MODERN TREATMENT OF METASTATIC MELANOMA: FROM STANDARDS TO AN INDIVIDUALIZED APPROACH IN REAL CLINICAL PRACTICE by N. V. Zhukova, R. V. Orlova, N. Yu. Antimonik, S. I. Kutukova, N. P. Belyak, N. V. Popova, S. P. Erdniev

“…It should be noted that the proportion of patients with melanoma of late stages remains high. Until recently, only ineffective chemotherapy regimens were available for such patients. …”
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Intravenous nicardipine and labetalol use in hypertensive patients with signs or symptoms suggestive of end-organ damage in the emergency department: a subgroup analysis of the CLU... by Brian Hiestand, Phillip Levy, W Frank Peacock, Brigitte M Baumann, Richard M Nowak, Amy Hsu, Joseph Varon, Chad M Cannon, David M Cline, Pierre Borczuk, Abhinav Chandra, Deborah B Diercks, Preeti Jois, Brian Kaminski, Jon W Schrock

“…Objective To compare the efficacy of Food and Drug Administration recommended dosing of nicardipine versus labetalol for the management of hypertensive patients with signs and/or symptoms (S/S) suggestive of end-organ damage (EOD).Design Secondary analysis of the multicentre prospective, randomised CLUE trial.Setting 13 academic emergency departments in the USA.Participants Eligible patients had two systolic blood pressure (SBP) measures ≥180 mm Hg at least 10 min apart, no contraindications to nicardipine or labetalol and predefined S/S suggestive of EOD on arrival.Interventions Medications were administered by continuous infusion (nicardipine) or repeat intravenous bolus (labetalol) for a study period of 30 min or until a specified target SBP ±20 mm Hg was achieved.Primary outcome measure Percentage of participants achieving a predefined target SBP range (TR) defined as an SBP within ±20 mm Hg as established by the treating physician.Results Of the 141 eligible patients, 49.6% received nicardipine, 51.7% were women and 81.6% were black. …”
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Effect of Al/Cu Ratio on Microstructure and High-Temperature Oxidation Resistance of Al_xCoCrCu_yFeNi High-Entropy Alloy Coatings by Ling Zhou, Hongxi Liu, Qinghua Zhang, Jiazhu Liang, Yuanrun Peng, Xuanhong Hao, Chen Yang, Yaxia Liu, Yueyi Wang

“…The Cu-rich phases decreased with a decreasing Cu content and completely disappeared until the Al content reached 1.0. The microhardnesses of the Cu_1.0, Cu_0.7Al_0.3, Cu_0.5Al_0.5, Cu_0.3Al_0.7, and Al_1.0 HEA coatings were 2.01, 2.06, 2.08, 2.09, and 2.11 times that of the substrate, and compared with those of a Ti6Al4V alloy substrate, the oxidation rates of the HEA coatings decreased by 55%, 51%, 47%, 42%, and 35%, respectively. …”
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Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD by Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen

“…The trafficking of mRNAs along the hippocampal neuron dendrites remains translationally silent until they are selectively transported into the spines upon glutamate-induced receptor activation. …”
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Sensitive windows for within- and trans-generational plasticity of anti-predator defences by Tariel-Adam, Juliette, Luquet, Émilien, Plénet, Sandrine

“…However, the sensitive window also persisted until late developmental stages for some defences, providing evidence that the early-life is not the only sensitive window as empirical and theoretical studies often state. …”
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START—the Swiss tele-assisted rehabilitation and training program to support transition from inpatient to outpatient care in the subacute phase after a stroke: feasibility, safety... by Szabina Gäumann, Carina Ziller, Carina Ziller, Nele Paulissen, Nele Paulissen, Frank Behrendt, Frank Behrendt, Zorica Suica, Zorica Suica, Björn Crüts, Luana Gammerschlag, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…The Swiss tele-assisted rehabilitation and training program (START), delivered through the Blended Clinic mobile application, seeks to support patients to start during inpatient rehabilitation, continue during the transition to the home environment, continue until outpatient rehabilitation starts and beyond. …”
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Effects of Dietary Tea Polyphenols on the Growth, Antioxidant Status, Immune Function, and Intestinal Microbiota of Largemouth Bass (<i>Micropterus salmoides</i>) by Zixin Yang, Qiuwen Su, Jiafa Yang, Zhijun Li, Shanren Lan, Xu Jia, Paihuai Ouyang, Huijuan Tang

