UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy by Lin Li, Rong Fu, Yan Chen, Jin Yao, Xiaobing Jiang, Tao Liang, Jun jun Li, Qian zhi Chen, Liang Liang Shi, Ming Xing Xie, Xin Wei Qiao, Qi Hong Cheng, Min Jie Wang

“…The precise molecular mechanism responsible for this phenomenon has not yet been completely established, so it is vital to comprehend the molecular mechanism behind it.Methods The protein chip analysis was conducted to identify any abnormal UBE2T protein expression in TNBC, especially BrM. …”
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Avirulence depletion assay: Combining R gene-mediated selection with bulk sequencing for rapid avirulence gene identification in wheat powdery mildew. by Lukas Kunz, Jigisha Jigisha, Fabrizio Menardo, Alexandros G Sotiropoulos, Helen Zbinden, Shenghao Zou, Dingzhong Tang, Ralph Hückelhoven, Beat Keller, Marion C Müller

“…While R gene cloning has accelerated recently, AVR identification in many pathogens including Bgt lags behind, preventing pathogen-informed deployment of resistance sources. …”
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The Case for Brutalist Honesty in Medical Education by Markle DT

“…Compared to the past, students now have access to a wealth of outside data to evaluate their curricular progress and career prospects against, and yet institutions are lagging behind in openly disclosing information related to metrics of student success (course passing rates, number of repeat students per class, Step 1 pass rate, etc.) that would engender trust and afford students greater agency in their academic decisions.Approach: In developing a new academic counseling office, the author deployed a method of using brutalist honesty as a means of student support, both in terms of answering all curriculum questions truthfully no matter the topic and with individualized data analytics to provide objective evidence as to student performance progress. …”
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The impact of relaxation music (Weightless by Marconi Union) on production performance, welfare, and hematological and biochemical blood parameters in broiler chickens by Patrycja Ciborowska, Damian Bień, Artur Żbikowski, Karol Pawłowski, Jakub Urban, Anna Zalewska, Arkadiusz Matuszewski, Karwan Yaseen Kareem, Klara Piotrowska, Monika Michalczuk

“…However, further research is necessary to verify the mechanism behind these effects.…”
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Paper Bags vis-à-vis LDPE Bags: Gleanings from Peer-reviewed E-LCA Publications by Isabell Lidbrand, Govindarajan Venkatesh, Magnus Lestelius

“…The ‘What’, ‘How’ and ‘Where’, so to say were studied carefully to understand the reasons behind any differences or similarities detected. On the basis of this focused review, even though no new knowledge is being added, the common belief that the paper bag is environmentally superior to the LDPE alternative is further consolidated. …”
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Studies of the Adsorption of SO, H and O on a CrO Surface by an Electrical Conductivity Technique by Mahmoud M. Khader, Mahmoud M. Saleh, Ahmad M. Mohammad

“…The surface then dehydroxylated due to the interaction of surface hydroxy groups with gaseous hydrogen, leaving coordinatively unsaturated surface chromium ions behind. In an oxygen flow at 400°C and above, either SO 2 or H 2 treatments led to a sharp increase in conductivity due to oxygen adsorption. …”
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Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis by Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng, Kutty Selva Nandakumar

“…Conclusion These findings uncover a novel mechanism in S. aureus-infected wounds, highlighting how the disruption of efferocytosis via the TLR2-MyD88-p38 MAPK-MerTK axis becomes a key force behind impaired healing of wounds. Targeting this pathway could open up a new therapeutic avenue facilitating the treatment of chronic, non-healing skin injuries.…”
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Infusion of Autologous Retrodifferentiated Stem Cells into Patients with Beta-Thalassemia by Ilham Saleh Abuljadayel, Tasnim Ahsan, Huma Quereshi, Shakil Rizvi, Tamseela Ahmed, Sabiha Mirza Khan, Jawaid Akhtar, Ghazi Dhoot

“…Fetal hemoglobin switching agents have been proposed to treat genetic blood disorders, such as sickle cell anemia and beta-thalassemia, in an effort to compensate for the dysfunctional form of the beta-globin chain in adult hemoglobin. The rationale behind this approach is to pair the excess normal alpha-globin chain with the alternative fetal gamma-chain to promote red blood cell survival and ameliorate the anemia. …”
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Disaster-inducing mechanism of the movement of high-position combination cantilever plate structures in non-uniform and extra-thick coal seam mining by ZHU Weibing, GUO Chunlei, LUO Xun, CHAI Faying, XIE Jianlin, CHAI Yi

“…To reveal the mechanism behind the occurrence of large-energy events in the roof during the mining of extra-thick coal seams at a deep mine in Gansu Province, numerical simulation, physical simulation, borehole detection, and internal rock movement monitoring were used to investigate the roof breaking structure and disaster-inducing mechanism in the mining of non-uniform and extra-thick coal seams. …”
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miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding by Juan Wen, Baiyi Tang, Lan Guo, Wei Chen, Xiaohong Tang

“…However, the molecular mechanisms behind these pathological processes in hypertension are not fully elucidated. …”
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Military security in the Arctic: New threats to Russia by V. N. Konyshev, A. A. Sergunin

“…This article attempts to identify the causes and driving forces behind these processes, as well as to assess the threats they pose to Russia’s national security. …”
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Efektivitas Ifdil perceptual light technique untuk mengurangi social anxiety siswa obesitas by Iqbal Arrahman, Ifdil Ifdil, Yeni Karneli, Rima Pratiwi Fadli, Annisaislami Khairati

