Epigenome-wide DNA methylation profiling in septic and non-septic patients with similar infections: potential use as sepsis biomarkers by Ian López-Cruz, Ian López-Cruz, José Luis García-Giménez, José Luis García-Giménez, José Luis García-Giménez, Manuel Madrazo, Manuel Madrazo, Judit García-Guallarte, Laura Piles, Federico V. Pallardó, Federico V. Pallardó, Federico V. Pallardó, Arturo Artero, Arturo Artero

“…IntroductionSepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ failure. Despite its significant global burden, the underlying mechanisms of immune dysfunction in sepsis remain incompletely understood. …”
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Genome‐Wide Diversity in Lowland and Highland Maize Landraces From Southern South America: Population Genetics Insights to Assist Conservation by Pia Guadalupe Dominguez, Angela Veronica Gutierrez, Monica Irina Fass, Carla Valeria Filippi, Pablo Vera, Andrea Puebla, Raquel Alicia Defacio, Norma Beatriz Paniego, Veronica Viviana Lia

“…These results suggest that maize landraces from Northern Argentina may be unable to cope with climate change. Therefore, active conservation policies are advisable.…”
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Exoskeleton Training for Spinal Cord Injury Neuropathic Pain (ExSCIP): Protocol for a Phase 2 Feasibility Randomised Trial [version 1; peer review: 1 approved, 2 approved with rese... by Orlaith Doherty, Conor White, Nanna Brix Finnerup, Eimear Smith, Mark Pollock, Nathan Kirwan, Olive Lennon, Catherine Blake

“…Sensorimotor stimulation using active walking with robotic assistance has not been well studied in NP after SCI, despite convincing locomotor-based pre-clinical studies, identifying prevention and reversal of NP. …”
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Annotated Checklist of Poroid Hymenochaetoid Fungi in Central Asia: Taxonomic Diversity, Ecological Roles, and Potential Distribution Patterns by Yusufjon Gafforov, Manzura Yarasheva, Xue-Wei Wang, Milena Rašeta, Yelena Rakhimova, Lyazzat Kyzmetova, Kanaim Bavlankulova, Sylvie Rapior, Jia-Jia Chen, Ewald Langer, Burkhon Munnavarov, Zafar Aslonov, Bobozoda Bakokhoja, Li-Wei Zhou

“…Central Asia, located at the heart of Eurasia, is renowned for its varied climate and vertical vegetative distribution, which support diverse biomes and position it as a global biodiversity hotspot. …”
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Oral Supplementation with Three Vegetable Oils Differing in Fatty Acid Composition Alleviates High-Fat Diet-Induced Obesity in Mice by Regulating Inflammation and Lipid Metabolism by Waleed Aldamarany, Huang Taocui, Deng Liling, Yang Wanfu, Geng Zhong

“…Moreover, PSO, SFO, and TSO administration increased the expression levels of fatty acid β-oxidation-related genes, including peroxisome proliferator-activated receptor-alpha (PPAR-α), carnitine palmitoyltransferase 1a (CPT1a) and CPT1b, and thermogenesis-related genes such as uncoupling protein 1 (UCP1), and decreased the expression levels of lipid synthesis-related genes, including fatty acid synthase (FAS) and PPAR-γ in EAT. …”
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Normative Values of Brainstem Auditory-Evoked Responses in Sheep by Katharina Suntinger, Adrian Dalbert, Lukas Prochazka, Milena Tegelkamp, Peter Kronen, Karina Klein, Christof Röösli, Alexander Huber, Flurin Pfiffner

“…<b>Background:</b> The brainstem auditory-evoked response (BAER) is an established electrophysiological measure of neural activity from the auditory nerve up to the brain stem. …”
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HfC–HfO2 modified high/superhigh temperature thermal protection coating for superior hot corrosion resistance and antioxidation performance by Zhiyun Ye, Shuqi Wang, Shuang Yu, Xinrui Zhao, Yongchun Zou, Guoliang Chen, Lei Wen, Lina Zhao, Guangxi Zhang, Yaming Wang, Jiahu Ouyang, Dechang Jia, Yu Zhou

