Why India is struggling to feed their young children? A qualitative analysis for tribal communities by Sanjay Sharma, Monica Lakhanpaul, Logan Manikam, Priti Parikh, Lorna Benton, Shereen Allaham, Rajesh Khanna, Susrita Roy, Marie Lall, Virendra Kumar Vijay, Neha Santwani, Hanimi Reddy, Hemant Chaturvedi, Satya Prakash Pattanaik, Tol Singh, Pramod Pandya, Priyanka Dang

“…The ultimate goal of the Participatory Approach for Nutrition in Children: Strengthening Health Education Engineering and Environment Linkages project is to identify challenges and opportunities for improvement to subsequently develop socioculturally appropriate, tailored, innovative interventions for the successful implementation of appropriate infant and young child feeding (IYCF) practices locally.Design Qualitative research method, involving five phases: (1) identification of local feeding practices; (2) identification of the local needs and opportunities for children aged 6–24 months; and (3–5) analysis of the gathered qualitative data, intervention design, review and distribution.Setting Nine villages in two community development blocks, that is, Ghatol and Kushalgarh, located in the Banswara district in Rajasthan, India.Participants 68 participants completed semistructured interviews or focus group discussions including: mothers, grandmothers, auxiliary nurse midwife, Anganwadi worker, ASHA Sahyogini, school teachers and local elected representative.Phenomenon of interest IYCF practices and the factors associated with it.Analysis Thematic analysis.Results Our results could be broadly categorised into two domains: (1) the current practices of IYCF and (2) the key drivers and challenges of IYCF. …”
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Prospects for mine geological work in the intelligence age: Architecture of the intelligent geological guarantee technology system for mine exploitation by Yucheng XIA, Xueyang SUN, Lintian MIAO, Chen GUO, Rongjun DU

“…., the intelligent management subsystem for fundamental geological survey information, the intelligent prediction and early warning subsystem for geologic hazards in mines, the intelligent monitoring, prediction, and early warning subsystem for ecosystems in mining areas, the intelligent identification subsystem for favorable mining blocks, and the transparent mining face subsystem), as well as their core modules. …”
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ROS anchor PAMPs-mediated extracellular HMGB1 self-association and its dimerization enhances pro-inflammatory signaling by Man Sup Kwak, Myeonggil Han, Yong Joon Lee, Seoyeon Choi, Jeonghwa Kim, In Ho Park, Jeon-Soo Shin

“…Despite treatment with H2O2, LPS, or LTA, HMGB1 dimerization was blocked in presence of Cys106 residue mutation, the ROS scavenger NAC, and the thiol-reducing agent DTT. …”
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Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro by Fenghua Zhou, Yan Shi, Sujun Tan, Xiaoli Wang, Weicheng Yuan, Shuqi Tao, Ping Xiang, Bin Cong, Chunling Ma, Di Wen

“….), unlike JWH-019. These effects were blocked by the selective cannabinoid receptor 1 (CB1R) antagonist AM251. …”
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Normalization of Cystic Fibrosis Immune System Reverses Intestinal Neutrophilic Inflammation and Significantly Improves the Survival of Cystic Fibrosis MiceSummary by Callie E. Scull, Yawen Hu, Scott Jennings, Guoshun Wang

“…CF neutrophils expressed significantly more iNOS and produced significantly more NO. Pharmaceutical blocking of iNOS significantly improved intestinal transit and survival of CF mice. …”
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Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice by Qi Li, Chenyi Wu, Zhenlong Liu, Huiqing Zhang, Yuna Du, Yuxiang Liu, Kuangyu Song, Qiaofa Shi, Rong Li

“…Many studies have proven that an attenuated Gram-positive bacterium induces sepsis in a CD38-blocking model. However, the pathogenesis of Gram-negative bacteria-induced sepsis in a CD38−/− mouse model remains unclear. …”
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Optimization of a microarray for fission yeast by Dong-Uk Kim, Minho Lee, Sangjo Han, Miyoung Nam, Sol Lee, Jaewoong Lee, Jihye Woo, Dongsup Kim, Kwang-Lae Hoe

“…Intriguingly, up-tags required 3× higher amounts of blocking oligonucleotides than down-tags. A 1:1 mix ratio between up- and down-tags was satisfactory. …”
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Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

“…These were followed by PET scans and biodistribution studies on nude mice bearing subcutaneous A375 cell-induced melanoma. [ 11 C]CEP-32496 showed high binding affinity for BRAF V600E -positive A375 melanoma cells and densely accumulated in the respective tissue sections; this could be blocked by the BRAF V600E selective antagonist sorafenib and by unlabeled CEP-32496. …”
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Identification of cepharanthine as an effective inhibitor of African swine fever virus replication by Chuanxiang Qi, Jiyoung Lee, Yongqiang Zhang, Huan Chen, Jiaxuan Lv, Zhenzhong Wang, Jinming Li, Xiaodong Wu, Yong-Sam Jung, Zhiliang Wang, Yingjuan Qian

“…Transcriptomic analysis suggested that CEP blocks ASFV entry through the clathrin-mediated endocytosis pathway by increasing EHD2 gene expression in macrophages. …”
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Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis by Fujun Yu, Zhongqiu Lu, Bicheng Chen, Peihong Dong, Jianjian Zheng

“…All these effects induced by lincRNA-p21 were blocked down by the loss of PTEN, suggesting that lincRNA-p21 suppressed HSC activation via PTEN. …”
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Assessing dynamic coastal vulnerability to climate hazards: A geospatial approach in Kakinada District, Andhra Pradesh, India by Ganni Satya Venkata Sai Aditya Bharadwaz, Indrajit Pal, Chitrini Mozumder, Mokbul Morshed Ahmad

