Brodalumab: Six-Year US Pharmacovigilance Report by Mark G. Lebwohl, John Y. Koo, April W. Armstrong, Bruce E. Strober, Soo Han Yoon, Nicole N. Rawnsley, Earl L. Goehring, Gina D. Mangin, Abby A. Jacobson

“…Adverse events were defined by Medical Dictionary for Regulatory Activities v26.0 Preferred Terms and standardized MedDRA queries. …”
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Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [99mTc]Tc-labeled counterparts be used to estimate dosimetry? by Panagiotis Kanellopoulos, Quanyi Yu, Abouzayed Abouzayed, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova

“…In GRPR expressing PC-3 cells, both [188Re]Re-labeled peptides displayed high cellular uptake (8.5 ± 0.1% and 5 ± 0.3% of added activity, respectively), heavily GRPR-driven, while retaining the radioantagonistic profile with slow internalization rates. …”
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A New Strain of Preponderant Amphitriploid Carassius Clone Juvenile With Integrated Genomes Partly From White Crucian Carp (C. auratus cuvieri) Requires Low Dietary Protein by Xing Wang, Dong Han, Junyan Jin, Xiaoming Zhu, Haokun Liu, Zhimin Zhang, Yunxia Yang, Shouqi Xie

“…Decreased protein retention efficiency (PRE) and improved activity of liver alanine aminotransferase (ALT) and content of plasma ammonia suggested intensified fish amino acid catabolism in high dietary protein groups. …”
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TLR2 Expression in Relation to IL-6 and IL-1<mml:math alttext="$eta$"> <mml:mi>&#x03B2;</mml:mi> </mml:math> and their Natural Regulators Production by PMN and...

“…For the purpose of comparison, the same activity of autologous peripheral blood mononuclear cells (PBMCs) was estimated. …”
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Accumulation and Transport of Cd, Pb, As, and Cr in Different Maize Varieties in Southwest China by Qi Liu, Sheng Wang, Jijiang Zhou, Li Bao, Wenbing Zhou, Naiming Zhang

“…The accumulation of HMs in maize was primarily derived from human activities such as the extraction, storage, and smelting of non-ferrous metals, while the HMs in soil parent material and weathering products played a secondary role. …”
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Simulation of Flow Around a Finite Rectangular Prism: Influence of Mesh, Model, and Subgrid Length Scale by Xutong Zhang, Maxime Savoie, Mark K. Quinn, Ben Parslew, Alistair Revell

“…Experimental measurements were shown to agree well with reference data for the same geometry, after which particle image velocimetry (PIV) data were gathered to extend the reference dataset. …”
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Climate Change Impact on Cereal Production in Northern Africa: A Comprehensive Modeling and Control Approach by Sabrina De Nardi, Claudio Carnevale, Sara Raccagni, Lucia Sangiorgi

“…The Earth&#x2019;s climate is undergoing unprecedented and rapid changes primarily due to human activities, especially greenhouse gas emissions, leading to a temperature rise of 1.1&#x00B0;C to 1.2&#x00B0;C in the last fifty years. …”
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The Effects of Soft Tissue Flossing on Hamstring Range of Motion and Lower Extremity Power by Zachary Maust, Debbie Bradney, Sean M Collins, Caroline Wesley, Thomas G Bowman

“… # Participants Twenty-one recreationally active individuals (8 male, 13 female; age = 22.62±2.99 years; height = 171.52±9.08 cm; mass = 73.57±11.37 kg)…”
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Midwives’ knowledge and perspectives on neonatal resuscitation and survival before and after Helping Babies Breathe training: a qualitative study in Uganda by Anna Bergstrom, Josaphat Byamugisha, Susanna Myrnerts Höök, Marielle Abrahamsson, Sarah Namusoko

“…A data-driven inductive content analysis approach was used for the analysis.Setting The high-risk labour ward and theatre at a National Referral Hospital, Uganda.Participants 45 clinically active midwives were enrolled; all had recently completed the HBB training programme.Intervention Semistructured individual interviews (n=2) and focus group discussions (n=43, distributed across seven groups) were held from 26 April to 4 May 2018. …”
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Therapeutic Approaches in Mitochondrial Dysfunction, Inflammation, and Autophagy in Uremic Cachexia: Role of Aerobic Exercise by Yumei Zhang, Yuqing Liu, Xiao Bi, Chun Hu, Feng Ding, Wei Ding

“…Furthermore, aerobic exercise significantly decreased MDA levels, increased SOD2 activity and ATP production, and improved mitochondrial configuration, relative to the CKD group. …”
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Network Pharmacology Combined With Metabolomics Reveals the Mechanism of Yangxuerongjin Pill Against Type 2 Diabetic Peripheral Neuropathy in Rats by Jin R, Pei H, Yue F, Zhang X, Zhang Z, Xu Y, Li J

