Effect of mRNA formulated with lipid nanoparticles on the transcriptomic and epigenetic profiles of F4/80+ liver-associated macrophages by Chitsuda Pongma, Pornlapat Keawvilai, Atsadang Boonmee, Benjawan Wongprom, Thitiporn Pattarakankul, Chutamath Sittplangkoon, Mohamad-Gabriel Alameh, Patipark Kueanjinda, James Heyes, Kieu Lam, Benjawan Saechue, Kiat Ruxrungtham, Tanapat Palaga

“…The cis-regulatory regions of Tnf, Il6 and Marco showed enrichment of H3K4me3 marks, which correlated well with their increased transcription. …”
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Characteristics of injuries associated with electric personal mobility devices: a nationwide cross-sectional study in South Korea by Maro Kim, Dongbum Suh, Jin Hee Lee, Hyuksool Kwon, Yujin Choi, Joo Jeong, Sola Kim, Soyun Hwang, Joong Wan Park, You Hwan Jo

“…Old age and drunk driving are both associated with serious injuries. Active traffic enforcement and safety regulations regarding ePMDs should be implemented to prevent severe injuries caused by ePMD-related accidents.…”
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Optimization and action mechanism of pollutant removal performance of unsaturated vertical flow constructed wetland (UVFCW) driven by substained-release carbon source by Yuechang Wang, Lin-Lan Zhuang, Shuang Liu, Yuanjun Su, Zhen Hu, Jian Zhang, Xiaoping Wang, Shaoming Cui, Gang Peng, Shuting Xie

“…The results showed that the sustained-release of carbon source increased the carbon source in UVFCW, thus increasing the abundance and activity of denitrifying microorganisms and enhancing the denitrification reaction, ultimately improving the removal of NO3−-N, with its removal efficiency reaching up to 95.50%. …”
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Preliminary analysis of the role of small hepatitis B surface proteins mutations in the pathogenesis of occult hepatitis B infection via the endoplasmic reticulum stress-induced UP... by Huang Chengrong, Zhang Hao, Wang Jing, Li Jianfei, Liu Qian, Zong Qiyin, Zhang Yunyun, Wang Qin, Zhou Qiang

“…These results suggest that proteins harboring OBI-related mutations may tend to accumulate in the ER, thereby triggering an ERS response and impairing the transcription and translation of HBsAg via the activation of the unfolded protein response and ER-associated protein degradation pathway. …”
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A preliminary account of Culicoides (Diptera: Ceratopogonidae) from the Andaman and Nicobar Islands with 13 new records and updated species inventory from India by Koustav Mukherjee, Surajit Kar, Atanu Naskar, Chandrakasan Sivaperuman, Dhriti Banerjee

“…Midges were collected using CDC light traps, light sheets, Malaise traps, and manual collection from exposed body parts of the author and volunteers (biting collection). Identification was carried out using relevant taxonomic keys and original descriptions. …”
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Clinical determinants and prognostic implications of renin and aldosterone in patients with symptomatic heart failure by Masatake Kobayashi, Susan Stienen, Jozine M. terMaaten, Kenneth Dickstein, Nilesh J. Samani, Chim C. Lang, Leong L. Ng, Stefan D. Anker, Macro Metra, Gregoire Preud'homme, Kevin Duarte, Zohra Lamiral, Nicolas Girerd, Patrick Rossignol, Dirk J. vanVeldhuisen, Adriaan A. Voors, Faiez Zannad, João Pedro Ferreira

“…Abstract Aims Activation of the renin–angiotensin–aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis. …”
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Neopterin and Beta-2 Microglobulin Relations to Immunity and Inflammatory Status in Nonischemic Dilated Cardiomyopathy Patients by Celina Wojciechowska, Jan Wodniecki, Romuald Wojnicz, Ewa Romuk, Wojciech Jacheć, Andrzej Tomasik, Bronisława Skrzep-Poloczek, Beata Spinczyk, Ewa Nowalany-Kozielska

