Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle by Gustavo R. D. Rodrigues, Joslaine N. S. G. Cyrillo, Lúcio F. M. Mota, Patrícia I. Schmidt, Júlia P. S. Valente, Eduarda S. Oliveira, Lúcia G. Albuquerque, Luiz F. Brito, Maria E. Z. Mercadante

“…The gene networks were involved in metabolic pathways including ovarian steroidogenesis, oocyte meiosis, and insulin secretion. Matings between carrier dam and carrier sire led to a reduction of up to -203.46% in pregnancy success probability, an increase of 275.15% in probability of pregnancy loss, 295.03% for stillbirth occurrence, and 301.40% for pre-weaning mortality when compared to non-carrier dam and sire matings. …”
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Emerging roles of extracellular vesicles in oral and maxillofacial areas by Qianting Wang, Jiayu Sun, Haci Jiang, Mengfei Yu

“…Extracellular vesicles are a group of heterogeneous lipid-bilayer membrane structures secreted by most cell types, including exosomes, microvesicles, and apoptotic bodies. …”
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A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study by Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J. Dibble, Braxton Morrison, Chimere L. Smith, Ronald W. Davis, Wenzhong Xiao

“…Our pathway analysis revealed potential associations between ME/CFS and conditions such as COVID-19, Epstein–Barr virus (EBV) infection, neurodegenerative diseases, and pathways involved in cortisol synthesis and secretion, supporting the hypothesis that ME/CFS is a neuroimmune disorder. …”
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Association between sleep deprivation and fertility - a literature review by Adriana Dukacz, Anna Konarska, Anna Machowiak, Barbara Ufnalska, Justyna Lisiecka, Mateusz Janik, Michał Nowak, Joanna Rychlewska-Duda, Wojciech Firlej, Artur Fabijański

“…There is a probability that Leydig cells function and count, cortisol secretion and testosterone levels can be affected but for now we have to conduct more research to rule it out or confirm. …”
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FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking by Sophia Vincoff, Shrey Goel, Kseniia Kholina, Rishab Pulugurta, Pranay Vure, Pranam Chatterjee

“…These proteins are intrinsically disordered and lack druggable pockets, making them highly challenging therapeutic targets for both small molecule-based and structure-based approaches. …”
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How endocrine disruptors affect fish reproduction on multiple levels: A review by Socha Magdalena, Chyb Jarosław, Suder Aleksandra, Bojarski Bartosz

“…They can affect the functioning of certain systems within the hypothalamus (Kiss/GPR54, GnRH) and can also impact luteinizing hormone (LH) secretion in the pituitary. These compounds have negative impacts on gonads, oocyte maturation, steroidogenesis, and gametes. …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…In synergy with the effect of anti-PD-1 Ab, Met boosts CD8TIL proliferation and IFN-γ secretion, resulting in decreased glycolysis and oxidative phosphorylation in tumor cells. …”
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Factor de riesgo suicida según dos cuestionarios, y factores asociados en estudiantes de la universidad nacional de Colombia sede Manizales by José Jaime Castaño Castrillón, Sandra Constanza Cañón, Marcela Betancur Betancur, Paula Lorena Castellanos Sánchez, Johanna Guerrero González, Alejandra Gallego Rivas, Catalina Llanos Calderón

“…Resultados: Prevalen - cia de riesgo suicida: 6,7 %, según Plutchik; 19,7 %, según Beck. Buena funcionalidad familiar: 39,8 %. …”
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Effect of Robusta Coffee Bean Extract as Immunoregulator on Dental Pulp Mesenchymal Stem Cells via Paracrine Pathway by Desi Sandra Sari, Millenieo Martinindo, Syafika Nuring Fadiyah, Indah Yulia Ningsih, Tantin Ermawati Tantin Ermawati, Zahara Meilawaty, Dessy Rachmawati, Ernie Maduratna, Fedik Abdul Rantam

“…Objective: To analyze the  effect of Robusta Coffee Bean Extract (RCBE) on Dental Pulp Mesenchymal Stem Cells (DPSCs) culture in secreting cytokines, growth factors, and cell differentiation. …”
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Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity. by Haleema Sadia Malik, James B Bliska

“…For example, virulent bacterial pathogens have proteins called effectors that are typically enzymes and are secreted into host cells. To detect and respond to the activities of effectors, diverse phyla of host organisms evolved effector-triggered immunity (ETI). …”
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Expanding Yarrowia lipolytica’s metabolic potential for detoxification of cyanogenic glycosides in edible plants by Fidelis Azi, Zhiyu Li, Peng Xu

