Availability and accessibility of cytotoxic medicines in the WHO model list of essential medicines for childhood cancer in low and lower-middle- income countries: a systematic revi... by Maheeka Seneviwickrama, Sashini Shehana Denagamagei, Surangi Jayakody, Sanjeeva Gunasekera, Guwani Liyanage

“…Enablers and barriers were discussed based on the World Health Organization (WHO) health system building blocks. Results Out of the 29 articles retrieved for full-text screening, the final synthesis included nine articles. …”
Get full text

IMPACT OF THE COVID-19 PANDEMIC AND MARTIAL LAW ON THE SATISFACTION OF THE LVIV REGION RESIDENTS WITH THE DIAGNOSTIC RADIOLOGY SERVICE (BASED ON THE RESULTS OF A SOCIOLOGICAL SURVE... by Galyna Shcherbata, Oksana Kovalska

“…It is necessary to focus the attention of heads of medical institutions on the specified blocks of issues since most of them require an organizational solution and do not require additional funding.…”
Get full text

Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3+CD8+CD56+ Natural Killer T Population in Women with Recurrent Spontaneous Abortion by Fatemeh Rezayat, Nafiseh Esmaeil, Abbas Rezaei, Roya Sherkat

“…Conclusion: The lower capability of LIT in changing the population of NKT cells compared to prednisolone therapy may be due to its mechanism of action, which is related to the production of blocking antibodies. These treatment approaches had different effects on NKT cells, indicating that NKT cell population and function can be affected using LIT and prednisolone therapy distinctly. …”
Get full text

Effectiveness of Fewer Falls, an online group-based self-management fall prevention programme for people with multiple sclerosis: protocol of a randomised controlled trial by Maria Flink, Charlotte Ytterberg, Kristina Gottberg, Marie Kierkegaard, Susanna Tuvemo Johnson, Elizabeth Walker Peterson, Ulrika Meijer, Johanna Bylinder

“…We aim to recruit 240 PwMS, who will be stratified by ambulation level and randomised 1:1 in blocks of eight to intervention or control. The group-based self-management fall prevention intervention involves eight 2-hour online synchronous sessions (approximately eight participants/group) facilitated by a licensed healthcare professional and home assignments to be completed by participants between sessions. …”
Get full text

Inhibition and evasion of neutrophil microbicidal responses by Legionella longbeachae by Hannah E. Hanford, Christopher T. D. Price, Silvia Uriarte, Yousef Abu Kwaik

“…By inhibiting of assembly of the phagocyte NADPH oxidase complex, the pathogen blocks neutrophils from generating microbicide reactive oxygen species. …”
Get full text

Collagen-1 and elastin expression in cervical tissue: A comparison across cervical elongation, pelvic organ prolapse, and combined conditions by Anis Widyasari, Gatut Hardianto, Etty Hari Kusumastuti, Eighty Mardiyan Kurniawati

“…Materials and Methods: An analytical study with a cross-sectional design was conducted, using immunohistochemistry (IHC) to analyze cervical tissue samples preserved in paraffin blocks. Patient groups included those diagnosed with CE, POP, CE combined with POP, and a control group without CE or POP. …”
Get full text

Efficacy of Simple Eye Ointment, Polyethylene Cover, and Eyelid Taping in Prevention of Ocular Surface Disorders in Critically Ill Patients: A Randomized Clinical Trial by Mehdi Ahmadinejad, Esmat Karbasi, Yunes Jahani, Maryam Ahmadipour, Maryam Soltaninejad, Zahra Karzari

“…However, patients admitted to the intensive care unit (ICU) for several reasons including loss of consciousness, receiving sedative and neuromuscular blocking agents, and mechanical ventilation may lose eye-protective mechanisms causing exposure keratopathy. …”
Get full text

Loss of phosphatase and tensin homolog (PTEN) increases Lysyl oxidase-like 2 (LOXL2) expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroi... by Angela Russo, Junlone Moy, Manead Khin, Timothy R. Dorsey, Alfredo Lopez Carrero, Joanna E. Burdette

“…Conclusions: These results reveal for the first time that PTEN loss in FTE cells increases LOXL2 expression through downregulation of Pax2, and LOXL2 deletion blocks 3D spheroid formation.…”
Get full text

Impact of cooling diabetic patients’ fingertips compared to vibrating stimulation on pain from the glucometer needle: A cross-over trial study by Vahid Vejdanihemmat, Hiva Azami, Leili Tapak, Shiva Borzouei, khodayar Oshvandi

“…The study design consisted of six blocks, each containing three interventions: vibration stimulation (A), cold therapy (B), and a combination of both C. …”
Get full text

Bank Credit and Loan Repayment During Covid-19 In Kabale District: A Case of Lyamujungu SACCO. by Byamukama, Dicky

“…Finally, results on the third objective indicated that quarantine and social distancing which blocked financial opportunities (M=4.78, SD=.418), consequences that drove SACCO members into loan repayment failure (M=4.70, SD=.459) and loss of savings leading to absolute poverty (M=4.56, SD=.600) were the major factors that determined the borrower’s credit on loan repayment during Covid-19 pandemic. …”
Get full text

Impact of circulating lymphoma cells at diagnosis on outcomes in patients with newly diagnosed de novo diffuse large B-cell lymphoma by Sayan Mullick Chowdhury, Subodh Bhatta, Timothy J. Voorhees, Kaitlin Annunzio, David A. Bond, Yazeed Sawalha, Audrey Sigmund, Walter Hanel, Lalit Sehgal, Lapo Alinari, Robert Baiocchi, Kami Maddocks, Beth Christian, Dan Jones, Narendranath Epperla

