Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP by Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan

“…These results revealed comparable disturbances induced by both compounds, including disruptions in nucleic acid synthesis and energy metabolism, blocking ADP to ATP conversion by reducing TCA cycle intermediates, consequently leading to ATP depletion. …”
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Most High-density Exoplanets Are Unlikely to Be Remnant Giant Planet's Cores by Zifan Lin, Saverio Cambioni, Sara Seager

“…There are two theories—metal-rich formation hypothesis and naked core hypothesis—that explain how formation and evolution can alter the compositions and structures of rocky planets to diverge from their primordial building blocks. Here we revisit the naked core hypothesis, which states that high-density planets are remnant cores of giant planets that remain in a fossil-compressed state, even after envelope loss. …”
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Learning and working on an interprofessional training ward in neonatology improves interprofessional competencies by Hannah L. Schwarz, Christine Straub, Sebastian F. N. Bode, Nicole Ferschl, Christian Brickmann, Christian Brickmann, Pascal O. Berberat, Marcus Krüger

“…We report on the concept and the results with regard to the interprofessional competencies of the participants, including parent satisfaction.MethodsSupervision by medical and nursing learning facilitators, 2week blocks each with 2 NT (n = 30) and 2 MS (n = 23) in their final year, ward-in-ward concept, 3 patients cared for. …”
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The large and central Caligo martia eyespot may reduce fatal attacks by birds: a case study supports the deflection hypothesis in nature by Iserhard, Cristiano Agra, Malta, Shimene, Penz, Carla, Fraga, Brenda Barbon, Costa, Camila Abel, Schwantz, Taiane, Bordin, Kauane Maiara

“…In both experiments facsimiles were placed in two forest sites, organized in 50 blocks with four facsimiles each, and checked for predator attacks every 24 h for five consecutive days. …”
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Maternal Diet Supplementation with n-6/n-3 Essential Fatty Acids in a 1.2 : 1.0 Ratio Attenuates Metabolic Dysfunction in MSG-Induced Obese Mice by Josiane Morais Martin, Rosiane Aparecida Miranda, Luiz Felipe Barella, Kesia Palma-Rigo, Vander Silva Alves, Gabriel Sergio Fabricio, Audrei Pavanello, Claudinéia Conationi da Silva Franco, Tatiane Aparecida Ribeiro, Jesuí Vergílio Visentainer, Elton Guntendeorfer Banafé, Clayton Antunes Martin, Paulo Cezar de Freitas Mathias, Júlio Cezar de Oliveira

“…Maternal flaxseed diet-supplementation decreased n-6/n-3 PUFAs ratio in the brain and pancreas and blocked glucose intolerance, insulin resistance, GIIS impairment, and obesity development. …”
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Echinococcal Cyst Blockade — the Rare Cause of Acute Pancreatitis and Obstructive Jaundice by S. A. Budzinskiy, S. G. Shapovaliants, R. V. Plakhov, M. V. Murashkina, E. A. Vorobyeva, D. R. Berdieva, P. V. Usyaky, E. D. Fedorov

“…Duodenoscopy revealed a fixed yellowish-white oval formation with transluent capsule, completely blocking bile and pancreatic juice outflow at the major duodenal papilla. …”
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Pericardial Involvement in Hereditary Hemorrhagic Telangiectasia by Abir Derbel, Mouna Snoussi, Raida Ben Salah, Faten Frikha, Leila Abid, Imed Frikha, Sameh Marzouk, Zouhir Bahloul

“…Only 500cc of hemorrhagic fluid could be aspirated before the needle became blocked. Unfortunately, one week after, re-accumulation of pericardial fluid and worsening occurred. …”
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Multiscale Adaptively Spatial Feature Fusion Network for Spacecraft Component Recognition by Wuxia Zhang, Xiaoxiao Shao, Chao Mei, Xiaoying Pan, Xiaoqiang Lu

“…Second, the multi-scale adaptively spatial feature fusion module within the Multi-ASFFD cascades four adaptively spatial feature fusion blocks to fuse low-level, middle-level, and high-level features at various scales to enrich the semantic information for different spacecraft components. …”
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Machine learning based identification of an amino acid metabolism related signature for predicting prognosis and immune microenvironment in pancreatic cancer by Xiaohong Liu, Xing Wang, Jie Ren, Yuan Fang, Minzhi Gu, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Jialu Bai, Decheng Jiang, Yuemeng Tang, Bo Ren, Lei You, Yupei Zhao

“…Amino acids play a prominent role in the occurrence and progression of pancreatic cancer as essential building blocks for protein synthesis and key regulators of cellular metabolism. …”
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Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells by Annarita Nappi, Vittoria D’Esposito, Caterina Miro, Alessia Parascandolo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Sepehr Torabinejad, Federica Restolfer, Maddalena Raia, Melania Murolo, Emery Di Cicco, Pietro Formisano, Monica Dentice

