Development of a Web-Based Intervention for Middle Managers to Enhance Resilience at the Individual, Team, and Organizational Levels in Health Care Systems: Multiphase Study by Eva Gil-Hernández, Irene Carrillo, Jimmy Martin-Delgado, Daniel García-Torres, José Joaquín Mira

“…ResultsThe tool, eResiliencia, was structured into 2 main blocks: individual and team resilience and organizational resilience. …”
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Fast Near‐Infrared Organic Photodetectors with Enhanced Detectivity by Molecular Engineering of Acceptor Materials by Wentao Zhong, Xinyuan Wang, Wei Wang, Zhulu Song, Yirong Tang, Bulin Chen, Tingbin Yang, Yongye Liang

“…By further introducing a secondary acceptor of PC61 BM, the doping compensation, and unfavored hole injection blocking enable further improvement of detectivity. …”
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A Nanoparticle Comprising the Receptor-Binding Domains of Norovirus and <i>Plasmodium</i> as a Combination Vaccine Candidate by Ming Xia, Pengwei Huang, Frank S. Vago, Wen Jiang, Xi Jiang, Ming Tan

“…Notably, sera from mice immunized with the P₂₄-αTSR NP bound strongly to <i>Plasmodium</i> sporozoites and blocked norovirus VLP attachment to their glycan receptors. …”
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Digital health interventions for improving access to primary care in India: A scoping review. by Lenny Vasanthan, Sindhu Kulandaipalayam Natarajan, Andrew Babu, Mohan S Kamath, Sureshkumar Kamalakannan

“…Virtual primary health care with the specialist in the hub supporting general physicians at the primary health centres in blocks and districts was another such model used for improving access to primary care. …”
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Effects of Sewage Sludge Compost on Carbon, Nitrogen, Phosphorus, and Sulfur Ratios and Soil Enzyme Activities in a Long-Term Experiment by Csilla Almási, Viktória Orosz, Timea Tóth, Mostafa M. Mansour, Ibolya Demeter, István Henzsel, Zsolt Bogdányi, Tamás András Szegi, Marianna Makádi

“…The plots were grouped into five blocks and treated every third year with SSC at the rates of 0, 9, 18, or 27 t ha⁻¹. …”
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ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway by Xiaofei Huang, Xiaofei Huang, Yuqun Zeng, Jingru Lin, Huazhen Liu, Huazhen Liu, Chun-Ling Liang, Chun-Ling Liang, Yuchao Chen, Yuchao Chen, Feifei Qiu, Feifei Qiu, Jonathan S. Bromberg, Zhenhua Dai, Zhenhua Dai

“…ESAT-6 also induced CD4+Foxp3+ Tregs from CD4+CD25- T cells in vitro by activating IĸBα/c-Rel signaling pathway, whereas inhibition of c-Rel signaling blocked Treg induction. Moreover, it suppressed conventional CD4+CD25- T cell proliferation in vitro in the absence of antigen-presenting cells (APCs), with an increase in IL-10 and decrease in IFN-γ production. …”
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Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model by Haoshu Fang, Chuanfeng Hua, Stefanie Weiss, Anding Liu, Wenhui Cheng, Ralf Claus, Jürgen Rödel, Olaf Dirsch, Uta Dahmen

“…The inflammatory response was decreased using various doses of the LPS-blocking peptide LBPK95A (5 mg/kg=100% Combi group, 0.5 mg/kg=10% Combi group, and 0.05 mg/kg=1% Combi group). …”
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Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC by Xiangxian Che, Xi Tian, Zhenda Wang, Shuxuan Zhu, Shiqi Ye, Yue Wang, Yihan Chen, Yiyun Huang, Aihetaimujiang Anwaier, Peifeng Yao, Yijia Chen, Keting Wu, Yifei Liu, Wenhao Xu, Hailiang Zhang, Dingwei Ye

“…Through overexpressing, silencing, and blocking ITGA5, we verified the role of ITGA5 in promoting ccRCC adverse biological activities; and the potential functions of ITGA5 in ccRCC were bioinformatically demonstrated, summarizing as cell proliferation, migration, and angiogenesis. …”
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Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice by Caroline Daems, Sophie Welsch, Hasnae Boughaleb, Juliette Vanderroost, Annie Robert, Etienne Sokal, Philippe A. Lysy

“…Empagliflozin is a SGLT2 (sodium-dependent glucose cotransporter) inhibitor which thereby blocks glucose recapture by the kidney and promotes glucose excretion in urine. …”
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Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection by Juliane Lokau, Juliane Lokau, Yvonne Garbers, Manuel M. Vicente, Anna Dittrich, Stefan Meltendorf, Holger Lingel, Anja K. Münster-Kühnel, Monika Brunner-Weinzierl, Christoph Garbers, Christoph Garbers

“…IL-6 is an effective therapeutic target in inflammatory diseases and tocilizumab, a monoclonal antibody that blocks signaling via the IL-6 receptor (IL-6R), is used to treat patients with severe COVID-19. …”
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Exogenous 2,4-Epibrassinolide Alleviates Alkaline Stress in Cucumber by Modulating Photosynthetic Performance by Wenjing Nie, Qinghai He, Jinzhao Ma, Hongen Guo, Qinghua Shi