“…Neopterin correlated with acute phase proteins and stage of heart failure and may indicate a general immune and inflammatory activation in heart failure.…”
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Changes in the Expression of Mitochondrial Morphology-Related Genes during the Differentiation of Murine Embryonic Stem Cells by Jeong Eon Lee, Bong Jong Seo, Min Ji Han, Yean Ju Hong, Kwonho Hong, Hyuk Song, Jeong Woong Lee, Jeong Tae Do

“…During embryonic development, cells undergo changes in gene expression, signaling pathway activation/inactivation, metabolism, and intracellular organelle structures, which are mediated by mitochondria. …”
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Assessing subtle changes in arid land river basin ecological quality: A study utilizing the PIE engine platform and RSEI by Aizemaitijiang Maimaitituersun, Han Yang, Nuerbiye Aobuliaisan, Kamuran Maimaitiaili, Ouyang Chenyu

“…The ecological environment in arid regions is fragile, with its quality highly sensitive to human activities. …”
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Contamination profile of heavy metals in marine fish and shellfish by M.A. Salam, S.C. Paul, S.N.B.M. Noor, S.A. Siddiqua, T.D. Aka, R. Wahab, E.R. Aweng

“…Rapid industrialization along with advanced agricultural activities led to the contamination in aquatic environment with heavy metals. …”
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mHealth Intervention for Dementia Prevention through lifestyle Optimisation (MIND-PRO) in a primary care setting: protocol for a randomised controlled trial in people with low SES... by Edo Richard, Esther Van den Berg, Ron Handels, Henrike Galenkamp, Eric P Moll van Charante, Marieke P Hoevenaar-blom, Anne Roos van der Endt, Martien J H Kas

“…Secondary outcomes include the Cardiovascular Risk Factors, Ageing and Dementia risk score and its individual risk factors, and disability, physical activity, depressive symptoms, cognitive functioning and daily distance moved.Ethics and dissemination The MIND-PRO trial is funded by the Netherlands Organisation for Health Research and Development (ZonMw, grant number 10510032120004) and approved by the Ethics Committee of Amsterdam UMC (reference: METC 2023.0770). …”
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Work ability following breast cancer – the MyHealth randomized controlled trial by Trine A. Horsbøl, Lena Saltbæk, Caroline Urhammer, Randi V. Karlsen, Christoffer Johansen, Pernille E. Bidstrup, Beverley L. Høeg, Vibeke Zoffmann, Federica Belmonte, Ingelise Andersen, Anne S. Friberg, Mads N. Svendsen, Helle G. Christensen, Vesna Glavicic, Dorte L. Nielsen, Susanne O. Dalton

“…Results: Work ability increased significantly in both groups during the first 6 months (mean WAS increase MyHealth: 1.64, 95% confidence interval [CI]: 1.26; 2.02 and control: 1.57, 95% CI: 1.17; 1.97) and continued to increase slightly but non-significantly (p-values > 0.13) until end of follow-up at 36 months. …”
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Profiling of Indigenous Biosurfactant-Producing Bacillus Isolates in the Bioremediation of Soil Contaminated by Petroleum Products and Olive Oil by Paola Sandra Elenga-Wilson, Christian Aimé Kayath, Nicaise Saturnin Mokemiabeka, Stech Anomene Eckzechel Nzaou, Etienne Nguimbi, Gabriel Ahombo

“…Microbiological and biochemical methods have been used including isolation of oil-degrading bacteria, enzymatic activities, the determination of physicochemical parameters, biosurfactant production and extraction assay, oil displacement assay, antimicrobial assay of the biosurfactants, and bioremediation kinetics. …”
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Nutritional Quality and Starch Gelatinization Characteristics of Main Highland Barley Cultivars from Qinghai and Tibet by Qian WANG, Yanan TONG, Lili WANG, Bin DANG, Kunlun WU, Xijuan YANG, Fengzhong WANG, Liya LIU

