Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs by Wang Wusan, Ji Hui, Li Tingting, Jia Yuanwei, Xie Haitang

“…A pharmacokinetic comparison and conformational stability study of S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. …”
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Pimobendan oral solution is bioequivalent to pimobendan chewable tablets in beagle dogs by Olaf Kuhlmann, Michael Markert

“…In the pharmacodynamic study, 4 mongrel and 2 beagle dogs implanted with telemetry probes were included in a 2‐way crossover design. …”
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Age-Related Changes in Gut Health and Behavioral Biomarkers in a Beagle Dog Population by Anna Fernández-Pinteño, Rachel Pilla, Jan Suchodolski, Emmanuelle Apper, Celina Torre, Anna Salas-Mani, Xavier Manteca

“…This study aims to examine multiple blood and fecal biomarkers of intestinal health, along with various behavioral indicators based on saliva, blood, observations, and activity, in different age populations (junior: <2 y.o.; adult: 2–7 y.o.; senior: >7 y.o.) of thirty-seven Beagle dogs. …”
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Validated UPLC-MS/MS Method for Determination of Futibatinib and Its Pharmacokinetics in Beagle Dogs by Heng Li, Hao-Zhe Ding, Yi-Lin Wang, Feng Zhang, Ya-Hao Song, Xiang-Jun Qiu

“…Futibatinib and IS were separated in an UPLC BEH C18 column (2.1 mm × 50 mm, 1.7 μm) with acetonitrile and 0.1% formic acid as the mobile phase, and the flow rate was 0.3 mL/min. …”
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Determination of Tropifexor in Beagle Dog Plasma by UPLC-MS/MS and Its Application in Pharmacokinetics by Yan-Ding Su, Xin-Yi Wei, Xiao-Hang Su, Ghulam Woshur, Xiao-Nan Geng, Xiang-Jun Qiu

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Urinary Fractional Clearance of Sodium in 8 Healthy Beagle Dogs Fed Normal, Low, or Ultralow Sodium Diets by R. G. Lobetti

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Impact of Cordyceps sinensis on coronary computed tomography angiography image quality and renal function in a beagle model of renal impairment by Peiji Song, Peiji Song, Kun Li, Xiaodie Xu, Guifeng Zhang, Zengkun Wang, Linbing Sun, Zekai Zhao, Ting Li, Ximing Wang, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia

“…In Groups A and D, significant changes were observed in renal function parameters, as well as in D, D*, f, and R2* values, both pre- and post-CCTA (P &lt; 0.05). …”
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Becoming Charles Darwin: Travel Experiences, Personal Writings, and the Genesis of a Method by Shadia Uteem

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Simultaneous Determination of Six Components in Beagle Dog Plasma by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study of Three Different Yuanhu Zhitong Prepara... by Yang Wang, Zhaorui Yin, Kai Zhang, Qingfen Meng, Jianli Guan, Guanwei Fan

“…Six analytes and one internal standard were separated on a Waters Acquity UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm) by gradient elution with 0.1% formic acid-water and 0.1% formic acid-acetonitrile at a flow rate of 0.4 mL/min. …”
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Simultaneous Determination of Five Components of Chaihu-Shugan-San in Beagle Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study after a Single Dose of Chaihu-Shuga... by Yong-liang Zhu, Hui-jun Wang, Hao Xue, Yi Zhang, Qian-shi Cheng, Ling-yun Chen, Xiang-jun Qiu

“…An Agilent C18 column (2.1 × 150 mm, 3.5 μm) was used to separate the analytes, and the column temperature was maintained at 40°C. …”
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Role of Wireless Sensor Network in Precision Agriculture by Haifa Alqahtani

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Inquiring in the Science Classroom by PBL: A Design-Based Research Study by Jorge Pozuelo-Muñoz, Ana de Echave Sanz, Esther Cascarosa Salillas

