Mixed methods evaluation of the Getting it Right First Time programme in elective orthopaedic surgery in England: an analysis from the National Joint Registry and Hospital Episode... by Stephen Morris, James Mason, Rosalind Raine, Peter Martin, Naomi J Fulop, Elena Pizzo, Andrew Hutchings, Helen Barratt, Jean Ledger, Raj Mehta, Sarah Jasim, Fiona Aspinal, Rafael Gafoor

“…Objective To evaluate the impact of the ‘Getting it Right First Time’ (GIRFT) national improvement programme in orthopaedics, which started in 2012.Design Mixed-methods study comprising statistical analysis of linked national datasets (National Joint Registry; Hospital Episode Statistics; Patient-Reported Outcomes); economic analysis and qualitative case studies in six National Health Service (NHS) Trusts.Setting NHS elective orthopaedic surgery in England.Participants 736 088 patients who underwent primary hip or knee replacement at 126 NHS Trusts between 1 April 2009 and 31 March 2018, plus 50 NHS staff.Intervention Improvement bundle including ‘deep dive’ visits by senior clinician to NHS Trusts, informed by bespoke set of routine performance data, to discuss how improvements could be made locally.Main outcome measures Number of procedures conducted by low volume surgeons; use of uncemented hip implants in patients >65; arthroscopy in year prior to knee replacement; hospital length of stay; emergency readmissions within 30 days; revision surgery within 1 year; health-related quality of life and functional status.Results National trends demonstrated substantial improvements beginning prior to GIRFT. …”
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TINGKAT KEBISINGAN PADA PERUMAHAN BARU DI DALAM KAMPUNG MANGKUKUSUMAN, KOTA YOGYAKARTA by Tabita Febriawaty Kartika Putri, Eddy Prianto

“…Kebisingan pada area perumahan baru tersebut bisa melebihi batas nyaman yang ditentukan karena sumber bunyi yang berbeda-beda. Kata kunci : Kebisingan; Rumah Tinggal; Sumber Kebisingan.   …”
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Quantifying the spatial patterns of retinal ganglion cell loss and progression in optic neuropathy by applying a deep learning variational autoencoder approach to optical coherence... by Jui-Kai Wang, Jui-Kai Wang, Brett A. Johnson, Zhi Chen, Zhi Chen, Honghai Zhang, Honghai Zhang, David Szanto, Brian Woods, Brian Woods, Michael Wall, Young H. Kwon, Young H. Kwon, Edward F. Linton, Edward F. Linton, Andrew Pouw, Mark J. Kupersmith, Mark J. Kupersmith, Mark J. Kupersmith, Mona K. Garvin, Mona K. Garvin, Mona K. Garvin, Mona K. Garvin, Randy H. Kardon, Randy H. Kardon

“…We propose a booster Variational Autoencoder (bVAE) to capture spatial variations in RGC loss and generate latent space (LS) montage maps that visualize different degrees and spatial patterns of optic nerve bundle injury. Furthermore, the bVAE model is capable of tracking the spatial pattern of RGC thinning over time and classifying the underlying cause.MethodsThe bVAE model consists of an encoder, a display decoder, and a booster decoder. …”
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Implementation of Uterine Artery Doppler Scanning: Improving the Care of Women and Babies High Risk for Fetal Growth Restriction by Emmanuel Ekanem, Faris Karouni, Emmanuoil Katsanevakis, Habiba Kapaya

“…The second version of Saving Babies’ Lives Care Bundle (SBLCBv2) recommends the second trimester uterine artery Doppler (UtAD) pulsatility index (PI) screening for pregnancies at high risk of FGR. …”
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Variabilidade espacial dos parâmetros da equação de van Genuchten em um Latossolo Vermelho-Amarelo by Jaedson Cláudio Anunciato Mota, Paulo Leonel Libardi, Alexsandro Santos Brito, Sergio Oliveira Moraes, Ícaro Vasconcelos Nascimento, Thiago Leite Alencar

“…A curva foi construída considerando as tensões 1, 2, 3, 4, 5, 6, 7, 8, 9 e 10 kPa (no funil de Haines) e 30, 50, 70 e 100 kPa (no extrator de placa porosa de Richards). …”
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Susceptibility to Ventricular Arrhythmias Resulting from Mutations in FKBP1B, PXDNL, and SCN9A Evaluated in hiPSC Cardiomyocytes by Hector Barajas-Martinez, Maya Smith, Dan Hu, Robert J. Goodrow, Colleen Puleo, Can Hasdemir, Charles Antzelevitch, Ryan Pfeiffer, Jacqueline A. Treat, Jonathan M. Cordeiro