“…Thondangi and Kakinada urban were identified as the most vulnerable blocks, requiring urgent adaptation and mitigation strategies. …”
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Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus by Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin

“…We found that pharmacological inhibition of sEH to stabilize endogenous EETs and exogenous 14,15-EET significantly increased the field excitatory postsynaptic potential (fEPSP) response in the CA1 area of the hippocampus, while additionally enhancing high-frequency stimulation- (HFS-) induced long-term potentiation (LTP) and forskolin- (FSK-) induced LTP. sEH inhibitor (sEHI) N-[1-(oxopropyl)-4-piperidinyl]-N’-[4-(trifluoromethoxy) phenyl)-urea (TPPU) and exogenous 14,15-EET increased HFS-LTP, which could be blocked by an N-methyl-D-aspartate (NMDA) receptor subunit NR2B antagonist. …”
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Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration by Wen Jie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao, Chongquan Huang, Jian Yuan Yang, Hon Cheung Lee, Yong Juan Zhao

“…It is activated by nicotinamide mononucleotide (NMN) to produce a calcium messenger, cyclic ADP-ribose (cADPR). This activity is blocked by elevated NAD level. Here, we verified this metabolic regulation in somatic HEK-293T cells by overexpressing NMN-adenyltransferase to elevate cellular NAD, which resulted not only in inhibition of their own SARM1 from producing cADPR but, surprisingly, also in the 5–10 neighboring wildtype cells in mixed cultures via connexin (Cx)-43. …”
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Accumulation Mechanism of Marine Shale Gas Reservoir in Anticlines: A Case Study of the Southern Sichuan Basin and Xiuwu Basin in the Yangtze Region by Kun Zhang, Yan Song, Shu Jiang, Zhenxue Jiang, Chengzao Jia, Yizhou Huang, Ming Wen, Weiwei Liu, Pengfei Wang, Xin Li, Tianlin Liu, Xuelian Xie, Chang’an Shan, Xiaoxue Liu, Xin Wang

“…This paper focuses on typical shale blocks in the southern Sichuan Basin and shale in the Upper Ordovician and the Lower Silurian. …”
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Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition by Zhi-Hui Zhang, Hai-Xin Yan, Ming-Dong Liu, Feng-Wen Niu, Kai Yao, Shi-Yao Feng, Xi Li, Yuan-Hua Chen, Dong-Dong Xie

“…Ly294002, a selective phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, suppressed the β-catenin/TCF4 complex activation and EMT through blocking Akt-mediated GSK-3β inactivation in the ''disruption complex'' in chronic NaAsO2 exposed DU145 and PC-3 cells. …”
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Modulation of iron metabolism by new chemicals interacting with the iron regulatory system by Yoshiaki Tsuji, Jun Ninomiya-Tsuji, Maurice Y.F. Shen, Benjamin R. DiFrancesco

“…We previously demonstrated that cisplatin was an inhibitor of the iron regulatory system by blocking IRP2 (iron regulatory protein 2) binding to an iron-responsive element (IRE) located in the 3′- or 5′-UTR (untranslated region) of key iron metabolism genes such as transferrin receptor 1 (TfR1) and ferritin mRNAs. …”
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Perceptions of healthcare workers on implementing the 2022 WHO verbal autopsy instrument in rural India through the existing public health system by Stuti Tripathi, Shefali Gupta, Sandeep Sharma, Saritha Nair, Geetha Menon, Bal Kishan Gulati, Jeetendra Yadav, Manjeet Singh Chalga, Chalapati Rao, Saurabh Sharma

“…Methods: This article is derived from a qualitative arm of study that was conducted in one of the blocks of Kanpur district, Uttar Pradesh. Frontline health workers (FHWs), as well as Medical Officers (MOs) serving in the Community Health Centre (CHC) area, were selected as study participants. …”
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Research on the basic theory and application of enhanced recovery in tight sandstone gas reservoirs by Gao Shusheng, Ye Liyou, Liu Huaxun, Zhang Jianzhong, Zhu Wenqing, An Weiguo

“…Our findings reveal: (1) Detailed characterization of the microscopic pore characteristics in tight sandstone reservoirs helps disclose the status and mechanisms of gas-water occurrence and the principal mechanisms of water production under gas-water co-sealing conditions, such as gas expansion, energy of water-sealed gas, movable water volume, and displacement pressure gradient; (2) Testing single-phase and gas-water two-phase seepage characteristics under bound water saturation identifies permeability and water saturation as critical parameters influencing gas seepage characteristics; (3) Inter-layer gas-water interaction flow experiments demonstrate the interference in multi-layer commingled production and introduce the concept of an interference index, a predictive model for well productivity and dynamic performance in the Sulige tight sandstone gas reservoir; (4) A model correlating reservoir recovery rates with drive indices has been developed, highlighting that increasing production pressure differential and reducing seepage resistance are the primary strategies for enhancing recovery rates in tight sandstone gas reservoirs, supplemented by six technological countermeasures including water-blocking, water control, and densifying well networks. …”
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miR-7-5p Promotes Hepatic Stellate Cell Activation by Targeting Fibroblast Growth Factor Receptor 4 by Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen

“…The miR-7-5p inhibitor blocked the lipopolysaccharide-induced proliferation and activation of LX-2 cells, and FGFR4 overexpression inhibited LX-2 cell proliferation and activation triggered by miR-7-5p. …”
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Effects of Land Uses on Soil Quality Indicators: The Case of Geshy Subcatchment, Gojeb River Catchment, Ethiopia by Melku Dagnachew, Awdenegest Moges, Asfaw Kebede Kassa

“…Accordingly, a total of 54 soil samples (three LU types × three slope classes (blocks) × three replications × two soil depths) were collected with an “X” plot design for data analysis. …”
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