Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors by Maryam Anjomshoa, Shakiba Nasiri Boroujeni, Sorayya Ghasemi, Zahra Lorigooini, Ahmad Amiri, Shima Balali-dehkordi, Hossein Amini-khoei

“…Rutin is a flavonol with neuroprotective activity. The aim of the present study is to investigate the role of the glutamatergic system in the antidepressant-like effect of rutin in a mouse model of maternal separation (MS) stress focusing on histological changes in the CA3 area of the hippocampus. …”
Get full text

Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring by Amrita Kaimal, Jessica M. Hooversmith, Maryam H. Al Mansi, Ariana D. Cherry, Jillian T. Garrity, Philip V. Holmes, Puliyur S. MohanKumar, Puliyur S. MohanKumar, Sheba M. J. MohanKumar, Sheba M. J. MohanKumar

“…Following a 90-day treatment period, behavioral testing was conducted, and serum hormones and brain monoamine levels were analyzed.ResultsChronic E2 treatment in controls increased anxiety and reduced active coping behaviors. In DEHP- and BPA+DEHP-exposed offspring, E2 treatment reversed some of these effects. …”
Get full text

Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis by Likai Yu, Di Tian, Zishan Su, Li Zhang, Shaobo Guo, Wenhui Zhu, Yuan Fang, Peimin Wang, Nongshan Zhang

“…Gallic acid (GA) is a polyphenolic extract that has anti-inflammatory and antioxidant biological activities. However, its function and mechanism in skeletal muscle injury remain unclear. …”
Get full text

Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma by Dandan Gao, Yang Lv, Fei Hong, Dong Wu, Ting Wang, Gongzhizi Gao, Zujie Lin, Ruoyu Yang, Jinsong Hu, Aili He, Pengyu Zhang

“…Mechanically, PRDX6 serves as an anti-oxidative enzyme, and its deficiency led to over-accumulation of reactive oxygen species (ROS), resulting in oxidative stress, following the activation of MAPK signaling pathway, which manifested as phosphorylation of JNK and p38. …”
Get full text

Relationship between Obesity and Cognitive Function in Young Women: The Food, Mood and Mind Study by Rebecca L. Cook, Nicholas J. O’Dwyer, Cheyne E. Donges, Helen M. Parker, Hoi Lun Cheng, Katharine S. Steinbeck, Eka P. Cox, Janet L. Franklin, Manohar L. Garg, Kieron B. Rooney, Helen T. O’Connor

“…Cognition scores were within normal range (±1 z-score), but OB had lower attention (NW: 0.31 ± 1.38; OB: −0.25 ± 1.39; ES: 0.41, CI: 0.17–0.64; p<0.001) and higher impulsivity (NW: 0.36 ± 1.14; OB: −0.07 ± 1.07; ES: 0.39, CI: 0.15–0.62; p=0.033). …”
Get full text

Polydomus karssenii gen. nov. sp. nov. is a dark septate endophyte with a bifunctional lifestyle parasitising eggs of plant parasitic cyst nematodes (Heterodera spp.) by Samad Ashrafi, Jan-Peer Wennrich, Yvonne Becker, Jose G. Maciá-Vicente, Anke Brißke-Rode, Matthias Daub, Torsten Thünen, Abdelfattah A. Dababat, Maria R. Finckh, Marc Stadler, Wolfgang Maier

“…The pathogenicity tests against nematode eggs fulfilled Koch’s postulates using in vitro nematode bioassays and showed that the fungus could parasitise its original nematode host H. filipjevi as well as the sugar beet cyst nematode H. schachtii, and colonise cysts and eggs of its hosts by forming highly melanised moniliform hyphae. …”
Get full text

Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients’ Assessment by Radu-Stefan Miftode, Ionela-Lăcrămioara Şerban, Amalia-Stefana Timpau, Ionela-Larisa Miftode, Adriana Ion, Ana-Maria Buburuz, Alexandru-Dan Costache, Irina-Iuliana Costache

“…Many studies highlighted its role in the development of cardiac fibrosis or atherogenesis, being significantly correlated with the activity of angiotensin II. …”
Get full text

SVR model and OLCI images reveal a declining trend in phycocyanin levels in typical lakes across Northeast China by Changchun Song, Yipei Xu, Chong Fang, Chi Zhang, Zhuohang Xin, Zhihong Liu

“…Recently, the frequency of cyanobacterial blooms in lakes across Northeast China has noticeably increased, because of the combined effect of global climate change and human activities. Phycocyanin (PC), a distinctive pigment found in cyanobacteria, plays a pivotal role in detecting and predicting harmful cyanobacterial blooms. …”
Get full text

BINGO! Elevating Medical Physiology Tutorials Through Gamification by Kelsey Temprine Grellinger, Hong Phan, Maria Sheakley, Gerrit J. Bouma, Alexandra Bayer, Biren A. Shah

“…Introduction We introduced a BINGO game as an active learning strategy for pulmonary, renal, and endocrine physiology, aiming to enhance student engagement and application of physiology knowledge. …”
Get full text

Staphylococcus aureus susceptibilities from wounds of patients who use illicit fentanyl by Drew T. Dickinson, Stephen Saw, Lauren Dutcher, Christina Maguire, Adrienne Terico, Margaret Lowenstein, Sonal Patel

