Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature by Youde Jiang, Li Liu, Elizabeth Curtiss, Jena J. Steinle

“…Thus, we hypothesized that Epac1, a downstream mediator of β-adrenergic receptors, would block TLR4/HMGB1-mediated stimulation of the NLRP3 inflammasome, leading to reduced cleavage of caspase-1 and interleukin-1 beta (IL-1β). …”
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Geochronology and geochemistry of the Neoproterozoic–Mesozoic intrusive rocks in the Xinlin area, northeastern China: new constraints on the tectonic evolution of the Erguna block by Sheng Lu, Sheng Lu, Sheng Lu, Sheng Lu, Chenglu Li, Masroor Alam, Zhichao Song, Xiannan Zhu, Anzong Fu, Wenpeng Yang

“…The Paleozoic intrusive rocks are associated with the collision and amalgamation of the Erguna and Xing’an blocks, as well as the Songnen and Xing’an blocks. …”
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Dentoskeletal effects of aesthetic and conventional twin block appliances in the treatment of skeletal class II malocclusion: a randomized controlled trial by Mohamed Najati Alsilq, Mohamed Youssef

Subjects: “…Twin block…”
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Does the Use of Nitroglycerin Patch Improve Local Anaesthetic Effects in Bier’s Block? A Double-Blind Placebo Controlled Study by Ahmed Said Elgebaly

“…The aim of the study was to assess the nitroglycerin patch as a new additive to Bier’s block and its impact on the effects and dose of lidocaine. …”
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Block-Constraint Laplacian-Regularized Low-Rank Representation and Its Application for Cancer Sample Clustering Based on Integrated TCGA Data by Juan Wang, Jin-Xing Liu, Chun-Hou Zheng, Cong-Hai Lu, Ling-Yun Dai, Xiang-Zhen Kong

“…Considering the heterogeneity of different genome data, we introduce the block-constraint idea into our method. In BLLRR decomposition, we treat each genome data as a data block and impose different constraints on different data blocks. …”
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Petrogenesis of REE-rich two-mica granite from the Indosinian Xiekeng pluton in South China Block with implications for REE metallogenesis by Defu Zhang, Defu Zhang, Tingting Lv, Xiangaung Wang, Xiangaung Wang, Mingxuan Cao, Xiquan Chen, Xiquan Chen, Yongwen Zhang, Liangxin Gong

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Numerical Investigation of Impact Characteristics of Rigid Retaining Wall for Blocking Landslides: A Case Study of the Shum Wan Road Landslide by Yunyun Fan, Feng Zhang, Ying Liu, Dongyang Ma

“…Under the condition of setting a rigid retaining wall, the landslide can be effectively blocked and form a final deposition behind the retaining wall. …”
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Evaluation method and application for in-situ stress in No. 8+9 coal seam, southern Shenfu block, northeastern margin of Ordos Basin by Jiawei WU, Wei TANG, Yanhe ZHU, Cunwu WANG, Yongjing TIAN, Jingyu ZI, Jianghao YANG, Xian SHI

“…This study focused on the direction and magnitude of the current in-situ stress in the No. 8+9 coal seam in the southern Shenfu block, northeastern margin of the Ordos Basin. Array acoustic logging, microseismic monitoring, and imaging logging were used to evaluate the direction of the present maximum horizontal principal stress in the coal seam and its roof and floor. …”
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pH-responsive Vesicles with Tunable Membrane Permeability and Hydrodynamic Diameters from a Cross- linkable Amphiphilic Block Copolymer by Ruixue Chang, Yuelan Tian, Yong Wang, Jianglei Qin

Subjects: “…Block Copolymer…”
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Postanesthetic Cold Sensibility Test as an Indicator for the Efficacy of Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis of Mandibular Molars by Mohamed El Sayed, Kamis Gaballah

“…To anesthetize the affected molars, all patients received a single carpule of 2% lidocaine with 1 : 100000 epinephrine using a standardized inferior alveolar nerve block (IANB) technique. The cold test was conducted before beginning the endodontic procedures and after gaining lip numbness, and the results were reported as either positive or negative response. …”
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The Effect of a Combined Modified Pectoral and Stellate Ganglion Block on Stress and Inflammatory Response in Patients Undergoing Modified Radical Mastectomy by Jun Geng, Jing Wang, Yaowen Zhang, Wenxiang Song, Junjia Zhu, Jianqing Chen, Zhen Wu