“…The proband displayed right bundle branch block and exhibited episodes of syncope. …”
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Long-Term Evaluation of Capsulotomy Shape and Posterior Capsule Opacification after Low-Energy Bimanual Femtosecond Laser-Assisted Cataract Surgery by Tommaso Verdina, Chiara Peppoloni, Lucrezia Barbieri, Maria Rosaria Carbotti, Bruno Battaglia, Rodolfo Mastropasqua, Gian Maria Cavallini

“…Another 91 eyes, which underwent standard bimanual microincision cataract surgery (B-MICS), served as a control group. In all cases, a BunnyLens AF (Hanita Lenses, Israel) intraocular lens was implanted in the bag. …”
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Study protocol: type II hybrid effectiveness-implementation study of routine functional status screening in VA primary care by Francesca M. Nicosia, Kara Zamora, LauraEllen Ashcraft, Gregory Krautner, Marybeth Groot, Bruce Kinosian, Cathy C. Schubert, Sumedha Chhatre, Helene Moriarty, Orna Intrator, Andrea Wershof Schwartz, Ariela R. Orkaby, Jason Prigge, Rebecca T. Brown

“…During an Implementation phase, we will launch a standard bundle of implementation strategies (coalition building, champions, technical assistance) and system-level audit and feedback, identify sites with low uptake, and randomize those sites to receive continued standard vs. enhanced strategies (standard strategies plus clinician-level audit and feedback). …”
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Potential of right ventricular function assessment with echocardiography in transcatheter aortic valve replacement: by Yoshihisa Morita, Taro Kariya, Michael Dougherty, Andrew Peters, Nicholas Ruggiero

“…The secondary goal is to assess the correlation of RV free wall longitudinal strain (FWLS) with any newly diagnosed postoperative ventricular arrhythmia, including complete atrioventricular block (CAVB) and left bundle branch block (LBBB). Results Among 33 patients who underwent TAVR, 4 patients were excluded due to poor image quality, and 7 patients were excluded due to existing pacemaker. …”
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Supporting implementation of universal prevention initiatives in K-12 schools: impacts on fidelity through organizational readiness and team functioning in a cluster-randomized tri... by Christopher M. Fleming, Hannah G. Calvert, Lindsey Turner

“…Abstract Background Rural School Support Strategies (RS3) is a bundle of implementation supports (including training, technical assistance, and a virtual learning collaborative) designed for the scale-up of universal prevention initiatives. …”
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Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescentsResearch in context by Qiong Wu, Bingyu Zhang, Jiayi Tong, L. Charles Bailey, H. Timothy Bunnell, Jiajie Chen, Elizabeth A. Chrischilles, Dimitri A. Christakis, Stephen M. Downs, Kathryn Hirabayashi, Aaron D. Mishkin, Abu S.M. Mosa, Nathan M. Pajor, Suchitra Rao, Hanieh Razzaghi, Hayden T. Schwenk, Marion R. Sills, Huiyuan Wang, Linbo Wang, Yudong Wang, Dazheng Zhang, Ting Zhou, Ravi Jhaveri, Eric J. Tchetgen Tchetgen, Jeffrey S. Morris, Christopher B. Forrest, Yong Chen

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Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes by Peter Vo, Denise M. Imai-Leonard, Benjamin Yang, Andrew Briere, Andy Shao, M. Isabel Casanova, David Adams, Takanori Amano, Oana Amarie, Zorana Berberovic, Lynette Bower, Robert Braun, Steve Brown, Samantha Burrill, Soo Young Cho, Sharon Clementson-Mobbs, Abigail D’Souza, Mary Dickinson, Mohammad Eskandarian, Ann M. Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Jason Heaney, Yann Hérault, Martin Hrabe de Angelis, Chih-Wei Hsu, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Hamid Meziane, Steve Murray, Ki-Hoan Nam, Hyuna Noh, Lauryl M. J. Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jennifer Ryan, Jason Salazar, Zachery Seavey, John Richard Seavitt, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Michelle Stewart, Karen Svenson, Masaru Tamura, Heather Tolentino, Uchechukwu Udensi, Sara Wells, Jacqueline White, Amelia Willett, Janine Wotton, Wolfgang Wurst, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Louise Lanoue, K. C. Kent Lloyd, Brian C. Leonard, Michel J. Roux, Colin McKerlie, Ala Moshiri

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Improving antibiotic utilization in West Africa: enhancing interventions through systematic review and evidence synthesis by Eric S. Donkor, Abdul-Halim Osman, Bill Clinton Aglomasa, Aaron Awere-Duodu, Alex Odoom, Bismark Opoku-Asare, Gilbert Lazarus