“…PWUF would benefit from joint management by infectious diseases and addiction medicine experts to ensure prescription of active therapy. Additional study is needed of PWUF in other regions. …”
Get full text

Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids by Annabell Reinhold, Annegret Glasow, Sandra Nürnberger, Annett Weimann, Lucie Telemann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz

“…Results: PDT and/or IR resulted in concentration-dependent reduction of metabolic activity, organoid diameter and integrity. Higher cytotoxicity of IR+PDT vs. monotherapies was observed after 72 h. …”
Get full text

The control effect and induced disease resistance mechanism of Bacillus tequilensis on wheat powdery mildew by Qiuyan Bi, Fen Lu, Jie Wu, Xiangyu Liu, Xiuying Han, Jianjiang Zhao

“…The relative enzymic activities induced by B. tequilensis presented maximum differences between 2.63-fold and 3.43-fold. …”
Get full text

Lateralization study of the basal ganglia, thalamus and supplying arteries in healthy individuals based on structure and connectivity analysis using 7.0T MRI by Hongqin Liang, Yawei Gu, Xiaoqi Yi, Li Kong, Jian Wang, Fajin Lv

“…The human cerebral cortex is known for its hemispheric specialization, which underpins a variety of functions and activities. …”
Get full text

Smoking Cessation in Chinese Patients Undergoing Thoracic Surgery: A Multicenter Prospective Observational Study by Jianxing He, Dingpei Han, Kun Qian, Weijie Guan, Ge Zhang, Weiqing Lu, Hecheng Li, Xiuyi Zhi

“…Conclusions In patients undergoing lung surgery with a low risk of PCs, active smoking does not significantly increase the risk of PCs or PPCs relative to quitters, suggesting that there is likely no need to postpone lung surgery for those who have not yet quit smoking. …”
Get full text

High-time-cadence Spectroscopy and Photometry of Stellar Flares on M dwarf YZ Canis Minoris with the Seimei Telescope and TESS. I. Discovery of Rapid and Short-duration Prominence... by Yuto Kajikiya, Kosuke Namekata, Yuta Notsu, Hiroyuki Maehara, Bunei Sato, Daisaku Nogami

“…We conducted spectroscopic monitoring observations of the active M dwarf YZ Canis Minoris with an ∼1 minute time cadence using the Seimei telescope, simultaneously with the optical photometric observations by Transiting Exoplanet Survey Satellite. …”
Get full text

Biocontrol efficacy of Bacillus licheniformis and Bacillus amyloliquefaciens against rice pathogens by Mohsin Tariq, Mehvish Zahoor, Tahira Yasmeen, Tahir Naqqash, Muhammad Abdul Rehman Rashid, Muhammad Abdullah, Abdul Rafay Rafiq, Marriam Zafar, Iqra Irfan, Ijaz Rasul

“…This study was conducted to assess the plant growth-promoting potential and biocontrol activity of root-associated bacteria against the rice pathogens, Xoo and Bo. …”
Get full text

HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) by Aijaz Zeeshan Khan, Omer Sabir, Adnan Hussain Shahid, Muhammad Bilal Basit, Syeda Arzinda Fatima Shah, Qamar Sajad

“… Background: Dengue Fever, also known as break-bone fever, is a viral illness and transmitted to humans by bites of infected Aedes aegypti and Aedes albopictus mosquitoes. …”
Get full text

Clinicopathological and predictive value of MAIT cells in non-small cell lung cancer for immunotherapy by Dongyan Shi, Lin Lin, Yun Chen, Jian Liu, Lin Shi, Jinying Lu, Da Zhong, Meijuan Song, Wenhua You, Wen-Hui Li

“…Little is known about the immune characteristics of MAIT cells in NSCLC and correlation with prognosis and response rate of ICIs treatment.Methods To investigate the distribution, activation status, and function of MAIT cells in NSCLC patients and their correlations with anti-PD-1 immunotherapy, MAIT cells in peripheral blood, tumor and paratumor samples from NSCLC patients with or without anti-PD-1 immunotherapy were analyzed using flow cytometry and single-cell RNA-sequencing.Results MAIT cells were enriched in the tumor lesions of NSCLC patients migrating from peripheral blood via the CCR6-CCL20 axis. …”
Get full text

Impact of the COVID-19 Pandemic on Acute Ischemic Stroke Presentation, Treatment, and Outcomes by Timothy G. White, Gabriela Martinez, Jason Wang, Michele Gribko, Artem Boltyenkov, Rohan Arora, Jeffrey M. Katz, Henry H. Woo, Pina C. Sanelli

“…While a clear impact of COVID-19 on the declining stroke volume has been reported, its overall impact on stroke presentation and clinical outcomes has not been established. …”
Get full text

Characterization of rhizosphere bacterial communities in oilseed rape cultivars with different susceptibility to Plasmodiophora brassicae infection by Yue Deng, Yue Deng, Wenxian Wu, Xiaoqing Huang, Xiaoqing Huang, Xiaoxiang Yang, Xiaoxiang Yang, Yaoyin Yu, Yaoyin Yu, Zhongmei Zhang, Zhongmei Zhang, Zijin Hu, Xiquan Zhou, Kang Zhou, Kang Zhou, Yong Liu, Yong Liu, Lei Zhang, Lei Zhang

“…However, few studies have examined the activities of rhizosphere microbiomes in plants with different susceptibilities to soil-borne pathogens, especially those that cause clubroot disease. …”
Get full text