Get full text

A sweeping view of avian mycoplasmas biology drawn from comparative genomic analyses by Elhem Yacoub, Vincent Baby, Pascal Sirand-Pugnet, Yonathan Arfi, Helmi Mardassi, Alain Blanchard, Salim Chibani, Boutheina Ben Abdelmoumen Mardassi

“…Virulence determinants survey showed that the involved gene arsenals vary significantly within and between species, and could even be found in species often reported apathogenic. Immunoglobulin-blocking proteins were detected in almost all avian mycoplasmas. …”
Get full text

Grouting Mechanism in Water-Bearing Fractured Rock Based on Two-Phase Flow by Bo Ren, Wenqiang Mu, Bingyou Jiang, Guofeng Yu, Lianchong Li, Tingshuang Wei, Yunchun Han, Diancai Xiao

“…Based on the two-phase flow diffusion theory, a slurry diffusion model considering flowing water condition was established for a blocking area of a fracture zone in one case from China. …”
Get full text

Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…Formation of abnormal blood vessels increases area of hypoxia which recruits suppressor cells, blocks tumor infiltration by CD8+ T lymphocytes, inhibits efficacy of chemoterapeutic drug and leads to cancer relapse. …”
Get full text

β-receptor blocker enhances anti-tumor immunity via inhibiting lactate-induced norepinephrine metabolism of macrophages during malignant pleural effusion by Ru Zhang, Weijia Wang, Aitian Li, Huishang Wang, Xiaoyan Liu, Feifei Fan, Ying Wang, Huanyu Zhang, Jingxia Chang, Yinyin Zhang, Hongmin Wang, Lijun Miao, Bo Huang, Li Yang, Li Yang, Li Yang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang

“…Our findings highlight that blocking norepinephrine signaling by β-receptor blockers is an attractive therapeutic strategy to enhance anti-tumor immunity in the context of MPE…”
Get full text

Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve by Yuanyuan Li, Ruoyao Xu, Muyan Chen, Kaige Zheng, Huimin Nie, Chengyu Yin, Boyu Liu, Yan Tai, Junying Du, Jie Wang, Jianqiao Fang, Boyi Liu

“…EA reduced CCL2 overproduction by DRG neurons and reduced macrophage infiltration. Blocking CCR2 mimicked EA’s anti-allodynic effect, whereas exogenously applying recombinant CCL2 reversed the ameliorative effect of EA on macrophage infiltration and abolished EA’s anti-allodynia on model mice. …”
Get full text

Preoperative Education is Associated with Adherence to Downstream Components and Outcomes in a Colorectal Surgery Enhanced Recovery Program by Bayley A. Jones, MD, Joshua Richman, MD, PhD, Michael Rubyan, PhD, MPH, Lauren Wood, MSPH, Alfonsus Adrian H. Harsono, MD, MSPH, Wendelyn Oslock, MD, MBA, Nathan English, MBChB, Burkely P. Smith, MD, Robert Hollis, MD, MSPH, Larry R. Hearld, PhD, Isabel Scarinci, PhD, MPH, Daniel I. Chu, MD, MSPH

“…On adjusted analysis, patients who received preoperative education (n = 877, 88%) had higher adherence rates for the following ERP components: no prolonged fasting (estimate = +19.6%; P < 0.001), preoperative blocks (+8.0%; P = 0.02), preoperative multimodal analgesia (+18.0%; P < 0.001), early regular diet (+15.9%; P < 0.001), and postoperative multimodal analgesia (+6.4%; P < 0.001). …”
Get full text

Yorkshire Enhanced Stop Smoking (YESS) study: a protocol for a randomised controlled trial to evaluate the effect of adding a personalised smoking cessation intervention to a lung... by Richard D Neal, David Baldwin, Sarah Lewis, John Britton, Rachael L Murray, Qi Wu, Kate Brain, Samantha L Quaife, Matthew EJ Callister, Philip A J Crosbie, Harriet D Quinn-Scoggins, Grace M McCutchan, Alex Ashurst, Suzanne Rogerson, Rebecca Thorley

“…Eligible smokers will be randomised (1:1 in permuted blocks of random size up to size 6) to receive either an enhanced, personalised SC support package, including CT scan images, or continued standard best practice. …”
Get full text

RvXmBlendNet: A Multi-architecture Hybrid Model for Improved Skin Cancer Detection by Farida Siddiqi Prity, Ahmed Jabid Hasan, Md Mehedi Hassan Anik, Rakib Hossain, Md. Maruf Hossain, Sazzad Hossain Bhuiyan, Md. Ariful Islam, Md Tousif Hasan Lavlu

“…The integration of these models is achieved through a synergistic combination of architectures, incorporating self-attention mechanisms using attention layers and adaptive content blocks. This study used the HAM10000 dataset to refine dermoscopic image preprocessing and enhance deep learning model accuracy. …”
Get full text

Transcriptome integration analysis revealed that miR-103-3p regulates goat myoblast proliferation by targeting FGF18 by Kunyu Li, Yize Song, Yekai Fan, Hui Zhang, Mingxing Chu, Yufang Liu

“…Abstract Background Myoblasts serve as the fundamental building blocks of muscle fibers, and there is a positive correlation between the diameter of myofibers during the juvenile phase and the rate of muscle growth, which does not change in adulthood. …”
Get full text