“…AMS was effective to varying degrees with bundled interventions and gamified antimicrobial stewardship decision support application being the most effective. …”
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Intranasal Testing and Treatment for Staphylococcus aureus With Intravenous Vancomycin and Intranasal Povidone-iodine Prior to Posterior Spinal Fusion: A Retrospective Cohort Study... by Jason Malone, DO, Alex Lee-Norris, DO, Austin Wynn, MD, Kaitlin Maher, PA-C, John Lovejoy, III, MD, Ryan Illgenfritz, MD, Margaret Baldwin, MD, Adriana Cadilla, MD, Kathryn Farrell, MSN, Emily Craver, MS

“…Both hospitals had the same preoperative surgical bundle except that Group B included testing for S. aureus and treatment preoperatively if positive. …”
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Perinatal interventions to prevent Adverse Childhood Experiences (ACEs): A scoping review. by Jane Kinsey, Jaime La Charite, Shirley Russ, Adam Schickedanz

“…Intentional incorporation of life course characteristics and bundling of evidence-based components into comprehensive perinatal interventions hold promise for future ACEs prevention.…”
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Imaging and Clinical Characteristics of 8 Cases of COVID-19 Complicated with Pneumomediastinum in Children by FU Qiang, REN Zuolei, LIN Zhiqiang, GONG Jianfeng, WANG Changzheng, WANG Ting, HU Yalan, TAN Jufang

“…The pulmonary manifestations were various: subpleural ground glass shadow, consolidation, tree bud sign, vascular bronchial bundle thickening and bronchial wall thickening, grid sign, etc., no large consolidation and "white lung" found. …”
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The RISES Model: A New Approach to Promoting Health Professionals’ Motivation to Engage in Research by D'Arrietta LM, Vangaveti VN, Crowe MJ, Malau-Aduli BS

“…Louisa M D’Arrietta,1,2 Venkat N Vangaveti,1,3 Melissa J Crowe,4 Bunmi S Malau-Aduli1,5 1College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia; 2Library Services, Townsville University Hospital, Townsville Hospital and Health Service, Townsville, Queensland, Australia; 3Townsville Institute of Health Research and Innovation, Townsville University Hospital, Townsville Hospital and Health Service, Townsville, Queensland, Australia; 4College of Healthcare Sciences, James Cook University, Townsville, Queensland, Australia; 5School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, AustraliaCorrespondence: Louisa M D’Arrietta, College of Medicine and Dentistry, Division of Tropical Health and Medicine, James Cook University, Townsville, QLD, 4811, Australia, Tel +61 7 4781 4060, Fax +61 7 4779 6371, Email louisa.darrietta@jcu.edu.auPurpose: A decline in the number of health professionals (HPs) engaging in clinical and healthcare research has spurred governments, educational and healthcare organisations to focus on developing strategies to promote a resurgence of clinical researchers. …”
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Construction of water injection seepage model for coal body and microscopic dominant influence law by Enmao WANG, Gang WANG, Shuliang XIE, Hongzhao WEI, Jing FENG, Handan LIANG

“…Initially, we developed a percolation model, incorporating elements such as pore throats, equivalent pore diameter, effective porosity, capillary bundles, tortuosity, and flow paths. Furthermore, an online CT scanning loading percolation system was used to reconstruct three-dimensional visualizations of effective microfracture structures in coal bodies from five mines with varying metamorphic degrees: Inner Mongolia, Tongfuxin, Meihuajing, Dahuang Mountain, and Ciyaogou. …”
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Clinical Outcomes in Diabetic Females Presenting with STEMI: A Cohort Study by Anjana Ajith Beena, Priya Shanmukhan, Veena Felix, Alummoottil George Koshy, Kunjukrishnapilla Sivaprasad

“…Among those with in-hospital mortality, a higher proportion had Anterior Wall Myocardial Infarction (AWMI) (p=0.043), were in Killip class>II (p-value <0.0001), and had qRBBB (Right Bundle Branch Block) (p-value <0.0001). They presented later, with higher blood sugar (p-value <0.0001) and creatinine values (p-value=0.009) and had a lower Ejection Fraction (EF) (p-value=0.003). …”
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Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer&rsquo;s Disease by Zhou H, Peng Y, Huo X, Li B, Liu H, Wang J, Zhang G

“…Huiqin Zhou,1– 3,&ast; Yunjia Peng,2,3,&ast; Xinhua Huo,2,3 Bingqing Li,2,3 Huasheng Liu,4 Jian Wang,3,5 Gaihua Zhang1 1College of Life Sciences, Hunan Normal University, Changsha, People’s Republic of China; 2Hunan Guangxiu Hospital, Hunan Normal University, Changsha, People’s Republic of China; 3National Engineering Center of Human Stem Cell, Changsha, People’s Republic of China; 4Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 5The Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Gaihua Zhang, The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China. …”
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