Detailed cytogenetic analysis of three duck species (the northern pintail, mallard, and common goldeneye) and karyotype evolution in the family Anatidae (Anseriformes, Aves) by V. R. Beklemisheva, K. V. Tishakova, S. A. Romanenko, D. A. Andreushkova, V. A. Yudkin, E. А. Interesova, F. Yang, M. A. Ferguson-Smith, A. S. Graphodatsky, A. A. Proskuryakova

“…Additionally, in this species, the presence of massive heterochromatic blocks in most macroautosomes and sex chromosomes was discovered. …”
Get full text

PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling by Qinghui Zhang, Shihao Xiang, Qingqian Liu, Tao Gu, Yongliang Yao, Xiaojie Lu

“…Moreover, PI3K/AKT signaling or PDE5 blocked the above response of PPARγ. Conclusion. sGC/cGMP/PKG and PI3K/AKT signals act on PPARγ synergistically to attenuate hypoxia-induced HSC activation.…”
Get full text

NcSWP8, a New Spore Wall Protein, Interacts with Polar Tube Proteins in the Parasitic Microsporidia <i>Vairimorpha (Nosema) ceranae</i> by Pengfei Wang, Dufu Li, Qianmin Hai, Siming Liu, Yueyue Zhang, Jun Zhang, Jinshan Xu, Zhengang Ma, Zeyang Zhou

“…Co-immunoprecipitation and Far-Western blotting experiments demonstrated that NcSWP8 could stably interact with polar tube proteins, NcPTP2 and NcPTP3. The antibody blocking assay significantly decreased their infection rate, indicating that NcSWP8 played a significant role in the process of <i>V. ceranae</i> infection. …”
Get full text

Engineering p‐Orbital States via Molecular Modules in All‐Organic Electrocatalysts toward Direct Water Oxidation by Li‐Hong Yu, Xue‐Feng Zhang, Zi‐Ming Ye, Hong‐Gang Du, Li‐Dong Wang, Ping‐Ping Xu, Yuhai Dou, Li‐Ming Cao, Chun‐Ting He

“…Optimized combination of benzodioxazole/benzodiimide‐based building blocks achieves an impressive applied potential of 1.670 ± 0.004 V versus reversible hydrogen electrode (RHE) and 1.735 ± 0.006 V versus RHE to deliver enhanced current densities of 0.5 and 1.0 A cm−2, respectively. …”
Get full text

Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review by Rahul G. Matnani, Rachel L. Stewart, Joseph Pulliam, Chester D. Jennings, Melissa Kesler

“…Gene rearrangement studies performed on paraffin blocks demonstrated monoclonal T-cell receptor gamma chain rearrangement with no evidence of clonal heavy chain rearrangement. …”
Get full text

Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade by Chun-Bing Chen, Shuen-Iu Hung, John Wen-Cheng Chang, Chan-Keng Yang, David Hui-Kang Ma, Yu-Chuan Teng, Chun-Wei Lu, Wei-Ti Chen, Hsiao-Yin Yang, Cheng-Chang Tsai, Chih Liang Wang, Pin-Hsuan Chiang, Jennifer Wu, Ya-Wen Tsai, Lai-Ying Lu, Yang Yu-Wei Lin, Rosaline Chung-Yee Hui, Fu-Mei Hsieh, Chao-Kai Hsu, Chaw-Ning Lee, Yi-Ju Chen, Chih-Chiang Chen, Yilei Cui, Hung-Chih Hsu, Ya-Ching Chang, Chih-Jung Chang, Ho-Chen Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Chuang-Wei Wang, Wen-Hung Chung

“…ScRNA expression profiles and ex vivo blocking studies further identify TNF signaling as a pathway responsible for macrophage-derived CXCL10 and CTL activation. …”
Get full text

The potential of polyphenol compounds in grapes to reduce oxidative stress and inflammation after exercise: systematic review by Novadri Ayubi, Atika Syafawi, Anton Komaini, Dhea Regita Sastika Putri, Ilham Ilham, Deby Tri Mario, Dyah Fitria Padmasari, Junian Cahyanto Wibawa, Procopio B. Dafun Jr.

“…In this case, grapes work by blocking several inflammatory pathways and decreasing inflammatory markers. …”
Get full text

IL-34 aggravates myocardial ischemia-reperfusion injury by upregulating the HMGB1-IL-17A-IL-6 axis through the JAK signaling pathway. by Ruisong Ma, Xiaochun Hu, Wenwen Fu, Xiaorong Hu

“…Together, these results showed that IL-34 aggravates MI/R injury by inducing the expression of the HMGB1-IL-17A-IL-6 axis and apoptosis after MI/R, which is partially dependent on the JAK pathway. Therefore, blocking the JAK signaling pathway or inhibiting IL-34 expression might provide a new idea to reduce MI/R injury, but further researches are needed.…”
Get full text

Spatiotemporal requirements of nuclear β-catenin define early sea urchin embryogenesis. by Guy Lhomond, Michael Schubert, Jenifer Croce

“…In this study, we used an inducible, conditional knockdown system in the sea urchin to characterize all possible requirements of β-catenin for germ layer establishment and patterning. By blocking β-catenin protein production starting at 7 different time points of early development, between fertilization and 12 h post fertilization, we established a clear correlation between the position of a germ layer along the primary embryonic axis (the animal-vegetal axis) and its dependence on nuclear β-catenin activity. …”
Get full text