“…Regional anaesthesia reports to attenuate stress and inflammatory responses associated with surgical resection; however, the effectiveness of combined nerve blocks is less often investigated. We evaluated whether a combination of a pectoral nerve block (PNB) and stellate ganglion block (SGB) is more effective than a PNB alone in reducing these responses in women undergoing modified radical mastectomy (MRM). …”
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EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation by Patrick Discepola, Mohamed Bouhara, Minho Kwon, Bilal A. Siddiqui, Trevor A. Whitwell, Swetha Y. Sanghvi, Keith D. Cook, Ross E. Moore, Anna Korban, Jean D. Eloy

“…We conducted a clinical case series of 4 patients using EXPAREL® for sciatic blocks via the popliteal fossa approach. Our results suggested that there is a large degree of variability in response to the medication. …”
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Evidence-Based Guideline for Neuropathic Pain Interventional Treatments: Spinal Cord Stimulation, Intravenous Infusions, Epidural Injections and Nerve Blocks by Angela Mailis, Paul Taenzer

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Effects of Forest Resource Use Conflicts on Conservation Efforts; a Case Study of Enderit Forest Block in Mau Forest Complex by Shamrock Mulei KITHIIA, Robert Kipkemoi KOECH

“…The study was carried out in Enderit forest block, Mau forest Complex. The study findings indicate that the forest block has lost considerable vegetation cover in the recent past due to resource use conflict which in turn attracted conservation efforts from various stakeholders. …”
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Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgfβ1/Smad Signaling Pathway by Quan Wang, Shuai Ni, Li Ling, Siqi Wang, Hanbin Xie, Zhanhong Ren

“…In conclusion, our data identify that GB could be a potential novel therapeutic agent to block vessel injury-associated vascular remodeling and further restenosis and show significant repression of Tgfβ1/Smad signaling pathway.…”
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Main controlling factors of production and reasonable fracturing scale optimization of deep coalbed methane wells in Shenfu block, Ordos Basin by Lichun SUN, Jia LIU, Na LI, Xinze LI, Heng WEN

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Fragile Histidine Triad (FHIT) Suppresses Proliferation and Promotes Apoptosis in Cholangiocarcinoma Cells by Blocking PI3K-Akt Pathway by Qiang Huang, Zhen Liu, Fang Xie, Chenhai Liu, Feng Shao, Cheng-lin Zhu, Sanyuan Hu

“…These results suggest that FHIT can block the PI3K-Akt-survivin pathway by suppressing the phosphorylation of Akt and the expression of survivin and Bcl-2 and upregulating caspase 3.…”
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Joint intelligent optimization design of the active region and electron blocking layer for AlGaN-based deep ultraviolet LEDs by Jinglei Wang, Huimin Lu, Jianhua Ma, Yifan Zhu, Zihua Zhang, Tongjun Yu, Xuecheng Wei, Hua Yang, Jianping Wang

“…Aiming to enhance the internal quantum efficiency (IQE) of AlGaN-based deep ultraviolet light-emitting diodes (DUV LEDs), the active region based on the V-shaped quantum well (QW) and the electron-blocking layer (EBL) structure are jointly optimized using intelligent algorithms in this work. …”
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A RANDOMIZED CONTROLLED TRIAL EXPERIENCE OF TRANSVERSEABDOMINAL PLANE (TAP) BLOCK VERSUS LOCAL ANESTHESIAINFILTRATION AT SURGICAL SITE IN OPEN APPENDICECTOMIES by Rabia Tabassum et al

“… OBJECTIVE: To know the duration of analgesia of right-sided transversus abdominis plane block versus local anaesthetic infiltration around incision site after open appendicectomy. …”
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Optimal Injection Parameters for Enhancing Coalbed Methane Recovery: A Simulation Study from the Shizhuang Block, Qinshui Basin, China by Du Liu, Longyong Shu, Yanbin Wang, Zhonggang Huo, Shihu Zhao, Xing Xiong

“…In this study, a numerical model was established based on the GEM component model to evaluate the influences of different N2 injection parameters (production injection well spacing, gas injection timing, gas injection duration, gas injection rate, and the bottom-hole injection pressure) on the production of CBM in the Shizhuang Block of Qinshui Basin, China. Based on the economic benefit of CBM production, the production increasing rate and nitrogen replacement ratio were established to optimize the N2 injection parameters. …”
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