“…It upregulated ribosome biogenesis, the sec-dependent protein export pathway, and the sulfur relay system to facilitate the production and transmembrane efflux of the secreted GH1 hydrolase. It efficiently degraded linamarin, amygdalin, prunasin, and dhurrin in food plants including cassava, germinated sorghum and Apricot seeds. …”
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Constructing Identities: Amos Tutuola and the Ibadan Literary Elite in the wake of Nigerian Independence by Mackenzie Finley

“…The lecture’s transcriber utilized graphic devices (italicized and bolded words, brackets denoting pauses and movements) to preserve the dynamic oral experience of the lecture. …”
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SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2 by Katarzyna Blaszczyk, Anna P. Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A. Beamish, Jolanta Chmielowiec, Omaima M. Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak

“…Treatment with the MMP2 protein resulted in pronounced short- and long-term SC-β-cell expansion, significantly increasing glucose-stimulated insulin secretion in vitro and in vivo. These findings suggest that SPOCK2 mediates fetal β-cell proliferation and maturation. …”
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First in situ calcite U–Pb dating revealing the past episodes of the 2019 Le Teil Earthquake (France) by Gébelin, Aude, Matonti, Christophe, Larroque, Christophe, Carr, Patrick, Ampuero, Jean-Paul

“…In agreement with relative chronology data based on microstructural observations, our results allow us to define four main tectonic events: A first event from ~90 to 75 interpreted to reflect a thermal subsidence at the regional scale (Ardèche—South-East basin of France), a second event bracketed between ~60 to 50 Ma related to the N–S trending shortening of the South-East basin, a third tectonic event dated from ~40 to 37 Ma that we interpret to reflect the opening of the Gulf of Lion and European Cenozoic Rift System (ECRIS), and a fourth and final event at ~25 Ma that very likely represents a middle to late stage of the ECRIS. …”
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Gastric Cytoprotection as Basis of Gastrointestinal Mucosa Protection and Repair in Erosive Ulcerative Lesions of Various Aetiologies by K. V. Ivashkin, E. A. Izatullaev, V. R. Korneeva

“…Aside to damage prevention in exposure to aggressive agents, gastroprotection implies healing promotion under the preserved level of hydrochloric acid secretion. Prostaglandins (PG) and SH-antioxidants are key mediators of gastroprotection in acute and chronic damage. …”
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Effects of pollen enriched diet on hypopharyngeal glands’ morphology and morphometry and vitellogenin transcription levels in honey bees by Claudia D’Emilio, Viviana Valenzano, Paola Maiolino, Karen Power, Manuela Martano, Gennaro Di Prisco

“…Our results confirm that a diet rich in pollen is necessary for the normal development and function of HPGs and that the amount of secretion is positively correlated with glandular activity and acinar size. …”
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Unilocular adipocyte and lipid tracer for immunofluorescent images by Elizabeth K. Johnston, Tal Dassau, Nickia A. Muraskin, Rosalyn D. Abbott

“…Adipocyte cellular size has been recognized as an indicator of cellular status; hypertrophic adipocytes are more prone to insulin resistance and the secretion of pro-inflammatory cytokines. Thus, the size and number of lipids is important to consider both in the clinic with a biopsy and when developing disease models and regenerative tissue constructs. …”
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Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential by Jingyi Yuan, Zhenmin Li, Yongjiang Yu, Xiuge Wang, Yunyun Zhao

“…Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder characterized by irregularities in gonadotropin secretion, hyperandrogenism, chronic anovulation, and polycystic ovarian morphology. …”
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MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes by Néron, Bertrand, Denise, Rémi, Coluzzi, Charles, Touchon, Marie, Rocha, Eduardo P.C., Abby, Sophie S.

“…Finally, we have updated and improved MacSyFinder popular models: TXSScan to identify protein secretion systems, TFFscan to identify type IV filaments, CONJscan to identify conjugative systems, and CasFinder to identify CRISPR associated proteins. …”
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Sarcoidosis: molecular mechanisms and therapeutic strategies by Danfeng Xu, Xiaohua Tao, Yibin Fan, Yan Teng

“…CD4 + T cells initiate dysregulated immune responses and secrete significant quantities of inflammatory cytokines, including interleukin (IL)-2 and interferon-gamma (IFN-γ), which play a crucial role in modulating the aggregation and fusion of macrophages to form granulomas. …”
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