“…Four diets with varying levels of TPs (0.00%, 0.02%, 0.04%, and 0.08%) were devised to feed LMB with an initial weight of 4.3 ± 0.02 g for 56 days, among which the intermittent feeding (IF) group was fed a diet supplemented with TP8 for 7 days, followed by a basal diet for another 7 days, and this was repeated until the end (56th day). The results demonstrated that supplementation with 0.04% or 0.08% TPs in the diet could reduce the crude lipid content and increase the crude protein content of LMB (<i>p</i> < 0.05). …”
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Machine Learning and Intelligent Diagnostics in Dental and Orofacial Pain Management: A Systematic Review by Taseef Hasan Farook, Nafij Bin Jamayet, Johari Yap Abdullah, Mohammad Khursheed Alam

“…Scopus, PubMed, and Web of Science (all databases) were searched by 2 reviewers until 29th October 2020. Articles were screened and narratively synthesized according to PRISMA-DTA guidelines based on predefined eligibility criteria. …”
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Black Orpheus by Hlonipha Mokoena

“…The fate of African Nationalism, Pan-Africanism, Negritude and Black Internationalism was also bundled up with Cold War politics and this has in some ways resulted in the conclusion that the thawing of American and Soviet Union also led to the depreciation of these liberation and anti-colonial ideas. …”
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Enhancing the Survival Rate of Sand Goby, Oxyeleotris marmorata (Blkr.), Larvae with Antibiotics by Irzal Effendi, Yani Hadiroseyani

“… ABSTRACT Penicillin G and streptomycin sulphate were administered for 18 days of rearing of sand goby larvae. 7'wo-days larvae (3,37-3,41 mm) were reared in 160 1 aerated water at stocking density of 50 fish/1.  Until 17 days of rearing period, the larvae were fed plankton (50-300 gm) at stocking density of 20-30 individual/mi, and at day 13-I8, were fed Artemia sp. (1-2 individual/ml).  …”
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A Review of Needle Navigation Technologies in Minimally Invasive Cardiovascular Surgeries—Toward a More Effective and Easy-to-Apply Process by Katharina Steeg, Gabriele Anja Krombach, Michael Horst Friebe

“…<b>Methods:</b> A systematic search of PubMed, Web of Science, and IEEE databases up until June 2024 identified original studies on needle navigation in MICS. …”
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Accelerating phase field simulations through a hybrid adaptive Fourier neural operator with U-net backbone by Christophe Bonneville, Nathan Bieberdorf, Arun Hegde, Mark Asta, Habib N. Najm, Laurent Capolungo, Cosmin Safta

“…This computational bottleneck is especially problematic when running LMD simulation until a late time horizon is required. This motivates the development of surrogate models capable of leaping forward in time, by skipping several consecutive time steps at-once. …”
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Quantification of ecosystem services from mangrove silvofishery by E. Sumarga, D. Rosleine, G.B. Hutajulu, R.P. Plaurint, Tsabita ., M. Basyuni, S.H. Larekeng, M.F. Taqiyudin, N.N. Shohihah, H. Ali

“…Visitor numbers vary, averaging around 128 people per month until mid-2023. The Blanakan mangroves are home to a total of 23 bird species, contributing to a species diversity index of 2.1. …”
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A cross-sectional study exploring the predictors of herpes zoster vaccination for people aged over 50 years old in Chaoyang district, Beijing by Jiao Zhang, Shuo Zhang, Bin Jia, Yunhua Bai, Zhen Li, Fang Liu, Yingxue Hu, Xiaojing Guo, Jianxin Ma, Shuming Li, Qian Shi

