Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease by Yi Zhang, Yi Zhang, Guangyang Ou, Lei Peng, Jian Pan, Shaohua Zhang, Jianguo Shi

“…This Mendelian randomization (MR) study aims to elucidate the potential effects of lipid-lowering drug targets on CKD development.MethodsWe extracted 11 genetic variants encoding targets of lipid-lowering drugs from published genome-wide association study (GWAS) summary statistics, encompassing LDLR, HMGCR, PCSK9, NPC1L1, APOB, ABCG5/ABCG8, LPL, APOC3, ANGPTL3, and PPARA. …”
Get full text