Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model by Tu Zhilan, Zhang Zengyu, Jin Pengpeng, Yang Hualan, Li Chao, Xi Yan, Guo Zimin, Hou Shuangxing, Li Weiwei

“…In addition, we confirmed that SAL could activate Notch signal path, and then up-regulate ITGB1 to promote pro-angiogenesis and thus protect BBB from disruption. …”
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Changes in Methylation Patterns of Tumor Suppressor Genes during Extended Human Embryonic Stem Cell Cultures by Kyung Min Kang, Jeoung Eun Lee, Ji Eun Park, Hyunjin Kim, Hee Yeon Jang, Minyeon Go, Dong Ryul Lee, Sung Han Shim

“…While studies on embryonic stem cells have been actively conducted, little is known about the epigenetic mechanisms in human embryonic stem cells (hESCs) in extended culture systems. …”
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Novel MOF-based vanadium and 2,2 -bipyridine-4,4 -dicarboxylic acid as phenomenal dye adsorbent and antimicrobial agent by Baraa Mohammed Yaseen, Farag M. A. Altalbawy, Farag M. A. Altalbawy, Rafid Jihad Albadr, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Hiba Mushtaq, Khursheed Muzammil, Ahmed Hussein Zwamel, Ahmed Hussein Zwamel, Ahmed Hussein Zwamel

“…In the investigation of CR absorption activity, several factors such as concentration of V/BP-MOF, pH, time, and temperature were investigated. …”
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Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis [version 2; peer review: 1 approve... by Spyridon Siafis, Johannes Schneider-Thoma, Alexandra Bannach-Brown, Oliver D. Howes, Virginia Chiocchia, Ulf Tölch, Natascha I. Drude, Sabine M. Hölter, Andrea de Bartolomeis, Anthony C. Vernon, Georgia Salanti, Sridhar Natesan, Stefan Leucht, Irene Bighelli, Sameer Jauhar, Ioannis Mantas, Josef Priller, Francesca Tinsdeall, Wulf-Peter Hansen, Fiona J. Ramage, Nobuyuki Nomura, Malcolm R. Macleod

“…Our primary outcomes include locomotor activity and prepulse inhibition measured with standardized mean differences. …”
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Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target by Chao Xu, Litao Liang, Guoqing Liu, Yanzhi Feng, Bin Xu, Deming Zhu, Wenbo Jia, Jinyi Wang, Wenhu Zhao, Xiangyu Ling, Yongping Zhou, Wenzhou Ding, Lianbao Kong

“…Experimentally, MORF4L1 was demonstrated to enhance cancer stemness by activating the Hedgehog signaling pathway, as supported by both in vitro and in vivo assays. …”
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Use of Digital Health Interventions for Cancer Prevention Among People Living With Disabilities in the United States: A Scoping Review by Chinenye Lynette Ejezie, Lea Sacca, Sylvia Ayieko, Sara Burgoa, Yasmine Zerrouki, Diana Lobaina, Goodness Okwaraji, Christine Markham

“…Interventions focused on education (n = 4), screening (n = 3), smoking cessation (n = 3), physical activity (n = 1), and cessation support (n = 1). Digital health strategies consisted of educational content delivered online, text messaging, interactive educational games, and downloadable informational applications. …”
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Effects of a Newly Developed Therapeutic Deep Heating Device Using High Frequency in Patients with Shoulder Pain and Disability: A Pilot Study by Gi-Wook Kim, Yu Hui Won, Sung-Hee Park, Jeong-Hwan Seo, Dae-hyun Kim, Hyung Nam Lee, Myoung-Hwan Ko

“…HIPER-500® may be a useful modality for treating shoulder pain and improving physical activity in patients with shoulder disease.…”
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Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells by Zhen Yu, Xianfeng Wang, Yusen Hu, Xinfa Wang, Zhenghuan Zhu, Xu Xu, Yiming Wang, Ailiang Zhang

“…In this research, we examined the change effect of quercetin on NP cell apoptosis, ER stress, and the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation element 2α (eIF2α)-activating transcription element 4 (ATF4). Results: High glucose decreased the viability and induced ER stress-related apoptosis in NP cells. …”
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Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats by Gisela Belén Sarrible, María Victoria Bazzano, Caterina Koutsovitis, María Guillermina Bilbao, Rodrigo Hernán Da Cuña, Melanie Neira, Julián Alberto Bartolomé, Evelin Mariel Elia

“…Coenzyme Q10 (CoQ10), known for enhancing reproductive outcomes in various pathologies, is not fully understood for its effects on obesity treatment. Here, obesity was modeled using CAF-fed rats to assess CoQ10's impact on metabolic and ovarian disruptions caused by obesity. …”
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Influence of luteolin on the apoptosis of esophageal cancer Eca109 cells and its mechanism of action by Shaokang Wang, Lingmeng Fu, Yi Wu, Hongmei Xiao, Jing Wang, Guiju Sun

“…The specific mechanism has not yet been clarified and the other activation pathways inducing apoptosis need to be further studied. …”
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Efficacy and Safety of Rivaroxaban versus Warfarin for the Treatment of Acute Pulmonary Embolism: A Real-World Study by Yan Huang, Linli Duan, Wenjun He, Cheng Hong, Yehui Guo, Xinni Wang, Nuofu Zhang, Yanghang Chen, Tao Wang, Jian Wang, Chunli Liu

