Design and Mechanism Study of 6c, a Novel Artesunate Derivatives, for Anti-Hepatocellular Carcinoma by Xiong SS

“…Among the hybrid hits with anticancer activity, a representative 6c compound increased the reactive oxygen species (ROS) level in hepatocellular carcinoma cells and activated mitochondrial apoptosis and ferroptosis, leading to cell cycle arrest at G2/M phase. …”
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Astaxanthin Inhibits Interleukin-6 Expression in Cerulein/Resistin-Stimulated Pancreatic Acinar Cells by Min Seung Kwak, Joo Weon Lim, Hyeyoung Kim

“…We found that resistin enhanced intracellular Ca2+ levels, NADPH oxidase activity, intracellular reactive oxygen species (ROS) production, NF-κB activity, and IL-6 expression in cerulein-stimulated AR42J cells, which were inhibited by ASX in a dose-dependent manner. …”
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Induction of translation-suppressive G3BP1+ stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA by Vladimir Majerciak, Zhi-Ming Zheng

“…Here, we found that plasmid DNA transfection mediated by liposomes activates multiple innate immune responses in several widely used cell lines. …”
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Comparison of treatment of severe rheumatoid arthritis patients with biological agents and JAK-STAT inhibitors. An extension study by Małgorzata Wisłowska

“…Remission or low disease activity, switching between drugs and adverse events were assessed and compared between studied groups. …”
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Phytoremediation of Oil-Contaminated Soil by <i>Tagetes erecta</i> L. Combined with Biochar and Microbial Agent by Xin Fang, Pufan Zheng, Haomin Wang, Kefan Wang, Cong Shi, Fuchen Shi

“…Compared with the treatments with biochar, the chlorophyll fluorescence parameter NPQ_Lss and plant antioxidant enzyme activities significantly decreased in the treatments applied with the microbial agent, while soil enzyme activities, especially oxidoreductase activities, significantly increased. …”
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Characterization of Streptomyces Isolates Associated with Estuarine Fish Chanos chanos and Profiling of Their Antibacterial Metabolites-Crude-Extract by Muhammad A. Kurnianto, Harsi D. Kusumaningrum, Hanifah N. Lioe

“…Further characterization of the active compound was needed to find out which compounds were responsible for the antibacterial activity. …”
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Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration by Daxue Zhu, Zhaoheng Wang, Shijie Chen, Yanhu Li, Xuewen Kang

“…Results Deletion of POSTN significantly alleviated IDD by suppressing NLRP3 inflammasome activity and pyroptosis in NP cells. POSTN was found to aggravate NP cell pyroptosis by activating the NLRP3 inflammasome through the NF-κB (P65) and cGAS/STING signaling pathways. …”
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CYCLICAL DYNAMICS OF THE «EXTERNAL» AND «INTERNAL» ENVIRONMENTS OF BUSINESS-ORGANIZATIONS IN GR-MANAGEMENT by A. A. Degtyarev, М. D. Bondarev, A. S. Teteryuk

“…The complexity of those activities for business organizations proceeds from its specific location at the intersection of two environments (sectors): internal (in-house) and external (political and public) ones. …”
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Methods Used in Urban Search and Rescue in Disasters and Evaluation of Current Approaches by Gürkan Yılmaz, Sevda Demiröz Yıldırım

“…The initiation of urban search and rescue activities in the first hours of the disaster increases the rate of live removal of the stranded. …”
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GC–MS analysis and in silico approaches to Stichopus hermanii as anti-inflammatory through PKC-β inhibition by Kurnia Fatwati, Asmawati Amin, Lenni Indriani, Rusdina Bte Ladju, Fuad Husain Akbar, Nurlindah Hamrun

“…Inhibition of the PKC-β pathway has shown to reducing NF-κB activity. In silico studies using molecular docking techniques used to determine the potentialof Stichopus hermanii as an anti-inflammatory agent are based on PKC-β interactions.The extract was identified via GC–MS to determine the active compound of Stichopus hermanii. …”
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Exosomes and microRNAs as mediators of the exercise by Haoyuan Li, Guifang Liu, Bing Wang, Mohammad Reza Momeni

