PortNet: Achieving lightweight architecture and high accuracy in lung cancer cell classification by Kaikai Zhao, Youjiao Si, Liangchao Sun, Xiangjiao Meng

“…We incorporated 1 × 1 convolutional blocks into the Depthwise Separable Convolution architecture to further decrease the model's parameter count. …”
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Multi-institutional evaluation comparing guidance from International Ki67 Working Group vs National Health Commission of China on immunohistochemistry-based Ki67 assessment alongsi... by Yin Wang, Jiarui Zou, Qinghua Cao, Guihong Dai, Panhong Fan, Xue Gong, Jinyan Jiang, Yanqing Kong, Chao Liu, Chunhui Liu, Chenjia Lu, Meiren Li, Zhiqiang Lang, Yang Lin, Yan Peng, Haiyan Shi, Yuhuan Wang, Jiu Wang, Bichen Xie, Bing Yang, Guohua Yu, Cuiping Zhang, Hengming Zhang, Luting Zhou, Zilan Zhang, Zhenli Zhu, Junmei Hao

“…They were evaluated in this multi-institutional study alongside the results from the Quantitative Dot Blot (QDB) method.MethodsThree alternative adjacent sections from 40 primary ER+ breast cancer resection blocks were randomly assigned a number from 1 to 120 for Ki67 staining and reviewed by 21 pathologists, while the other three alternative sections were sent for QDB analysis of Ki67 protein levels. …”
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Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension by Xiao‐ting Tian, Zhou‐yang‐fan Peng, Yu‐si Wu, Yuan‐yuan Cao, Xue‐chun Li, Ying Li, Si‐Yuan Tang, Alex F. Chen, Xiao‐hui Li

“…Knockout of NLRP3 or short hairpin RNA interference of GSDME in animal models can alleviate the development of pyroptosis, accompanied with improved endothelial integrity, vascular remodeling, and right ventricular systolic pressure. Blocking BMPR2 is sufficient to induce NLRP3 upregulation and release of inflammatory factor IL‐1β (interleukin‐1β) in pulmonary arterial endothelial cells. …”
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Towards Better Perovskite Absorber Materials: Cu+ Doping Improves Photostability and Radiation Hardness of Complex Lead Halides by Marina I. Ustinova, Maxim N. Sarychev, Nikita A. Emelianov, Yiqun Li, Yuling Zhuo, Tongjun Zheng, Sergey D. Babenko, Evgeniy D. Tarasov, Pavel P. Kushch, Nadezhda N. Dremova, Galina A. Kichigina, Alexandra V. Rasmetyeva, Andrey I. Kukharenko, Dmitry P. Kiryukhin, Ernst Z. Kurmaev, Xueqing Xu, Pavel A. Troshin, Lyubov A. Frolova, Ivan S. Zhidkov

“…Importantly, the presence of Cu+ enhances photostability of perovskite films and blocks the formation of metallic lead as a photolysis product. …”
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Use of a wearable device to improve sleep quality by Susan L. Moore, Susan L. Moore, Evan P. Carey, Kristyna Finikiotis, Kelsey L. Ford, Richard D. Zane, Richard D. Zane, Katherine K. Green

“…Among the subjective secondary outcomes, 100% of participants felt the device blocked environmental noise, 86% reported falling asleep more easily, 76% felt they stayed asleep longer, and 82% felt overall sleep quality was improved. …”
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Modeling of peatland fire risk early warning based on water dynamics by B. Kartiwa, . Maswar, A. Dariah, . Suratman, N.L. Nurida, N. Heryani, P. Rejekiningrum, H. Sosiawan, S.H. Adi, I. Lenin, S. Nurzakiah, Ch. Tafakresnanto

“…Herein, the observed parameters were climate and dynamics of ground water level and soil moisture, which were monitored using data loggers installed on predefined representative locations and distributed over three blocks of 30 hectares in the palm oil plantation research site. …”
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End-to-End Security Mechanism Using Blockchain for Industrial Internet of Things by Muhammad Shahid Dildar, Adnan Shahid Khan, Irshad Ahmed Abbasi, Reema Shaheen Naseem Akhtar, Khalil Al Ruqaishi, Shakeel Ahmed Ghulam Sarwar

“…Moreover, our algorithm for the blockchain implementation is hybrid because this approach incorporates all the best features of the private and public implementation due to the individual blocks containing feasible information rather than the entire history.…”
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Influence of Mine Earthquake Disturbance on the Principal Stress of the Main Roadway near the Goaf and Its Prevention and Control Measures by Penghui Guo, Jiazhuo Li, Xiqing Hao, Heng Cui, Lihua Tian, Wenhao Xie, Jiaqi Chu

“…The transmission direction of principal stress can be changed by blasting pressure relief method; meanwhile, the transmission of principal stress can be blocked; through the comparison of microseismic activity law before and after pressure relief, pressure relief effect is good. …”
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Apoptosis in the liver of male <em>db/db</em> mice during the development of obesity and type 2 diabetes by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, M. A. Cherepanova, D. V. Vasendin, E. L. Zavjalov

“…The Bcl-2/Bad expression area ratio in 10-week-old animals was twice as high as in 18-week-old animals, which indicates the presence of conditions for blocking apoptosis in the liver of younger db/db mice. …”
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Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease by Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu

