Enhanced biomechanical and biological performance of titanium scaffolds with gradient in pore sizes by Ara Jung, Jinju Jang, Hun Yeong Ban, Hee Jin Kim, Bomi Gweon, Dohyung Lim

“…Among various methods, powder bed fusion (PBF) stands out for its precision in implant design and fabrication. …”
Get full text

Optimization of Flaxseed Meal Protein Extraction Process and Study of Protein Structure and Functional Properties by Tingting LUO, Jingjing LI, Haiyue HU, Yajun HE, Yuzhuo LI, Lingxuan ZHAO, Lina WANG, Chen YANG, Jianming WANG

“…In addition, the functional properties of FPI were highly dependent on pH, when the pH away from the isoelectric point of FPI (pH4), there was a significant improvement in its functional properties. At pH8, FPI exhibited optimal solubility (99.52%), water-holding capacity (8.87 g/g), emulsifying activity (8.92 m2/g), and emulsion stability (122.58 min). …”
Get full text

Ampelopsin induces MDA-MB-231 cell cycle arrest through cyclin B1-mediated PI3K/AKT/mTOR pathway in vitro and in vivo by Meng Minjun, Yang Qiaolu, Ouyang Zhong, Yang Qingmo, Wu Xinyi, Huang Yufan, Su Yonghui, Chen Shuanglong, Chen Wenlin

“…In addition, treatment with AMP decreased the levels of PI3K, AKT and mTOR, as well as cyclin B1 expression, followed by p53/p21 pathway activation to arrest the cell cycle at G2/M. Moreover, it demonstrated a positive association between cyclin B1 and PI3K/AKT/mTOR levels. …”
Get full text

Psychosocial wellbeing and risk perception of older adults during COVID-19 pandemic in Nigeria: perspectives on the role of social workers by Farah Naz Rahman, Farah Naz Rahman, Anthony Obinna Iwuagwu, Christopher Ndubuisi Ngwu, Michael Ebe Kalu, Amani Kasherwa, Anika Tasnim, Mohamman Rocky Khan Chowdhury, Mamunur Rashid, Manzur Kader

“…BackgroundThe COVID-19 pandemic presented a ‘double-edged sword’ for older adults: not only were they more susceptible to the virus, but its broader consequences also exacerbated other challenges, particularly those related to psychosocial well-being. …”
Get full text

Lower trapezius tendon transfer for massive irreparable rotator cuff tears improves outcomes in patients with high grade fatty infiltration of teres minor by Eva Gusnowski, MD, FRCSC, Eric Wagner, MD, Sheila McRae, PhD, Hayden Cooke, MD, Anthony Karzon, MD, Michael Gottschalk, MD, Peter MacDonald, MD, FRCSC, Jarret Woodmass, MD, FRCSC

“…No group differences were found in preoperative SANE score, forward elevation or active external rotation (ER). Both groups showed significant postoperative improvements in SANE score with no differences between the groups. …”
Get full text

C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Relationship with Ventricular Tachycardia by Aimé Bonny, Nicolas Lellouche, Ivo Ditah, Françoise Hidden-Lucet, Martial T. Yitemben, Benjamin Granger, Fabrice Larrazet, Robert Frank, Guy Fontaine

“…Inflammatory state is an active process in patients with ARVD/C. Moreover, there is a higher level of CRP in patients soon after ventricular tachycardia, and this probably tends to decrease after the event.…”
Get full text

Innovative development, microstructure and hydration characteristics of recycled brick powder-circulating fluidized bed fly ash-based earthwork subgrade backfill by Wenhuan Liu, Kaize Li, Xiaoyu Jiao, Hui Li, Honghong Cao, Yongping Qu

“…It employs CFBFA to synergistically activate RBP for the preparation of solid waste-based earthwork subgrade backfill. …”
Get full text

Acute Stroke in northern Portugal: outcomes and characteristics of patients in a Medical-Surgical Emergency Department by Sandra Domingues, Tiago Barros, João Correia, Arlindo Cruz, Nuno Araújo, Liliana Silva

“…Age >70 years (OR 1.8, 95% CI: 1.3-2.5) and arrival within 3 hours (OR 2.3, 95% CI: 1.7-3.1) predicted reperfusion therapy. …”
Get full text

Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 Expression by André L. F. Sampaio, Jesmond Dalli, Vincenzo Brancaleone, Fulvio D'Acquisto, Mauro Perretti, Carmen Wheatley

“…In resolution, 24 h after LPS, HOCbl completely abrogates a major late mediator of sepsis mortality, high mobility group box 1 (HMGB1) mRNA, inhibits iNOS mRNA, and attenuates LPS-induced hepatic inhibition of eNOS mRNA, whilst showing increased, but still moderate, NOS activity, relative to LPS only. experiments (LPS+D-Galactosamine) HOCbl afforded significant, dose-dependent protection in mice Conclusions. …”
Get full text

Cortico-Muscular Phase Connectivity During an Isometric Knee Extension Task in People With Early Parkinson’s Disease by Nina Omejc, Tomislav Stankovski, Manca Peskar, Milos Kalc, Paolo Manganotti, Klaus Gramann, Saso Dzeroski, Uros Marusic