“…Xining Chaiqing No.1 with the characteristics of high β-glucan, high AX, high gelatinization temperature, and moderate total phenolic content, may have advantages in the development of functional food with high activity and low glycemic index (GI).…”
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Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease by Yihuai He, Jinlian Jiang, Lili Ou, Yunfen Chen, Aikedaimu Abudukeremu, Guimei Chen, Weiwei Zhong, Zhigang Jiang, Nuerbiye Nuermaimaiti, Yaqun Guan

“…RelA signaling upregulated the expression of activating transcription factor 4 and glucose-regulated protein 78, thereby alleviating ER stress. …”
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Protocol for an intervention development and pilot implementation evaluation study of an e-health solution to improve newborn care quality and survival in two low-resource settings... by Hassan Haghparast-Bidgoli, Michelle Heys, Caroline Crehan, Erin Kesler, Monica Lakhanpaul, Emma Wilson, Fabiana Lorencatto, Felicity Fitzgerald, Mario Cortina Borja, Msandeni Chiume, Hannah Gannon, Simbarashe Chimhuya, Gwendoline Chimhini, Tim Hull-Bailey, Tarisai Chiyaka, Yali Sassoon, Deliwe Nkhoma, Nushrat Khan, Alexander G. Stevenson, Kristina Curtis

“…Results will be disseminated via academic publications and public and policy engagement activities. In this study, the care for an estimated 15 000 babies across three sites will be impacted.Trial registration number NCT0512707; Pre-results…”
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The Effect of Whole-Body Vibration on Upper Extremity Function in Children with Cerebral Palsy: A Pilot Study by Marianna Kelaiditi, Alexandra Lepoura, Anna Christakou, Nikolaos Chrysagis, Vasiliki Sakellari

“…Upper extremity dysfunction, alongside spasticity and coordination challenges, significantly impacts independence in daily activities. Whole-Body Vibration (WBV) has been proposed as a therapeutic modality to improve functionality in neurological populations, though its effects on upper extremity function in children with CP remain relatively unclear. …”
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Bariatric surgery and LDL cholesterol (BASALTO) trial study protocol: randomised controlled study evaluating the effect of gastric bypass versus sleeve gastrectomy on high LDL chol... by David Benaiges, Albert Goday, Juana A Flores-Le Roux, Montserrat Fitó, Oscar Pozo, Jose Rodríguez-Morató, Carme Serra, Manuel Pera, Gemma Llauradó, Elisenda Climent, Olga Castañer, Jose M Ramon, Juan Pedro-Botet

“…The study and its conclusions regarding the primary and secondary objectives will be presented as manuscripts submitted for peer-reviewed journal publication.Trial registration number NCT03975478.…”
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Intravenous liposomal irinotecan in metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy: a phase Ib study by Ying Fan, Qingyuan Zhang, Min Yan, Xiujuan Qu, Yongmei Yin, Tao Sun, Jin Yang, Ying Wang, Xu Wang, Zhaofeng Niu, Xinshuai Wang, Sanyuan Sun, Weihong Zhao, Yanping Liu, Miao Niu, Xuemin Zhao, Binghe Xu

“…Promising antitumor activity in heavily pre-treated patients with mTNBC was observed, which warrants further validation.…”
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Circulating MicroRNAs in Patients with Psoriasis Treated with Anti-IL-23: A Cohort Study by Federico Diotallevi, Giulia Matacchione, Anna Campanati, Elena Marinelli Busilacchi, Nadia Viola, Ilaria Pace, Beatrice Fontana, Roberta Roncarati, Massimiliano Bonafè, Manuela Ferracin, Jacopo Sabbatinelli, Fabiola Olivieri

“…Abstract Introduction Psoriasis is characterized by aberrant keratinocyte activity and immune cell infiltration, driven by immune-mediated pathways. …”
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