“…Moreover, NaHCO₃ stress hindered chlorophyll synthesis, primarily by blocking the conversion from porphobilinogen (PBG) to uroporphyrinogen III (UroIII) and by increasing chlorophyllase (Chlase) and decreasing porphobilinogen deaminase (PBGD) activity. …”
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Cutting-edge Bioinformatics strategies for synthesizing Cyclotriazadisulfonamide (CADA) analogs in next-Generation HIV therapies by Jay Gabriel B. Larga, Wrynan T. Munabirul, Abu Tayab Moin, Md Maisum Sarwar Jyoti, Mst Sanjida Nasrin, Minhaz Abdullah Al Mueid, Abdul Ahad, Anwar Parvez, Mst Sabrina Yeasmin, Rupali M. Barhate, Rajesh B. Patil, Margel C. Bonifacio

“…One proposed mechanism for CADA’s inhibition of the CD4 receptor involves blocking the gates of the Sec61 channel, thereby preventing its translocation. …”
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AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease by Lulu Zhang, Yi Zheng, Mingyan Shao, Aiping Chen, Meiyi Liu, Wenlong Sun, Tianxing Li, Yini Fang, Yang Dong, Shipeng Zhao, Hui Luo, Juan Feng, Qi Wang, Lingru Li, Yanfei Zheng

“…In vitro, QGJZF inhibited the lipid deposition in PA/OA-stimulated HepG2 cells, and its effect was blocked by an autophagy inhibitor Baf-A1, which was mediated through upregulation of TFEB and its mediated autophagy-lysosomal pathway. …”
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Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways by Nami Lee, Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim

“…These three treatments also attenuated the secretion and mRNA expression of proinflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IFN-γ, and proinflammatory chemokines, such as CCL3, CCL4, CCL5, and CXCL10. All of them blocked NF-κB, JNK, and STAT1/3 phosphorylation through IKKα/β, MKK4/7, and JAK2 signalling. …”
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Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose by Yijun Zhou, Chaojun Qi, Shu Li, Xinghua Shao, Zhaohui Ni

“…HUVECs were also incubated with CaD (25 μM, 50 μM, and 100 μM) for 3 days to determine the effects of CaD on HUVEC viability. db/db mice were treated with CaD. 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) blocked the nuclear factor-κB (NF-κB) pathway in HUVECs. …”
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Effects of Dual-Site Anodal Transcranial Direct Current Stimulation on Attention, Decision-Making, and Working Memory during Sports Fatigue in Elite Soccer Athletes by Fengxue Qi, Na Zhang, Michael A. Nitsche, Longyan Yi, Yingqiu Zhang, Tian Yue

“…Net scores in the Iowa Gambling task during blocks 4 (p = 0.019) and 5 (p = 0.014) significantly decreased under dual-site tDCS targeting the DLPFC compared with the sham intervention. …”
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Comparison of the Fixation Effects of Six Composite Fixatives on Retinal Tissue of Golden Hamsters by WU Haifeng, ZHOU Xiaojiang, LI Chenjiang, LI Huaiyin, GAO Ming

“…The eye tissues of each animal were taken out to make eye cups and put into the corresponding compound fixative solution for fixation, and then taken out for paraffin embedding after 48 h. The embedded blocks were sliced using microtome, and then stained with hematoxylin and eosin (HE). …”
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Characterization of the complete genome sequence of the recombinant norovirus GII.P16/GII.4_Sydney_2012 revealed in Russia by E. V. Zhirakovskaia, A. Y. Tikunov, S. N. Sokolov, B. I. Kravchuk, E. I. Krasnova, N. V. Tikunova

“…A functional significance of these changes suggests that a wide distribution of the strains with the novel GII.P16 polymerase may be associated both with several amino acid substitutions in the polymerase active center and with the insertion of glutamic acid or glycine in an N-terminal p48 protein that blocks the secretory immunity of intestinal epithelial cells. …”
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Evolution and effectiveness of bilateral and multilateral development assistance for health: a mixed-methods review of trends and strategic shifts (1990–2022) by Yan Luo, Ying Chen, Beibei Yuan, Ming Xu, Shuduo Zhou, Zhijie Zheng, Siwei Xie, Sijin Du, Yuxin Huang

“…Qualitative data were analysed through thematic synthesis based on the WHO’s six health system building blocks.Results The DAH has predominantly focused on HIV/AIDS and maternal and child health. …”
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Inhibition of p70 Ribosomal S6K1 Protects the Myocardium against Ischemia/Reperfusion-Induced Necrosis through Downregulation of RIP3 by Hui Shang, Jinjin Shi, Jun Zhu, Yunfeng Guo, Xiaoyan Wang

“…In addition, RIP3 is a direct target of S6K1, and activation of RIP3 blocked the protective effect of the S6K1 inhibitor PF-4708671 against myocardial I/R injury (p < 0.05). …”
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