“…There was no significant difference in thrombus absorption between rivaroxaban and standard therapy after 3-month treatment (P=0.798, 95% confidence interval (CI) 0.686 to 1.336) or more than 6-month treatment (P=0.534, 95% confidence interval (CI) 0.795 to 1.556). …”
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Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway by Qiaoli Chen MS, Quanxiang Hao MBBS, Yanping Yang MBBS, Limei Li PhD, Danping Li MS, Ran Zhao MS, Wanqi Wei MBBS, Lixian Deng MBBS, Jiaming Su MBBS, Ziyuan Liang MBBS, Shiyue Tang MS, Yaomin Lu MBBS, Yushan Liang PhD, Zhe Zhang PhD, Xiaoying Zhou PhD, Xue Xiao PhD, Ping Li PhD, Yi Huang PhD, Weilin Zhao PhD

“…Background Carboxylesterase 4A (CES4A) belongs to the member of the carboxylesterase family, yet there has been limited research into its malignant biological behavior in malignant tumors. …”
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Dynamic simulation of landscape ecological risk in Gansu’s farming-pastoral ecotone based on topographic gradients by Le Yang, Jixuan Yan, Guang Li, Weiwei Ma, Tao Li, Pengcheng Gao, Qiang Li, Xiangdong Yao, Jie Li, Wenning Wang

“…The area of high-risk zones has steadily decreased by approximately 50% since 2010, primarily in regions with low topographic gradients and high human activity. In other areas, high-risk levels are directly proportional to the topographic gradient, showing a high degree of spatial clustering. …”
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Transition from pediatric to adult health services: A survey of challenges, needs, and preferences of youths and parents by Eric Racine, François Ouimet, Rocio Gissel Gutierrez Rojas, Marie-José Clermont, Anne Fournier

“…Youths and adults want to be involved and informed to prepare actively for transition through meetings or adapted materials.…”
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Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes by Bo Hu, Ying Yu, Xin-Wen Yu, Min-Hua Ni, Yan-Yan Cui, Xin-Yu Cao, Ai-Li Yang, Yu-Xin Jin, Sheng-Ru Liang, Si-Ning Li, Pan Dai, Ke Wu, Lin-Feng Yan, Bin Gao, Guang-Bin Cui

“…In the progression of T2D, functional interaction between brain regions showed abnormalities first, followed by memory tests, the cerebral spontaneous neural activity, and finally the gray matter volume. Besides, abnormalities appeared earlier in the entorhinal cortex than in the anterior cingulate cortex. …”
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Groundwater vulnerability and, risk assessment of seawater intrusion for the development of a strategy plan towards sustainability: Case of the Souss-Massa coastal area, Morocco by Yassine Ez-zaouy, Lhoussaine Bouchaou, Mohammed Hssaisoune, Abdelhaq Aangri, Gianluigi Busico, Saadou Oumarou Danni, Oumaima Attar, Mohamed Nehmadou, Aicha Saad, Yassine Ait Brahim

“…Study focus: The Souss-Massa coastal area (SMCA) is known for tourism, fishing, and agriculture activities, which require intensive pumping of groundwater. …”
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Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses by Tiqian Liu, Tiqian Liu, Adrian Ujin Yap, Adrian Ujin Yap, Adrian Ujin Yap, Yanyu Sun, Yanyu Sun, Yunhao Zheng, Yunhao Zheng, Tianqi Wang, Tianqi Wang, Shiya Zeng, Shiya Zeng, Zhen Liu, Xin Xiong, Xin Xiong

“…Exploratory factor analysis, along with confirmatory factor analysis, was applied to waking-state oral behaviors, revealing two key factors: Chinese non-functional (C-NFA) and functional (C-FA) oral activities. Items were contrasted with those of Italian TMDs patients (I-NFA and I-FA), and subscale scores were computed, compared, and correlated using Kruskal Wallis and Post-hoc and Spearman’s rank-order correlation (α = 0.05).ResultsVariations in NFA and FA items were observed between Chinese and Italian TMDs patients. …”
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The Associations Between Temperament and Self-Oriented, Other-Oriented, and Dual-Harmful Behaviors in Emerging Adults by Serafine Dierickx, Dirk Smits, Glenn Kiekens, Laurence Claes

“…Results highlight a hyper-reactive Behavioral inhibitions system (BIS) and a hypo-reactive Behavioral activation system (BAS)-Impulsivity in individuals who engage in NSSI-only, compared to no-harm and aggression-only. …”
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The focal mechanism and field investigations of mining-induced earthquake by super-thick and weak cementation overburden strata fracturing by Xianxi Bai, Anye Cao, Changbin Wang, Yaoqi Liu, Chengchun Xue, Xu Yang, Yao Yang, Songwei Wang, Qi Hao

“…Abstract Mining-induced earthquake (MIE) is a non-natural earthquake induced by mining activities. In Ordos mining area, super-thick and weak cementation overburden strata (STWCS) are common occurrence in Jurassic coal seam overlying strata. …”
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Genome-Wide Association Study on Imputed Genotypes of 180 Eurasian Soybean <i>Glycine max</i> Varieties for Oil and Protein Contents in Seeds by Nadezhda A. Potapova, Irina V. Zorkoltseva, Alexander S. Zlobin, Andrey B. Shcherban, Anna V. Fedyaeva, Elena A. Salina, Gulnara R. Svishcheva, Tatiana I. Aksenovich, Yakov A. Tsepilov

“…Soybean (<i>Glycine max</i>) is a leguminous plant with a broad range of applications, particularly in agriculture and food production, where its seed composition—especially oil and protein content—is highly valued. …”
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