“…Pharmaceutical factory, Beijing, 100079, People’s Republic of China, Tel +86-10-87632655, Email xy706@sina.com; yarily@126.comPurpose: This study aims to explore the mechanism of Yangxuerongjin pill (YXRJP) in the treatment of diabetic peripheral neuropathy (DPN) by network pharmacology and metabolomics technology combined with animal experiments, and to provide scientific basis for the treatment of DPN.Methods: In this study, network pharmacology analysis was applied to identify the active compounds, core targets and signal pathways, which might be responsible for the effect of DPN. …”
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Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation by Md Ruhul Amin, Lakhan Khara, Joshua Szaszkiewicz, Andrew M. Kim, Trevor J. Hamilton, Declan W. Ali

“…Abstract Cannabis is one of the most widely used drugs, and yet an understanding of its impact on the human brain and body is inconclusive. …”
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Economic and Humanistic Burden of Moderate and Severe Hemophilia A and B in Spain: Real-World Evidence Insights from the CHESS II Study by Carmen Peral, Alfonso De Lossada Juste, Nadia Lwoff, Nataly Espinoza-Cámac, Miguel Ángel Casado, Tom Burke, Jose Alvir, Sheena Thakkar, Enrico Ferri Grazzi

“…Severity is classified by the patient's baseline level of clotting factor activity as mild (>5%-40%), moderate (1%-5%), or severe (<1%). …”
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Ecosystem services value for water provisioning in the Shule River Basin of northwestern China: Spatial and temporal evolution and drivers from 2000 to 2022 by Peng Shi, Dongmei Zhou, Jing Jiang, Jing Ma, Xiaoyan Zhu, Jun Zhang, Zihe Li, Qinghan Dong

“…Following the order of decreasing importance, these were land cover, land-use type, topographic surface (represented by the DEM), precipitation, temperature, population density, and economic activity (represented by nighttime lighting). The spatiotemporal evolution of water-provisioning ecosystem services in the Shule River Basin and its driving mechanisms are important for the sustainable development of the local economy. …”
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Enhancing Older Adults’ Lives Through Positive Aging Perception, Quality-of-Life Enhancement, and Social Support to Drive Acceptance and Readiness Toward Indoor Assistive Technolog... by Ka Po Wong, Pei-Lee Teh, Weng Marc Lim, Shaun Wen Huey Lee

“…Indoor mobility is essential for daily activities and significantly impacts their lives. Limited indoor mobility can reduce quality of life and heighten the risk of falls. …”
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Psilocybin-assisted therapy for reducing alcohol intake in patients with alcohol use disorder: protocol for a randomised, double-blinded, placebo-controlled 12-week clinical trial... by Claus Thorn Ekstrøm, Patrick MacDonald Fisher, Gitte Moos Knudsen, Dea Siggaard Stenbæk, Anders Fink-Jensen, Mathias Ebbesen Jensen, Tobias Søgaard Juul

“…The study results will be disseminated by peer-review publications and conference presentations.Trial registration number EudraCT 2020-000829-55 and NCT05416229.…”
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Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of Betatrophin by Hendra Susanto, Ahmad Taufiq, Sugiharto, Desiana Merawati, Khumaira Marsyidah Badu, Jerry Dwi Trijoyo Purnomo, Adeodatus Yuda Handaya

“…In general, the significant contribution of lack of physical activity is strongly correlated with lipid metabolism and metabolic disorder. …”
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The WF1 (White Flower 1) gene controlling the white color of petals and flowering time in lines from a mapping population of flax (Linum usitatissimum L.) by N. B. Brutch, I. I. Matvienko, E. A. Porokhovinova, A. V. Pavlov

“…Thus, different groups  of genes  are active in different light schedules. More than 200 lines of the 6th generation of inbreeding were obtained from the plants of the hybrid population. …”
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Assessing molecular changes underlying isopropylated phenyl phosphate (IPP)-induced larval sensorimotor response deficits in zebrafish by Sunil Sharma, Alfredo Rojas, Abhishek Gour, Rosemaria Serradimigni, Connor Leong, Abhisheak Sharma, Subham Dasgupta

“…Isopropylated phenyl phosphates (IPP) are an additive organophosphate flame retardant (OPFR) that has been extensively used in furniture, electronics, automobiles, plastics, and children’s products to slow down the spread of fire but its continued leaching leads to toxicity concerns. …”
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Non-inferiority study to compare the efficacy of relugolix with dienogest for endometriosis-associated pain and usefulness of administering relugolix prior to dienogest (READY stud... by Fuminori Taniguchi, Motoko Fukui, Yutaka Osuga, Tasuku Harada, Jo Kitawaki

“…Methods A multicenter, open-label, active-controlled, non-inferiority randomized study will be conducted at 11 sites in Japan. …”
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