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    Oyster Mushroom (Pleurotus ostreatus) Ethanolic Extract Inhibits Pparg Expression While Maintaining the Methylation of the Pparg Promoter During 3T3-L1 Adipocyte Differentiation by Ariyanto EF, Farahana AK, Sudirman GSJ, Widiarsih E, Qomarilla N, Rahayu NS, Wikayani TP, Heryaman H, Wira DW, Triatin RD, Bashari MH, Pamela Y, Pratiwi YS, Ghozali M

    Published 2025-01-01
    “…Eko Fuji Ariyanto,1,2 Anastasya Kania Farahana,3 Gabriella Sachiko Jannesha Sudirman,3 Erlina Widiarsih,4 Nurul Qomarilla,5 Nurul Setia Rahayu,4 Tenny Putri Wikayani,5 Henhen Heryaman,1 Dwi Wahyudha Wira,1 Rima Destya Triatin,1,2 Muhammad Hasan Bashari,1 Yunisa Pamela,1 Yuni Susanti Pratiwi,1 Mohammad Ghozali1 1Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia; 2Research Center for Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 3Undergraduate Program of Medical Doctor, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia; 4Molecular Genetics Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 5Cell Culture Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, IndonesiaCorrespondence: Eko Fuji Ariyanto, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia, Tel +6281316099791, Email fuji@unpad.ac.idPurpose: This study aims to provide new insights into the potential of oyster mushroom (Pleurotus ostreatus) ethanolic extract in preventing obesity through the inhibition of Pparg expression and modulation of methylation level on Pparg promoter during 3T3-L1 adipocyte differentiation.Methods: This in vitro quantitative experimental study was conducted by treating the 3T3-L1 cell line differentiated using 0.5 mM methyl-isobutyl-xanthine, 1 μM dexamethasone, and 10 μg/mL insulin-containing medium with oyster mushroom ethanolic extract. …”
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    Two Novel Compounds Isolated from the Marine Fungal Symbiont of Aspergillus unguis Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells: In vitro Study by Bashari MH, Agung MUK, Ariyanto EF, Al Muqarrabun LMR, Salsabila S, Chahyadi A, Rosandy AR, Afifah E, Afni M, Atmaja HE, Putri T, Utami F, Subhan B, Syafrizayanti, Andriani Y, Elfahmi

    Published 2025-01-01
    “…Muhammad Hasan Bashari,1 Mochamad Untung Kurnia Agung,2 Eko Fuji Ariyanto,1 Laode Muhammad Ramadhan Al Muqarrabun,3 Syefira Salsabila,3 Agus Chahyadi,3 Andi Rifki Rosandy,3 Ervi Afifah,4 Merry Afni,5 Harold Eka Atmaja,5 Tenny Putri,5 Fitria Utami,5 Beginer Subhan,6 Syafrizayanti,7 Yosie Andriani,8 Elfahmi3,9 1Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Padjadjaran, Bandung, West Java, Indonesia; 3University Center of Excellence for Nutraceuticals, Bioscience and Biotechnology Research Center, Bandung Institute of Technology, Bandung, West Java, Indonesia; 4Graduate School of Master Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 5Biomedical Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 6Department of Marine Science and Technology, Faculty of Fisheries and Marine Science, IPB University, Bogor, West Java, Indonesia; 7Biochemistry Laboratory, Department of Chemistry, Universitas Andalas, Padang, West Sumatera, Indonesia; 8Institute of Climate Adaptation and Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, Malaysia; 9School of Pharmacy, Bandung Institute of Technology, Bandung, West Java, IndonesiaCorrespondence: Muhammad Hasan Bashari, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, West Java, Indonesia, Email bashari@unpad.ac.id Elfahmi, School of Pharmacy, Bandung Institute of Technology, Bandung, West Java, Indonesia, Email elfahmi@fa.itb.ac.idPurpose: A promising feature of marine sponges is the potential anticancer efficacy of their secondary metabolites. …”
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