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64641
Sleep disturbance and social reward processing as characteristics linking minority victimization and suicidal ideation in youth
Published 2025-01-01“…Region-of-interest analyses examined ventral striatum (VS) activity during positive feedback. Mediation and moderation effects were examined using linear regressions. …”
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64642
RAZNOLIKOST I UGROŽENOST TRAVNJAKA NACIONALNOG PARKA SJEVERNI VELEBIT
Published 2019-01-01“…Očuvanje travnjaka morao bi biti prioritet upravljanja Parkom jer, osim iznimne bioraznolikosti, travnjaci nam ujedno govore i o prošlosti čitava područja, načinu života, privređivanja, kretanja te čine neizostavan i nemjerljivo važan dio prirodne i kulturne baštine.…”
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64643
TURSKE UTVRDE I KULE U LICI I KRBAVI 1527. – 1689. GODINE
Published 2013-01-01“…Mnoga pitanja iz tih područja nisu usto dovoljno jasno niti postavljena a još su dalje potrebni na njih odgovori.…”
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64644
OsBBX2 Delays Flowering by Repressing <i>Hd3a</i> Expression Under Long-Day Conditions in Rice
Published 2024-12-01“…Furthermore, <i>OsBBX2</i> enhanced the transcriptional repression of <i>Hd3a</i> through its interaction with <i>Hd1</i>, as demonstrated in the protoplast-based assay. …”
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64645
Toxicity effect of Ricinus communis methanolic extracts against Bactrocera cucurbitae (Diptera: Tephritidae)
Published 2025-01-01“…The crude extract of R. communis was subjected to fractionating using different organic solvents in an increasing order of polarity, where the fraction indicating maximum activity was then taken for the isolation of the bioactive compounds using various chromatographic and spectroscopic techniques such as column chromatography, thin layer chromatography (TLC), gas chromatography-mass spectrometry (GC-MS). …”
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64646
Analysis of the dynamics of occupational morbidity and its consequences in Ukraine in comparison with other countries of the world
Published 2023-09-01“…The results obtained in the study indicate the discrepancy of statistical data on occupational morbidity and its consequences with the real situation: the level of occupational morbidity in Ukraine is 17 times lower than the European average, despite the fact that the working conditions in most of them do not meet hygienic standards. …”
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64647
aDolescent and prEconception health peRspectiVe of Adult Non-communicable diseases (DERVAN): protocol for rural prospective adolescent girls cohort study in Ratnagiri district of K...
Published 2020-09-01“…IEC is registered with Government of India. Its registration code is EC/755/INST/MH/2015/RR-18. …”
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64648
Chemical Composition, In Vivo, and In Silico Molecular Docking Studies of the Effect of <i>Syzygium aromaticum</i> (Clove) Essential Oil on Ochratoxin A-Induced Acute Neurotoxicity
Published 2025-01-01“…The essential oils were extracted by hydrodistillation, a yield of 12.70% was obtained for EOC, and the GC-MS characterization of this essential oil revealed that its principal major components are eugenol (80.95%), eugenyl acetate (10.48%), β-caryophyllene (7.21%), and α-humulene (0.87%). …”
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64649
EDF1 accelerates ganglioside GD3 accumulation to boost CD52-mediated CD8+ T cell dysfunction in neuroblastoma
Published 2025-02-01“…It was verified that high EDF1 expression in NB cells led to Lactosylceramide (LacCer) accumulation, as well as downstream ganglioside-GD3, which subsequently increased the expression of CD52 and immune checkpoint genes, chemotaxis, and apoptosis-related events in activated CD8+T cells. Mechanistically, EDF1 was recruited as a coactivator to form the NF-κB/RelA/EDF1 complex, which further prevented the promoter region methylation of ST8SIA1, to elevate its transcription. …”
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64650
Nicotinic α7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food reward
Published 2025-01-01“…Cocaine induction of striatal immediate early gene expression of cFos, FosB, Arc and EGR2 was blocked in α7 nAChR-ChATCre mice, demonstrating the importance of α7 nAChRs on cholinergic neurons for striatal neuronal activity changes. Collectively, our findings show that α7 nAChRs on cholinergic interneurons in the striatum are pivotal for learning processes related to cocaine, but not food reward.…”
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64651
Identifying the function of novel cross-species microRNAs from the excretory-secretory products of Angiostrongylus cantonensis fifth-stage larvae
Published 2025-02-01“…Moreover, we also demonstrated that the AcNOVEL31 microRNA can affect the inflammation activation via regulating the presenilin-1/GSK3B/β-catenin/NF-κB pathway. …”
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64652
Assessing inter-basin groundwater input to the Verlorenvlei estuarine lake using stable isotopes and hydrochemistry
Published 2025-02-01“…Furthermore, Verlorenvlei experiences high evaporation (evaporation best fit line: δ2H = 12.49 x δ18O - 47.68, average δ2H value of 47.1 ‰ and average δ18O value of 7.64 ‰) compared to its feeding rivers. …”
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64653
Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach
Published 2025-02-01“…Finally, SSA also induced G1-phase blockade and apoptosis in PC3 cells, further highlighting its potential role in prostate cancer treatment.ConclusionThe present study revealed that SSA exerts anti-tumorigenic effects in prostate cancer by targeting multiple pathways, laying a theoretical reference for its use as a therapeutic candidate for prostate cancer.…”
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64654
Localization and expression of C1QTNF6 in chicken follicles and its regulatory effect on follicular granulosa cells
Published 2025-01-01“…C1q/tumor necrosis factor-related protein 6 (C1QTNF6) is a newly discovered adiponectin analog that plays a significant role in female reproduction. However, its expression and function in chickens remain unclear. …”
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64655
The Generation and Modulation of Distinct Gamma Oscillations with Local, Horizontal, and Feedback Connections in the Primary Visual Cortex: A Model Study on Large-Scale Networks
Published 2021-01-01“…Gamma oscillation (GAMMA) in the local field potential (LFP) is a synchronized activity commonly found in many brain regions, and it has been thought as a functional signature of network connectivity in the brain, which plays important roles in information processing. …”
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64656
Timp2 loss-of-function mutation and TIMP2 treatment in a murine model of NSCLC: Modulation of immunosuppression and oncogenic signaling
Published 2025-03-01“…However, the demonstration of such anti-tumor activity and associated mechanisms using in vivo tumor models is lacking. …”
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64657
Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association
Published 2018-08-01“…In routine clinical practice PEI is diagnosed mainly on the basis of decreased pancreatic enzymes activity in stool in patients with verified pancreatic disease but can result in decreased exocrine function. …”
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64658
Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis...
Published 2023-12-01“…It is known that disruptions in the regulation of apoptosis activation are some of the key features inherent in most cancer cells, which determines the pharmacological induction of apoptosis as an important strategy for cancer therapy. …”
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64659
Promise and Peril: Stellar Contamination and Strict Limits on the Atmosphere Composition of TRAPPIST-1 c from JWST NIRISS Transmission Spectra
Published 2025-01-01“…While their favorable planet-to-star radius ratios enable searches for even thin secondary atmospheres, their high activity levels and high-energy outputs threaten atmosphere survival. …”
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64660
Skrb na kraju života – o skrbi i šire (što znamo i možemo)
Published 2024-01-01“…Osnovni cilj intenzivnog liječenja jest sveobuhvatna skrb kritično bolesnih, što uključuje smanjenje mortaliteta i morbiditeta, održavanje funkcije organa, ozdravljenje i sprječavanje komplikacija, ali i skrb bolesnika na kraju života. …”
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