“…Conclusions: Thus, we argue that intracellular activation of THs via D2 is a critical requirement for invasive and metastatic conversion of breast cancer cells, advising the blocking of D2 as a potential therapeutic tool for cancer therapy.…”
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Doctors’ satisfaction with the rehabilitation system for anti-terrorist operation participants: A factor analysis by Irina Holovanova, Oleksandr Havlovsky, Shanshan Wang, Oleksandr Korneta, Maksym Khorosh, Igor Kaydashev, Renee Robinson, Ubydul Haque

“…The questionnaire consisted of three blocks: 1) Main characteristics of the existing system of rehabilitation of ATO veterans (14 items); 2) Strengths of the existing system of rehabilitation of ATO veterans (11 items); and 3) Weaknesses of the existing system of rehabilitation of ATO veterans (8 items). …”
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WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation by Mario Mauthe, Wenqi Yu, Oleg Krut, Martin Krönke, Friedrich Götz, Horst Robenek, Tassula Proikas-Cezanne

“…Moreover, the number of WIPI-1 positive autophagosome-like vesicles entrapping Staphylococci significantly increased upon (i) lysosomal inhibition by bafilomycin A1 and (ii) blocking PIKfyve-mediated PtdIns(3,5)P2 generation by YM201636. …”
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Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis by Xinxin Zhou, Mengting Ren, Jinpu Yang, Hanghai Pan, Mosang Yu, Feng Ji

“…Furthermore, curcumin administration greatly blocked the protein kinase-like endoplasmic reticulum kinase- (PERK-) eukaryotic translation initiation factor 2α- (eIF2α-) activating transcription factor 4- (ATF4-) CHOP signaling pathway. …”
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CDK4/6 inhibitors promote PARP1 degradation and synergize with PARP inhibitors in non-small cell lung cancer by Carlos M Roggero, Anwesha B Ghosh, Anvita Devineni, Shihong Ma, Eliot Blatt, Ganesh V. Raj, Yi Yin

“…We then confirmed that combining PARPi and CDK4/6i blocked the growth of NSCLC xenografts in vivo and patient-derived explant models ex vivo. …”
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The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion by Ping Wang, Min Cong, Tianhui Liu, Aiting Yang, Guangyong Sun, Dong Zhang, Jian Huang, Shujie Sun, Jia Mao, Hong Ma, Jidong Jia, Hong You

“…Our previous data found that epidermal growth factor (EGF) blocks and reverses TGF-β1-induced transition. The aim of this study is to determine the characteristic changes of hepatic progenitors after TGF-β1-induced transition and EGF-induced reversion. …”
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Anti-Inflammatory Effect of Columbianetin on Lipopolysaccharide-Stimulated Human Peripheral Blood Mononuclear Cells by Junying Lu, Keyong Fang, Shiji Wang, Lingxin Xiong, Chao Zhang, Zhongmin Liu, Xuewa Guan, Ruipeng Zheng, Guoqiang Wang, Jingtong Zheng, Fang Wang

“…Furthermore, the inhibitory effects of CBT on NOD1/NF-κB pathways were blocked by ML130. These findings indicated that CBT inhibits the production of inflammatory cytokines induced by LPS involved in the downregulation of NOD1/NF-κB pathways.…”
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Bullatine A suppresses glioma cell growth by targeting SIRT6 by Zhi Wang, Yushuai Zhu, Can Luo, Fan Zhang, Jiannong Zhao, Chuanyi Fu

“…Mechanistic studies revealed that the effect of BLA on inducing apoptosis and inhibiting the proliferation of glioma cells was blocked by SIRT6 knockout. In summary, our study indicated that BLA is a potential therapeutic agent for glioma that targets SIRT6 to inhibit glioma cell proliferation and induce apoptosis.…”
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Telbivudine Treatment during Late Pregnancy Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Retrospective Study by Mengzhi Cai, Yanli Hao, Jianxin Zhong, Wei Yao, Xia Cao, Guifang Gu, Gang Qin

“…To investigate the efficacy of telbivudine (LdT) in blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) during late pregnancy. …”
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Microstructural, Morphological, and Magnetic Effects of NiFe₂O₄ Shell Formation Around Nanospherical ZnFe₂O₄ Cores by Marija Šuljagić, Vuk Uskoković, Lukasz Kilanski, Sabina Lewinska, Abdul Khaliq, Anna Ślawska-Waniewska, Aleksandar Kremenović, Vladimir Pavlović, Dejan A. Jeremić, Ljubica Andjelković

“…These effects combined led to improved spin coupling and stronger magnetism, as evidenced by higher saturation magnetization and the doubling of the blocking temperature for the ZnFe₂O₄@NiFe₂O₄ core–shell particles relative to the ZnFe₂O₄ cores.…”
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Osimertinib exacerbates immune checkpoint inhibitor-related severe adverse events by activating the IL-6/JAK/STAT3 pathway in macrophages by Yuan Li, Yanping Chen, Yuan Meng, Meng Shen, Fan Yang, Xiubao Ren

“…RNA-seq and simple Western blot analysis of mouse liver macrophages confirmed that that the IL-6/JAK/STAT3 pathway was activated in the combination treatment group. Ruxolitinib blocked the IL-6/JAK/STAT3 pathway and significantly decreased the serum IL-6, ALT, and ferritin levels in the combination treatment group. …”
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