“…In this study, a HfC–HfO2-modified silicide coating was prepared via an innovative method of halide-activated pack cementation (HAPC) combined with liquid-plasma-assisted particle deposition and sintering of niobium alloys, resulting in a composite coating with excellent hot corrosion resistance and high-temperature oxidation resistance. …”
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The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Furthermore, K-means algorithm identified an impairment of pathways related to the development and progression of cancer, such as angiogenesis, as well as pathways related to the immune system regulation, such as T cell activation. Our data confirmed the preservation of the genomic landscape from tumour tissue to GSCs, supporting the relevance of this cellular model to test in vitro new target therapies for GBM.…”
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AN ASSESSMENT OF PERCEPTION OF THE PEOPLE ON MALARIA PREVENTION AND CONTROL IN DONGA LOCAL GOVERNMENT AREA OF TARABA STATE by SILAS JOSHUA, SUNDAY EMMANUEL BAMISE

“…The study identified other protective practices against mosquito’s bites and further assessed whether such practices do affect insecticide treated net (ITN) usage. …”
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Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats by Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M. Nichols, Andrew J. Shepherd, Vijay S. Gorantla, Jelena M. Janjic

“…Therefore, we aimed to suppress the pro-inflammatory activity of M1-like macrophages and decrease their infiltration at the site of inflammatory insult to resolve tissue inflammation. …”
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Construction of a rodent neural network-skeletal muscle assembloid that simulate the postnatal development of spinal cord motor neuronal network by Haiyang Yu, Shangbin Yang, Yuanfeng Chen, Chuangran Wu, Jing Xu, Yue Yang, Rongjie Wu, Yinan Guo, Zhen Chen, Ying Ding, Xiang Zeng, Ge Li, Yuanhuan Ma, Qiujian Zheng, Yuanshan Zeng, Biqin Lai

“…The coculture process involves the secretion of neurotrophin-3 and insulin growth factor-1 by SkM cells, which activate the related ERK-MAPK and PI3K-AKT signaling pathways in NNs. …”
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Revealing novel protein interaction partners of glyphosate in Escherichia coli by Alix Sarah Aldehoff, Dominique Türkowsky, Patrick Lohmann, Masun Nabhan Homsi, Ulrike Rolle–Kampczyk, Elke Ueberham, Jörg Lehmann, Martin von Bergen, Nico Jehmlich, Sven–Bastiaan Haange

“…Despite all debates about its safe use, glyphosate remains the most widely applied active ingredient in herbicide products, with renewed approval in the European Union until 2033. …”
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Photon sensor-based monitoring of spatial variations in canopy FIPAR for crop growth assessment by Jian Wang, Zhenggui Zhang, Xin Li, Lu Feng, Xiaofei Li, Minghua Xin, Shiwu Xiong, Yingchun Han, Shijie Zhang, Xiaoyu Zhi, Beifang Yang, Guoping Wang, Yaping Lei, Zhanbiao Wang, Yabing Li

“…The photon sensor-based fraction of intercepted photosynthetically active radiation (FIPAR) monitoring system was demonstrated to provide accurate real-time tracking of crop growth. …”
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Protocol for the enhanced management of multimorbid patients with COPD and severe asthma: role of indoor air quality by Emili Vela, Isaac Cano, Josep Roca, Antoni Sisó-Almirall, Carme Hernandez, Ebymar Arismendi, Ramon Farré, Alba Gómez-López, María Figols, Antonio Montilla-Ibarra, Núria Sánchez-Ruano, Benigno Sánchez, Marta Sorribes, Jordi Piera-Jiménez, Jaume Benavent, Jose Fermoso, Rubèn González-Colom