“…This article presents an overview of the present knowledge on the principal miRNAs influenced by physical activity in different tissues and bodily fluids. Numerous research projects have emphasized the significant impact of miRNAs on controlling biological changes brought about by physical activity. …”
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Ex Situ Conservation, DNA Barcoding and Enzymatic Potential Evaluation of Macrofungi (Basidiomycota, Ascomycota) from Vietnam by Nadezhda V. Psurtseva, Anna A. Kiyashko, Svetlana V. Senik, Thi Ha Giang Pham

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Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia In Vitro by Ivan Mikhailovich Rashchupkin, Ekaterina Yakovlevna Shevela, Aleksandra Aleksandrovna Maksimova, Marina Aleksandrovna Tikhonova, Aleksandr Anatolevich Ostanin, Elena Removna Chernykh

“…The aim of this study was to compare the neuroregenerative and neuroprotective activity of soluble factors secreted by variously activated human macrophages on the functions of neural progenitors in an in vitro model of ischemia or ischemia/hypoxia. …”
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Antibacterial Potential of Crude Extracts from <i>Cylindrospermum alatosporum</i> NR125682 and <i>Loriellopsis cavernicola</i> NR117881 by Albert Olufemi Ikhane, Foluso Oluwagbemiga Osunsanmi, Rebamang Anthony Mosa, Andrew Rowland Opoku

“…All the crude extracts inhibited efflux pump activity against the bacteria tested. However, the extracts poorly inhibited β-lactamase. …”
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The Phenolic Content of Pistacia lentiscus Leaf Extract and Its Antioxidant and Antidiabetic Properties by Hamza Bouakline, Saliha Bouknana, Mohammed Merzouki, Imane Ziani, Allal Challioui, Mohamed Bnouham, Abdesselam Tahani, Ali EL Bachiri

“…In order to explain the antidiabetic activity, molecular docking has been performed on the main constituents of the leaf extract. …”
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Binding Mode Investigation of Polyphenols from Scrophularia Targeting Human Aldose Reductase Using Molecular Docking and Molecular Dynamics Simulations by Abinaya Manivannan, Prabhakaran Soundararajan, Yoo Gyeong Park, Sugunadevi Sakkiah, Byoung Ryong Jeong

“…Among the compounds investigated, acacetin, a methoxy flavonoid, displayed the stable binding to the active site of ALR2 with least binding energy value. …”
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Syntheses, Characterization, and Antimicrobial Screening of N-(benzothiazol-2-yl)benzenesulphonamide and its Cu(I), Ni(II), Mn(II), Co(II), and Zn(II) Complexes by N. L. Obasi, Okoye C. O. Benedict, P. O. Ukoha, A. O. Anaga

“…However, they were less active than the standard drugs used except Fluconazole which did not show any activity against Candida krusei (ATCC 6258) but most of the compounds synthesized were very active against it. …”
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An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish by Samantha Carrothers, Rafael Trevisan, Nishad Jayasundara, Nicole Pelletier, Emma Weeks, Joel N. Meyer, Richard Di Giulio, Caren Weinhouse

“…Since CYP1A metabolically activates PAH, this memory protects these fish from PAH-mediated cancer. …”
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Noncanonical effects of vasopressin in angiogenesis by I. I. Khegay

“…Activated endotheliocytes secrete von Willebrand factor and P-selectin. …”
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A scoping review to map the concept, content, and outcome of wilderness programs for childhood cancer survivors. by Mats Jong, E Anne Lown, Winnie Schats, Michelle L Mills, Heather R Otto, Leiv E Gabrielsen, Miek C Jong

“…The majority of programs (73%) employed adventure therapy. Five activity categories were identified as components of wilderness programs: challenge/risk, free time/leisure, experiential learning, physical activity and psychotherapeutic activities. …”
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