“…Logistic regression analysis and decision tree models were employed to explore the predictors herpes zoster vaccination behavior.ResultsThe herpes zoster vaccination coverage was 13.26% (403/3040), with 52.4% of respondents expressing willingness but not yet receiving the vaccine, while 34.31% (1,043/3040) were unwilling to be vaccinated. Among those willing but not vaccinated, 48.06% cited high cost as the reason for abstaining from vaccination. …”
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Effects of apple cider vinegar on glycemic control and insulin sensitivity in patients with type 2 diabetes: A GRADE-assessed systematic review and dose–response meta-analysis of c... by Donya Arjmandfard, Mehrdad Behzadi, Zahra Sohrabi, Mohsen Mohammadi Sartang

“…This study aimed to evaluate the effects of ACV on glycemic profile in type 2 diabetes patients (T2DM) in controlled trials (CTs) by systematically reviewing and dose–response meta-analysis.MethodsThe Scopus, PubMed, and Web of Science databases were searched until November 2024 according to a systematic approach. …”
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Firearms control as an element of criminological security in the concept of transitional justice for Ukraine by Yu. V. Orlov, A. M. Yashchenko

“…The article proposes a criminological model for establishing control over firearms circulation which provides for: 1) preservation of the existing legal regime of firearms circulation for civilians until the end of the armed conflict and the legal regime of martial law; after the lifting of martial law, a balanced legalisation of civilian (short-barreled) weapons with strict control, verification and constant monitoring is required; 2) for military personnel (including those discharged from service): a) a special type of exemption from criminal liability under Articles 263 and 410 (regarding misappropriation of firearms, ammunition, explosives or other munitions) of the Criminal Code of Ukraine, subject to presentation for inspection, registration and issuance of a permit (de lege ferenda); b) obtaining a permit (de lege ferenda) for storage of firearms (in the amount of no more than one unit per person) and ammunition (in the amount of no more than 60 pieces); 3) criminal liability for violation of the conditions of the permit to keep and carry firearms. …”
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Expansion of a stationary retail trading network in Vilnius and the Vilnius district in 1861-1904 by Aelita Ambrulevičiūtė

“…Vilnius, a city that is the center of gubernatorial and general gubernatorial administration, became the biggest Russian imperial North-West Land retail trade center in the 19th century and therefore clearly shows the stationary retail trade net development and citizens' needs changes in the Lithuanian and Byelorussian territories when industrial manufacture extended from the 19th century's second half until the beginning of the 20th century. The organization of the trade net in Lithuania started at the same time as the industrialization process when the manufacture order changed and began intensive trade structure reorganization. …”
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Nurses’ experiences of text-based digital triage at primary healthcare centres in Sweden: a qualitative interview study by Ester Rydell, Ulf Jakobsson, Sigrid Stjernswärd

“…Telephone-based communication has until recent years been the predominant means for triage and health guidance, but now includes written communication via computer or smartphone. …”
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Gambaran Morfologi Spermatozoa pada Perokok Sedang di Lingkungan PE Group yang Datang ke Bagian Biologi Fakultas Kedokteran Universitas Andalas by Vinda Dwi Apriora, Arni Amir, Oea Khairsyaf

“…In this descriptive study, started from September 2012 until 2013. A total of thirty three males who were classified as medium smokers were enrolled to Biology Laboratory Medical Faculty of Andalas University Padang. …”
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PM2.5 in Sri Lanka: Trend Analysis, Low-cost Sensor Correlations and Spatial Distribution by Ranil Dhammapala, Ashani Basnayake, Sarath Premasiri, Lakmal Chathuranga, Karen Mera

“…Abstract The South Asian island nation of Sri Lanka did not have any permanent PM2.5 monitors sharing data publicly in near-real-time until the U.S. Embassy installed a Beta Attenuation Monitor (BAM) in September 2017. …”
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