The electroweak effective field theory from on-shell amplitudes by Gauthier Durieux, Teppei Kitahara, Yael Shadmi, Yaniv Weiss

“…The most general massive three-point amplitudes consistent with these symmetries are derived and studied in detail, as the primary building blocks for the construction of scattering amplitudes. …”
Get full text

Psychological Well-Being in Adolescents with Different Types of Socialization by Elena N. Volkova

“…Constructive relationships both in case of positive socialization and in case of traumatic and even deviant socialization determine the success of socialization processes or possibilities of successful socialization, while violation of relationships and interaction blocks the positive development of sociality and attitude to oneself.…”
Get full text

K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. by Joanne Van Der Velden, Grace Sum, Donna Barker, Emmanuel Koumoundouros, Garry Barcham, Heike Wulff, Neil Castle, Peter Bradding, Kenneth Snibson

“…<h4>Conclusions</h4>These findings suggest that K(Ca)3.1-activity contributes to allergen-induced airway responses, inflammation and vascular remodelling in a sheep model of asthma, and that inhibition of K(Ca)3.1 may be an effective strategy for blocking allergen-induced airway inflammation and hyperresponsiveness in humans.…”
Get full text

The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment. by William R Hardin, Germain C M Alas, Nikita Taparia, Elizabeth B Thomas, Melissa C Steele-Ogus, Kelli L Hvorecny, Aaron R Halpern, Pavla Tůmová, Justin M Kollman, Joshua C Vaughan, Nathan J Sniadecki, Alexander R Paredez

“…A flangin truncation mutant stabilizes the flange and blocks cytokinesis, indicating that flange disassembly is necessary for rapid myosin-independent cytokinesis in Giardia. …”
Get full text

Soil nutrients, microbial biomass, and crop response to organic amendments in rice cropping system in the Shiwaliks of Indian Himalayas by Richa Rajput, Priya Pokhriya, Pooja Panwar, A. Arunachalam, Kusum Arunachalam

“…Recycled waste of rice–wheat agrosystem is utilized to determine optimal sustainable solution for hilly areas. Methods Randomly blocked design experiment was conducted with rice plants, each amended with organic inputs including rice straw residue (T1), rice biochar (T2), rice compost (T3), wheat straw residue (T4), wheat biochar (T5), wheat compost (T6), mix of wheat + rice compost (T7), green manure (T8) and control (no amendment). …”
Get full text

Enamel Matrix Derivative Enhances the Odontoblastic Differentiation of Dental Pulp Stem Cells via Activating MAPK Signaling Pathways by Beidi Zhang, Min Xiao, Xiaogang Cheng, Yu Bai, Hanze Chen, Qing Yu, Lihong Qiu

“…The results revealed that EMD did not interfere with DPSCs proliferation but promoted the odontoblastic differentiation of DPSCs in vitro and in vivo. Furthermore, blocking the MAPK pathways suppressed the EMD-enhanced differentiation of DPSCs. …”
Get full text

Augmented Feedback Response Prediction by Peak Vertical Ground Reaction Force in Adolescent Female Athletes by Hannah Jaime, Drew Rutherford, Becky Heinert, C. Nate Vannatta, Sherwin Toribio, Thomas W Kernozek

“…When change in vGRF was assessed following two blocks of augmented feedback training, prediction of responders improved with post-feedback vGRF and transfer vGRF (R2=0.911 and R2=0.761)…”
Get full text

In Vitro and In Vivo Evaluation of Alexa Fluor 680-Bombesin[7–14]NH Peptide Conjugate, a High-Affinity Fluorescent Probe with High Selectivity for the Gastrin-Releasing Peptide Rec... by Lixin Ma, Ping Yu, Bhadrasetty Veerendra, Tammy L. Rold, Lauren Retzloff, Adam Prasanphanich, Gary Sieckman, Timothy J. Hoffman, Wynn A. Volkert, Charles J. Smith

“…Confocal fluorescence microscopy images of Alexa Fluor 680-G-G-G-BBN[7–14]NH 2 in human T-47D breast cancer cells indicated specific uptake, internalization, and receptor blocking of the fluorescent bioprobe in vitro. In vivo investigations in SCID mice bearing xenografted T-47D breast cancer lesions demonstrated the ability of this new conjugate to specifically target tumor tissue with high selectivity and affinity.…”
Get full text

Features of the use of innovative technologies in the personnel management system by Іryna Dashko, Liubomyr Mykhailichenko

“…It was determined that the system of modular education and personnel development is gaining particular popularity, which involves the development of a program for the development of individual categories of personnel based on a set of thematic, interconnected blocks or so-called modules. The main areas of application of innovative technologies in the personnel management system are substantiated. …”
Get full text

An Experimental Study on Coal Fines Migration during Single Phase Water Flow by Wenlong Han, Yanbin Wang, Jingjing Fan, Yong Li, Xiang Wu, Yun Yu

“…The fractures can be totally blocked by coal fines, while penetration also happened during the flooding process, causing permeability fluctuation. …”
Get full text

Peptide nucleic acid (PNA) clamps reduce amplification of host chloroplast and mitochondria rRNA gene sequences and increase detected diversity in 16S rRNA gene profiling analysis... by Usman Hussain, Jim Downie, Amy Ellison, Sandra Denman, James McDonald, Marine C. Cambon

“…Peptide Nucleic Acid (PNA) clamps prevent this by blocking PCR primer binding or binding within the amplified region of non-target DNA to stop the function of DNA polymerase. …”
Get full text