafeeri, Z. Rasheed, M. Al-Foudaree

“…Analytical kinetic estimation methods relying on model free solutions enabled the determination of the apparent activation energy (Ea) of the specimens postexposure to degradation media. …”
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Synthesis, Characterization, and Catalytic Studies of Mn(III)-Schiff Base-Dicyanamide Complexes: Checking the Rhombicity Effect in Peroxidase Studies by Manuel R. Bermejo, Rocío Carballido, M. Isabel Fernández-García, Ana M. González-Noya, Gustavo González-Riopedre, Marcelino Maneiro, Laura Rodríguez-Silva

“…The manganese complexes were also tested as peroxidase mimics for the H2O2-mediated reaction with the water-soluble trap ABTS, showing complexes 1-2 relevant peroxidase activity in contrast with 3. The rhombicity around the metal ion can explain this catalytic behaviour.…”
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Comparative cross-sectional study on the prevalence, determinants and willingness to use long-acting reversible contraception among female students attending public and private uni... by Tope Michael Ipinnimo, Taofeek Adedayo Sanni, Kabir Adekunle Durowade, Olusegun Elijah Elegbede, Kayode Rasaq Adewoye, Oluseyi Adedeji Aderinwale, John Olujide Ojo, Ayo Kamal Alabi, Richard Dele Agbana, Joy Bosan

“…The prevalence of LARC usage among the sexually active respondents was 12.5% for public universities and 12.7% for private universities. …”
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Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents by Erivaldo Machado Araújo, Hélio José Coelho-Júnior, Caio Victor Sousa, Thiago dos Santos Rosa, Ivo Vieira Sousa Neto, Emanuele Marzetti, Octávio Luiz Franco, Samuel da Silva Aguiar

“…It also decreased the completion time for the sit-and-stand test both post-training (p = 0.008) and post-detraining (p = 0.015) relative to baseline. …”
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Chemical Composition and In Vitro Evaluation of the Mosquito (Anopheles) Repellent Property of Neem (Azadirachta indica) Seed Oil by Olive Aidoo, Noble Kuntworbe, Fredrick William Akuffo Owusu, Deryl Nii Okantey Kuevi

“…The use of synthetic mosquito repellents with N,N-Diethyl-meta-toluamide (DEET) is one of the popular interventions despite its dermatological limitations such as skin irritations. …”
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Improving protein hydrolysis and digestibility in Arthrospira platensis biomass through recombinant peptidases (EC 3.4): Opportunities for monogastric animal diets by Maria P. Spínola, Mónica M. Costa, Rita S. Simões, Vânia O. Fernandes, Vânia Cardoso, Virgínia M.R. Pires, Cláudia Afonso, Carlos Cardoso, Narcisa M. Bandarra, Carlos M.G.A. Fontes, José A.M. Prates

“…A library of 192 peptidases was generated, from which 142 soluble peptidases were expressed in Escherichia coli and subsequently screened for activity against an A. platensis suspension in vitro. …”
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Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin by Prastika Krisma Jiwanti, Dewi Kartika Azizah Sukardi, Anis Puspita Sari, Mai Tomisaki, Siti Wafiroh, Sri Hartati, Arramel, Yew Hoong Wong, Pei Meng Woi, Joon Ching Juan

“…The uncontrolled use of ciprofloxacin (CIP) has led to increased resistance in patients and potential health issues such as kidney disorders, digestive disorder, and liver complications. …”
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Subacute toxicity of isoliquiritigenin-zein phosphatidylcholine nanoparticles on biochemical, hematological, and histopathological parameters in Sprague-Dawley rats by Ke Yang, Kumar Ganesan, Fei Gao, Chunguang Xie, Jianping Chen

“…Aim: Isoliquiritigenin (ISL) is a natural flavonoid found in many natural plants, which exhibits numerous pharmacological properties including anti-inflammatory, antioxidant, antitumor, and antiviral activities. However, the low bioavailability and stability of ISL limit its application in clinical practice. …”
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PDZRN3 regulates adipogenesis of mesenchymal progenitors in muscle by Hiroki Iida, Minako Kawai-Takaishi, Yoshihiro Miyagawa, Yasuhiko Takegami, Akiyoshi Uezumi, Takeshi Honda, Shiro Imagama, Tohru Hosoyama

“…Results: PDZRN3 was more expressed in MPs than in muscle stem cells, and its expression profile of PDZRN3 fluctuated with the adipogenic differentiation of MPs. …”
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