Deep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii by Aleksandra Maria Kocot, Tomasz Swebocki, Karolina Ciemińska, Adrianna Łupkowska, Małgorzata Kapusta, Dennis Grimon, Ewa Laskowska, Anna-Karina Kaczorowska, Tadeusz Kaczorowski, Rabah Boukherroub, Yves Briers, Magdalena Plotka

“…Abstract In this study, we evaluated the combined effect between MLE-15, a modular lytic enzyme composed of four building blocks, and reline, a natural deep eutectic solvent. …”
Get full text

Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression by Tongjiang Xu, Xiaodong Zhai, RuiWei Wang, Xiaoben Wu, ZhiZhen Zhou, MiaoMiao Shang, Chongcheng Wang, Tengfei Qi, Wei Yang

“…Further investigation demonstrated that PI stimulation increased the expression of PITPNM1, POU1F1, C2orf15 and LDHA as well as the phosphorylation of AKT and ERK, and promoted the proliferation, migration and invasion of GH3 cells, which were blocked by PITPNM1knockdown. Inhibiting AKT phosphorylation reduced the expression of POU1F1, C2orf15 and LDHA in PI-stimulated cells while activating AKT increased their expression in PITPNM1-silencing cells, which was similar to the function of ERK. …”
Get full text

Dye-based fluorescent organic nanoparticles made from polar and polarizable chromophores for bioimaging purposes: a bottom-up approach by Daniel, Jonathan, Dal Pra, Ophélie, Kurek, Eleonore, Grazon, Chloé, Blanchard-Desce, Mireille

“…Our strategy is based on the design and synthesis of custom-designed (multi)polar and polarizable dyes (PPDs) as building blocks of dFONs. These nanoparticles are readily prepared using expeditious and green protocols involving nanoprecipitation of the hydrophobic dyes in water. …”
Get full text

Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study by Serena Tagliente, Brigida Minafra, Simona Aresta, Simona Aresta, Paola Santacesaria, Andrea Buccoliero, Cinzia Palmirotta, Gianvito Lagravinese, Davide Mongelli, Christian Gelao, Luigi Macchitella, Stefania Pazzi, Domenico Scrutinio, Paola Baiardi, Petronilla Battista

“…All participants completed both the Neurotablet intervention and Standard Care blocks in a randomized order. After a Shapiro-Wilk test, non-parametric repeated measures analyses of variance (Friedman's test) and post-hoc comparisons corrected with the Benjamini-Hochberg approach were performed to compare the effects on primary and secondary cognitive outcomes over experimental intervention and Standard Care.ResultsThe results from the Friedman analysis revealed significant improvements in Word List Immediate Recall, Digit Span Forward and Complex Figure Recall (all p < 0.001) following the HB-CCT, compared to the Baseline. …”
Get full text

Enhanced Control Efficacy of Different Insecticides Mixed with Mineral Oil Against Asian Citrus Psyllid, <i>Diaphorina citri</i> Kuwayama, Under Varying Climates by Wei Hu, Kejing Wang, Xiaoyue Zhong, Pei Jiang, Shunchang Zhang, Zhanjun Lu, Zhixiang Zhang, Long Yi, Ning Zhang

“…LY at a rate of 1.0% exhibited excellent efficacy against ACP nymphs, and observations using scanning electron microscopy (SEM) showed that LY altered ACP mouthpart morphology and blocked spiracles, likely contributing to its insecticidal effects. …”
Get full text

Impaired Fibrinolysis in Angiographically Documented Coronary Artery Disease by Adriano Basques Fernandes, Luciana Moreira Lima, Marinez Oliveira Sousa, Vicente de Paulo Coelho Toledo, Rashid Saeed Kazmi, Bashir Abdulgader Lwaleed, Maria das Graças Carvalho

“…A novel regulator of fibrinolytic activity, thrombin activatable fibrinolysis inhibitor (TAFI), has attracted attention in recent years. It acts by blocking the formation of a ternary complex of plasminogen, fibrin, and tissue plasminogen activator (t-PA). …”
Get full text

Impact of pathogenic mutations of the GLUT1 glucose transporter on solute carrier dynamics using ComDYN enhanced sampling [version 2; peer review: 2 approved, 1 approved with reser... by K. Anton Feenstra, Akiko Higuchi, Kei Yura, Sanne Abeln, Halima Mouhib

“…Our results clearly indicate that the pathogenic mutation in GLUT1, G91D, situated at the highly conserved RXGRR motif between helices 2 and 3, has a strong impact on transporter function, as it blocks the protein from sampling both conformational states. …”
Get full text

Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer by Pankaj Ahluwalia, Ashis K. Mondal, Ashutosh Vashisht, Harmanpreet Singh, Ahmet Alptekin, Kalyani Ballur, Nivin Omar, Meenakshi Ahluwalia, Kimya Jones, Amanda Barrett, Vamsi Kota, Ravindra Kolhe

“…Method In this retrospective study, we used FFPE blocks of tissue samples from CRC patients at Augusta University (AU) to quantify a custom 15-gene panel. …”
Get full text

HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis by Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike

“…Interestingly, CR not only suppressed age-related declines in cardiac function and mitochondrial biogenesis but blocked concomitant increases in cardiac HINT1 protein levels and maintained Tfam transcription. …”
Get full text