“…The phase dynamics model additionally revealed stronger directional coupling from the Cz electrode to the active muscle, than in the reverse direction, with less pronounced phase coupling in the PD cohort. …”
Get full text

Renal impairment and in-hospital adverse renal events in critically ill patients assessed by age-adapted estimated glomerular filtration rate criteria by Chong Zhang, Weiru Liang, Meng Ning, Bin Su, Tingting Guo, Kun Hu, Wei Su, Yi Chen, Wenjin Peng, Yingwu Liu

“…In addition, a trend toward an increased risk of MARE was observed in younger patients. Consequently, active monitoring and timely intervention in younger patients are imperative.…”
Get full text

A Randomized Clinical Trial of a Functional Electrical Stimulation Mimic to Gait Promotes Motor Recovery and Brain Remodeling in Acute Stroke by Xiuyuan Zheng, Danfeng Chen, Tiebin Yan, Dongmei Jin, Zhiqiang Zhuang, Zhimei Tan, Wei Wu

“…The mechanism may involve activity-dependent plasticity and brain remodeling. …”
Get full text

Multiomics profiling reveals the benefits of gamma-delta (γδ) T lymphocytes for improving the tumor microenvironment, immunotherapy efficacy and prognosis in cervical cancer by Xiaofeng Wang, Chen Li, Jie Chen, Zhiqiang Wu, Zhen Zhang, Junyi Li, Lu Yu, Yong Guan, Yuhan Zhang, Yuanjie Cao, Yancheng Liu, Hui Bai, Shaochuan Liu, Miaomiao Gao, Chenglu Lu, Zhen Tao, Zhiyong Yuan

“…Second, higher levels of γδ T-cell infiltration also shape the microenvironment of immune activation with cancer-suppressive properties. We found that these intricate features can be observed by MRI-based radiomics models to non-invasively assess γδ T-cell proportions in tumor tissues in patients. …”
Get full text

Tumor-Infiltrating Lymphocytes and Neutrophils and Their Location in Canine Mammary Neoplasms with a Solid Arrangement: A Prognostic Factor? by Mayra C. Flecher, Marina P. Reys, Débora Balabram, Karen Y. R. Nakagaki, Geovanni D. Cassali

“…Neoplasms with a higher density of peritumoral CD3⁺ and CD79⁺ had significantly greater proliferative activity. High infiltration of intratumoral BCD79⁺ lymphocytes was related to nodal metastasis (<i>p</i> = 0.03). …”
Get full text

The simplified GLIM criteria for assessment of malnutrition and its correlation with clinical outcomes in Crohn’s disease patients by Xiaomei Song, Xiaomei Song, Xiaomei Song, Xiaoxin Zhou, Xiaoxin Zhou, Hao Wang, Hong Guo, Jian Yang, Jian Yang

“…The malnourished group had significantly higher Crohn’s Disease Activity Index (CDAI) scores compared to the non-malnourished group (p &lt; 0.001). …”
Get full text

Successful Multimodal Management of an Aggressive Functional Gonadotropic Pituitary Macroadenoma by Jeffrey J. Feng, MS, Sophie M. Cannon, MD, Stephanie K. Cheok, MD, Mark S. Shiroishi, MD, Kyle M. Hurth, MD, PhD, Anna J. Mathew, MD, Gabriel Zada, MD, John D. Carmichael, MD

“…Background/Objective: Although most gonadotroph cell–derived pituitary adenomas (PAs) give rise to nonfunctional PAs, hormonally active functional gonadotroph adenomas (FGAs) are exceedingly rare. …”
Get full text

Combination of ataxia telangiectasia and Rad3-related inhibition with ablative radiotherapy remodels the tumor microenvironment and enhances immunotherapy response in lung cancer by Jenny Ling-Yu Chen, Chun-Kai Pan, Li-Cheng Lin, Yu-Sen Huang, Tsung-Hsuan Huang, Shu-Jyuan Yang, Sung-Hsin Kuo, Yu-Li Lin

“…ATR inhibitor was administered combined with ablative radiotherapy to assess its radiosensitizing effect on lung cancer cells. …”
Get full text

WRF-Chem simulations of snow nitrate and other physicochemical properties in northern China by X. Wang, X. Wang, T. Che, T. Che, X. Ruan, S. Yue, S. Yue, J. Wang, J. Wang, C. Zhao, C. Zhao, C. Zhao, L. Geng, L. Geng, L. Geng

“…The model results show an underestimation especially in regions closes to large cities in northeastern China, most likely due to the underestimation of NO<span class="inline-formula">_<i>x</i></span> emissions in these regions. …”
Get full text

Anti-ceramide antibody and sphingosine-1-phosphate as potential biomarkers of unresectable non-small cell lung cancer by Lilla Bűdi, Dániel Hammer, Rita Varga, Veronika Müller, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Martina Mészáros, András Bikov, András Bikov, Péter Horváth

“…OS was not affected by anti-ceramide antibody or S1P levels.ConclusionHigher levels of S1P and anti-ceramide antibody were associated with active cancer. These results suggest that sphingolipid alterations might be important features of NSCLC.…”
Get full text