Efficacy of tezepelumab in patients with severe asthma and persistent airflow obstruction by Elliot Israel, Mario Castro, Christopher S. Ambrose, Jean-Pierre Llanos, Nestor A. Molfino, Nicole L. Martin, Sandhia S. Ponnarambil, Neil Martin

“…Background Persistent airflow obstruction (PAO) in patients with asthma can be difficult to treat. Tezepelumab blocks thymic stromal lymphopoietin, an epithelial cytokine implicated in asthma pathogenesis. …”
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Genome-wide association analysis and KASP markers development for protein quality traits in winter wheat by Yousheng Tian, Pengpeng Liu, Dezhen Kong, Yingbin Nie, Hongjun Xu, Xinnian Han, Wei Sang, Weihua Li

“…Haplotype analysis of loci associated with the gluten index in the 412–416 Mb interval on chromosome 1D identified three blocks. Accessions with superior haplotypes showed a significantly higher gluten index than those with inferior haplotypes. …”
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Dissolution of Different Reservoir Rocks by Organic Acids in Laboratory Simulations: Implications for the Effect of Alteration on Deep Reservoirs by Jian Chen, Jie Xu, Susu Wang, Zhenyu Sun, Zhong Li, Wanglu Jia, Ping’an Peng

“…Both carbonate samples showed the development of large voids, including holes and cavities of micrometer scale, but nanopores of various sizes were blocked. In contrast, lithic arkose was heterogeneously altered, losing a weight proportion of about 13% by dissolution of calcite cement. …”
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Bradykinin B1 receptor signaling triggers complement activation on endothelial cells by Ingrid Lopatko Fagerström, Alexandra Gerogianni, Markus Wendler, Ida Arvidsson, Ashmita Tontanahal, Ann-Charlotte Kristoffersson, Fatimunnisa Qadri, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Diana Karpman

“…B1/B2 receptor double knock-out mice exhibited less C3 and C5b-9 deposition in glomeruli compared to wild-type mice.ConclusionThis study demonstrates that KKS activation contributes to complement activation on the endothelium by B1R signaling. Blocking the B1R may have a role in reducing complement deposition and its effects on the endothelium.…”
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Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis by Xiao Fei, Sihai Chen, Leyan Li, Xinbo Xu, Huan Wang, Huajing Ke, Cong He, Chuan Xie, Xidong Wu, Jianping Liu, Yong Xie, Nonghua Lu, Yin Zhu, Nianshuang Li

“…Furthermore, NLRP3 inflammasome activation upon TNFα, or H. pylori stimulation, was partially blocked by TNFα/TNFR1 signaling inhibitors. Deletion of TNFR1 in BMDMs significantly impaired NLRP3 inflammasome activation and M1 macrophages induced by H. pylori. …”
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GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis by Wen-Ke Wang, Hui-Yu Lin, Che-Hsuan Lin, Hsun-Hua Lee, Yen-Lin Chen, Yu-Hsien Kent Lin, Hui-Wen Chiu, Shry-Ming Sheen-Chen, Yuan-Feng Lin

“…Accordingly, the pharmaceutical inhibition of GRK6 kinase activity dramatically suppressed the activation of β-Arrestin 2, MAPKs and NF-κB and the cellular migration ability of highly metastatic MDA-MB231 cells. Sequentially blocking the β-Arrestin 2/MAPKs/NF-κB axis with their inhibitors predominantly mitigated the GRK6-promoted migration ability of poorly metastatic HCC1937 cells. …”
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Pretreatment with AM1241 Enhances the Analgesic Effect of Intrathecally Administrated Mesenchymal Stem Cells by Junran Xie, Jinxuan Ren, Na Liu, Chengwei Wu, Dongju Xiao, Huanyu Luo, Jingxian Du

“…In addition, i.t. injection of exogenous TGF-β1 slightly alleviated neuropathic pain whilst neutralization of TGF-β1 potently blocked the effect of AM1241-treated mesenchymal stem cells on thermal hyperalgesia and mechanical allodynia of CCI mice. …”
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Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB by José Roberto Macías-Pérez, Bruno Jesús Vázquez-López, Martin Humberto Muñoz-Ortega, Liseth Rubí Aldaba-Muruato, Sandra Luz Martínez-Hernández, Esperanza Sánchez-Alemán, Javier Ventura-Juárez

“…Therefore, in the present work, the capacity of doxazosin (α1 antagonist), carvedilol (nonselective beta-adrenoceptor blocker with alpha 1-blocking properties), and curcumin (antioxidant and anti-inflammatory compound) to reverse liver cirrhosis and studying the possible modulation of Nrf-2 and NF-κB were evaluated. …”
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Fracture resistance and marginal fit of three different overlay designs using advanced zirconia-reinforced lithium disilicate CAD/CAM material by Heidi Saad Refaey, Sanaa H. Abdelkader, Yasser M. Aly

“…Aim of the study This study investigated the impact of three distinct overlay preparation designs on the marginal fit (both before and after thermal aging) and the fracture resistance of overlay restorations fabricated using advanced zirconia-reinforced lithium disilicate (ALD) CAD/CAM glass-ceramic blocks. Materials and methods Using a standardized preparation protocol, three typodont molars were prepared to receive three different indirect overlay ceramic restoration designs. …”
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Facial expression recognition through muscle synergies and estimation of facial keypoint displacements through a skin-musculoskeletal model using facial sEMG signals by Lun Shu, Victor R. Barradas, Zixuan Qin, Yasuharu Koike