Transcanalicular laser-assisted and external dacryocystorhinostomy anatomical and functional success in primary acquired nasolacrimal duct obstruction: systematic review and meta-a... by Khalid W. Helmi, Ahmed S. Abdulhamid, Mohammed S. Alomari, Ali S. Alsudais, Badran S. Alqurashi, Abdullah Alsharif, Abdulrahman H. Alzahrani, Abdulrahman M. Bahalaq, Mohammed F. Qutub, Hashem S. Almarzouki

“…Abstract Background Primary acquired nasolacrimal duct obstruction (PANDO) is a condition in which tear ducts are blocked, leading to epiphora and dacryocystitis. This systematic review and meta-analysis aimed to measure the ability of transcanalicular dacryocystorhinostomy (TC-DCR) as an alternative approach to PANDO compared to traditional external dacryocystorhinostomy (EX-DCR). …”
Get full text

Beclin-1 as a potential prognostic marker in correlation with E-cadherin in oral lichen planus and oral squamous cell carcinoma: an immunohistochemical analysis by Heba N. Shalash, Radwa R. Hussein, Fatma Seragel-Deen

“…Sixty formalin-fixed paraffin-embedded tissue blocks, along with their clinicopathologic records, were retrieved from the archives of the Department of Oral Pathology, Faculty of Dentistry, Ain Shams University, Egypt. …”
Get full text

CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells by You-Yu Liu, Wei-Lun Huang, Sin-Tian Wang, Hui-Ping Hsu, Tzu-Ching Kao, Wei-Pang Chung, Kung-Chia Young

“…CD36 was upregulated by blocking the PI3K signal pathway or limited serum supplementation, indicating that suppressing CD36 may decrease the excess transport of exogenous FA. …”
Get full text

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Han... by Chunlai Feng, Jiaxi Cheng, Mengqiu Sun, Chunxue Qiao, Qiuqi Feng, Naying Fang, Yingying Ge, Mengjie Rui

“…The bioinformatics analysis revealed that these compounds could regulate tumor-related pathways synergistically, inhibiting tumor cell growth, inducing cell apoptosis, and blocking cell cycle progression. Furthermore, the concentration ratio and total content of compounds in F973 and T271 were closely associated with their anti-breast cancer effects in extracts from various geographical origins. …”
Get full text

Analysis of the terms of development of infectious complications in patients after osteosynthesis of long bones by P.V. Tanasienko, H.B. Kolov, V.M. Tsokalo

“…The second group included 59 patients who developed infectious complications after osteosynthesis of long bones with a blocking intramedullary rod. In 51.5% of patients of the first group after closed fractures, infectious complications were detected in the first 6 weeks after surgery. …”
Get full text

Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-&kappa;B Pathway by Shi Y, Tang Y, Sun Z, Sui P, Shao Y, Wang Z, Zhang J, Gao M

“…Furthermore, SCU was revealed to suppress OS cell proliferation by targeting TLR4 in vitro and in vivo.Conclusion: SCU exhibited a dual impact by inhibiting TLR4 expression and disrupting TLR4–TRAF6 interaction, resulting in NF-κB inactivation, thereby blocking OS growth. Keywords: scutellarein, osteosarcoma, TLR4, NF-κB pathway, molecular modeling…”
Get full text

Environmental microbial communications in gram-positive and gram-negative bacteria by P. Srikanth, D. Sivakumar, J. Nouri

“…The larger part of quorum sensing recognizing inhibitor takes bacterial quorum sensing share identifying as the even-handed and simply blocks the larger part recognizing plan of pathogenic organisms, which can demolish the pathogenicity of microorganisms without applying explicit squeezing factor, and doesn't execute the regular organisms or then again intrude with their standard physiological activities. …”
Get full text

Role of Vigilin and RACK1 in dengue virus-Aedes aegypti-Wolbachia interactions by Guijie Wang, Mazhar Hussain, Zhi Qi, Sassan Asgari

“…Furthermore, we found that both genes are induced in mosquito cells transinfected with Wolbachia, a bacterium that blocks DENV replication. The results help better understand the role of the common factors supporting DENV replication in mosquitoes and human cells.…”
Get full text

No easy way out: towards a framework concept of long-term governance by Dirk Scheer, Sandra Venghaus, Stefania Sardo, Sascha Stark, Sophie Kuppler, Michael W. Schmidt, Carsten Hoyer-Klick

“…Main text We elaborate an analytical framework for long-term governance (LTG), based on five building blocks: the ‘environment’, which details the policy-making arena; the ‘policy issues’, which elaborates on the problems to be dealt with by LTG; the ‘key challenges and driving force’, revealing LTG mechanisms; the ‘key strategies’, in which promising approaches for LTG are identified; and the ‘policy cycle’, where governance impacts on different policy phases are discussed. …”
Get full text

Effects of ruminal short-chain fatty acid concentration and pH on histology, hematology, and inflammation in cannulated Holstein dairy calves by A.R. Wolfe, M.H.P.M. Narciso, R.R.E. Uwiera, A.H. Laarman

“…Holstein calves (n = 32) had the rumen cannulated within the first week of life and at wk 2 were blocked by BW and randomly assigned in a 2 × 2 factorial arrangement of treatments. …”
Get full text

Effect of E-learning clinical management of substance-dependent pregnant women on the knowledge and clinical skill performance of midwives: a randomized controlled trial by Hasti Heidarian, Manoosh Mehrabi, Parvin Ghaemmaghami, Roksana Janghorban

“…One hundred midwives working in governmental maternity hospitals were recruited and randomly assigned to the intervention (n = 50) or control (n = 50) group through blocked randomization. The intervention group underwent e-learning for 4 weeks on clinical considerations during labor and post-partum of substance-dependent mothers. …”
Get full text