“…Moreover, ALB+KRT7+ epithelium‐derived ALD organoids promote the tumour growth by activating Wnt/β‐catenin signalling of liver cancer cells. Most importantly, blocking the Wnt protein secretion or knockdown the Wnt receptor suppressed the tumour promoting effect of ALD organoids. …”
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The expression of apoptosis-regulating proteins Bcl-2 and Bad in liver cells of C57Bl/6 mice under light-induced functional pinealectomy and after correction with melatonin by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, A. Yu. Letyagin, M. A. Korolev, E. L. Zavjalov

“…Thus, melatonin treatment of animals cancels the effect of LIFP, restoring the Bcl-2 expression area and increasing this protein concentration, which indicates an increase in antiapoptotic protection and creates conditions for blocking the development of the “mitochondrial branch” of apoptosis in liver cells.…”
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A ten-year evaluation of central nervous system cystic echinococcosis in a highly endemic area of Iran: Molecular epidemiology and clinicopathological characteristics by Mohsen Najjari, Ali Dehesht Manesh, Shahab Rezaeian, Bibi Razieh Hosseini Farrash, Mohammad Ali Mohammadi, Mohammad Ebrahimipour

“…Demographic and clinicopathological data were collected for CNS echinococcosis cases and formalin-fixed paraffin-embedded (FFPE) blocks were used for molecular analysis. The total prevalence of CNS echinococcosis cases was 1. 8 %. …”
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MyD88 inhibitor TJ-M2010-5 alleviates spleen impairment and inflammation by inhibiting the PI3K/miR-136-5p/AKT3 pathway in the early infection of Trichinella spiralis by Huifang Bai, Qianqian Dang, Guoliang Chen, Lingfeng Xie, Saining Wang, Ning Jiang, Xiaoxia Wu, Shuyan Zhang, Xuelin Wang

“…In conclusion, the study demonstrates that TJ-M2010-5 could effectively alleviate spleen impairment and reduce inflammation in mice infected with T. spiralis in its early stages by blocking the activation of PI3K/miR-136-5p/AKT3.…”
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Opioid-free versus opioid-based anesthesia in laparoscopic sleeve gastrectomy: a single-center, randomized, controlled trial by Hanane Barakat, Linda Gholmieh, Jessy Abou Nader, Vanda Yazbeck Karam, Obey Albaini, Mohamad El Helou, Rony Al Nawwar

“…All patients received intra-operative propofol, sevoflurane, a neuromuscular blocking agent, and ketamine. The primary outcome included opioid consumption during the post-anesthesia care unit (PACU). …”
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Scoping review to identify strategies and interventions improving interprofessional collaboration and integration in primary care by Roy Remmen, Kris Van den Broeck, Peter Pype, Peter Van Bogaert, Muhammed Mustafa Sirimsi, Hans De Loof, Kristel De Vliegher

“…The identified strategies and interventions were inductively categorised under five main themes: (1) Acceptance and team readiness towards collaboration, (2) acting as a team and not as an individual; (3) communication strategies and shared decision making, (4) coordination in primary care and (5) integration of caregivers and their skills and competences.Conclusions We identified a mix of strategies and interventions that can function as ‘building blocks’, for the development of a generic intervention to improve collaboration in different types of primary care settings and organisations.…”
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Organomineral fertilizer based on wood ash in bean cultivation in acidic tropical soil by Rackel Danielly de Souza Alves, Edna Maria Bonfim-Silva, Tonny José Araújo da Silva, Jakeline Rosa de Oliveira, Jholian Maicon Ribeiro-Santos, Luana Aparecida Menegaz Meneghetti

“…Method: The experimental design used was randomized blocks, in a 4x3 factorial scheme, corresponding to three levels of base saturation (no liming - 0%, V = 30% and V = 60%), and four fertilization treatments: mineral, wood ash, organomineral and granulated organomineral, with four replications. …”
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Influence of substituted quinones on the excretory function of the rat kidney and evaluation of the prospects of their use as potential diuretics by K.V. Sokolova, O.A. Podpletnya, S.О. Konovalova, A.P. Avdeenko, S.I. Kovalenko

“…Compounds AVD-6, AVD-7, AVD-8 and AVD-9, in contrast to Hydrochlorothiazide, which blocks carbonic anhydrase in the proximal part of the convoluted tubules and accelerates the excretion of potassium with from the urine, have a much lower excretory index as for these ions. …”
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LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure by Yongjuan Wang, Xiaoli Xie, Hongqun Liu, Huimin Liu, Huiqing Jiang

“…Besides, neutralization of CCL20 blocked the effects of LR12, thus inhibited the proliferation of LO2 cells in vitro, aggregated the liver inflammation, and restrained hepatocyte regeneration in ALF mice in vivo. …”
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Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury by Wenjun Zhang, Chao Guo, Yi Li, Hao Wang, Huabing Wang, Yingying Wang, Tingting Wu, Huinan Wang, Gang Cheng, Jiangwei Man, Siyu Chen, Shengjun Fu, Li Yang

“…Additionally, FUNDC1 overexpression reversed the effects of LW6 on the altered expression of light chain 3 (LC3) BII and voltage-dependent anion channels as well as blocked the effects of HIF-1α inhibition in cells. …”
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Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Conclusions In conclusion, our results unveil lactate as a key regulator of immune escape and BM fibrotic transformation in MF patients, suggesting MCT1 blocking as a novel antifibrotic strategy.…”
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