“…Muscle synergies are groups of muscles that show coordinated patterns of activity, as measured by their sEMG signals, and are hypothesized to form the building blocks of human motor control. We then trained two classifiers for the facial expressions based on extracted features from the sEMG signals and the synergy activation coefficients of the extracted muscle synergies, respectively. …”
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Long-Term Safety and Effectiveness of Canakinumab in Patients with MKD/HIDS: Interim Analysis of the RELIANCE Registry by Prasad T. Oommen, Tilmann Kallinich, Juergen Rech, Norbert Blank, Julia Weber-Arden, Jasmin B. Kuemmerle-Deschner

“…Conclusion Data from this interim analysis of a unique registry of patients with a rare disease support the long-term safety and effectiveness of the IL-1-blocking agent canakinumab for the treatment of MKD/HIDS.…”
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Optimization of Development Strategies and Injection-Production Parameters in a Fractured-Vuggy Carbonate Reservoir by Considering the Effect of Karst Patterns: Taking C Oilfield i... by Mengqin Li, Qi Wang, Chao Yao, Fangfang Chen, Qinghong Wang, Jing Zhang

“…In the northern facing karst fractured-vuggy units, there are two main types of remaining oil: well-spacing type and local-blocking type, and the reasonable development strategies are affected by reservoir morphology and the connectivity of structure patterns. …”
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RESULTS OF EXPEDITIONS CARRIED OUT BY KRYMSK EXPERIMENT BREEDING STATION OF VIR TO COLLECT WILD AND RUN-WILD FRUIT AND BERRY PLANTS IN SOUTHERN REGIONS OF RUSSIA by G. V. Eremin, V. N. Podorozhnyi

“…In particular, the Republic of Crimea, especially its steppe zone, has been experiencing a real ecological disaster since 2016 because of water deficiency due to the drying up of the North-Crimean Canal after it has been blocked by Ukraine. All this makes it urgent to search for and collect wild and run-wild plant species in their natural habitats, and con­serve them in controlled conditions at VIR’s branches.  …”
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Factors affecting arteriovenous access patency after percutaneous transluminal angioplasty in chronic haemodialysis patients under vascular access monitoring and surveillance: a si... by Chung-Kuan Wu, Der-Cherng Tarng, Chia-Hsun Lin, Jyh-Gang Leu, Chih-Yu Yang

“…Significant between-group differences were observed for β-adrenergic blocking agents (with PTA, 49.8%; without PTA, 37.5%; p, 0.007) and ADP inhibitors (with PTA, 23.8%; without PTA, 11.2%; p<0.001). …”
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A Low Dose of Naloxone Added to Ropivacaine Prolongs Femoral Nerve Blockade: A Randomized Clinical Trial by Seung Cheol Lee, Jeong Ho Kim, So Ron Choi, Sang Yoong Park

“…Femoral nerve blocks (FNBs) are used as safe and useful procedures to control severe postoperative pain from total knee arthroplasty (TKA). …”
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Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice by Hiroki Goto, Aiko Inoue, Limei Piao, Lina Hu, Zhe Huang, Xiangkun Meng, Yusuke Suzuki, Hiroyuki Umegaki, Masafumi Kuzuya, Xian Wu Cheng

“…An enzyme-linked immunosorbent assay revealed that rPLF-1 suppressed the levels of plasma tumor necrosis factor-α and interleukin-1β in CTX mice. PLF-1 blocking accelerated CTX-related muscle damage and dysfunction. …”
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Hybrid Carbohydrate–Lipid Nanocarriers: In Vitro Efficacy Gene-Rated by Association of UV-Absorbers and Raspberry Polyphenols Rich-Fraction by Nicoleta Badea, Diego Samayoa, Alina Moroşan, Cristina Ott, Ioana Lacatusu

“…To establish the performance profile of antioxidant activity, release of active substances, sun blocking action, and photostability, in vitro studies were conducted. …”
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Numerical Analysis on Sliding-Type Transverse Splicing Connection Applied in Widening Continuous Concrete Box-Girder Bridge by Wenqing Wu, Chong Cao, Yuqin Wu, Jiyang Liu, Dan Liu, Liang Chen, Zheng Liu

“…When traditional joint structures are used to widen multi-span continuous concrete box girder bridges, excessive lateral deformation often occurs at the girder ends, typically leading to the squeezing and cracking of seismic blocks by the girder webs. To address these technical challenges, this paper investigates a new type of slide-rail lateral joint structure that can create a longitudinal sliding effect between two bridge decks of the old and new bridge box girders, thereby effectively reducing the lateral deformation at the girder ends. …”
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Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells by S. González-Ochoa, M. C. Tellez-Bañuelos, A. S. Méndez-Clemente, A. Bravo-Cuellar, G. Hernández Flores, L. A. Palafox-Mariscal, J. Haramati, E. J. Pedraza-Brindis, K. Sánchez-Reyes, P. C. Ortiz-Lazareno

“…Finally, the disruption of the IL6R/STAT-3 axis in prostate cancer cells and the blocking of TIGIT on NK-92 were observed to increase the cytotoxicity of NK-92 cells against DU145 cells through an increase in sFasL, granzyme A, granzyme B, and granulysin. …”
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Sustainability of Mahogany Production in Plantations: Does Resource Availability Influence Susceptibility of Young Mahogany Plantation Stands to Hypsipyla robusta Infestation? by C. B. Darko, E. Opuni-Frimpong, S. A. Owusu, B. Kyere, A. J. Storer

“…H. robusta attacks were recorded by month 12 after planting in the field, and only Khaya spp. was attacked, with attacks evident on 15.5% of K grandifoliola and 6.6% K. ivorensis. Saplings in blocks closer to an older H. robusta infested K. grandifoliola stand had more infestation compared to saplings further away. …”
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