“…Pada gangguan ini penderitanya akan merasakan kekhawatiran yang berlebihan ketika berada di sekitar orang banyak. Beberapa gejala fisik yang dapat diamati adalah munculnya keringat dan gemetar saat berinteraksi dengan orang banyak. …”
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Providing appropriate health and social care for people with dementia or mild cognitive impairment in the criminal justice system of England and Wales: a thematic analysis of priso... by Adam O’Neill, Leanne Heathcote, Laura Archer-Power, Stuart Ware, Jenny Shaw, Jane Senior, Katrina Forsyth

“…(IV) A lack of collaboration leading to sub-optimum management of the support needs of people with dementia/MCI in prison; (V) Peer support ‘plugging the gap’; and (VI) staff ‘hands tied behind back’. Conclusions Results point towards a pressing need to develop more appropriate support systems for individuals with dementia/MCI throughout the criminal justice system. …”
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Improved Antibacterial Activity of Water-Soluble Nanoformulated Kaempferol and Combretastatin Polyphenolic Compounds by Y. Santhosh Kumar, Langeswaran Kulanthaivel, G. S. Hikku, R. Saravanan, Thangavelu Lakshmi, C. Kirubhanand, Murugesan Karthikeyan, P. Vijayalakshmi, Gowtham Kumar Subbaraj

“…The antibacterial activity was assessed by measuring the optical density at 600 nm using UV-vis spectrophotometer and displayed significant activity against gram-positive Staphylococcus aureus strain. The mechanisms behind the antibacterial activity of NF-k and NF-c were discussed in detail. …”
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Related studies on measuring the normal values of optic nerve sheath diameter in healthy Chinese adults based on CT scans by Lei Han, Ning Su, Chao Wu, Jiamin Yang, Xiaolin Liu

“…The ETD of both eyes and the ONSD (ONSD3mm, ONSD10mm) at 3 mm and 10 mm behind the eyeball were measured, and the relationship between ONSD and age, sex and ETD was analyzed by linear regression. …”
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The Wayqecha Amazon Cloud Curtain Ecosystem Experiment: A new experimental method to manipulate fog water inputs in terrestrial systems by Daniel B. Metcalfe, Darcy F. Galiano Cabrera, Luis Miguel Alvarez Mayorga, Roxana Sacatuma Cruz, Daniela Corrales Alvarez, Blanca Rosa Espinoza Otazu, Walter Huaraca Huasco, Jimmy R. Chambi, Maria E. Ezquerra, Beisit L. Puma Vilca, Mark Mulligan, Matthew A. Vadeboncoeur, Heidi Asbjornsen, Paulo R. L. Bittencourt, Aline B. Horwath, David C. Bartholomew

“…The curtains divert and intercept airborne water droplets in fog moving upslope, thereby depriving a ~420 m2 patch of forest immediately behind the curtains of this water source. We monitored inside the treatment and a nearby unmodified control plot various metrics of water availability (air humidity, vapour pressure deficit, leaf wetness and soil moisture) and other potentially confounding variables (radiation, air and soil temperature) above and below the forest canopy. …”
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Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co production by Jonathan Siikanen, Stefan Milton, Klas Bratteby, Wilson Lin, Jonathan W. Engle, Emma Jussing, Thuy A. Tran

“…Mg dissolves rapidly in the acid mixture, leaving behind a porous, sponge-like Ni matrix increasing the surface area of the Ni and therefore accelerating the dissolution. …”
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About the Master’s Program “Creative Personnel Management”: Methodological Foundations by A. O. Grudzinskiy, I. V. Guskova, N. E. Serebrovskaya, V. V. Mariko

“…The main driving force behind the growth of innovative economies of developed and developing countries is a social group of people characterized by a high level of education, creative abilities and entrepreneurial behavior skills. …”
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The European Union’s Policies Towards Iraq (2014–2020) by L. D. Oganisyan

“…However, these efforts have not yet been explored in depth by the Russian experts, who traditionally focus on the EU relations with the Southern Mediterranean countries.The author aims to reveal the logic behind the evolution of the European Union’s policy towards Iraq since 2014, as well as its impact on the EU assistance programmes to this country. …”
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Healthy food prescription incentive programme for adults with type 2 diabetes who are experiencing food insecurity: protocol for a randomised controlled trial, modelling and implem... by Colleen Norris, Tyler Williamson, Richard Oster, Dana Lee Olstad, Laura White, David J T Campbell, Sharlette Dunn, Kim D Raine, Mary L'Abbé, Richard Lewanczuk, Lorraine L Lipscombe, Eldon Spackman, Reed Beall, Kienan Williams, Sara Scott, Gabrielle L Zimmermann, Kerry A McBrien, Kieran J D Steer, Catherine B Chan, Sheila Tyminski, Seth Berkowitz, Alun L Edwards, Terry Saunders-Smith, Saania Tariq, Naomi Popeski, Sara Nejatinamini, Aruba Naser, Carlota Basualdo-Hammond, Petra O’Connell, Judy Seidel, Jason Cabaj

“…An implementation study will examine all RE-AIM domains to understand determinants of effective implementation and reasons behind programme successes and failures.Methods and analysis 594 adults who are experiencing food insecurity and persistent hyperglycaemia will be randomised to a healthy food prescription incentive (n=297) or a healthy food prescription comparison group (n=297). …”
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