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Exploring the Pharmacokinetics and Gut Microbiota Modulation of Hesperidin and Nobiletin from Mandarin Orange Peel in Experimental Dogs: A Pilot Study by Jun Nakahigashi, Makoto Kurikami, Satomi Iwai, Sadahiko Iwamoto, Shou Kobayashi, Eiji Kobayashi

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Plasma Treatment Maintains Surface Energy of the Implant Surface and Enhances Osseointegration by Fernando P. S. Guastaldi, Daniel Yoo, Charles Marin, Ryo Jimbo, Nick Tovar, Darceny Zanetta-Barbosa, Paulo G. Coelho

“…The surface energy was characterized by the Owens-Wendt-Rabel-Kaelble method and the chemistry by X-ray photoelectron spectroscopy (XPS). Five adult beagle dogs received 8 implants (n=2 per surface, per tibia). …”
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The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs by Hongting Jin, Taotao Xu, Qiqing Chen, Chengliang Wu, Pinger Wang, Qiang Mao, Shanxing Zhang, Jiayi Shen, Peijian Tong

“…This study aimed to investigate if autologous bone marrow mesenchymal stem cells (MSCs) could treat osteonecrosis of the femoral head (ONFH) and what the fate and distribution of the cells are in dogs. Twelve Beagle dogs were randomly divided into two groups: MSCs group and SHAM operated group. …”
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In Vivo Assessment of Osseous Wound Healing Using a Novel Bone Putty Containing Lidocaine in the Surgical Management of Tooth Extractions by Akshay Kumarswamy, Antonio Moretti, David Paquette, Ricardo Padilla, Eric Everett, Salvador Nares

“…This preclinical pilot study evaluated the systemic, radiographic, and histological responses to bone putty containing lidocaine in a canine tooth extraction model. Methods. In five beagle dogs the right mandibular premolars were extracted and sockets grafted with (1) xenograft particulate bone and a collagen sponge plug (control), (2) bone putty alone, (3) bone putty mixed with xenograft (3 : 1), or (4) xenograft sandwiched between bone putty. …”
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Use of D-Squame^® as a Minimally Invasive Technique to Evaluate Skin Immune Response Biomarkers in Canine Atopic Dermatitis by Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Xavier Langon, Didier Pin

“…Two sites were determined: lesional site (L) and non-lesional site (NL) on eight dogs affected spontaneously with AD. …”
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Dose‐exposure‐response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin‐angiotensin‐aldosterone system in healthy dogs by Elizabeth Manson, Jessica L. Ward, Maria Merodio, Emilie Guillot, Thomas Blondel, Karin Allenspach, Oliver Domenig, Jonathan P. Mochel

“…Animals Eighteen purpose‐bred healthy beagle dogs. Methods Three groups of 6 dogs received different doses of CARDALIS® for 14 days following induction of RAAS activation by feeding a low‐sodium diet: (a) benazepril 0.25 mg/kg + spironolactone 2 mg/kg PO q24h (label dose); (b) benazepril 0.25 mg/kg + spironolactone 2 mg/kg PO q12h; or (c) benazepril 0.5 mg/kg + spironolactone 4 mg/kg PO q12h. …”
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Role of nasal microbiota in regulating host anti-influenza immunity in dogs by Jinzhu Geng, Yuhao Dong, Hao Huang, Xia Wen, Ting Xu, Yanbing Zhao, Yongjie Liu

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The role of Ashwagandha in modulating gut parameters in dogs—a randomized double-blind placebo-controlled trial by Kala Kumar Bharani, Ashok Kumar Devarasetti, Rajendar Bobbili, Amit Khurana, Donga Durga Veera Hanuman, Roupesh Gudepu, Swapna Guda

“…Twelve healthy geriatric Beagle dogs aged 12–15 years were enrolled. The dogs were divided into two groups to receive ARE (15 mg/kg, once daily, orally, for 2 months) or a placebo control. …”
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