“…Accordingly, the main objective is to implement a novel integrated care preventive service for enhanced management of these patients, as well as to evaluate its potential for value generation.Methods and analysis At the end of 2024, the specifics of the novel service will be defined through the articulation of its four main components: (1) enhanced lung function testing through oscillometry, (2) continuous monitoring of indoor air quality as a potential triggering factor, (3) digital support with an adaptive case management (ACM) approach and (4) predictive modelling for early identification and management of exacerbations. …”
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Agronomic performance of curly lettuce seedlings from mill compost substrate under organic cropping system by Luiz Fernando de Sousa Antunes, Adelson Paulo Araújo, Maria Elizabeth Fernandes Correia, Norma Gouvêa Rumjanek, José Guilherme Marinho Guerra

“…Purpose: Millicompost is an organic substrate generated by the activity of millipedes (diplopods) with high potential for seedling production. …”
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Transcriptome analysis reveals hypoxic response key genes and modules as well as adaptive mechanism of crucian carp (Carassius auratus) gill under hypoxic stress by Mengchao Xing, Mengchao Xing, Zhen Rong, Zhen Rong, Xin Zhao, Xin Zhao, Xiaowei Gao, Xiaowei Gao, Zhiguang Hou, Lihan Zhang, Lihan Zhang, Waiho Khor, Yihuan Xu, Yihuan Xu, Li Chen, Li Chen, Chengbin Wu, Chengbin Wu

“…The VEGF pathway genes are significantly expressed, enhancing the generation of microvessels in the gill filaments, and improving the capacity to carry oxygen, thus enabling the crucian carp to adapt to hypoxia stress. Hypoxia activated glycolysis, enhanced anaerobic metabolism, promoted β-oxidation of fatty acids, providing energy and maintaining normal physiological metabolism, eventually improving antioxidant and immune capabilities in crucian carp. …”
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Chloroquine and Rapamycin Augment Interleukin-37 Expression via the LC3, ERK, and AP-1 Axis in the Presence of Lipopolysaccharides by Xiaoyi Shi, Chunhui Lai, Lianyu Zhao, Mingying Zhang, Xi Liu, Shanqin Peng, Weizhong Guo, Qiuying Xu, Song Chen, Guang-xing Chen

“…Four rhesus monkeys were also administered chloroquine to evaluate IL-37 induction in vivo and its bioactivity on CD4 proliferation and activation. …”
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OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review by Cristian Metrangolo, Simone Donati, Marco Mazzola, Liviana Fontanel, Walter Messina, Giulia D’alterio, Marisa Rubino, Paolo Radice, Elias Premi, Claudio Azzolini

“…While central retinal thickness has been the most common and one of the first OCT identified biomarkers, today, other qualitative and quantitative biomarkers provide novel insight into disease activity and offer superior prognostic value and better guidance for tailored therapeutic management. …”
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Promotion mechanism of hydroxyl groups in catalyzing CO2 cycloaddition by Yiming Wang, Wensheng Wei, Yuxin Wang, Guangwen Xu, Jinggang Zhao, Lei Shi

“…., NEt3(HE)Br, NEt2(HE)2Br, NEt1(HE)3Br, and N(HE)4Br, were successfully prepared by quantitatively grafting hydrogen-bond donors (HBDs) as electrophilic sites on quaternary ammonium salts and then used to catalyze the cycloaddition of propylene oxide (PO) and carbon dioxide (CO2). …”
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Can muscle synergies shed light on the mechanisms underlying motor gains in response to robot-assisted gait training in children with cerebral palsy? by Gloria P. Vergara-Diaz, Stefano Sapienza, Jean-François Daneault, Eric Fabara, Catherine Adans-Dester, Giacomo Severini, Vincent C. K. Cheung, Carmen Echevarría Ruiz de Vargas, Donna Nimec, Paolo Bonato

“…Linear mixed effect models showed that composition of the muscle synergies and their temporal activation coefficients present deviations from normative data proportional to the severity of functional limitations (i.e., GMFCS levels, p < 0.01). …”
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